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The International Journal of Gastroenterology and Hepatology Diseases

Author(s): Tarun Sharma, Md. Moidul Islam, Akshay Kumar Lunawat and Sarjana Raikwar*

DOI: 10.2174/0126662906299154240613083710

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Targeting to Overexpressed Receptor in Colon Cancer: A Review

Article ID: e080724231732 Pages: 8

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Abstract

Colon cancer is a major global health concern characterized by complex interactions of genetic, environmental, and lifestyle factors. The "hallmarks of cancer" encompass various distinctions between cancerous and normal tissues, including vascular characteristics, making it a possible target for medication administration with specificity. The tumor microenvironment in colon cancer is a dynamic ecosystem comprising various cell types like cancer- associated fibroblasts, immune cells, and endothelial cells, influencing tumor progression and response to therapy. Various overexpressed receptors in colon cancer, like G-proteincoupled receptors (GPCRs), integrins, folate receptors, transferrin receptors, epidermal growth factor receptors (EGFRs), and CD-44 receptors, offer opportunities for targeted drug delivery. These receptors play vital roles in cancer cell growth, proliferation, and metastasis, making them important targets for therapeutic intervention.

Keywords: Colon cancer, G-protein-coupled receptors, integrin receptors, folate receptor, transferrin receptor, epidermal growth factor receptor, CD-44 receptor.

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