A Complex Interplay between Nutrition and Alcohol use Disorder:
Implications for Breaking the Vicious Cycle

Brooke      White; Sunil      Sirohi
Abstract

Approximately 16.5% of the United States population met the diagnostic criteria for substance use disorder (SUD) in 2021, including 29.5 million individuals with alcohol use disorder (AUD). Individuals with AUD are at increased risk for malnutrition, and impairments in nutritional status in chronic alcohol users can be detrimental to physical and emotional well-being. Furthermore, these nutritional deficiencies could contribute to the never-ending cycle of alcoholism and related pathologies, thereby jeopardizing the prospects of recovery and treatment outcomes. Improving nutritional status in AUD patients may not only compensate for general malnutrition but could also reduce adverse symptoms during recovery, thereby promoting abstinence and successful treatment of AUD. In this review, we briefly summarize alterations in the nutritional status of people with addictive disorders, in addition to the underlying neurobiological mechanisms and clinical implications regarding the role of nutritional intervention in recovery from alcohol use disorder.
[1]
UNODC. World Drug Report 2023. 2023. Available from: https://www.unodc.org/unodc/en/data-and-analysis/world-drug-report-2023.html

[2]
Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: Results from the 2021 National Survey on Drug Use and Health.  (HHS Publication No. PEP22-07-01-005, NSDUH Series H-57). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration.  https://www.samhsa.gov/data/report/2021-nsduh-annual-national-report2022. Available from: www.samhsa.gov/data/sites/default/files/reports/rpt39443/2021NSDUHFFRRev010323.pdf

[3]
Spencer MR, Miniño AM, Warner M. Drug overdose deaths in the United States, 2001–2021 NCHS Data Brief, no 457. Hyattsville, MD: National Center for Health Statistics 2022.
 [http://dx.doi.org/10.15620/cdc:122556]

[4]
Pilar MR, Eyler AA, Moreland-Russell S, Brownson RC. Actual causes of death in relation to media, policy, and funding attention: Examining public health priorities. Front Public Health  2020; 8: 279.
 [http://dx.doi.org/10.3389/fpubh.2020.00279] [PMID: 32733836]

[5]
Sacks JJ, Gonzales KR, Bouchery EE, Tomedi LE, Brewer RD. 2010 national and state costs of excessive alcohol consumption. Am J Prev Med  2015; 49(5): e73-9.
 [http://dx.doi.org/10.1016/j.amepre.2015.05.031] [PMID: 26477807]

[6]
Mestre-Bach G, Potenza MN. Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders. Dialogues Clin Neurosci  2023; 25(1): 75-91.
 [http://dx.doi.org/10.1080/19585969.2023.2242359] [PMID: 37594217]

[7]
Kramer J, Dick DM, King A, et al. Mechanisms of alcohol addiction: Bridging human and animal studies. Alcohol Alcohol  2020; 55(6): 603-7.
 [http://dx.doi.org/10.1093/alcalc/agaa068] [PMID: 32781467]

[8]
Perkins FN, Freeman KB. Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug. Pharmacol Biochem Behav  2018; 164: 40-9.
 [http://dx.doi.org/10.1016/j.pbb.2017.06.015] [PMID: 28666892]

[9]
Mason BJ. Emerging pharmacotherapies for alcohol use disorder. Neuropharmacology  2017; 122: 244-53.
 [http://dx.doi.org/10.1016/j.neuropharm.2017.04.032] [PMID: 28454983]

[10]
Charney DA, Zikos E, Gill KJ. Early recovery from alcohol dependence: Factors that promote or impede abstinence. J Subst Abuse Treat  2010; 38(1): 42-50.
 [http://dx.doi.org/10.1016/j.jsat.2009.06.002] [PMID: 19632079]

[11]
Blum K, Bowirrat A, Gomez LL, et al. Why haven’t we solved the addiction crisis? J Neurol Sci  2022; 442: 120404.
 [http://dx.doi.org/10.1016/j.jns.2022.120404] [PMID: 36084363]

[12]
Waddington F, Naunton M, Thomas J, Kyle G, Wheatley B, Oguoma V. Examination of the nutritional intake of patients undergoing opioid replacement therapy: A systematic review. Nutr Diet  2023; 80(1): 55-64.
 [http://dx.doi.org/10.1111/1747-0080.12784] [PMID: 36535902]

[13]
Sebastiani G, Borrás-Novell C, Casanova MA, et al. The effects of alcohol and drugs of abuse on maternal nutritional profile during pregnancy. Nutrients  2018; 10(8): 1008.
 [http://dx.doi.org/10.3390/nu10081008] [PMID: 30072661]

[14]
Lieber CS. Alcohol and malnutrition in the pathogenesis of liver disease. JAMA  1975; 233(10): 1077-80.
 [http://dx.doi.org/10.1001/jama.1975.03260100047019] [PMID: 1174154]

[15]
Lieber CS. Relationships between nutrition, alcohol use, and liver disease. Alcohol Res Health  2003; 27(3): 220-31.
 [PMID: 15535450]

[16]
Dasarathy S. Nutrition and alcoholic liver disease: Effects of alcoholism on nutrition, Effects of nutrition on ALD and nutritional therapies for ALD. Clin Liver Dis  2016; 20(3): 535-50.
 [http://dx.doi.org/10.1016/j.cld.2016.02.010] [PMID: 27373615]

[17]
Mellion M, Gilchrist JM, De La Monte S. Alcohol-related peripheral neuropathy: Nutritional, toxic, or both? Muscle Nerve  2011; 43(3): 309-16.
 [http://dx.doi.org/10.1002/mus.21946] [PMID: 21321947]

[18]
Grant LP, Haughton B, Sachan DS. Nutrition education is positively associated with substance abuse treatment program outcomes. J Am Diet Assoc  2004; 104(4): 604-10.
 [http://dx.doi.org/10.1016/j.jada.2004.01.008] [PMID: 15054346]

[19]
Biery JR, Williford JH Jr, McMullen EA. Alcohol craving in rehabilitation: Assessment of nutrition therapy. J Am Diet Assoc  1991; 91(4): 463-6.
 [http://dx.doi.org/10.1016/S0002-8223(21)01147-0] [PMID: 2016494]

[20]
Thomson AD, Cook CCH, Touquet R, Henry JA. The royal college of physicians report on alcohol: Guidelines for managing Wernicke’s encephalopathy in the accident and Emergency Department. Alcohol Alcohol  2002; 37(6): 513-21.
 [http://dx.doi.org/10.1093/alcalc/37.6.513] [PMID: 12414541]

[21]
Addolorato G, Capristo E, Leggio L, et al. Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients. Alcohol Clin Exp Res  2006; 30(11): 1933-7.
 [http://dx.doi.org/10.1111/j.1530-0277.2006.00238.x] [PMID: 17067359]

[22]
Skibicka KP. The central GLP-1: Implications for food and drug reward. Front Neurosci  2013; 7: 181.
 [http://dx.doi.org/10.3389/fnins.2013.00181] [PMID: 24133407]

[23]
Yung L, Gordis E, Holt J. Dietary choices and likelihood of abstinence among alcoholic patients in an outpatient clinic. Drug Alcohol Depend  1983; 12(4): 355-62.
 [http://dx.doi.org/10.1016/0376-8716(83)90007-8] [PMID: 6671419]

[24]
Stickel A, Rohdemann M, Landes T, et al. Changes in nutrition-related behaviors in alcohol-dependent patients after outpatient detoxification: The role of chocolate. Subst Use Misuse  2016; 51(5): 545-52.
 [http://dx.doi.org/10.3109/10826084.2015.1117107] [PMID: 27050118]

[25]
Alcoholics Anonymous World Service. Living Sober, New York, NY, USA: Alcoholics Anonymous World Services Inc. Alcoholics Anonymous World Services, 475 Riverside Drive, New York, NY 10115. 2007. Available from: http://aaposigintergrouptrinidad.org/wordpress/wp-content/uploads/2015/12/Living-Sober.pdf [cited 2019 Oct 17]. 

[26]
Schroeder RD, Higgins GE. You are what you eat: The impact of nutrition on alcohol and drug use. Subst Use Misuse  2017; 52(1): 10-24.
 [http://dx.doi.org/10.1080/10826084.2016.1212603] [PMID: 27617497]

[27]
Santolaria-Fernández F, Gómez-Sirvent JL, González-Reimers CE, et al. Nutritional assessment of drug addicts. Drug Alcohol Depend  1995; 38(1): 11-8.
 [http://dx.doi.org/10.1016/0376-8716(94)01088-3] [PMID: 7648992]

[28]
Nazrul Islam SK, Hossain KJ, Ahmed A, Ahsan M. Nutritional status of drug addicts undergoing detoxification: prevalence of malnutrition and influence of illicit drugs and lifestyle. Br J Nutr  2002; 88(5): 507-13.
 [http://dx.doi.org/10.1079/BJN2002702] [PMID: 12425731]

[29]
Ross LJ, Wilson M, Banks M, Rezannah F, Daglish M. Prevalence of malnutrition and nutritional risk factors in patients undergoing alcohol and drug treatment. Nutrition  2012; 28(7-8): 738-43.
 [http://dx.doi.org/10.1016/j.nut.2011.11.003] [PMID: 22356728]

[30]
Ersche KD, Stochl J, Woodward JM, Fletcher PC. The skinny on cocaine: Insights into eating behavior and body weight in cocaine-dependent men. Appetite  2013; 71: 75-80.
 [http://dx.doi.org/10.1016/j.appet.2013.07.011] [PMID: 23920064]

[31]
Morabia A, Fabre J, Ghee E, Zeger S, Orsat E, Robert A. Diet and opiate addiction: A quantitative assessment of the diet of non-institutionalized opiate addicts. Br J Addict  1989; 84(2): 173-80.
 [http://dx.doi.org/10.1111/j.1360-0443.1989.tb00566.x] [PMID: 2720181]

[32]
Jeynes KD, Gibson EL. The importance of nutrition in aiding recovery from substance use disorders: A review. Drug Alcohol Depend  2017; 179: 229-39.
 [http://dx.doi.org/10.1016/j.drugalcdep.2017.07.006] [PMID: 28806640]

[33]
Sæland M, Haugen M, Eriksen FL, et al. High sugar consumption and poor nutrient intake among drug addicts in Oslo, Norway. Br J Nutr  2011; 105(4): 618-24.
 [http://dx.doi.org/10.1017/S0007114510003971] [PMID: 20880416]

[34]
Neale J, Nettleton S, Pickering L, Fischer J. Eating patterns among heroin users: A qualitative study with implications for nutritional interventions. Addiction  2012; 107(3): 635-41.
 [http://dx.doi.org/10.1111/j.1360-0443.2011.03660.x] [PMID: 21933297]

[35]
Nolte-Troha C, Roser P, Henkel D, Scherbaum N, Koller G, Franke AG. Unemployment and substance use: An updated review of studies from North America and Europe. Healthcare  2023; 11(8): 1182.
 [http://dx.doi.org/10.3390/healthcare11081182] [PMID: 37108016]

[36]
Forrester JE, Tucker KL, Gorbach SL. The effect of drug abuse on body mass index in Hispanics with and without HIV infection. Public Health Nutr  2005; 8(1): 61-8.
 [http://dx.doi.org/10.1079/PHN2005667] [PMID: 15705246]

[37]
Li J, Yang C, Davey-Rothwell M, Latkin C. Associations between body weight status and substance use among African American women in Baltimore, Maryland: The chat study. Subst Use Misuse  2016; 51(6): 669-81.
 [http://dx.doi.org/10.3109/10826084.2015.1135950] [PMID: 27050238]

[38]
Lv D, Zhang M, Jin X, et al. The body mass index, blood pressure, and fasting blood glucose in patients with methamphetamine dependence. Medicine  2016; 95(12): e3152.
 [http://dx.doi.org/10.1097/MD.0000000000003152] [PMID: 27015198]

[39]
McIlwraith F, Betts KS, Jenkinson R, Hickey S, Burns L, Alati R. Is low BMI associated with specific drug use among injecting drug users? Subst Use Misuse  2014; 49(4): 374-82.
 [http://dx.doi.org/10.3109/10826084.2013.841246] [PMID: 24102254]

[40]
Aguinaga D, Medrano M, Cordomí A, et al. Cocaine blocks effects of hunger hormone, ghrelin, via interaction with neuronal sigma-1 receptors. Mol Neurobiol  2019; 56(2): 1196-210.
 [http://dx.doi.org/10.1007/s12035-018-1140-7] [PMID: 29876881]

[41]
Richardson RA, Wiest K. A preliminary study examining nutritional risk factors, body mass index, and treatment retention in opioid-dependent patients. J Behav Health Serv Res  2015; 42(3): 401-8.
 [http://dx.doi.org/10.1007/s11414-013-9371-x] [PMID: 24091612]

[42]
Díaz-Flores JF, Sañudo RI, Rodríguez EM, Romero CD. Serum concentrations of macro and trace elements in heroin addicts of the Canary Islands. J Trace Elem Med Biol  2004; 17(4): 235-42.
 [http://dx.doi.org/10.1016/S0946-672X(04)80024-5] [PMID: 15139385]

[43]
Hossain KJ, Kamal MM, Ahsan M, Islam SKN. Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle. Subst Abuse Treat Prev Policy  2007; 2(1): 12.
 [http://dx.doi.org/10.1186/1747-597X-2-12] [PMID: 17417973]

[44]
Mahboub N, Rizk R, Karavetian M, de Vries N. Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: A narrative review. Nutr Rev  2021; 79(6): 627-35.
 [http://dx.doi.org/10.1093/nutrit/nuaa095] [PMID: 32974658]

[45]
Wilkens Knudsen A, Jensen JEB, Nordgaard-Lassen I, Almdal T, Kondrup J, Becker U. Nutritional intake and status in persons with alcohol dependency: Data from an outpatient treatment programme. Eur J Nutr  2014; 53(7): 1483-92.
 [http://dx.doi.org/10.1007/s00394-014-0651-x] [PMID: 24442425]

[46]
Amadieu C, Leclercq S, Coste V, et al. Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder. Clin Nutr  2021; 40(5): 2673-82.
 [http://dx.doi.org/10.1016/j.clnu.2021.03.029] [PMID: 33933733]

[47]
Cummings JR, Gearhardt AN, Ray LA, Choi AK, Tomiyama AJ. Experimental and observational studies on alcohol use and dietary intake: A systematic review. Obes Rev  2020; 21(2): e12950.
 [http://dx.doi.org/10.1111/obr.12950] [PMID: 31691442]

[48]
Colditz GA, Giovannucci E, Rimm EB, et al. Alcohol intake in relation to diet and obesity in women and men. Am J Clin Nutr  1991; 54(1): 49-55.
 [http://dx.doi.org/10.1093/ajcn/54.1.49] [PMID: 2058587]

[49]
Liangpunsakul S. Relationship between alcohol intake and dietary pattern: Findings from NHANES III. World J Gastroenterol  2010; 16(32): 4055-60.
 [http://dx.doi.org/10.3748/wjg.v16.i32.4055] [PMID: 20731019]

[50]
Badawy AAB. Pellagra and alcoholism: A biochemical perspective. Alcohol Alcohol  2014; 49(3): 238-50.
 [http://dx.doi.org/10.1093/alcalc/agu010] [PMID: 24627570]

[51]
Brown G. Defects of thiamine transport and metabolism. J Inherit Metab Dis  2014; 37(4): 577-85.
 [http://dx.doi.org/10.1007/s10545-014-9712-9] [PMID: 24789339]

[52]
Ghorbani Z, Hajizadeh M, Hekmatdoost A. Dietary supplementation in patients with alcoholic liver disease: A review on current evidence. Hepatobiliary Pancreat Dis Int  2016; 15(4): 348-60.
 [http://dx.doi.org/10.1016/S1499-3872(16)60096-6] [PMID: 27498574]

[53]
Hoyumpa AM Jr. Mechanisms of thiamin deficiency in chronic alcoholism. Am J Clin Nutr  1980; 33(12): 2750-61.
 [http://dx.doi.org/10.1093/ajcn/33.12.2750] [PMID: 6254354]

[54]
McLean J, Manchip S. Wernicke’s encephalopathy induced by magnesium depletion. Lancet  1999; 353(9166): 1768.
 [http://dx.doi.org/10.1016/S0140-6736(99)00182-8] [PMID: 10348000]

[55]
Rink EB. Magnesium deficiency in alcoholism. Alcohol Clin Exp Res  1986; 10(6): 590-4.
 [http://dx.doi.org/10.1111/j.1530-0277.1986.tb05150.x] [PMID: 3544909]

[56]
Gleissenthall G, Geisler S, Malik P, et al. Tryptophan metabolism in post-withdrawal alcohol-dependent patients. Alcohol Alcohol  2014; 49(3): 251-5.
 [http://dx.doi.org/10.1093/alcalc/agu011] [PMID: 24644258]

[57]
McClain CJ, Antonow DR, Cohen DA, Shedlofsky SI. Zinc metabolism in alcoholic liver disease. Alcohol Clin Exp Res  1986; 10(6): 582-9.
 [http://dx.doi.org/10.1111/j.1530-0277.1986.tb05149.x] [PMID: 3544908]

[58]
Vech RL, Lumeng L, Li TK. Vitamin B6 metabolism in chronic alcohol abuse the effect of ethanol oxidation on hepatic pyridoxal 5′-phosphate metabolism. J Clin Invest  1975; 55(5): 1026-32.
 [http://dx.doi.org/10.1172/JCI108003] [PMID: 1168205]

[59]
Vodoz JF, Luisier M, Donath A, Courvoisier B, Garcia B. Decrease of intestinal absorption of 47-calcium in chronic alcoholism. Schweiz Med Wochenschr  1977; 107(43): 1525-9.
 [PMID: 929126]

[60]
Wani NA, Kaur J. Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism. J Cell Physiol  2011; 226(3): 579-87.
 [http://dx.doi.org/10.1002/jcp.22525] [PMID: 21069807]

[61]
Mezey E. Liver disease and protein needs. Annu Rev Nutr  1982; 2(1): 21-50.
 [http://dx.doi.org/10.1146/annurev.nu.02.070182.000321] [PMID: 6764731]

[62]
Ebuehi OAT, Asonye C. Gender and alcohol consumption affect human serum enzymes, protein and bilirubin. Asian Journal of Biochemistry  2007; 2(5): 330-6.
 [http://dx.doi.org/10.3923/ajb.2007.330.336]

[63]
Ho AMC, Pozsonyiova S, Waller TC, et al. Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study. Drug Alcohol Depend  2023; 244: 109781.
 [http://dx.doi.org/10.1016/j.drugalcdep.2023.109781] [PMID: 36701934]

[64]
Zhu C, Hou X, Li M, et al. Serum glycated albumin levels are affected by alcohol in men of the jinuo ethnic group in China. Can J Infect Dis Med Microbiol  2021; 2021: 1-7.
 [http://dx.doi.org/10.1155/2021/6627074] [PMID: 33628351]

[65]
Rothschild MA, Oratz M, Morland J, Schreiber SS, Burks A, Martin B. Effects of ethanol on protein synthesis and secretion. Pharmacol Biochem Behav  1980; 13 (Suppl. 1): 31-6.
 [http://dx.doi.org/10.1016/S0091-3057(80)80005-0] [PMID: 7243832]

[66]
Baraona E, Lieber CS. Effects of alcohol on hepatic transport of proteins. Annu Rev Med  1982; 33(1): 281-92.
 [http://dx.doi.org/10.1146/annurev.me.33.020182.001433] [PMID: 7044272]

[67]
Dean JT, Richard BJ, Michael FS. Effect of ethanol on the synthesis and secretion of hepatic secretory glycoproteins and albumin. Hepatology  1981; 1(6): 590-8.

[68]
Rothschild MA, Schreiber SS, Oratz M. Effects of ethanol on protein synthesis. Adv Exp Med Biol  1975; 56: 179-94.
 [http://dx.doi.org/10.1007/978-1-4684-7529-6_8] [PMID: 1096551]

[69]
Wu N, Liu T, Tian M, et al. Albumin, an interesting and functionally diverse protein, varies from ‘native’ to ‘effective’ (Review). Mol Med Rep  2023; 29(2): 24.
 [http://dx.doi.org/10.3892/mmr.2023.13147] [PMID: 38099350]

[70]
Borgohain DL, Das A, Phukan J. Serum protein and its fractions in patients of alcohol dependence and healthy individuals – A comparative study. JMSCR  2017; 5(10): 29596-603.
 [http://dx.doi.org/10.18535/jmscr/v5i10.187]

[71]
Das SK, Vasudevan DM. Biochemical diagnosis of alcoholism. Indian J Clin Biochem  2005; 20(1): 35-42.
 [http://dx.doi.org/10.1007/BF02893039] [PMID: 23105491]

[72]
Marsano LS, Mendez C, Hill D, Barve S, McClain CJ. Diagnosis and treatment of alcoholic liver disease and its complications. Alcohol Res Health  2003; 27(3): 247-56.
 [PMID: 15535453]

[73]
Eckart A, Struja T, Kutz A, et al. Relationship of nutritional status, inflammation, and serum albumin levels during acute illness: A prospective study. Am J Med  2020; 133(6): 713-722.e7.
 [http://dx.doi.org/10.1016/j.amjmed.2019.10.031] [PMID: 31751531]

[74]
Gremese E, Bruno D, Varriano V, Perniola S, Petricca L, Ferraccioli G. Serum albumin levels: A biomarker to be repurposed in different disease settings in clinical practice. J Clin Med  2023; 12(18): 6017.
 [http://dx.doi.org/10.3390/jcm12186017] [PMID: 37762957]

[75]
Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: Pathogenesis and clinical significance. JPEN J Parenter Enteral Nutr  2019; 43(2): 181-93.
 [http://dx.doi.org/10.1002/jpen.1451] [PMID: 30288759]

[76]
Wiedermann CJ. Hypoalbuminemia as surrogate and culprit of infections. Int J Mol Sci  2021; 22(9): 4496.
 [http://dx.doi.org/10.3390/ijms22094496] [PMID: 33925831]

[77]
Arques S. Serum albumin and cardiovascular disease: State-of-the-art review. Ann Cardiol Angeiol  2020; 69(4): 192-200.
 [http://dx.doi.org/10.1016/j.ancard.2020.07.012] [PMID: 32797938]

[78]
Seidu S, Kunutsor SK, Khunti K. Serum albumin, cardiometabolic and other adverse outcomes: Systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants. Scand Cardiovasc J  2020; 54(5): 280-93.
 [http://dx.doi.org/10.1080/14017431.2020.1762918] [PMID: 32378436]

[79]
Zoanni B, Brioschi M, Mallia A, et al. Novel insights about albumin in cardiovascular diseases: Focus on heart failure. Mass Spectrom Rev  2023; 42(4): 1113-28.
 [http://dx.doi.org/10.1002/mas.21743] [PMID: 34747521]

[80]
Vincent JL, Dubois MJ, Navickis RJ, Wilkes MM. Hypoalbuminemia in acute illness: Is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials. Ann Surg  2003; 237(3): 319-34.
 [http://dx.doi.org/10.1097/01.SLA.0000055547.93484.87] [PMID: 12616115]

[81]
Djoussé L, Rothman KJ, Cupples LA, Levy D, Ellison RC. Serum albumin and risk of myocardial infarction and all-cause mortality in the Framingham Offspring Study. Circulation  2002; 106(23): 2919-24.
 [http://dx.doi.org/10.1161/01.CIR.0000042673.07632.76] [PMID: 12460872]

[82]
Yang Q, He YM, Cai DP, Yang XJ, Xu HF. Risk burdens of modifiable risk factors incorporating lipoprotein (a) and low serum albumin concentrations for first incident acute myocardial infarction. Sci Rep  2016; 6(1): 35463.
 [http://dx.doi.org/10.1038/srep35463] [PMID: 27748452]

[83]
Ronit A, Kirkegaard-Klitbo DM, Dohlmann TL, et al. Plasma albumin and incident cardiovascular disease. Arterioscler Thromb Vasc Biol  2020; 40(2): 473-82.
 [http://dx.doi.org/10.1161/ATVBAHA.119.313681] [PMID: 31852221]

[84]
Selçuk M, Çınar T, Şaylık F, et al. Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction. Rev Invest Clin  2022; 74(3): 156-64.
 [PMID: 35797660]

[85]
Çınar T, Şaylık F, Hayıroğlu Mİ, et al. The association of serum uric acid/albumin ratio with no-reflow in patients with ST elevation myocardial infarction. Angiology  2023; 74(4): 381-6.
 [http://dx.doi.org/10.1177/00033197221110700] [PMID: 35726733]

[86]
Hayıroğlu Mİ, Çınar T, Çinier G, et al. Cardiac variables associated with atrial fibrillation occurrence and mortality in octogenarians implanted with dual chamber permanent pacemakers. Aging Clin Exp Res  2022; 34(10): 2533-9.
 [http://dx.doi.org/10.1007/s40520-022-02194-w] [PMID: 35834163]

[87]
Hayıroğlu Mİ, Çınar T, Çinier G, et al. Prognostic value of serum albumin for long-term mortality in patients with dual-chamber permanent pacemakers. Biomarkers Med  2022; 16(5): 341-8.
 [http://dx.doi.org/10.2217/bmm-2021-0991] [PMID: 35234522]

[88]
Galizia G, Lieto E, Auricchio A, et al. Naples prognostic score, based on nutritional and inflammatory status, is an independent predictor of long-term outcome in patients undergoing surgery for colorectal cancer. Dis Colon Rectum  2017; 60(12): 1273-84.
 [http://dx.doi.org/10.1097/DCR.0000000000000961] [PMID: 29112563]

[89]
Şaylık F, Çınar T, Selçuk M, Akbulut T, Hayıroğlu Mİ, Tanboğa İH. Evaluation of naples score for long-term mortality in patients With ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Angiology  2023; 33197231170982.
 [PMID: 37058422]

[90]
Öner E, Kahraman S. Predictive value of the naples score for inhospital mortality in patients with st-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Koşuyolu Heart J  2023; 26(3): 115-20.
 [http://dx.doi.org/10.51645/khj.2023.m382]

[91]
Erdogan A, Genc O, Inan D, et al. Impact of naples prognostic score on midterm all-cause mortality in patients with decompensated heart failure. Biomarkers Med  2023; 17(4): 219-30.
 [http://dx.doi.org/10.2217/bmm-2022-0689] [PMID: 37129507]

[92]
Artac I, Karakayali M, Omar T, et al. Predictive value of the naples prognostic score on long-term outcomes in patients with peripheral artery disease revascularized via percutaneous intervention. Ann Vasc Surg  2024; 102: 121-32.
 [http://dx.doi.org/10.1016/j.avsg.2023.11.028] [PMID: 38307231]

[93]
Peng SM, Ren JJ, Yu N, et al. The prognostic value of the Naples prognostic score for patients with non-small-cell lung cancer. Sci Rep  2022; 12(1): 5782.
 [http://dx.doi.org/10.1038/s41598-022-09888-1] [PMID: 35388133]

[94]
Erol A, Karpyak VM. Sex and gender-related differences in alcohol use and its consequences: Contemporary knowledge and future research considerations. Drug Alcohol Depend  2015; 156: 1-13.
 [http://dx.doi.org/10.1016/j.drugalcdep.2015.08.023] [PMID: 26371405]

[95]
Peltier MR, Verplaetse TL, Mineur YS, et al. Sex differences in stress-related alcohol use. Neurobiol Stress  2019; 10: 100149.
 [http://dx.doi.org/10.1016/j.ynstr.2019.100149] [PMID: 30949562]

[96]
Flores-Bonilla A, Richardson HN. Sex differences in the neurobiology of alcohol use disorder. Alcohol Res Curr Rev  2020; 40(2): 4.
 [http://dx.doi.org/10.35946/arcr.v40.2.04]

[97]
Grace S, Rossetti MG, Allen N, et al. Sex differences in the neuroanatomy of alcohol dependence: Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Transl Psychiatry  2021; 11(1): 156.
 [http://dx.doi.org/10.1038/s41398-021-01204-1] [PMID: 33664226]

[98]
Holmila M, Raitasalo K. Gender differences in drinking: Why do they still exist? Addiction  2005; 100(12): 1763-9.
 [http://dx.doi.org/10.1111/j.1360-0443.2005.01249.x] [PMID: 16367976]

[99]
Schulte MT, Ramo D, Brown SA. Gender differences in factors influencing alcohol use and drinking progression among adolescents. Clin Psychol Rev  2009; 29(6): 535-47.
 [http://dx.doi.org/10.1016/j.cpr.2009.06.003] [PMID: 19592147]

[100]
Redgrave GW, Swartz KL, Romanoski AJ. Alcohol misuse by women. Int Rev Psychiatry  2003; 15(3): 256-68.
 [http://dx.doi.org/10.1080/0954026031000136875] [PMID: 15276964]

[101]
Nolen-Hoeksema S, Hilt L. Possible contributors to the gender differences in alcohol use and problems. J Gen Psychol  2006; 133(4): 357-74.
 [http://dx.doi.org/10.3200/GENP.133.4.357-374] [PMID: 17128956]

[102]
Ceylan-Isik AF, McBride SM, Ren J. Sex difference in alcoholism: Who is at a greater risk for development of alcoholic complication? Life Sci  2010; 87(5-6): 133-8.
 [http://dx.doi.org/10.1016/j.lfs.2010.06.002] [PMID: 20598716]

[103]
Blow FC, Barry KL. Use and misuse of alcohol among older women. Alcohol Res Health  2002; 26(4): 308-15.
 [PMID: 12875042]

[104]
Epstein EE, Fischer-Elber K, Al-Otaiba Z. Women, aging, and alcohol use disorders. J Women Aging  2007; 19(1-2): 31-48.
 [http://dx.doi.org/10.1300/J074v19n01_03] [PMID: 17588878]

[105]
Miller MA, Weafer J, Fillmore MT. Gender differences in alcohol impairment of simulated driving performance and driving-related skills. Alcohol Alcohol  2009; 44(6): 586-93.
 [http://dx.doi.org/10.1093/alcalc/agp051] [PMID: 19786725]

[106]
Schweinsburg BC, Alhassoon OM, Taylor MJ, et al. Effects of alcoholism and gender on brain metabolism. Am J Psychiatry  2003; 160(6): 1180-3.
 [http://dx.doi.org/10.1176/appi.ajp.160.6.1180] [PMID: 12777281]

[107]
Agabio R, Pisanu C, Gessa GL, Franconi F. Sex differences in alcohol use disorder. Curr Med Chem  2017; 24(24): 2661-70.
 [PMID: 27915987]

[108]
Center for Behavioral Health Statistics and Quality. 2022 National Survey on Drug Use and Health. Table 2.28-Binge alcohol use in past month: Among people aged 12 or older; by age group and demographic characteristics, numbers in thousands, 2021 and 2022. 2022. Available from: https://www.samhsa.gov/data/sites/default/files/reports/rpt42728/NSDUHDetailedTabs2022/NSDUHDetailedTabs2022/NSDUHDetTabsSect2pe2022.htm#tab2.25a [cited 2024 Apr 19]. 

[109]
Center for Behavioral Health Statistics and Quality. 2022 National Survey on Drug Use and Health. Table 2.44-Alcohol use in lifetime, past year, and past month and binge alcohol and heavy alcohol use in past month: among people aged 12 to 20; by demographic characteristics, numbers in thousands, 2021 and 2022. 2022. Available from: https://www.samhsa.gov/data/sites/default/files/reports/rpt42728/NSDUHDetailedTabs2022/NSDUHDetailedTabs2022/NSDUHDetTabs2-44and2-45pe2022.pdf [cited 2024 Apr 19]. 

[110]
Center for Behavioral Health Statistics and Quality. 2022 National Survey on Drug Use and Health. Table 5.9 -Alcohol use disorder in past year: among people aged 12 or older; by age group and demographic characteristics, numbers in thousands, 2021 and 2022. 2022. Available from: https://www.samhsa.gov/data/sites/default/files/reports/rpt42728/NSDUHDetailedTabs2022/NSDUHDetailedTabs2022/NSDUHDetTabsSect5pe2022.htm#tab5.9a [cited 2024 Apr 21]. 

[111]
Eagon PK. Alcoholic liver injury: Influence of gender and hormones. World J Gastroenterol  2010; 16(11): 1377-84.
 [http://dx.doi.org/10.3748/wjg.v16.i11.1377] [PMID: 20238405]

[112]
Fernández-Solà J, Nicolás-Arfelis JM. Gender differences in alcoholic cardiomyopathy. J Gend Specif Med  2002; 5(1): 41-7.
 [PMID: 11859686]

[113]
Kezer CA, Simonetto DA, Shah VH. Sex differences in alcohol consumption and alcohol-associated liver disease. Mayo Clin Proc  2021; 96(4): 1006-16.
 [http://dx.doi.org/10.1016/j.mayocp.2020.08.020] [PMID: 33714602]

[114]
Nolen-Hoeksema S. Gender differences in risk factors and consequences for alcohol use and problems. Clin Psychol Rev  2004; 24(8): 981-1010.
 [http://dx.doi.org/10.1016/j.cpr.2004.08.003] [PMID: 15533281]

[115]
Verplaetse TL, Peltier MR, Roberts W, et al. Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Addict Behav  2021; 123: 107055.
 [http://dx.doi.org/10.1016/j.addbeh.2021.107055] [PMID: 34311184]

[116]
Hydes TJ, Burton R, Inskip H, Bellis MA, Sheron N. A comparison of gender-linked population cancer risks between alcohol and tobacco: how many cigarettes are there in a bottle of wine? BMC Public Health  2019; 19(1): 316.
 [http://dx.doi.org/10.1186/s12889-019-6576-9] [PMID: 30917803]

[117]
Wilsnack SC, Wilsnack RW, Kantor LW. Focus on: Women and the costs of alcohol use. Alcohol Res  2013; 35(2): 219-28.
 [PMID: 24881330]

[118]
Bizzaro D, Becchetti C, Trapani S, et al. Influence of sex in alcohol-related liver disease: Pre-clinical and clinical settings. United European Gastroenterol J  2023; 11(2): 218-27.
 [http://dx.doi.org/10.1002/ueg2.12370] [PMID: 36866682]

[119]
Wagnerberger S, Schäfer C, Schwarz E, Bode C, Parlesak A. Is nutrient intake a gender-specific cause for enhanced susceptibility to alcohol-induced liver disease in women? Alcohol Alcohol  2007; 43(1): 9-14.
 [http://dx.doi.org/10.1093/alcalc/agm161] [PMID: 18003723]

[120]
Addolorato G, Capristo E, Greco AV, Caputo F, Stefanini GF, Gasbarrini G. Three months of abstinence from alcohol normalizes energy expenditure and substrate oxidation in alcoholics: A longitudinal study. Am J Gastroenterol  1998; 93(12): 2476-81.
 [http://dx.doi.org/10.1111/j.1572-0241.1998.00707.x] [PMID: 9860412]

[121]
Addolorato G, Capristo E, Marini M, et al. Body composition changes induced by chronic ethanol abuse: Evaluation by dual energy x-ray absorptiometry. Am J Gastroenterol  2000; 95(9): 2323-7.
 [http://dx.doi.org/10.1111/j.1572-0241.2000.02320.x] [PMID: 11007236]

[122]
de Timary P, Cani PD, Duchemin J, et al. The loss of metabolic control on alcohol drinking in heavy drinking alcohol-dependent subjects. PLoS One  2012; 7(7): e38682.
 [http://dx.doi.org/10.1371/journal.pone.0038682] [PMID: 22808013]

[123]
Liangpunsakul S, Crabb DW, Qi R. Relationship among alcohol intake, body fat, and physical activity: A population-based study. Ann Epidemiol  2010; 20(9): 670-5.
 [http://dx.doi.org/10.1016/j.annepidem.2010.05.014] [PMID: 20696406]

[124]
Gautron MA, Questel F, Lejoyeux M, Bellivier F, Vorspan F. Nutritional status during inpatient alcohol detoxification. Alcohol Alcohol  2018; 53(1): 64-70.
 [http://dx.doi.org/10.1093/alcalc/agx086] [PMID: 29136089]

[125]
Halsted CH, Medici V. Vitamin-dependent methionine metabolism and alcoholic liver disease. Adv Nutr  2011; 2(5): 421-7.
 [http://dx.doi.org/10.3945/an.111.000661] [PMID: 22332083]

[126]
Bonnet U, Pohlmann L, McAnally H, Claus BB. Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective pilot study of an inpatient detoxification with oral supplementation protocol. Alcohol Fayettev N   2023; 110: 23-31.

[127]
Clergue-Duval V, Azuar J, Fonsart J, et al. Ascorbic acid deficiency prevalence and associated cognitive impairment in alcohol detoxification inpatients: A pilot study. Antioxidants  2021; 10(12): 1892.
 [http://dx.doi.org/10.3390/antiox10121892] [PMID: 34942994]

[128]
Fama R, Le Berre AP, Hardcastle C, et al. Neurological, nutritional and alcohol consumption factors underlie cognitive and motor deficits in chronic alcoholism. Addict Biol  2019; 24(2): 290-302.
 [http://dx.doi.org/10.1111/adb.12584] [PMID: 29243370]

[129]
Vedder LC, Hall JM, Jabrouin KR, Savage LM. Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility. Alcohol Clin Exp Res  2015; 39(11): 2143-53.
 [http://dx.doi.org/10.1111/acer.12859] [PMID: 26419807]

[130]
Issac TG, Soundarya S, Christopher R, Chandra SR. Vitamin B12 deficiency: An important reversible co-morbidity in neuropsychiatric manifestations. Indian J Psychol Med  2015; 37(1): 26-9.
 [http://dx.doi.org/10.4103/0253-7176.150809] [PMID: 25722508]

[131]
Neupane SP, Lien L, Hilberg T, Bramness JG. Vitamin D deficiency in alcohol-use disorders and its relationship to comorbid major depression: A cross-sectional study of inpatients in Nepal. Drug Alcohol Depend  2013; 133(2): 480-5.
 [http://dx.doi.org/10.1016/j.drugalcdep.2013.07.006] [PMID: 23916323]

[132]
Sahu P, Thippeswamy H, Chaturvedi SK. Neuropsychiatric manifestations in vitamin B12 deficiency. Vitam Horm  2022; 119: 457-70.
 [http://dx.doi.org/10.1016/bs.vh.2022.01.001] [PMID: 35337631]

[133]
Bulik CM, Klump KL, Thornton L, et al. Alcohol use disorder comorbidity in eating disorders: A multicenter study. J Clin Psychiatry  2004; 65(7): 1000-6.
 [http://dx.doi.org/10.4088/JCP.v65n0718] [PMID: 15291691]

[134]
Krahn DD, Kurth CL, Gomberg E, Drewnowski A. Pathological dieting and alcohol use in college women-a continuum of behaviors. Eat Behav  2005; 6(1): 43-52.
 [http://dx.doi.org/10.1016/j.eatbeh.2004.08.004] [PMID: 15567110]

[135]
Kelly-Weeder S. Binge drinking and disordered eating in college students. J Am Acad Nurse Pract  2011; 23(1): 33-41.
 [http://dx.doi.org/10.1111/j.1745-7599.2010.00568.x] [PMID: 21208332]

[136]
Escrivá-Martínez T, Herrero R, Molinari G, Rodríguez-Arias M, Verdejo-García A, Baños RM. Binge eating and binge drinking: A two-way road? An integrative review. Curr Pharm Des  2020; 26(20): 2402-15.
 [http://dx.doi.org/10.2174/1381612826666200316153317] [PMID: 32175840]

[137]
Sonneville KR, Horton NJ, Micali N, et al. Longitudinal associations between binge eating and overeating and adverse outcomes among adolescents and young adults: Does loss of control matter? JAMA Pediatr  2013; 167(2): 149-55.
 [http://dx.doi.org/10.1001/2013.jamapediatrics.12] [PMID: 23229786]

[138]
Leggio L, Addolorato G, Cippitelli A, Jerlhag E, Kampov-Polevoy AB, Swift RM. Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. Alcohol Clin Exp Res  2011; 35(2): 194-202.
 [http://dx.doi.org/10.1111/j.1530-0277.2010.01334.x] [PMID: 21058960]

[139]
Vadnie CA, Park JH, Abdel Gawad N, Ho AMC, Hinton DJ, Choi DS. Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. Front Neurosci  2014; 8: 288.
 [http://dx.doi.org/10.3389/fnins.2014.00288] [PMID: 25278825]

[140]
Genders SG, Scheller KJ, Djouma E. Neuropeptide modulation of addiction: Focus on galanin. Neurosci Biobehav Rev  2020; 110: 133-49.
 [http://dx.doi.org/10.1016/j.neubiorev.2018.06.021] [PMID: 29949733]

[141]
Gorka SM, Phan KL. Orexin modulation of stress reactivity as a novel targeted treatment for anxiety and alcohol use disorder. Neuropsychopharmacology  2022; 47(1): 397-8.
 [http://dx.doi.org/10.1038/s41386-021-01120-4] [PMID: 34341494]

[142]
Engel JA, Jerlhag E. Role of appetite-regulating peptides in the pathophysiology of addiction: Implications for pharmacotherapy. CNS Drugs  2014; 28(10): 875-86.
 [http://dx.doi.org/10.1007/s40263-014-0178-y] [PMID: 24958205]

[143]
Egecioglu E, Engel JA, Jerlhag E. The glucagon-like peptide 1 analogue exendin-4 attenuates the nicotine-induced locomotor stimulation, accumbal dopamine release, conditioned place preference as well as the expression of locomotor sensitization in mice. PLoS ONE   2013; 8(10): e77284.

[144]
Egecioglu E, Engel JA, Jerlhag E. The glucagon-like peptide 1 analogue, exendin-4, attenuates the rewarding properties of psychostimulant drugs in mice. PLoS ONE  2013; 8(7): e69010.

[145]
Egecioglu E, Steensland P, Fredriksson I, Feltmann K, Engel JA, Jerlhag E. The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents. Psychoneuroendocrinology  2013; 38(8): 1259-70.
 [http://dx.doi.org/10.1016/j.psyneuen.2012.11.009] [PMID: 23219472]

[146]
Leggio L, Zywiak WH, Fricchione SR, et al. Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: A preliminary investigation. Biol Psychiatry  2014; 76(9): 734-41.
 [http://dx.doi.org/10.1016/j.biopsych.2014.03.019] [PMID: 24775991]

[147]
Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev  2007; 87(4): 1409-39.
 [http://dx.doi.org/10.1152/physrev.00034.2006] [PMID: 17928588]

[148]
Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol  1999; 403(2): 261-80.
 [http://dx.doi.org/10.1002/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5] [PMID: 9886047]

[149]
Kreymann B, Ghatei MA, Williams G, Bloom SR. Glucagon-like peptide-1 7-36: A physiological incretin in man. Lancet  1987; 330(8571): 1300-4.
 [http://dx.doi.org/10.1016/S0140-6736(87)91194-9] [PMID: 2890903]

[150]
Shirazi RH, Dickson SL, Skibicka KP. Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. PLoS One  2013; 8(4): e61965.
 [http://dx.doi.org/10.1371/journal.pone.0061965] [PMID: 23613987]

[151]
Vallöf D, Maccioni P, Colombo G, et al. The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents. Addict Biol  2016; 21(2): 422-37.
 [http://dx.doi.org/10.1111/adb.12295] [PMID: 26303264]

[152]
Marty VN, Farokhnia M, Munier JJ, Mulpuri Y, Leggio L, Spigelman I. Long-acting glucagon-like peptide-1 receptor agonists suppress voluntary alcohol intake in male wistar rats. Front Neurosci  2020; 14: 599646.
 [http://dx.doi.org/10.3389/fnins.2020.599646] [PMID: 33424537]

[153]
Thomsen M, Holst JJ, Molander A, Linnet K, Ptito M, Fink-Jensen A. Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys. Psychopharmacology  2019; 236(2): 603-11.
 [http://dx.doi.org/10.1007/s00213-018-5089-z] [PMID: 30382353]

[154]
Suchankova P, Yan J, Schwandt ML, et al. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: Evidence from human genetic association studies and a mouse model of alcohol dependence. Transl Psychiatry  2015; 5(6): e583.
 [http://dx.doi.org/10.1038/tp.2015.68] [PMID: 26080318]

[155]
Thomsen M, Dencker D, Wörtwein G, et al. The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice. Pharmacol Biochem Behav  2017; 160: 14-20.
 [http://dx.doi.org/10.1016/j.pbb.2017.07.014] [PMID: 28778739]

[156]
Sirohi S, Schurdak JD, Seeley RJ, Benoit SC, Davis JF. Central & peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors. Physiol Behav  2016; 161(161): 140-4.
 [http://dx.doi.org/10.1016/j.physbeh.2016.04.013] [PMID: 27072507]

[157]
Aranäs C, Edvardsson CE, Shevchouk OT, et al. Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats. EBioMedicine  2023; 93: 104642.
 [http://dx.doi.org/10.1016/j.ebiom.2023.104642] [PMID: 37295046]

[158]
Sharma AN, Pise A, Sharma JN, Shukla P. Glucagon-like peptide-1 (GLP-1) receptor agonist prevents development of tolerance to anti-anxiety effect of ethanol and withdrawal-induced anxiety in rats. Metab Brain Dis  2015; 30(3): 719-30.
 [http://dx.doi.org/10.1007/s11011-014-9627-z] [PMID: 25380665]

[159]
Sharma AN, Pise A, Sharma JN, Shukla P. Dipeptidyl-peptidase IV (DPP-IV) inhibitor delays tolerance to anxiolytic effect of ethanol and withdrawal-induced anxiety in rats. Metab Brain Dis  2015; 30(3): 659-67.
 [http://dx.doi.org/10.1007/s11011-014-9603-7] [PMID: 25129124]

[160]
Kalra S. Change in alcohol consumption following liraglutide initiation: A real life experience. Proceedings of the 71st American Diabetes Association Conference.  San Diego, CA: 2011, vol. 2011.

[161]
Klausen MK, Jensen ME, Møller M, et al. Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial. JCI Insight  2022; 7(19): e159863.
 [http://dx.doi.org/10.1172/jci.insight.159863] [PMID: 36066977]

[162]
Farokhnia M, Browning BD, Crozier ME, Sun H, Akhlaghi F, Leggio L. The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study. Addict Biol  2022; 27(5): e13211.
 [http://dx.doi.org/10.1111/adb.13211] [PMID: 36001436]

[163]
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature  1999; 402(6762): 656-60.
 [http://dx.doi.org/10.1038/45230] [PMID: 10604470]

[164]
Kharbanda KK, Farokhnia M, Deschaine SL, et al. Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review. Alcohol Clin Exp Res  2022; 46(12): 2149-59.
 [http://dx.doi.org/10.1111/acer.14967] [PMID: 36316764]

[165]
Jerlhag E. Animal studies reveal that the ghrelin pathway regulates alcohol-mediated responses. Front Psychiatry  2023; 14: 1050973.
 [http://dx.doi.org/10.3389/fpsyt.2023.1050973] [PMID: 36970276]

[166]
Jerlhag E, Egecioglu E, Landgren S, et al. Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci USA  2009; 106(27): 11318-23.
 [http://dx.doi.org/10.1073/pnas.0812809106] [PMID: 19564604]

[167]
Landgren S, Simms JA, Hyytiä P, Engel JA, Bartlett SE, Jerlhag E. Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addict Biol  2012; 17(1): 86-94.
 [http://dx.doi.org/10.1111/j.1369-1600.2010.00280.x] [PMID: 21309944]

[168]
Suchankova P, Steensland P, Fredriksson I, Engel JA, Jerlhag E. Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. PLoS One  2013; 8(8): e71284.
 [http://dx.doi.org/10.1371/journal.pone.0071284] [PMID: 23977009]

[169]
Suchankova P, Yan J, Schwandt ML, et al. The Leu72Met polymorphism of the prepro-ghrelin gene is associated with alcohol consumption and subjective responses to alcohol: Preliminary findings. Alcohol Alcohol  2017; 52(4): 425-30.
 [http://dx.doi.org/10.1093/alcalc/agx021] [PMID: 28481975]

[170]
Suchankova P, Nilsson S, von der Pahlen B, et al. Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking. Addict Biol  2016; 21(2): 481-8.
 [http://dx.doi.org/10.1111/adb.12277] [PMID: 26059200]

[171]
Landgren S, Jerlhag E, Hallman J, et al. Genetic variation of the ghrelin signaling system in females with severe alcohol dependence. Alcohol Clin Exp Res  2010; 34(9): 1519-24.
 [http://dx.doi.org/10.1111/j.1530-0277.2010.01236.x] [PMID: 20586762]

[172]
Zallar LJ, Beurmann S, Tunstall BJ, et al. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. J Neuroendocrinol  2019; 31(7): e12663.
 [http://dx.doi.org/10.1111/jne.12663] [PMID: 30456835]

[173]
Jerlhag E, Ivanoff L, Vater A, Engel JA. Peripherally circulating ghrelin does not mediate alcohol-induced reward and alcohol intake in rodents. Alcohol Clin Exp Res  2014; 38(4): 959-68.
 [http://dx.doi.org/10.1111/acer.12337] [PMID: 24428428]

[174]
Jerlhag E, Landgren S, Egecioglu E, Dickson SL, Engel JA. The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice.  Alcohol Fayettev N  2011; 45(4): 341-7.
 [http://dx.doi.org/10.1016/j.alcohol.2010.10.002]

[175]
Koopmann A, Bach P, Schuster R, et al. Ghrelin modulates mesolimbic reactivity to alcohol cues in alcohol-addicted subjects: A functional imaging study. Addict Biol  2019; 24(5): 1066-76.
 [http://dx.doi.org/10.1111/adb.12651] [PMID: 29984874]

[176]
Leggio L, Ferrulli A, Cardone S, et al. Ghrelin system in alcohol-dependent subjects: Role of plasma ghrelin levels in alcohol drinking and craving. Addict Biol  2012; 17(2): 452-64.
 [http://dx.doi.org/10.1111/j.1369-1600.2010.00308.x] [PMID: 21392177]

[177]
Farokhnia M, Grodin EN, Lee MR, et al. Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals. Mol Psychiatry  2018; 23(10): 2029-38.
 [http://dx.doi.org/10.1038/mp.2017.226] [PMID: 29133954]

[178]
Lee MR, Tapocik JD, Ghareeb M, et al. The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: Preclinical safety experiments and a phase 1b human laboratory study. Mol Psychiatry  2020; 25(2): 461-75.
 [http://dx.doi.org/10.1038/s41380-018-0064-y] [PMID: 29728704]

[179]
Tufvesson-Alm M, Shevchouk OT, Jerlhag E. Insight into the role of the gut-brain axis in alcohol-related responses: Emphasis on GLP-1, amylin, and ghrelin. Front Psychiatry  2023; 13: 1092828.
 [http://dx.doi.org/10.3389/fpsyt.2022.1092828] [PMID: 36699502]

[180]
Morganstern I, Barson JR, Leibowitz SF. Regulation of drug and palatable food overconsumption by similar peptide systems. Curr Drug Abuse Rev  2011; 4(3): 163-73.
 [http://dx.doi.org/10.2174/1874473711104030163] [PMID: 21999690]

[181]
Labarthe A, Fiquet O, Hassouna R, et al. Ghrelin-derived peptides: A link between appetite/reward, GH axis, and psychiatric disorders? Front Endocrinol  2014; 5: 163.
 [http://dx.doi.org/10.3389/fendo.2014.00163] [PMID: 25386163]

[182]
Schellekens H, Finger BC, Dinan TG, Cryan JF. Ghrelin signalling and obesity: At the interface of stress, mood and food reward. Pharmacol Ther  2012; 135(3): 316-26.
 [http://dx.doi.org/10.1016/j.pharmthera.2012.06.004] [PMID: 22749794]

[183]
Messman-Moore T, Ward RM, Zerubavel N, Chandley RB, Barton SN. Emotion dysregulation and drinking to cope as predictors and consequences of alcohol-involved sexual assault: Examination of short-term and long-term risk. J Interpers Violence  2015; 30(4): 601-21.
 [http://dx.doi.org/10.1177/0886260514535259] [PMID: 24919992]

[184]
Messman-Moore TL, Ward RM. Emotion dysregulation and coping drinking motives in college women. Am J Health Behav  2014; 38(4): 553-9.
 [http://dx.doi.org/10.5993/AJHB.38.4.8] [PMID: 24636117]

[185]
Howell AN, Leyro TM, Hogan J, Buckner JD, Zvolensky MJ. Anxiety sensitivity, distress tolerance, and discomfort intolerance in relation to coping and conformity motives for alcohol use and alcohol use problems among young adult drinkers. Addict Behav  2010; 35(12): 1144-7.
 [http://dx.doi.org/10.1016/j.addbeh.2010.07.003] [PMID: 20719435]

[186]
Da Silva GE, Vendruscolo LF, Takahashi RN. Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats. Life Sci  2005; 77(6): 693-706.
 [http://dx.doi.org/10.1016/j.lfs.2005.01.013] [PMID: 15922000]

[187]
Izídio GS, Ramos A. Positive association between ethanol consumption and anxiety-related behaviors in two selected rat lines. Alcohol Fayettev N  2007; 41(7): 517-24.
 [http://dx.doi.org/10.1016/j.alcohol.2007.07.008]

[188]
Braun TD, Kunicki ZJ, Blevins CE, et al. Prospective associations between attitudes toward sweet foods, sugar consumption, and cravings for alcohol and sweets in early recovery from alcohol use disorders. Alcohol Treat Q  2021; 39(3): 269-81.
 [http://dx.doi.org/10.1080/07347324.2020.1868958] [PMID: 34566252]

[189]
Nolan LJ, Scagnelli LM. Preference for sweet foods and higher body mass index in patients being treated in long-term methadone maintenance. Subst Use Misuse  2007; 42(10): 1555-66.
 [http://dx.doi.org/10.1080/10826080701517727] [PMID: 17918026]

[190]
Caan B, Coates A, Schaefer C, Finkler L, Sternfeld B, Corbett K. Women gain weight 1 year after smoking cessation while dietary intake temporarily increases. J Am Diet Assoc  1996; 96(11): 1150-5.
 [http://dx.doi.org/10.1016/S0002-8223(96)00296-9] [PMID: 8906140]

[191]
Cowan J, Devine C. Food, eating, and weight concerns of men in recovery from substance addiction. Appetite  2008; 50(1): 33-42.
 [http://dx.doi.org/10.1016/j.appet.2007.05.006] [PMID: 17602790]

[192]
Zador D, Wall PML, Webster I. High sugar intake in a group of women on methadone maintenance in South Western Sydney, Australia. Addiction  1996; 91(7): 1053-61.
 [http://dx.doi.org/10.1046/j.1360-0443.1996.917105311.x] [PMID: 8688819]

[193]
Samson HH, Roehrs TA, Tolliver GA. Ethanol reinforced responding in the rat: A concurrent analysis using sucrose as the alternate choice. Pharmacol Biochem Behav  1982; 17(2): 333-9.
 [http://dx.doi.org/10.1016/0091-3057(82)90088-0] [PMID: 7134241]

[194]
Kampov-Polevoy AB, Overstreet DH, Rezvani AH, Janowsky DS. Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption. Pharmacol Biochem Behav  1995; 52(1): 59-64.
 [http://dx.doi.org/10.1016/0091-3057(94)00430-Q] [PMID: 7501679]

[195]
Cummings JR, Ray LA, Nooteboom P, Tomiyama AJ. Acute effect of eating sweets on alcohol cravings in a sample with at-risk drinking. Ann Behav Med  2019; 54(2): 132-8.

[196]
Abrantes AM, Kunicki Z, Braun T, et al. Daily associations between alcohol and sweets craving and consumption in early AUD recovery: Results from an ecological momentary assessment study. J Subst Abuse Treat  2022; 132: 108614.
 [http://dx.doi.org/10.1016/j.jsat.2021.108614] [PMID: 34493429]

[197]
Wiers CE, Vendruscolo LF, van der Veen JW, et al. Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. Sci Adv  2021; 7(15): eabf6780.
 [http://dx.doi.org/10.1126/sciadv.abf6780] [PMID: 33837086]

[198]
Mahajan VR, Elvig SK, Vendruscolo LF, et al. Nutritional ketosis as a potential treatment for alcohol use disorder. Front Psychiatry  2021; 12: 781668.
 [http://dx.doi.org/10.3389/fpsyt.2021.781668] [PMID: 34916977]

[199]
Blanco-Gandía MC, Ródenas-González F, Pascual M, et al. Ketogenic diet decreases alcohol intake in adult male mice. Nutrients  2021; 13(7): 2167.
 [http://dx.doi.org/10.3390/nu13072167] [PMID: 34202492]

[200]
Dencker D, Molander A, Thomsen M, Schlumberger C, Wortwein G, Weikop P. Ketogenic diet suppresses alcohol withdrawal syndrome in rats. Alcohol Clin Exp Res  2018; 42(2): 270-7.
 [PMID: 29160944]

[201]
Bornebusch AB, Mason GF, Tonetto S, et al. Effects of ketogenic diet and ketone monoester supplement on acute alcohol withdrawal symptoms in male mice. Psychopharmacology  2021; 238(3): 833-44.
 [http://dx.doi.org/10.1007/s00213-020-05735-1] [PMID: 33410985]

[202]
Dikaiou P, Björck L, Adiels M, et al. Obesity, overweight and risk for cardiovascular disease and mortality in young women. Eur J Prev Cardiol  2021; 28(12): 1351-9.
 [http://dx.doi.org/10.1177/2047487320908983] [PMID: 34647583]

[203]
Yang Y, Shields GS, Guo C, Liu Y. Executive function performance in obesity and overweight individuals: A meta-analysis and review. Neurosci Biobehav Rev  2018; 84: 225-44.
 [http://dx.doi.org/10.1016/j.neubiorev.2017.11.020] [PMID: 29203421]

[204]
Luppino FS, de Wit LM, Bouvy PF, et al. Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry  2010; 67(3): 220-9.
 [http://dx.doi.org/10.1001/archgenpsychiatry.2010.2] [PMID: 20194822]

[205]
Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all- cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis. JAMA  2013; 309(1): 71-82.
 [http://dx.doi.org/10.1001/jama.2012.113905] [PMID: 23280227]

[206]
Sirohi S, Van Cleef A, Davis JF. Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats. Pharmacol Biochem Behav  2017; 153: 105-15.
 [http://dx.doi.org/10.1016/j.pbb.2016.12.009] [PMID: 27998722]

[207]
Shah K, Shaw C, Sirohi S. Reduced alcohol drinking following patterned feeding: Role of palatability and acute contingent availability. Physiol Behav  2020; 224: 113020.
 [http://dx.doi.org/10.1016/j.physbeh.2020.113020] [PMID: 32574662]

[208]
Villavasso S, Shaw C, Skripnikova E, Shah K, Davis JF, Sirohi S. Nutritional contingency reduces alcohol drinking by altering central neurotransmitter receptor gene expression in rats. Nutrients  2019; 11(11): 2731.
 [http://dx.doi.org/10.3390/nu11112731] [PMID: 31717954]

[209]
Leon Z, Shah K, Bailey LS, Karkhanis AN, Sirohi S. Patterned feeding of a hyper-palatable food (oreo cookies) reduces alcohol drinking in rats. Front Behav Neurosci  2021; 15: 725856.
 [http://dx.doi.org/10.3389/fnbeh.2021.725856] [PMID: 34744651]

[210]
Lewis MJ. Alcoholism and nutrition: A review of vitamin supplementation and treatment. Curr Opin Clin Nutr Metab Care  2020; 23(2): 138-44.
 [http://dx.doi.org/10.1097/MCO.0000000000000622] [PMID: 31977336]

[211]
Chandrakumar A, Bhardwaj A, ’t Jong GW. Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. J Basic Clin Physiol Pharmacol  2019; 30(2): 153-62.
 [http://dx.doi.org/10.1515/jbcpp-2018-0075] [PMID: 30281514]

[212]
Fernandes LMP, Bezerra FR, Monteiro MC, et al. Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: How poor nutrition contributes to the alcoholic syndrome, as Marchiafava–Bignami disease. Eur J Clin Nutr  2017; 71(5): 580-6.
 [http://dx.doi.org/10.1038/ejcn.2016.267] [PMID: 28225048]

[213]
Petrie WM, Ban TA. Vitamins in psychiatry. Do they have a role? Drugs  1985; 30(1): 58-65.
 [http://dx.doi.org/10.2165/00003495-198530010-00006] [PMID: 3896744]

[214]
Sriram K, Manzanares W, Joseph K. Thiamine in nutrition therapy. Nutr Clin Pract  2012; 27(1): 41-50.
 [http://dx.doi.org/10.1177/0884533611426149] [PMID: 22223666]

[215]
DiNicolantonio JJ, O’Keefe JH. The importance of marine omega-3s for brain development and the prevention and treatment of behavior, mood, and other brain disorders. Nutrients  2020; 12(8): 2333.
 [http://dx.doi.org/10.3390/nu12082333] [PMID: 32759851]

[216]
de Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: Implications for health and disease. Physiol Rev  2015; 95(1): 1-46.
 [http://dx.doi.org/10.1152/physrev.00012.2014] [PMID: 25540137]

[217]
Młyniec K, Davies CL, de Agüero Sánchez IG, Pytka K, Budziszewska B, Nowak G. Essential elements in depression and anxiety. Part I. Pharmacol Rep  2014; 66(4): 534-44.
 [http://dx.doi.org/10.1016/j.pharep.2014.03.001] [PMID: 24948052]

[218]
Młyniec K, Gaweł M, Doboszewska U, et al. Essential elements in depression and anxiety. Part II. Pharmacol Rep  2015; 67(2): 187-94.
 [http://dx.doi.org/10.1016/j.pharep.2014.09.009] [PMID: 25712638]

[219]
Sher L. Depression and suicidal behavior in alcohol abusing adolescents: Possible role of selenium deficiency. Minerva Pediatr  2008; 60(2): 201-9.
 [PMID: 18449137]

[220]
Skalny AV, Skalnaya MG, Grabeklis AR, Skalnaya AA, Tinkov AA. Zinc deficiency as a mediator of toxic effects of alcohol abuse. Eur J Nutr  2018; 57(7): 2313-22.
 [http://dx.doi.org/10.1007/s00394-017-1584-y] [PMID: 29177978]

[221]
Marik PE, Liggett A. Adding an orange to the banana bag: Vitamin C deficiency is common in alcohol use disorders. Crit Care  2019; 23(1): 165.
 [http://dx.doi.org/10.1186/s13054-019-2435-4] [PMID: 31077227]

[222]
Flannery AH, Adkins DA, Cook AM. Unpeeling the evidence for the banana bag: evidence-based recommendations for the management of alcohol-associated vitamin and electrolyte deficiencies in the ICU. Crit Care Med  2016; 44(8): 1545-52.
 [http://dx.doi.org/10.1097/CCM.0000000000001659] [PMID: 27002274]

[223]
Yang M, Zhou X, Tan X, et al. The status of oxidative stress in patients with alcohol dependence: A meta-analysis. Antioxidants  2022; 11(10): 1919.
 [http://dx.doi.org/10.3390/antiox11101919] [PMID: 36290642]

[224]
Fernández-Checa JC, Kaplowitz N, Colell A, García-Ruiz C. Oxidative stress and alcoholic liver disease. Alcohol Health Res World  1997; 21(4): 321-4.
 [PMID: 15706743]

[225]
Tobore TO. On the neurobiological role of oxidative stress in alcohol-induced impulsive, aggressive and suicidal behavior. Subst Use Misuse  2019; 54(14): 2290-303.
 [http://dx.doi.org/10.1080/10826084.2019.1645179] [PMID: 31369300]

[226]
Hovatta I, Juhila J, Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res  2010; 68(4): 261-75.
 [http://dx.doi.org/10.1016/j.neures.2010.08.007] [PMID: 20804792]

[227]
Kim SHK, K Cho S, Min TS, et al. Ameliorating effects of mango (Mangifera indica L.) fruit on plasma ethanol level in a mouse model assessed with H-NMR based metabolic profiling. J Clin Biochem Nutr  2011; 48(3): 214-21.
 [http://dx.doi.org/10.3164/jcbn.10-96] [PMID: 21562641]

[228]
Liu CT, Raghu R, Lin SH, et al. Metabolomics of ginger essential oil against alcoholic fatty liver in mice. J Agric Food Chem  2013; 61(46): 11231-40.
 [http://dx.doi.org/10.1021/jf403523g] [PMID: 24171385]

[229]
Marino MD, Aksenov MY, Kelly SJ. Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus. Int J Dev Neurosci  2004; 22(5-6): 363-77.
 [http://dx.doi.org/10.1016/j.ijdevneu.2004.04.005] [PMID: 15380836]

[230]
Carai MAM, Agabio R, Bombardelli E, et al. Potential use of medicinal plants in the treatment of alcoholism. Fitoterapia  2000; 71 (Suppl. 1): S38-42.
 [http://dx.doi.org/10.1016/S0367-326X(00)00178-7] [PMID: 10930711]

[231]
Fu L, Xu BT, Gan RY, et al. Total phenolic contents and antioxidant capacities of herbal and tea infusions. Int J Mol Sci  2011; 12(4): 2112-24.
 [http://dx.doi.org/10.3390/ijms12042112] [PMID: 21731430]

[232]
Fu L, Xu BT, Xu XR, et al. Antioxidant capacities and total phenolic contents of 62 fruits. Food Chem  2011; 129(2): 345-50.
 [http://dx.doi.org/10.1016/j.foodchem.2011.04.079] [PMID: 30634236]

[233]
Wang F, Li Y, Zhang YJ, Zhou Y, Li S, Li HB. Natural products for the prevention and treatment of hangover and alcohol use disorder. Molecules  2016; 21(1): 64.
 [http://dx.doi.org/10.3390/molecules21010064] [PMID: 26751438]

[234]
Shanmugam KR, Ramakrishna CH, Mallikarjuna K, Reddy KS. Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats. Indian J Exp Biol  2010; 48(2): 143-9.
 [PMID: 20455323]

[235]
Pekala J, Patkowska-Sokoła B, Bodkowski R, et al. L-carnitine-metabolic functions and meaning in humans life. Curr Drug Metab  2011; 12(7): 667-78.
 [http://dx.doi.org/10.2174/138920011796504536] [PMID: 21561431]

[236]
Martinotti G, Reina D, Di Nicola M, et al. Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: A randomized, double-blind, placebo-controlled pilot trial. Alcohol Alcohol  2010; 45(5): 449-55.
 [http://dx.doi.org/10.1093/alcalc/agq039] [PMID: 20595193]

[237]
Martinotti G, Andreoli S, Reina D, et al. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Prog Neuropsychopharmacol Biol Psychiatry  2011; 35(4): 953-8.
 [http://dx.doi.org/10.1016/j.pnpbp.2011.01.013] [PMID: 21256179]

[238]
Tempesta E, Troncon R, Janiri L, et al. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Int J Clin Pharmacol Res  1990; 10(1-2): 101-7.
 [PMID: 2201652]

[239]
Bota AB, Simmons JG, DiBattista A, Wilson K. Carnitine in alcohol use disorders: A scoping review. Alcohol Clin Exp Res  2021; 45(4): 666-74.
 [http://dx.doi.org/10.1111/acer.14568] [PMID: 33576525]

[240]
Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci  2011; 13: 3-30.
 [http://dx.doi.org/10.1007/978-3-642-28720-6_129] [PMID: 21744309]

[241]
Jukić T, Rojc B, Boben-Bardutzky D, Hafner M, Ihan A. The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms. Coll Antropol  2011; 35(4): 1225-30.
 [PMID: 22397264]

[242]
Mohajeri MH, Wittwer J, Vargas K, et al. Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women. Br J Nutr  2015; 113(2): 350-65.
 [http://dx.doi.org/10.1017/S0007114514003754] [PMID: 25572038]

[243]
Gibson EL, Vargas K, Hogan E, et al. Effects of acute treatment with a tryptophan-rich protein hydrolysate on plasma amino acids, mood and emotional functioning in older women. Psychopharmacology  2014; 231(24): 4595-610.
 [http://dx.doi.org/10.1007/s00213-014-3609-z] [PMID: 24858376]

[244]
Haque IM, Mishra A, Kalra BS, Chawla S. Role of standardized plant extracts in controlling alcohol withdrawal syndrome-an experimental study. Brain Sci  2021; 11(7): 919.
 [http://dx.doi.org/10.3390/brainsci11070919] [PMID: 34356153]

[245]
Coskun I, Tayfun Uzbay I, Ozturk N, Ozturk Y. Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats. Fundam Clin Pharmacol  2006; 20(5): 481-8.
 [http://dx.doi.org/10.1111/j.1472-8206.2006.00432.x] [PMID: 16968419]

[246]
Kim HJ, Lee MY, Kim GR, et al. Korean Red Ginseng extract attenuates alcohol-induced addictive responses and cognitive impairments by alleviating neuroinflammation. J Ginseng Res  2023; 47(4): 583-92.
 [http://dx.doi.org/10.1016/j.jgr.2023.02.003] [PMID: 37397415]

[247]
McLean C, Tapsell L, Grafenauer S, McMahon AT. Systematic review of nutritional interventions for people admitted to hospital for alcohol withdrawal. Nutr Diet  2020; 77(1): 76-89.
 [http://dx.doi.org/10.1111/1747-0080.12593] [PMID: 31797519]

[248]
Russell RM. Vitamin A and zinc metabolism in alcoholism. Am J Clin Nutr  1980; 33(12): 2741-9.
 [http://dx.doi.org/10.1093/ajcn/33.12.2741] [PMID: 7001892]

[249]
Manari A, Preedy V, Peters T. Nutritional intake of hazardous drinkers and dependent alcoholics in the UK. Addict Biol  2003; 8(2): 201-10.
 [http://dx.doi.org/10.1080/1355621031000117437] [PMID: 12850779]

[250]
Leevy CM. Thiamin deficiency and alcoholism. Ann N Y Acad Sci  1982; 378(1): 316-26.
 [http://dx.doi.org/10.1111/j.1749-6632.1982.tb31206.x] [PMID: 7044226]

[251]
Hoyumpa AM Jr. Alcohol and thiamine metabolism. Alcohol Clin Exp Res  1983; 7(1): 11-4.
 [http://dx.doi.org/10.1111/j.1530-0277.1983.tb05403.x] [PMID: 6342440]

[252]
Pitts TO, Van Thiel DH. Disorders of divalent ions and vitamin D metabolism in chronic alcoholism. Recent Dev Alcohol  1986; 4: 357-77.
 [http://dx.doi.org/10.1007/978-1-4899-1695-2_16] [PMID: 3754648]

[253]
Shane SR, Flink EB. Magnesium deficiency in alcohol addiction and withdrawal. Magnes Trace Elem   1992; 10(2-4): 263-8.

[254]
Suzuki H, Mamata Y, Mizuno H, et al. Influence of alcohol on branched-chain amino acid/tyrosine molar ratio in patients with cirrhosis. Alcohol Clin Exp Res  1998; 22(S3 Pt 1) (Suppl. 1): 137.
 [http://dx.doi.org/10.1097/00000374-199803001-00013] [PMID: 9622391]

[255]
Clugston RD, Blaner WS. The adverse effects of alcohol on vitamin A metabolism. Nutrients  2012; 4(5): 356-71.
 [http://dx.doi.org/10.3390/nu4050356] [PMID: 22690322]

[256]
Dimmitt SB, Rakic V, Puddey IB, et al. The effects of alcohol on coagulation and fibrinolytic factors. Blood Coagul Fibrinolysis  1998; 9(1): 39-46.
 [http://dx.doi.org/10.1097/00001721-199801000-00005] [PMID: 9607117]

[257]
Fonda ML, Brown SG, Pendleton MW. Concentration of vitamin B6 and activities of enzymes of B6 metabolism in the blood of alcoholic and nonalcoholic men. Alcohol Clin Exp Res  1989; 13(6): 804-9.
 [http://dx.doi.org/10.1111/j.1530-0277.1989.tb00426.x] [PMID: 2557775]

[258]
Branchey L, Lieber CS. Activation of tryptophan pyrrolase after chronic alcohol administration. Subst Alcohol Actions Misuse  1982; 3(4): 225-9.
 [PMID: 6891969]

[259]
Aagaard NK, Thøgersen T, Grøfte T, Greisen J, Vilstrup H. Alcohol acutely down-regulates urea synthesis in normal men. Alcohol Clin Exp Res  2004; 28(5): 697-701.
 [http://dx.doi.org/10.1097/01.ALC.0000125355.31808.DC] [PMID: 15166643]

[260]
Chang T, Lewis J, Glazko AJ. Effect of ethanol and other alcohols on the transport of amino acids and glucose by everted sacs of rat small intestine. Biochim Biophys Acta Biomembr  1967; 135(5): 1000-7.
 [http://dx.doi.org/10.1016/0005-2736(67)90070-3] [PMID: 6065668]

[261]
Subramanian VS, Subramanya SB, Ghosal A, Said HM. Chronic alcohol feeding inhibits physiological and molecular parameters of intestinal and renal riboflavin transport. Am J Physiol Cell Physiol  2013; 305(5): C539-46.
 [http://dx.doi.org/10.1152/ajpcell.00089.2013] [PMID: 23804199]

[262]
Lindenbaum J, Lieber CS. Alcohol-induced malabsorption of vitamin B12 in man. Nature  1969; 224(5221): 806.
 [http://dx.doi.org/10.1038/224806a0] [PMID: 5361658]

[263]
Duane P, Raja KB, Simpson RJ, Peters TJ. Intestinal iron absorption in chronic alcoholics. Alcohol Alcohol  1992; 27(5): 539-44.
 [PMID: 1476557]

[264]
Antonson DL, Vanderhoof JA. Effect of chronic ethanol ingestion on zinc absorption in rat small intestine. Dig Dis Sci  1983; 28(7): 604-8.
 [http://dx.doi.org/10.1007/BF01299920] [PMID: 6861590]

[265]
Pauluci R, Noto AR, Curado DF, Siqueira-Campos M Jr, Bezerra AG, Galduróz JCF. Omega-3 for the prevention of alcohol use disorder relapse: A placebo-controlled, randomized clinical trial. Front Psychiatry  2022; 13: 826448.
 [http://dx.doi.org/10.3389/fpsyt.2022.826448] [PMID: 35463514]

[266]
Barbadoro P, Annino I, Ponzio E, et al. Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr Food Res  2013; 57(6): 1110-4.
 [http://dx.doi.org/10.1002/mnfr.201200676] [PMID: 23390041]

[267]
Serrano M, Rico-Barrio I, Grandes P. The effect of omega-3 fatty acids on alcohol-induced damage. Front Nutr  2023; 10: 1068343.
 [http://dx.doi.org/10.3389/fnut.2023.1068343] [PMID: 37090780]

[268]
Shi Z, Xie Y, Ren H, et al. Fish oil treatment reduces chronic alcohol exposure induced synaptic changes. Addict Biol  2019; 24(4): 577-89.
 [http://dx.doi.org/10.1111/adb.12623] [PMID: 29569345]

[269]
Wang Y, Zhang N, Zhou J, Sun P, Zhao L, Zhou F. Protective effects of several common amino acids, vitamins, organic acids, flavonoids and phenolic acids against hepatocyte damage caused by alcohol. Foods  2022; 11(19): 3014.
 [http://dx.doi.org/10.3390/foods11193014] [PMID: 36230090]

[270]
Listabarth S, Vyssoki B, Marculescu R, et al. Can thiamine substitution restore cognitive function in alcohol use disorder? Alcohol Alcohol  2023; 58(3): 315-23.
 [http://dx.doi.org/10.1093/alcalc/agad017] [PMID: 36935203]

[271]
Back SE, McCauley JL, Korte KJ, et al. A double-blind, randomized, controlled pilot trial of N-acetylcysteine in veterans with posttraumatic stress disorder and substance use disorders. J Clin Psychiatry  2016; 77(11): e1439-46.
 [http://dx.doi.org/10.4088/JCP.15m10239] [PMID: 27736051]

[272]
Fernández-Rodríguez S, Cano-Cebrián MJ, Esposito-Zapero C, et al. N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: A preclinical study in long-term ethanol-experienced male rats. Psychopharmacology  2023; 240(4): 725-38.
 [http://dx.doi.org/10.1007/s00213-023-06311-z] [PMID: 36708386]

[273]
Ozaras R, Tahan V, Aydin S, Uzun H, Kaya S, Senturk H. N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat. World J Gastroenterol  2003; 9(1): 125-8.
 [http://dx.doi.org/10.3748/wjg.v9.i1.125] [PMID: 12508366]

[274]
Ferreira Seiva FR, Amauchi JF, Ribeiro Rocha KK, Souza GA, Ebaid GX, Burneiko RM. Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats. Alcohol Fayettev N  2009; 43(2): 127-35.

[275]
Fredriksson I, Jayaram-Lindström N, Kalivas PW, Melas PA, Steensland P. N-acetylcysteine improves impulse control and attenuates relapse-like alcohol intake in long-term drinking rats. Behav Brain Res  2023; 436: 114089.
 [http://dx.doi.org/10.1016/j.bbr.2022.114089] [PMID: 36063970]

[276]
Cano-Cebrián MJ, Fernández-Rodríguez S, Hipólito L, Granero L, Polache A, Zornoza T. Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats. J Neurosci Res  2021; 99(2): 638-48.
 [http://dx.doi.org/10.1002/jnr.24736] [PMID: 33063355]

[277]
Lee H, Ok H, Kwon O. Protective effects of korean red ginseng against alcohol-induced fatty liver in rats. Molecules  2015; 20(6): 11604-16.
 [http://dx.doi.org/10.3390/molecules200611604] [PMID: 26111184]

[278]
Yeo M, Kim DK, Cho SW, Hong HD. Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27. Dig Dis Sci  2008; 53(3): 606-13.
 [http://dx.doi.org/10.1007/s10620-007-9946-6] [PMID: 17763949]

[279]
Colombo G, Agabio R, Lobina C, Reali R, Morazzoni P, Bombardelli E. Salvia miltiorrhiza extract inhibits alcohol absorption, preference, and discrimination in sP rats. Alcohol Fayettev N   1999; 18(1): 65-70.
 [http://dx.doi.org/10.1016/S0741-8329(98)00069-X]

[280]
Colombo G, Serra S, Vacca G, et al. Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats. Alcohol Clin Exp Res  2006; 30(5): 754-62.
 [http://dx.doi.org/10.1111/j.1530-0277.2006.00088.x] [PMID: 16634843]

[281]
Serra S, Vacca G, Tumatis S, et al. Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats. J Ethnopharmacol  2003; 88(2-3): 249-52.
 [http://dx.doi.org/10.1016/S0378-8741(03)00260-5] [PMID: 12963151]

[282]
Brunetti G, Serra S, Vacca G, et al. IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats. J Ethnopharmacol  2003; 85(1): 93-7.
 [http://dx.doi.org/10.1016/S0378-8741(02)00363-X] [PMID: 12576207]

[283]
Penetar DM, Toto LH, Farmer SL, et al. The isoflavone puerarin reduces alcohol intake in heavy drinkers: A pilot study. Drug Alcohol Depend  2012; 126(1-2): 251-6.
 [http://dx.doi.org/10.1016/j.drugalcdep.2012.04.012] [PMID: 22578529]

[284]
Lukas SE, Penetar D, Berko J, et al. An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting. Alcohol Clin Exp Res  2005; 29(5): 756-62.
 [http://dx.doi.org/10.1097/01.ALC.0000163499.64347.92] [PMID: 15897719]

[285]
Benlhabib E, Baker JI, Keyler DE, Singh AK. Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. J Med Food  2004; 7(2): 168-79.
 [http://dx.doi.org/10.1089/1096620041224210] [PMID: 15298764]

[286]
Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DYW. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav  2003; 75(3): 619-25.
 [http://dx.doi.org/10.1016/S0091-3057(03)00114-X] [PMID: 12895679]

[287]
Li R, Xu L, Liang T, Li Y, Zhang S, Duan X. Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. Food Chem Toxicol  2013; 52: 69-75.
 [http://dx.doi.org/10.1016/j.fct.2012.10.059] [PMID: 23146695]

[288]
Perfumi M, Mattioli L, Cucculelli M, Massi M. Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats. J Psychopharmacol  2005; 19(5): 448-54.
 [http://dx.doi.org/10.1177/0269881105056519] [PMID: 16166181]

[289]
Rezvani AH, Overstreet DH, Yang Y, Clark E Jr. Attenuation of alcohol intake by extract of Hypericum perforatum (St. John’s Wort) in two different strains of alcohol-preferring rats. Alcohol Alcohol  1999; 34(5): 699-705.
 [http://dx.doi.org/10.1093/alcalc/34.5.699] [PMID: 10528812]

[290]
Perfumi M, Mattioli L, Forti L, Massi M, Ciccocioppo R. Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats. Alcohol Alcohol  2005; 40(4): 291-6.
 [http://dx.doi.org/10.1093/alcalc/agh133] [PMID: 15870093]

[291]
Wright CW, Gott M, Grayson B, et al. Correlation of hyperforin content of Hypericum perforatum (St John’s Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: A preliminary study. J Psychopharmacol  2003; 17(4): 403-8.
 [http://dx.doi.org/10.1177/0269881103174018] [PMID: 14870952]

[292]
Mishra A, Gupta P, Singh Kalr B, Kumar Tiwa Y. Efficacy of Ashwagandha and Brahmi extract on alcohol withdrawal syndrome in laboratory rats. Int J Pharmacol  2020; 16(4): 343-50.
 [http://dx.doi.org/10.3923/ijp.2020.343.350]

[293]
Ruby B, Benson MK, Kumar EP, Sudha S, Wilking JE. Evaluation of Ashwagandha in alcohol withdrawal syndrome. Asian Pac J Trop Dis  2012; 2: S856-60.
 [http://dx.doi.org/10.1016/S2222-1808(12)60279-5]

[294]
Banerjee S, Bansal P. Effect of Withinia somnifera and shilajit on alcohol addiction in mice. Pharmacogn Mag  2016; 12(46) (Suppl. 2): 121.
 [http://dx.doi.org/10.4103/0973-1296.182170] [PMID: 27279696]
Cite As
Current Pharmaceutical Design

A Complex Interplay between Nutrition and Alcohol use Disorder: Implications for Breaking the Vicious Cycle

Abstract
