Recent Advances in Anti-Infective Drug Discovery

Author(s): Asad Ahmad, Juber Akhtar*, Mohammad Ahmad, Badruddeen, Mohammad Irfan Khan, Aditya Singh and Anas Islam

DOI: 10.2174/0127724344318310241018113206

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Bedaquiline Delivery Innovations: A Review on Advancing MDR-TB Treatment Strategies

Page: [92 - 111] Pages: 20

  • * (Excluding Mailing and Handling)

Abstract

Multidrug-resistant tuberculosis (MDR-TB) poses a persistent challenge to global health, necessitating continuous efforts to enhance treatment efficacy. Bedaquiline, a cornerstone in MDR-TB management, presents biopharmaceutical challenges that impact its therapeutic potential. This review provides a comprehensive analysis of recent innovations in drug delivery strategies designed to optimize Bedaquiline's efficacy and improve MDR-TB treatment outcomes. Through a systematic examination of various delivery systems, including nanotechnology and formulation advancements, we explore their potential in addressing drug solubility and bioavailability challenges. Emphasizing the integration of Quality by Design (QbD) principles, this review aims to present a cohesive overview of evolving Bedaquiline delivery innovations, providing valuable insights for researchers and healthcare practitioners working towards advancing MDR-TB treatment strategies.

Keywords: Bedaquiline, multidrug resistance, tuberculosis, systematic, bioavailability drug delivery, MDR-TB Treatment.