Abstract

Introduction: Cancer, diabetes, and infection of bacteria and fungi are serious issues in the world. Synthesis of the potential drugs against them is a major challenge to the researcher. Hence, coordination chemistry has attracted researchers as it has various applications in medicinal and biological fields.

Methods: Synthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and VO(II) metal complexes were carried out. These compounds were characterized by Mass, 1H-NMR, FT-IR, Elemental analysis, Molar conductance, Magnetic susceptibility, UV-Vis., P-XRD, TGA, etc., and were screened for biological activities.

Result: Synthesised azo-Schiff base ligand and its metal complexes were evaluated for their antimicrobial, antidiabetic as well as anticáncer activities against various bacteria and fungi and MCF-7 breast cancer cell line, respectively.

Conclusion: From the findings of various results, we can conclude that the synthesized metal complexes exhibit higher biological activities than the azo-Schiff base ligand.

Keywords: Azo-aldehyde, Antifungal, Antibacterial, Coordination, Bromosalicylaldehyde alpha-amylase.