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Protein & Peptide Letters

Author(s): Virendra S. Gomase*, Suchita P. Dhamane and Pavan G. Kakade

DOI: 10.2174/0109298665333029240926092919

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Immunoproteomics: A Review of Techniques, Applications, and Advancements

Page: [827 - 849] Pages: 23

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Abstract

Immunoproteomics is the branch of proteomics with an emphasis on the study of functional peptides and proteins related to the immune system. Combining proteomics techniques with immunological research aims to uncover the complex interactions of proteins involved in immune responses. This review discusses the methods, applications, and recent advancements in immunoproteomics, highlighting its critical role in understanding immune responses, discovering biomarkers, and developing vaccines and therapeutics. This study offers a comprehensive exploration of the methodologies, applications, and advancements within immunoproteomics. Techniques such as mass spectrometry, antibody-based assays, and computational analysis are pivotal in unraveling the complexities of the immune system at the protein level. Immunoproteomics finds diverse applications in biomarker discovery, vaccine development, autoimmune disease research, infectious disease diagnostics, and cancer immunotherapy. Challenges, including data integration, sample heterogeneity, and biomarker validation, persist, necessitating innovative approaches and interdisciplinary collaborations. In the future, immunoproteomics will likely play a major role in expanding our knowledge of immune-related diseases and accelerating the creation of targeted and precise immunotherapies.

Keywords: Immunoproteomics, immunotherapies, mass spectrometry, antibody-based assays, computational analysis, cancer immunotherapy.

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