Abstract

Neurodegenerative disorders (NDs) are one of the prominent worldwide issues recently. Neurodegenerative disorders, like amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease, are characterized by ongoing neuronal failure and loss of structure and function, which ultimately results in neuronal death. There are many established synthetic approaches to target pathogenesis of NDs and to mitigate it but having several challenges researchers are now focusing the significant use of plant derived bio-active constituents against several NDs which ultimately leads safer and potent results. Among these phyto-compounds such as carotenoids, essential oils, essential fatty acids, polyphenols, have attracted great animus due to their strong antioxidant and anti-incendiary properties effective against NDs. Considering these green compounds having significant role to manage various NDs as potent therapeutic approach, we reviewed the sources, application, safety and clinical aspects of phyto-constituents against NDs.

Keywords: Neurodegeneration disorder, phytoconstituents, pharmacological activities, nano carriers, blood brain barrier, neuroprotection, clinical trials, patents.