Current Drug Metabolism

Author(s): Lu Tian*, Guiqin Liu, Junjun Han and Xiangyang Li*

DOI: 10.2174/0113892002318723240802100729

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Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism

Page: [416 - 424] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism and mechanisms of drug action, impacting medication therapy's effectiveness. This review aims to provide a theoretical basis for the treatment of central nervous system diseases in high-altitude areas by summarizing the progress and mechanism of sedative-hypnotics in hypoxic environments, as well as the impact of high-altitude hypoxia on sleep.

Keywords: Drug metabolism, sedative-hypnotics, sleep disorders, high-altitude hypoxia, drug transport, rational use of drugs.