Abstract

Endophytes are an appealing source of natural products with unique structures that can aid in the treatment of life-altering disorders because of the complexity and structural variety of the secondary metabolites they produce. The genus Cladosporium, which belongs to family Cladosporiaceae, class Dothideomycetes has received more attention due to the isolation of various classes of compounds with unique structures mainly alkaloids, azaphilones, benzofluoranthenones, coumarins, isocumarins, lactones, naphthalenones, macrolides, perylenequinones and steroids that exhibited diverse biological activities as: antiviral, antimicrobial, anti-inflammatory, antidiabetic, phytotoxicity and anti-Alzheimer, whereas anticancer compounds predominated. This review focuses on the isolated secondary metabolites from genus Cladosporium specifically, C. cladosporioides, C. sphaerospermum, C. herbarum, C. halotolerans, C. tenuissimum, C. oxyspormum, C. perangustum, C. uredinicola, C. colocasiae, C. delicatulum and C. phlei due to their exquisite bioactivity, the source of the strains, the culture media, the biological potential of isolated secondary metabolites and covers the literature from 2000 to 2023.

Keywords: Cladosporium, secondary metabolites, antimicrobial, cytotoxicity, culture media, endophytic fungi.