Abstract

Introduction: Synthesis of NiO nanoparticles using environmentally friendly Pongamia pinnata seeds as a source of fuel was demonstrated using a solution combustion approach.

Method: The protocol for the synthesis of NiO NPs is simple and efficient. NiO NPs were utilized as the catalyst for the synthesis of N-protected aminoalkyl sulfides from N-protected alkyl thiols and bromo esters of amino acids.

Results: The NiO NPs were characterized using XRD, SEM, and EDX techniques. N-protected aminoalkyl sulfides were characterized by HRMS, ¹H, and ¹³C NMR techniques and were evaluated for their in vitro antifungal activities, against A. Niger using Fluconazole as a standard.

Conclusion: The current study presents an effective approach for synthesizing a new class of sulfides from N-protected aminoalkyl thiols and bromomethyl esters in the presence of nano NiO as a catalyst.

Keywords: Peptidomimetics, C-S bond-formation, thiols, NiO catalysis, sulfides, Pongamia pinnata, antifungal activity, solution combustion synthesis.