Biopharmaceuticals: Challenges and Opportunities in Formulation and Delivery

Raj      Kamal; Priyanka      Paul; Amandeep      Singh; Ankit      Awasthi

Keywords: Biopharmaceuticals, nanotechnology, personalized medicine, quality-by-design, transdermal delivery, biological medical products.

[1]
Dasani S, Palanki R, Menon P, Bose SK. Biopharmaceuticals. In: Eltorai AEM, Bakal JA, Newell PC, Osband AJ, Eds. Translational Surgery.  Academic Press 2023; pp. 535-8.
 [http://dx.doi.org/10.1016/B978-0-323-90300-4.00056-2]

[2]
Bhatti A, Rehman A, John P. Challenges and opportunities in healthcare biotechnology. In: Barh D, Ed. Biotechnology in Healthcare 2.  Academic Press 2022; pp. 321-42.
 [http://dx.doi.org/10.1016/B978-0-323-90042-3.00014-1]

[3]
Behera B. Biopharmaceuticals: Challenges and opportunities. CRC Press 2020.
 [http://dx.doi.org/10.1201/9781351013154]

[4]
Ündey C, Ertunç S, Mistretta T, Looze B. Applied advanced process analytics in biopharmaceutical manufacturing: Challenges and prospects in real-time monitoring and control. J Process Contr  2010; 20(9): 1009-18.
 [http://dx.doi.org/10.1016/j.jprocont.2010.05.008]

[5]
Allmendinger A. Opportunities in an evolving pharmaceutical development landscape: Product differentiation of biopharmaceutical drug products. Pharm Res  2021; 38(5): 739-57.
 [http://dx.doi.org/10.1007/s11095-021-03037-5] [PMID: 33903976]

[6]
On body injectors: The future of drug delivery.  Available from: https://www.rootsanalysis.com/blog/exploring-large-volume-wearable-injectors/

[7]
Fang WJ, Liu JW, Barnard J, Wang H, Qian YC, Xu J. Effects of secondary package on freeze-dried biopharmaceutical formulation stability during dropping. J Pharm Sci  2021; 110(8): 2916-24.
 [http://dx.doi.org/10.1016/j.xphs.2021.04.019] [PMID: 33940028]

[8]
Homayun B, Lin X, Choi HJ. Challenges and recent progress in oral drug delivery systems for biopharmaceuticals. Pharmaceutics  2019; 11(3): 129.
 [http://dx.doi.org/10.3390/pharmaceutics11030129] [PMID: 30893852]

[9]
Gao J, Karp JM, Langer R, Joshi N. The future of drug delivery. Chem Mater  2023; 35(2): 359-63.
 [http://dx.doi.org/10.1021/acs.chemmater.2c03003] [PMID: 37799624]

[10]
Carvajal-Vidal P, González-Pizarro R, Araya C, et al. Nanostructured lipid carriers loaded with Halobetasol propionate for topical treatment of inflammation: Development, characterization, biopharmaceutical behavior and therapeutic efficacy of gel dosage forms. Int J Pharm  2020; 585: 119480.
 [http://dx.doi.org/10.1016/j.ijpharm.2020.119480] [PMID: 32479897]

[11]
Edmans JG, Harrison S, Hatton PV, Murdoch C, Spain SG, Colley HE. Electrospinning polymersomes into bead-on-string polyethylene oxide fibres for the delivery of biopharmaceuticals to mucosal epithelia. Biomat Adv  2024; 157: 213734.
 [http://dx.doi.org/10.1016/j.bioadv.2023.213734] [PMID: 38109830]

[12]
Yang Z, Teng Y, Wang H, Hou H. Enhancement of skin permeation of bufalin by limonene via reservoir type transdermal patch: Formulation design and biopharmaceutical evaluation. Int J Pharm  2013; 447(1-2): 231-40.
 [http://dx.doi.org/10.1016/j.ijpharm.2013.02.048] [PMID: 23467076]

[13]
Vicente-Pascual M, Gómez-Aguado I, Rodríguez-Castejón J, et al. Topical administration of SLN-based gene therapy for the treatment of corneal inflammation by de novo IL-10 production. Pharmaceutics  2020; 12(6): 584.
 [http://dx.doi.org/10.3390/pharmaceutics12060584] [PMID: 32586018]

Cite As

Current Pharmaceutical Design

Biopharmaceuticals: Challenges and Opportunities in Formulation and Delivery