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Current Medicinal Chemistry

Author(s): F. Fulop, I. Szatmari, E. Vamos, D. Zadori, J. Toldi and L. Vecsei

DOI: 10.2174/092986709789909602

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Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives

Page: [4828 - 4842] Pages: 15

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Abstract

The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.

Keywords: Kynurenic acid, kynurenic acid derivatives, neurological disorders, schizophrenia, retinal damage, diabetes mellitus, hypertension