Background: Although most cases of choriocarcinoma are of gestational origin, rare cases of extrauterine origin (such as pulmonary) have been reported, which have a poor prognosis.
Case Presentation: We present one such rare case involving a 35-year-old female patient who initially presented to the emergency department with hemothorax and was found to have primary lung choriocarcinoma after multiple biopsies. The patient was properly managed and discharged in a healthy condition. However, she subsequently returned to the hospital with an intracranial haemorrhage and, unfortunately, passed away despite all efforts.
Conclusion: Due to the life-threatening initial presentations of primary pulmonary choriocarcinoma, it is essential to conduct an intensive work-up and maintain close observation when a patient initially presents with such symptoms. Early diagnosis is crucial to initiate appropriate treatment and prevent further complications. Therefore, we aimed to discuss and establish an emergency medicine department-based diagnostic pathway to contribute to the early diagnosis of this deadly malignancy.