Abstract

Liver diseases pose a significant global health concern, particularly prevalent in developing nations, often induced by chemical exposure and high drug doses. Hepatic toxicity not only affects liver function but also extends to adjacent tissues, leading to diminished overall body function and necessitating effective treatment strategies. Despite modern medical advancements, stimulating liver function, protecting against damage, and promoting cell regeneration remain challenging tasks. Novel Drug Delivery Systems (NDDS), notably nanoemulsions, present promising avenues for addressing hepatic disorders. Nanoemulsions, characterized by biphasic dispersions of immiscible liquids stabilized by surfactants, possess unique drug-loading capabilities and viscoelastic properties that render them ideal candidates for liver-related conditions. However, their development, manufacturing, and manipulation for hepatic disorders are constrained by the partial applicability of conventional emulsion principles. This comprehensive review delves into various aspects of liver function, disease types, nanoemulsions, associated limitations and challenges, ongoing clinical trials, patents, and their inherent advantages. By shedding light on recent advancements in Nanoemulsion for hepatoprotective activity management, the review aims to illuminate the potential of tailored drug delivery systems in revolutionizing hepatic disease management. Exploring Nanoemulsion for hepatoprotective activity management signifies a crucial step toward offering targeted and efficient treatment modalities for liver diseases. Harnessing the unique capabilities of nanoemulsions could lead to significant improvements in patient outcomes and quality of life, thereby addressing the pressing global health concern posed by hepatic disorders.

Keywords: Hepatic diseases, nanoemulsion, limitations and challenges, advantages, clinical trial and patents.