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Current Organic Chemistry

Author(s): Roosenilson Muniz, Mateus J. Matos, Alex de N. de Oliveira, André L.M. Porto, Alexander Pokutsa, Francisco F. Oliveira, David E.Q. Jimenez and Irlon M. Ferreira*

DOI: 10.2174/0113852728310688240711064139

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“Green” Synthesis of Substituted Tetraketones with Prominent Bactericide Effect

  • * (Excluding Mailing and Handling)

Abstract

Effective and “green” synthesis of tetraketone derivatives was elaborated. The last compounds developed prominent bactericide activity against both MIC and MBC S. aureus (ATCC-6538P) bacteria. The novelty of this approach is concluded in the application of Al(OH)3 catalyst for the Knoevenagel-Michael cascade reaction of aromatic aldehydes and 1,3-cyclic diketones in water. The process is chemoselective and affords high yield of tetraketones under benign conditions. The catalyst maintained 80% of initial activity within four cycles. The proposed method can be regarded as an alternative to the existing syntheses of biologically active tetraketones that utilize homogeneous and expensive heterogeneous catalysts.

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