Abstract

Mycobacterium tuberculosis is the primary cause of tuberculosis (TB), which accounts for over two million deaths annually and is the leading infectious illness. Because of their significant therapeutic capabilities, a number of natural compounds, such as terpenoids generated from natural sources, have attracted interest in recent decades. Terpenoids have several different structures, displaying a variety of actions and modes of action. Some natural terpenoids and their derivatives have been selected as prototype molecules for the development of new anti-tubercular medications due to their strong anti-tubercular activity against Mycobacterium tuberculosis. This study assessed the roles and mechanisms of terpenoids. In this review article, we offer recent findings about the anti-tubercular activity of terpenoids.

Keywords: Terpenoids, drug discovery, tuberculosis, mycobacterium tuberculosis, natural products, secondary metabolites.1