Abstract

The multifaceted nature of Schiff bases and their metal complexes has garnered significant attention in the realm of coordination chemistry. Schiff bases are flexible ligands that have been frequently employed to form metal complexes via the nitrogen and oxygen atoms. This unique interaction imparts distinctive properties to the resulting complexes, rendering them valuable in various fields in catalysis, materials research, and bioinorganic chemistry. This comprehensive review delves into the specific aspects of antimicrobial activities associated with Schiff bases and their corresponding metal complexes. Understanding the interaction between Schiff bases and DNA is crucial in elucidating their potential therapeutic applications. Additionally, the antimicrobial activities underscore the diverse pharmacological implications of these compounds, providing insights into their role in drug development and disease treatment.

Keywords: Schiff bases, metal complexes, antimicrobial, DNA binding, anticancer, flexible ligands.