Alzheimer's Disease and Suicide: An Integrative Literature Review

Juliano   Flávio Rubatino   Rodrigues; Livia   Peregrino   Rodrigues; Gerardo   Maria   de Araújo Filho
Abstract

Introduction: Suicide has been described in patients with Alzheimer's disease. Some promising medications for treating Alzheimer's disease have had their studies suspended because they increase the risk of suicide. Understanding the correlations between suicide and Alzheimer's disease is essential in an aging world.
Methods: A search was carried out on electronic websites (PubMed and Scielo) using the MeSH Terms “suicide” and “Alzheimer” (1986-2023). Of a total of 115 articles, 26 were included in this review.
Results: Depression and the allele ε4 of Apolipoprotein (APOE4) were demonstrated to be the main risk factors for suicide in patients with Alzheimer's disease.
Conclusion: Adequately delineating which elderly people are vulnerable to suicide is important so that new treatments for Alzheimer's disease can be successful. This review showed a need for new studies to investigate the interface between Alzheimer's disease and suicide.
Keywords: Alzheimer's disease, suicide, review, integrative, old people, psychiatry.
[1]
Socarrás, V.S. Regulatory mechanisms of non-necrotic cell death. Rev. Cuba. Investig. Bioméd.,  2001, 20(4), 266-274.

[2]
Sharma, V.K.; Singh, T.G.; Singh, S.; Garg, N.; Dhiman, S. Apoptotic pathways and alzheimer’s disease: Probing therapeutic potential. Neurochem. Res.,  2021, 46(12), 3103-3122.
 [http://dx.doi.org/10.1007/s11064-021-03418-7] [PMID: 34386919]

[3]
Stelzmann, R.A.; Norman Schnitzlein, H.; Reed Murtagh, F.; Murtagh, F.R. An english translation of alzheimer’s 1907 paper, “über eine eigenartige erkankung der hirnrinde”. Clin. Anat.,  1995, 8(6), 429-431.
 [http://dx.doi.org/10.1002/ca.980080612] [PMID: 8713166]

[4]
Chen, Z.R.; Huang, J.B.; Yang, S.L.; Hong, F.F. Role of cholinergic signaling in alzheimer’s disease. Molecules,  2022, 27(6), 1816.
 [http://dx.doi.org/10.3390/molecules27061816] [PMID: 35335180]

[5]
Venkatesan, S.; Jeoung, H.S.; Chen, T.; Power, S.K.; Liu, Y.; Lambe, E.K. Endogenous acetylcholine and its modulation of cortical microcircuits to enhance cognition. Curr. Top. Behav. Neurosci.,  2020, 45, 47-69.
 [http://dx.doi.org/10.1007/7854_2020_138] [PMID: 32601996]

[6]
van Heeringen, K.; Mann, J.J. The neurobiology of suicide. Lancet Psychiatry,  2014, 1(1), 63-72.
 [http://dx.doi.org/10.1016/S2215-0366(14)70220-2] [PMID: 26360403]

[7]
Chu, C.; Buchman-Schmitt, J.M.; Stanley, I.H.; Hom, M.A.; Tucker, R.P.; Hagan, C.R.; Rogers, M.L.; Podlogar, M.C.; Chiurliza, B.; Ringer, F.B.; Michaels, M.S.; Patros, C.H.G.; Joiner, T.E. The interpersonal theory of suicide: A systematic review and meta-analysis of a decade of cross-national research. Psychol. Bull.,  2017, 143(12), 1313-1345.
 [http://dx.doi.org/10.1037/bul0000123] [PMID: 29072480]

[8]
Rodrigues, J.F.R. What is suicide: epidemiological profile of suicide in the city of Marília: propositions for prevention; Dialética: São Paulo, 2022. 
 [http://dx.doi.org/10.48021/978-65-252-5790-7]

[9]
Schmutte, T.; Olfson, M.; Maust, D.T.; Xie, M.; Marcus, S.C. Suicide risk in first year after dementia diagnosis in older adults. Alzheimers Dement.,  2022, 18(2), 262-271.
 [http://dx.doi.org/10.1002/alz.12390] [PMID: 34036738]

[10]
Lim, W.S.; Rubin, E.H.; Coats, M.; Morris, J.C. Early-stage Alzheimer disease represents increased suicidal risk in relation to later stages. Alzheimer Dis. Assoc. Disord.,  2005, 19(4), 214-219.
 [http://dx.doi.org/10.1097/01.wad.0000189051.48688.ed] [PMID: 16327348]

[11]
Davis, D.S. Alzheimer disease and pre-emptive suicide. J. Med. Ethics,  2014, (40), 543-549.
 [PMID: 23842079]

[12]
Choi, J.W.; Lee, K.S.; Han, E. Suicide risk within 1 year of dementia diagnosis in older adults: A nationwide retrospective cohort study. J. Psychiatry Neurosci.,  2021, 46(1), E119-E127.
 [http://dx.doi.org/10.1503/jpn.190219] [PMID: 33119492]

[13]
Haw, C.; Harwood, D.; Hawton, K. Dementia and suicidal behavior: A review of the literature. Int. Psychogeriatr.,  2009, 21(3), 440-453.
 [http://dx.doi.org/10.1017/S1041610209009065] [PMID: 19368760]

[14]
Bachmann, S. Epidemiology of suicide and the psychiatric perspective. Int. J. Environ. Res. Public Health.,  2018, 15(7), 1425.
 [http://dx.doi.org/10.3390/ijerph15071425]

[15]
Shneidman, E.S. Suicide as psychache: A clinical approach to self-desctructive behavior; Jason Aronson Book: Lanham, MA, 1993. 

[16]
Caixeta, L. Doença de Alzheimer; Artemed: Porto Alegre, RS, 2012. 

[17]
Conejero, I.; Navucet, S.; Keller, J.; Olié, E.; Courtet, P.; Gabelle, A. A complex relationship between suicide, dementia, and amyloid: A narrative review. Front. Neurosci.,  2018, 12, 371.
 [http://dx.doi.org/10.3389/fnins.2018.00371] [PMID: 29910709]

[18]

Suicide mortality and reports of self-harm in Brazil; Saúde, SdVe, Ed.; Ministry of Health: Brasilia (DF), 2021. 

[19]
Mayeux, R.; Stern, Y. Epidemiology of Alzheimer disease. Cold Spring Harb. Perspect. Med.,  2012, 2(8), a006239.
 [http://dx.doi.org/10.1101/cshperspect.a006239] [PMID: 22908189]

[20]
Ng, K.P.; Richard-Devantoy, S.; Bertrand, J.A.; Jiang, L.; Pascoal, T.A.; Mathotaarachchi, S.; Therriault, J.; Yatawara, C.; Kandiah, N.; Greenwood, C.M.T.; Rosa-Neto, P.; Gauthier, S. Suicidal ideation is common in autosomal dominant Alzheimer’s disease at-risk persons. Int. J. Geriatr. Psychiatry,  2020, 35(1), 60-68.
 [http://dx.doi.org/10.1002/gps.5215] [PMID: 31642105]

[21]
Abramova, O.; Soloveva, K.; Zorkina, Y.; Gryadunov, D.; Ikonnikova, A.; Fedoseeva, E.; Emelyanova, M.; Ochneva, A.; Andriushchenko, N.; Pavlov, K.; Pavlova, O.; Ushakova, V.; Syunyakov, T.; Andryushchenko, A.; Karpenko, O.; Savilov, V.; Kurmishev, M.; Andreuyk, D.; Gurina, O.; Chekhonin, V.; Kostyuk, G.; Morozova, A. Suicide-related single nucleotide polymorphisms, rs4918918 and rs10903034: Association with dementia in older adults. Genes,  2022, 13(11), 2174.
 [http://dx.doi.org/10.3390/genes13112174] [PMID: 36421848]

[22]
Ramakrishna, K.; Nalla, L.V.; Naresh, D.; Venkateswarlu, K.; Viswanadh, M.K.; Nalluri, B.N.; Chakravarthy, G.; Duguluri, S.; Singh, P.; Rai, S.N.; Kumar, A.; Singh, V.; Singh, S.K. WNT-β catenin signaling as a potential therapeutic target for neurodegenerative diseases: Current status and future perspective. Diseases,  2023, 11(3), 89.
 [http://dx.doi.org/10.3390/diseases11030089] [PMID: 37489441]

[23]
Panza, F.; Lozupone, M.; Bellomo, A.; Imbimbo, B.P. Do anti-amyloid-β drugs affect neuropsychiatric status in Alzheimer’s disease patients? Ageing Res. Rev.,  2019, 55, 100948.
 [http://dx.doi.org/10.1016/j.arr.2019.100948] [PMID: 31454563]

[24]
Klonsky, E.D.; Saffer, B.Y.; Bryan, C.J. Ideation-to-action theories of suicide: A conceptual and empirical update. Curr. Opin. Psychol.,  2018, 22, 38-43.
 [http://dx.doi.org/10.1016/j.copsyc.2017.07.020] [PMID: 30122276]

[25]
Vega, U.; Kishikawa, Y.; Ricanati, E.; Friedland, R.P. Suicide and Alzheimer disease. Am. J. Geriatr. Psychiatry,  2002, 10(4), 484-485.
 [http://dx.doi.org/10.1097/00019442-200207000-00021] [PMID: 12095909]

[26]
Kalin, N.H. Adversity, trauma, suicide, and alzheimer’s disease. Am. J. Psychiatry,  2021, 178(11), 985-987.
 [http://dx.doi.org/10.1176/appi.ajp.2021.21090916] [PMID: 34734745]

[27]
Richard-Devantoy, S.; Annweiler, C.; Le Gall, D.; Beauchet, O. Cognitive deficits in a suicidal depressed alzheimer’s patient: A specific vulnerability? Int. J. Geriatr. Psychiatry,  2014, 29(3), 326-328.
 [http://dx.doi.org/10.1002/gps.4022] [PMID: 24515447]

[28]
Ferris, S.H.; Hofeldt, G.T.; Carbone, G.; Masciandaro, P.; Troetel, W.M.; Imbimbo, B.P. Suicide in two patients with a diagnosis of probable Alzheimer disease. Alzheimer Dis. Assoc. Disord.,  1999, 13(2), 88-90.
 [http://dx.doi.org/10.1097/00002093-199904000-00005] [PMID: 10372951]

[29]
Peisah, C.; Snowdon, J.; Kril, J.; Rodriguez, M. Clinicopathological findings of suicide in the elderly: Three cases. Suicide Life Threat. Behav.,  2007, 37(6), 648-658.
 [http://dx.doi.org/10.1521/suli.2007.37.6.648] [PMID: 18275371]

[30]
Baptista, M.A.T.; Santos, R.L.; Kimura, N.; Lacerda, I.B.; Dourado, M.C.N. Disease awareness may increase risk of suicide in young onset dementia: A case report. Dement. Neuropsychol.,  2017, 11(3), 308-311.
 [http://dx.doi.org/10.1590/1980-57642016dn11-030015] [PMID: 29213530]

[31]
Bracha, H.S.; Kleinman, J.E. Postmortem studies in psychiatry. Psychiatr. Clin. North Am.,  1984, 7(3), 473-485.
 [http://dx.doi.org/10.1016/S0193-953X(18)30745-7] [PMID: 6384958]

[32]
Ahlbom, A. Neurodegenerative diseases, suicide and depressive symptoms in relation to EMF. Bioelectromagnetics,  2001, 2001(S5), S132-S143.

[33]
Norton, N.; Owen, M.J. HTR2A: Association and expression studies in neuropsychiatric genetics. Ann. Med.,  2005, 37(2), 121-129.
 [http://dx.doi.org/10.1080/07853890510037347] [PMID: 16026119]

[34]
Hünnerkopf, R.; Grassl, J.; Thome, J. Proteomics: biomarker research in psychiatry. Fortschr. Neurol. Psychiatr.,  2007, 75(10), 579-585.
 [http://dx.doi.org/10.1055/s-2007-959249] [PMID: 17566964]

[35]
Hesdorffer, D.C. Comorbidity between neurological illness and psychiatric disorders. CNS Spectr.,  2016, 21(3), 230-238.
 [http://dx.doi.org/10.1017/S1092852915000929] [PMID: 26898322]

[36]
Serafini, G.; Calcagno, P.; Lester, D.; Girardi, P.; Amore, M.; Pompili, M. Suicide risk in alzheimer’s disease: A systematic review. Curr. Alzheimer Res.,  2016, 13(10), 1083-1099.
 [http://dx.doi.org/10.2174/1567205013666160720112608] [PMID: 27449996]

[37]
Portacolone, E.; Byers, A.L.; Halpern, J.; Barnes, D.E. Addressing suicide risk in patients living with dementia during the COVID-19 pandemic and beyond. Gerontologist,  2022, 62(7), 956-963.
 [http://dx.doi.org/10.1093/geront/gnac042] [PMID: 35365827]

[38]
García-Sevilla, J.A.; Miralles, A.; Sastre, M.; Escribá, P.; Olmos, G.; Meana, J.J. I2-imidazoline receptors in the healthy and pathologic human brain. Ann. N. Y. Acad. Sci.,  1995, 763(1), 178-193.
 [http://dx.doi.org/10.1111/j.1749-6632.1995.tb32406.x] [PMID: 7677330]

[39]
Calderón-Garcidueñas, L.; Torres-Jardón, R.; Franco-Lira, M.; Kulesza, R.; González-Maciel, A.; Reynoso-Robles, R.; Brito-Aguilar, R.; García-Arreola, B.; Revueltas-Ficachi, P.; Barrera-Velázquez, J.A.; García-Alonso, G.; García-Rojas, E.; Mukherjee, P.S.; Delgado-Chávez, R. Environmental nanoparticles, SARS-CoV-2 brain involvement, and potential acceleration of alzheimer’s and parkinson’s diseases in young urbanites exposed to air pollution. J. Alzheimers Dis.,  2020, 78(2), 479-503.
 [http://dx.doi.org/10.3233/JAD-200891] [PMID: 32955466]

[40]
Calderón-Garcidueñas, L.; Hernández-Luna, J.; Aiello-Mora, M.; Brito-Aguilar, R.; Evelson, P.A.; Villarreal-Ríos, R.; Torres-Jardón, R.; Ayala, A.; Mukherjee, P.S. APOE peripheral and brain impact: APOE4 carriers accelerate their alzheimer continuum and have a high risk of suicide in PM2.5 polluted cities. Biomolecules,  2023, 13(6), 927.
 [http://dx.doi.org/10.3390/biom13060927] [PMID: 37371506]

[41]
Pearlson, G.D.; Ross, C.A.; Lohr, W.D.; Rovner, B.W.; Chase, G.A.; Folstein, M.F. Association between family history of affective disorder and the depressive syndrome of Alzheimer’s disease. Am. J. Psychiatry,  1990, 147(4), 452-456.
 [http://dx.doi.org/10.1176/ajp.147.4.452] [PMID: 2316731]

[42]
Rubio, A.; Vestner, A.L.; Stewart, J.M.; Forbes, N.T.; Conwell, Y.; Cox, C. Suicide and Alzheimer’s pathology in the elderly: A case–control study. Biol. Psychiatry,  2001, 49(2), 137-145.
 [http://dx.doi.org/10.1016/S0006-3223(00)00952-5] [PMID: 11164760]

[43]
Barak, Y.; Aizenberg, D. Suicide amongst Alzheimer’s disease patients: A 10-year survey. Dement. Geriatr. Cogn. Disord.,  2002, 14(2), 101-103.
 [http://dx.doi.org/10.1159/000064931] [PMID: 12145457]

[44]
Erlangsen, A.; Zarit, S.H.; Conwell, Y. Hospital-diagnosed dementia and suicide: A longitudinal study using prospective, nationwide register data. Am. J. Geriatr. Psychiatry,  2008, 16(3), 220-228.
 [http://dx.doi.org/10.1097/01.JGP.0000302930.75387.7e] [PMID: 18310552]

[45]
Crow, T.; Cross, A.J.; Cooper, S.J.; Deakin, J.F.W.; Ferrier, I.N.; Johnson, J.A.; Joseph, M.H.; Owen, F.; Poulter, M.; Lofthouse, R. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology,  1984, 23(12), 1561-1569.
 [http://dx.doi.org/10.1016/0028-3908(84)90100-X] [PMID: 6084823]

[46]
Matschke, J.; Sehner, S.; Gallinat, J.; Siegers, J.; Murroni, M.; Püschel, K.; Glatzel, M. No difference in the prevalence of Alzheimer-type neurodegenerative changes in the brains of suicides when compared with controls: An explorative neuropathologic study. Eur. Arch. Psychiatry Clin. Neurosci.,  2018, 268(5), 509-517.
 [http://dx.doi.org/10.1007/s00406-018-0876-4] [PMID: 29383449]

[47]
Calderón-Garcidueñas, L.; Gónzalez-Maciel, A.; Reynoso-Robles, R.; Delgado-Chávez, R.; Mukherjee, P.S.; Kulesza, R.J.; Torres-Jardón, R.; Ávila-Ramírez, J.; Villarreal-Ríos, R. Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age. Environ. Res.,  2018, 164, 475-487.
 [http://dx.doi.org/10.1016/j.envres.2018.03.023] [PMID: 29587223]

[48]
Calderón-Garcidueñas, L.; González-Maciel, A.; Reynoso-Robles, R.; Kulesza, R.J.; Mukherjee, P.S.; Torres-Jardón, R.; Rönkkö, T.; Doty, R.L. Alzheimer’s disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology. Environ. Res.,  2018, 166, 348-362.
 [http://dx.doi.org/10.1016/j.envres.2018.06.027] [PMID: 29935448]

[49]
Ferrer-Cairols, I.; Montoliu, T.; Crespo-Sanmiguel, I.; Pulopulos, M.M.; Hidalgo, V.; Gómez, E.; López-Cuevas, R.; Cuevas, A.; Martín, N.; Baquero, M.; Salvador, A. Depression and suicide risk in mild cognitive impairment: The role of alzheimer’s disease biomarkers. Psicothema,  2022, 34(4), 553-561.
 [PMID: 36268960]

[50]
Garcia-Argibay, M.; Hiyoshi, A.; Fall, K.; Montgomery, S. Association of 5α-reductase inhibitors with dementia, depression, and suicide. JAMA Netw. Open,  2022, 5(12), e2248135.
 [http://dx.doi.org/10.1001/jamanetworkopen.2022.48135] [PMID: 36547981]

[51]
Brunner, J.; Bronisch, T.; Uhr, M.; Ising, M.; Binder, E.; Holsboer, F.; Turck, C.W. Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters. Eur. Arch. Psychiatry Clin. Neurosci.,  2005, 255(6), 438-440.
 [http://dx.doi.org/10.1007/s00406-005-0575-9] [PMID: 16382377]

[52]
Draper, B.; MacCuspie-Moore, C.; Brodaty, H. Suicidal ideation and the ‘wish to die’ in dementia patients: The role of depression. Age Ageing,  1998, 27(4), 503-507.
 [http://dx.doi.org/10.1093/ageing/27.4.503] [PMID: 9884008]

[53]
Rao, R.; Dening; Brayne, C.; Huppert, F.A. Suicidal thinking in community residents over eighty. Int. J. Geriatr. Psychiatry,  1997, 12(3), 337-343.
 [http://dx.doi.org/10.1002/(SICI)1099-1166(199703)12:3<337::AID-GPS498>3.0.CO;2-T] [PMID: 9152718]

[54]
Dresser, R. Pre-emptive suicide, precedent autonomy and preclinical Alzheimer disease. J. Med. Ethics,  2013, 40(8), 550-1.
 [http://dx.doi.org/10.1136/medethics-2013-101615] [PMID: 23878404]

[55]
Henson, D.M. Balancing autonomy with relationships. Health Prog.,  2014, 95(1), 14-19.
 [PMID: 24624555]

[56]
Draper, B. Rational suicide and dementia. J. Med. Ethics,  2014, 44(2), 130-131.
 [http://dx.doi.org/10.1136/medethics-2012-101022]

[57]
Miller, D.G.; Dresser, R.; Kim, S.Y.H. Advance euthanasia directives: A controversial case and its ethical implications. J. Med. Ethics,  2019, 45(2), 84-89.
 [http://dx.doi.org/10.1136/medethics-2017-104644] [PMID: 29502099]

[58]
Largent, E.A.; Terrasse, M.; Harkins, K.; Sisti, D.A.; Sankar, P.; Karlawish, J. Attitudes toward physician-assisted death from individuals who learn they have an alzheimer disease biomarker. JAMA Neurol.,  2019, 76(7), 864-866.
 [http://dx.doi.org/10.1001/jamaneurol.2019.0797] [PMID: 31034041]

[59]
Bogado, F. Knowledge and attitudes about euthanasia and assisted suicide in students and professionals in the health area of ​​the Hospital de Clínicas, San Lorenzo. Paraguay Med clín soc.,  2020, 4(1), 10-17.

[60]
Braun, B.; Demling, J.; Loew, T.H. Alzheimer’s disease: History, ethics and medical humanities in the context of assisted suicide. Philos. Ethics Humanit. Med.,  2022, 17(1), 4.
 [http://dx.doi.org/10.1186/s13010-021-00111-z] [PMID: 35351154]

[61]
Kious, B.M. Medical assistance in dying in neurology. Neurol. Clin.,  2023, 41(3), 443-454.
 [http://dx.doi.org/10.1016/j.ncl.2023.03.002] [PMID: 37407098]

[62]
Rosenbaum, D.; Cho, M.; Schneider, E.; Hales, S.; Buchman, D.Z. Ethical considerations at the intersection between psychedelic-assisted psychotherapy and medical assistance in dying. AJOB Neurosci.,  2023, 14(2), 139-141.
 [http://dx.doi.org/10.1080/21507740.2023.2188297] [PMID: 37097844]

[63]
Hurst, S. Ethique: Quelques questions face à la démence. Praxis,  2017, 106(22), 1211-1213.
 [http://dx.doi.org/10.1024/1661-8157/a002844]

[64]
Post, S.G. Physician-assisted suicide in Alzheimer’s disease. J. Am. Geriatr. Soc.,  1997, 45(5), 647-651.
 [http://dx.doi.org/10.1111/j.1532-5415.1997.tb03106.x] [PMID: 9158595]

[65]
Karger, A.; Haupt, M. Euthanasia in dementia. Nervenarzt,  1997, 68(11), 907-913.
 [http://dx.doi.org/10.1007/s001150050215] [PMID: 9732735]

[66]
Post, S.G.; Whitehouse, P.J.; Nelson, J.L.; Sachs, G.A. Alzheimer disease ethics: A continuing area of public interest. Alzheimer Dis. Assoc. Disord.,  1999, 13(2), 63-65.
 [http://dx.doi.org/10.1097/00002093-199904000-00001] [PMID: 10372947]

[67]
Davis, D.S. Rational suicide and predictive genetic testing. J. Clin. Ethics,  1999, 10(4), 316-323.
 [http://dx.doi.org/10.1086/JCE199910407] [PMID: 10791282]

[68]
Kane, M.N.; Hamlin, E.R., II; Hawkins, W.E. Perceptions of preparedness to assist elders with end-of-life care preferences. J. Soc. Work End Life Palliat. Care,  2005, 1(1), 49-69.
 [http://dx.doi.org/10.1300/J457v01n01_04] [PMID: 17387056]

[69]
Hertogh, C.M.P.M.; de Boer, M.E.; Dröes, R.M.; Eefsting, J.A. Would we rather lose our life than lose our self? Lessons from the Dutch debate on euthanasia for patients with dementia. Am. J. Bioeth.,  2007, 7(4), 48-56.
 [http://dx.doi.org/10.1080/15265160701220881] [PMID: 17454999]

[70]
Sheldon, T. Dementia patient’s euthanasia was lawful, say Dutch authorities. BMJ,  2011, 343(nov21 2), d7510.
 [http://dx.doi.org/10.1136/bmj.d7510] [PMID: 22106373]

[71]
Holmes, D. UK High Court case to reignite debate over assisted death. Lancet Neurol.,  2012, 11(5), 392-393.
 [http://dx.doi.org/10.1016/S1474-4422(12)70086-8] [PMID: 22516075]

[72]
Alvargonzález, D. Alzheimer’s disease and euthanasia. J. Aging Stud.,  2012, 26(4), 377-385.
 [http://dx.doi.org/10.1016/j.jaging.2012.04.001] [PMID: 22939533]

[73]
Howe, E.G. Mediation approaches at the beginning or end of life. J. Clin. Ethics,  2015, 26(4), 275-285.
 [http://dx.doi.org/10.1086/JCE2015264275] [PMID: 26752381]

[74]
Post, S.G. Alzheimer disease and physician-assisted suicide. Alzheimer Dis. Assoc. Disord.,  1993, 7(2), 65-68.
 [http://dx.doi.org/10.1097/00002093-199307020-00001] [PMID: 8347329]

[75]
McBride, M.; Sachs, A. Dr. Death’s suicide machine. Time,  1990, 135(25), 69-70.
 [PMID: 10170567]

[76]
Donahue, J.W.D. Physician-assisted suicide: A “right” reserved for only the competent? Vt. Law Rev.,  1995, 19, 795-842.
 [PMID: 16086485]

[77]
Borger, G. The shadows lurking behind Dr. Death. US News World Rep.,  1990, 109(24), 30-31.
 [PMID: 10170635]

[78]
Honey, C.R. Simple assistance and difficult Issues. Med. J. Aust.,  1991, 154(3), 206-207.
 [http://dx.doi.org/10.5694/j.1326-5377.1991.tb121036.x] [PMID: 1988796]

[79]
Sowerby, E.M. A friend looks at euthanasia and suicide of BC couple. CMAJ,  1996, 154(11), 1620-1621.
 [PMID: 8646645]

[80]
Wilson, V. Murder-suicide involving BC doctor raises troubling questions about euthanasia. CMAJ,  1995, 152(11), 1855-1856.
 [PMID: 7773902]

[81]
Workman, S. Murder-suicide a crisis, not an ethical issue. CMAJ,  1995, 153(6), 739.
 [PMID: 7664220]

[82]
Hwang, J.P.; Yang, C.H.; Hong, C.J.; Lirng, J.F.; Yang, Y.M.; Tsai, S.J. Association of APOE genetic polymorphism with cognitive function and suicide history in geriatric depression. Dement. Geriatr. Cogn. Disord.,  2006, 22(4), 334-338.
 [http://dx.doi.org/10.1159/000095599] [PMID: 16954688]

[83]
Hauser, P.S.; Narayanaswami, V.; Ryan, R.O. Apolipoprotein E: From lipid transport to neurobiology. Prog. Lipid Res.,  2011, 50(1), 62-74.
 [http://dx.doi.org/10.1016/j.plipres.2010.09.001] [PMID: 20854843]

[84]
Ghiselli, G.; Schaefer, E.J.; Gascon, P.; Breser, H.B., Jr Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. Science,  1981, 214(4526), 1239-1241.
 [http://dx.doi.org/10.1126/science.6795720] [PMID: 6795720]

[85]
Weisgraber, K.H.; Innerarity, T.L.; Mahley, R.W. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J. Biol. Chem.,  1982, 257(5), 2518-2521.
 [http://dx.doi.org/10.1016/S0021-9258(18)34954-8] [PMID: 6277903]

[86]
Gregg, R.E.; Zech, L.A.; Schaefer, E.J.; Stark, D.; Wilson, D.; Brewer, H.B., Jr Abnormal in vivo metabolism of apolipoprotein E4 in humans. J. Clin. Invest.,  1986, 78(3), 815-821.
 [http://dx.doi.org/10.1172/JCI112645] [PMID: 3745440]

[87]
Zhang, M.; Chen, J.; Yin, Z.; Wang, L.; Peng, L. The association between depression and metabolic syndrome and its components: A bidirectional two-sample Mendelian randomization study. Transl. Psychiatry,  2021, 11(1), 633.
 [http://dx.doi.org/10.1038/s41398-021-01759-z] [PMID: 34903730]

[88]
Wagner, C.J.; Musenbichler, C.; Böhm, L.; Färber, K.; Fischer, A.I.; von Nippold, F.; Winkelmann, M.; Richter-Schmidinger, T.; Mühle, C.; Kornhuber, J.; Lenz, B. LDL cholesterol relates to depression, its severity, and the prospective course. Prog. Neuropsychopharmacol. Biol. Psychiatry,  2019, 92, 405-411.
 [http://dx.doi.org/10.1016/j.pnpbp.2019.01.010] [PMID: 30779936]

[89]
Lee, J.; Avramets, D.; Jeon, B.; Choo, H. Modulation of serotonin receptors in neurodevelopmental disorders: Focus on 5-HT7 receptor. Molecules,  2021, 26(11), 3348.
 [http://dx.doi.org/10.3390/molecules26113348] [PMID: 34199418]

[90]
Andrews, M.G.; Mukhtar, T.; Eze, U.C.; Simoneau, C.R.; Ross, J.; Parikshak, N.; Wang, S.; Zhou, L.; Koontz, M.; Velmeshev, D.; Siebert, C.V.; Gemenes, K.M.; Tabata, T.; Perez, Y.; Wang, L.; Mostajo-Radji, M.A.; de Majo, M.; Donohue, K.C.; Shin, D.; Salma, J.; Pollen, A.A.; Nowakowski, T.J.; Ullian, E.; Kumar, G.R.; Winkler, E.A.; Crouch, E.E.; Ott, M.; Kriegstein, A.R. Tropism of SARS-CoV-2 for human cortical astrocytes. Proc. Natl. Acad. Sci.,  2022, 119(30), e2122236119.
 [http://dx.doi.org/10.1073/pnas.2122236119] [PMID: 35858406]

[91]
Kuo, C.L.; Pilling, L.C.; Atkins, J.L.; Masoli, J.A.H.; Delgado, J.; Kuchel, G.A.; Melzer, D. APOE e4 genotype predicts severe COVID-19 in the UK biobank community cohort. J. Gerontol. A Biol. Sci. Med. Sci.,  2020, 75(11), 2231-2232.
 [http://dx.doi.org/10.1093/gerona/glaa131] [PMID: 32451547]

[92]
Carey, I.M.; Anderson, H.R.; Atkinson, R.W.; Beevers, S.D.; Cook, D.G.; Strachan, D.P.; Dajnak, D.; Gulliver, J.; Kelly, F.J. Are noise and air pollution related to the incidence of dementia? A cohort study in London, England. BMJ Open,  2018, 8(9), e022404.
 [http://dx.doi.org/10.1136/bmjopen-2018-022404] [PMID: 30206085]

[93]
Lee, Y.; Yoon, S.J.; Yoon, S.H.; Kang, S.W.; Jeon, S.; Kim, M.; Shin, D.A.; Nam, C.M.; Ye, B.S. Air pollution is associated with faster cognitive decline in Alzheimer’s disease. Ann. Clin. Transl. Neurol.,  2023, 10(6), 964-973.
 [http://dx.doi.org/10.1002/acn3.51779] [PMID: 37106569]

[94]
Rai, S.N.; Zahra, W.; Birla, H.; Singh, S.S.; Singh, S.P. Commentary: Mild endoplasmic reticulum stress ameliorates lpopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization. Front. Aging Neurosci.,  2018, 10, 192.
 [http://dx.doi.org/10.3389/fnagi.2018.00192] [PMID: 29988480]

[95]
Yoshida, K.; Hata, Y.; Ichimata, S.; Nishida, N. Tau and Amyloid-β Pathology in Japanese Forensic Autopsy Series Under 40 Years of Age: Prevalence and Association with APOE Genotype and Suicide Risk. J. Alzheimers Dis.,  2019, 72(2), 641-652.
 [http://dx.doi.org/10.3233/JAD-190196] [PMID: 31594218]

[96]
Domènech-Abella, J.; Lara, E.; Rubio-Valera, M.; Olaya, B.; Moneta, M.V.; Rico-Uribe, L.A.; Ayuso-Mateos, J.L.; Mundó, J.; Haro, J.M. Loneliness and depression in the elderly: The role of social network. Soc. Psychiatry Psychiatr. Epidemiol.,  2017, 52(4), 381-390.
 [http://dx.doi.org/10.1007/s00127-017-1339-3] [PMID: 28154893]

[97]
Jellinger, K.A. Pathomechanisms of vascular depression in older adults. Int. J. Mol. Sci.,  2021, 23(1), 308.
 [http://dx.doi.org/10.3390/ijms23010308] [PMID: 35008732]

[98]
Isik, K.; Basogul, C.; Yildirim, H. The relationship between perceived loneliness and depression in the elderly and influencing factors. Psychiatr Care,  2020, 1-7.

[99]
Cheavens, J.S.; Cukrowicz, K.C.; Hansen, R.; Mitchell, S.M. Incorporating resilience factors into the interpersonal theory of suicide: The role of hope and self-forgiveness in an older adult sample. J. Clin. Psychol.,  2016, 72(1), 58-69.
 [http://dx.doi.org/10.1002/jclp.22230] [PMID: 26448342]

[100]
Faye, C.; Mcgowan, J.C.; Denny, C.A.; David, D.J. Neurobiological mechanisms of stress resilience and implications for the aged population. Curr. Neuropharmacol.,  2018, 16(3), 234-270.
 [http://dx.doi.org/10.2174/1570159X15666170818095105] [PMID: 28820053]

[101]
Srivastava, P.; Tripathi, P.N.; Sharma, P.; Rai, S.N.; Singh, S.P.; Srivastava, R.K.; Shankar, S.; Shrivastava, S.K. Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory. Eur. J. Med. Chem.,  2019, 163, 116-135.
 [http://dx.doi.org/10.1016/j.ejmech.2018.11.049] [PMID: 30503937]

[102]
Tripathi, P.N.; Srivastava, P.; Sharma, P.; Tripathi, M.K.; Seth, A.; Tripathi, A. Biphenyl-3oxo-1,2,4-triazine linked piperazine derivates as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory. Bioorg. Chem.,  2019, 2109(85), 82-96.
Cite As
Current Alzheimer Research

Alzheimer's Disease and Suicide: An Integrative Literature Review

Abstract
