Abstract

Introduction: Fungal infections are growing more rapidly and becoming a public health concern worldwide. The use of herbal medicines is now increasing due to their many functional properties with fewer side effects. Emblica officinalis, an important medicinal plant, exhibits many therapeutic properties.

Methods: In this article, the active phytoconstituents of Emblica officinalis were explored for their multitargeting activity as anti-inflammatory and antifungal by computational analysis.

Results: A total of nine phytoconstituents including 3,6-di-O-galloyl-D-glucose, Mucic acid- 1,4-lactone-2-O-gallate, Mucic acid-1,4-lactone-5-O-gallate, Mucic acid-1,4-lactone-3-O-gallate, Mucic acid-1,4-lactone-3,5-di-O-gallate, 2,6-dimethoxy-4-(2-hydroxyethyl)phenol-1-Obeta- D-glucopyranoside, Apigenin-7-O-(6'-butyryl-beta-glucopyranoside), S-eriodictoyl-7-O- (6'-O-trans-p-coumaryl)-beta-D-glucopyranoside, and 1,2,3,4,6-penta-O-galloyl glucose showed better results as compared to standard drugs taken in the study.

Conclusion: Further, these constituents indicated good ADME properties during the SwissADME online analysis.

Keywords: Herbal, Emblica officinalis, anti-inflammatory, anti-fungal, multitargeting, ADME properties.