A Review on the use of Synthetic and Recombinant Antigens for the
Immunodiagnosis of Tegumentary Leishmaniasis

Kamila   Alves   Silva; Anna   Júlia   Ribeiro; Isadora   Braga   Gandra; Carlos   Ananias Aparecido   Resende; Lucas      da Silva Lopes; Carolina   Alves Petit   Couto; Verônica      de Araujo Freire; Isabelle   Caroline Santos   Barcelos; Sabrina   Paula   Pereira; Sandra   Rodrigues   Xavier; Mariana   Campos   da Paz; Rodolfo   Cordeiro   Giunchetti; Miguel   Angel   Chávez-Fumagalli; Ana Alice   Maia   Gonçalves; Eduardo   Antonio Ferraz   Coelho; Alexsandro   Sobreira   Galdino
Abstract

Improving the diagnostic technology used to detect tegumentary leishmaniasis (TL) is essential in view of it being a widespread, often neglected tropical disease, with cases reported from the Southern United States to Northern Argentina. Recombinant proteins, recombinant multiepitope proteins, and synthetic peptides have been extensively researched and used in disease diagnosis. One of the benefits of applying these antigens is a measurable increase in sensitivity and specificity, which improves test accuracy. The present review aims to describe the use of these antigens and their diagnostic effectiveness. With that in mind, a bibliographic survey was conducted on the PudMed platform using the search terms “tegumentary leishmaniasis” AND “diagno”, revealing that recombinant proteins have been described and evaluated for their value in TL diagnosis since the 1990s. However, there was a spike in the number of publications using all of the antigens between 2013 and 2022, confirming an expansion in research efforts to improve diagnosis. Moreover, all of the studies involving different antigens had promising results, including improved sensitivity and specificity. These data recognize the importance of doing research with new technologies focused on developing quick, more effective diagnostic kits as early diagnosis facilitates treatment.
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Cite As
Current Medicinal Chemistry

A Review on the use of Synthetic and Recombinant Antigens for the Immunodiagnosis of Tegumentary Leishmaniasis

Abstract
