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Current Alzheimer Research

Author(s): Zhi Hao Lim*, Junhong Yu, Sangita Kuparasundram, Rathi Mahendran and Ted Kheng Siang Ng

DOI: 10.2174/0115672050342857241025091918

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Associations between Physical Performance Tests with Cognitive Changes: The Moderating Effect of Cognitive Status

Page: [423 - 436] Pages: 14

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Abstract

Introduction/Objective: Age-related cognitive decline has been linked with risk factors, including physical performance. Prior studies investigating such associations were typically conducted in clinical settings within Western populations with a frequent focus on late neurocognitive diagnostic stages (i.e., Alzheimer’s disease), reducing their generalizability to the Asian population and early neurocognitive stages. To address these knowledge gaps, our study investigated longitudinal associations between physical performance measures at baseline and cognitive change in global cognition, executive functioning (EF) based and non-executive functioning (non- EF) based cognitive domains within the Singaporean population. The moderating role of early neurocognitive status, namely mild cognitive impairment (MCI) and cognitively normal (CN), was also examined.

Methods: This paper examined data from 347 participants (CN = 284; MCI = 63) who participated in the Community Health and Intergenerational (CHI) study at baseline and follow-up. Data from a neurocognitive battery and three physical performance tests, namely the timed-up and go (TUG), fast gait speed (FGS) and 30-second chair-stand test (30s-CST), were analysed using multivariate linear regression models.

Results: Only one significant association between FGS scores and cognitive change in Semantic Fluency was observed; other associations were not significant. Cognitive status also significantly moderated associations between TUG/30s-CST tasks with several neurocognitive tests.

Conclusion: The lack of significant longitudinal associations between baseline physical performance measures and cognitive change differed from findings in the literature. Nevertheless, the moderating role of cognitive status further highlighted the need to account for cognitive status when exploring such associations within a heterogeneous group of older adults without dementia.

Keywords: Cognitive dysfunction, physical functional performance, Alzheimer’s disease, dementia, neuropsychiatric, executive functioning.

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