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Current Organic Chemistry

Author(s): Dhanaji M. Mohite, Pandurang M. Chavhan and Arghya Basu*

DOI: 10.2174/0113852728311593240626091836

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Modified Microwave-assisted Solid-liquid Halex Reaction using Phosphonium Salt as Efficient and Robust Phase Transfer Catalyst

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Abstract

A modified solid-liquid halex reaction was developed in the presence of a robust phase transfer catalyst under microwave conditions. A fast, mild, and practical microwave- assisted synthesis of 2,3-difluoro-5-chloropyridine 3 starting from 2,3,5- trichlorpyridine 1 and spray-dried KF in polar aprotic solvent was developed. The addition of Tetrakis (piperidino) phosphonium chloride as phase transfer catalyst A was studied under microwave irritation (450W) and increased the yield and significantly reduced the reaction time in contrast to the conventional heating procedure. The highest reaction rate was observed at 5 wt% phase transfer phosphonium salt catalyst to 2,3,5-trichloropyridine 1.

Keywords: 2, 3, 5-Trichloropyridine, Halex reaction, KF, phosphonium salt, phase transfer catalyst, microwave.

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