Abstract

Coupled Plasma Mass Spectrometry (ICP-MS) has emerged as a powerful analytical technique for trace element analysis, finding widespread applications across diverse fields such as pharmaceuticals, food safety, and biological sciences. This technique is known for its exceptional sensitivity and capability to measure multiple elements simultaneously. Moreover, it provides critical insights into heavy metal and trace element content in diverse matrices, making it an indispensable tool in scientific research and regulatory compliance. Also, it plays a pivotal role in ensuring compliance with regulatory standards and safeguarding human health and the environment. Its sensitivity, versatility, and ability to provide accurate elemental analysis make it an invaluable tool for researchers, regulators, and industries alike. As technological advancements continue, addressing challenges and refining methodologies will further elevate the capabilities of ICP-MS in trace element analysis. The review discussed the various research performed using ICP-MS to detect heavy metals in raw materials, APIs, excipients, packaged food, seafood, blood samples, human hair, etc. Further, it mentioned the impact of higher concentrations of toxic metals on human health. This article provides a concise overview of ICP-MS, encompassing its principles, applications, and challenges, and highlighting its pivotal role in various fields.

Keywords: Heavy metals, ICP-MS, pharmaceutical, food analysis, biological samples.