Generic placeholder image

Anti-Infective Agents

Author(s): Ilnur Yagudin and Darya Suntsova*

DOI: 10.2174/0122113525287737240201050550

DownloadDownload PDF Flyer Cite As
Pyolytics: A Step Forward to Address Respiratory Hypoxia in Coronavirus Infection

Article ID: e130224226944 Pages: 3

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Respiratory failure and increasing hypoxia in the era of coronavirus infection is the cause of fatal outcomes in patients with SARS. The bronchoalveolar obstruction prevents the normal passage of air, resulting in decreased oxygenation. The available methods of oxygenation (ECMO) are often not cost-effective and are not readily available in pandemic settings. Hence, the search for alternatives has prompted the discovery of a new pharmacological group - pyolytics, the use of which is very promising due to its simplicity and availability.

Keywords: Coronavirus infection, bronchoalveolar obstruction, hypoxia, methods of oxygenation, pyolytics, accessibility in a pandemic.

[1]
Ludlow, M. Respiratory syncytial virus infection in the modern era. Curr. Opin. Infect. Dis., 2023, 36(3), 155-163.
[http://dx.doi.org/10.1097/QCO.0000000000000917] [PMID: 36939556]
[2]
Ramadori, G.P. SARS-CoV-2-infection (COVID-19): Clinical course, viral acute respiratory distress syndrome (ARDS) and cause(s) of death. Med. Sci., 2022, 10(4), 58.
[http://dx.doi.org/10.3390/medsci10040058] [PMID: 36278528]
[3]
Urakov, A.; Muhutdinov, N.; Yagudin, I.; Suntsova, D.; Svetova, M. Brain hypoxia caused by respiratory obstruction which should not be forgotten in COVID-19 disease. Turk. J. Med. Sci., 2022, 52(5), 1504-1505.
[http://dx.doi.org/10.55730/1300-0144.5489] [PMID: 36422499]
[4]
Urakov, A.L.; Urakova, N.A.; Shabanov, P.D.; Gurevich, K.G.; Fisher, E.L.; Stolyarenko, A.P.; Yagudin, I.I.; Suntsova, D.O. Warm alkaline hydrogen peroxide solution for intrapulmonary injection. RU Patent 2,807,851, 2023.
[5]
Urakov, A.L.; Urakova, N.A.; Yagudin, I.I.; Svetova, M.D.; Suntsova, D.O. COVID-19: Artificial sputum, respiratory obstruction method and screening of pyolitic and antihypoxic drugs. Bioimpacts, 2022, 12(4), 393-394.
[http://dx.doi.org/10.34172/bi.2022.23877] [PMID: 35975207]
[6]
Jiang, Y.; Rubin, L.; Peng, T.; Liu, L.; Xing, X.; Lazarovici, P.; Zheng, W. Cytokine storm in COVID-19: From viral infection to immune responses, diagnosis and therapy. Int. J. Biol. Sci., 2022, 18(2), 459-472.
[http://dx.doi.org/10.7150/ijbs.59272] [PMID: 35002503]
[7]
Urakov, A.; Yagudin, I.I.; Suntsova, D.O.; Svetova, M.O.; Stolyarenko, A.P. COVID-19: Thick pus, mucus and sputum with streaks of blood as a cause of airway obturation in SARS and oxygen-foaming pus solvent as a medicine for their recanalization. Acta Sci Women’s Health., 2021, 3, 75-77.
[8]
Ma, X.; Liang, M.; Ding, M.; Liu, W.; Ma, H.; Zhou, X.; Ren, H. Extracorporeal Membrane Oxygenation (ECMO) in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia and acute respiratory distress syndrome (ARDS). Med. Sci. Monit., 2020, 26, e925364.
[http://dx.doi.org/10.12659/MSM.925364] [PMID: 32759887]
[9]
Bertini, P.; Guarracino, F.; Falcone, M.; Nardelli, P.; Landoni, G.; Nocci, M.; Paternoster, G. ECMO in COVID-19 patients: A systematic review and meta-analysis. J. Cardiothorac. Vasc. Anesth., 2022, 36(8), 2700-2706.
[http://dx.doi.org/10.1053/j.jvca.2021.11.006] [PMID: 34906383]
[10]
Tramm, R.; Ilic, D.; Davies, A.R.; Pellegrino, V.A.; Romero, L.; Hodgson, C. Extracorporeal membrane oxygenation for critically ill adults. Cochrane Libr., 2015, 1(1), CD010381.
[http://dx.doi.org/10.1002/14651858.CD010381.pub2] [PMID: 25608845]
[11]
Supady, A.; Combes, A.; Barbaro, R.P.; Camporota, L.; Diaz, R.; Fan, E.; Giani, M.; Hodgson, C.; Hough, C.L.; Karagiannidis, C.; Kochanek, M.; Rabie, A.A.; Riera, J.; Slutsky, A.S.; Brodie, D. Respiratory indications for ECMO: Focus on COVID-19. Intensive Care Med., 2022, 48(10), 1326-1337.
[http://dx.doi.org/10.1007/s00134-022-06815-w] [PMID: 35945343]
[12]
Pormasoumi, H.; Rostami, D.; Jamebozorgi, K.; Mirshekarpour, H.; Heshmatnia, J. COVID-19 management in Iran and international sanctions. Eur. J. Transl. Myol., 2022, 32(4), 10777.
[http://dx.doi.org/10.4081/ejtm.2022.10777] [PMID: 36200579]
[13]
Urakov, A.; Urakova, N.; Reshetnikov, A.; Shchemeleva, A.; Shabanov, P.; Lovtsova, L.; Samorodov, A.; Fisher, E.; Stolyarenko, A.; Suntsova, D.; Yagudin, I.; Muhutdinov, N. Reprofiling hydrogen peroxide from antiseptics to pyolytics: A narrative overview of the history of inventions in Russia. J. Pharm. Res. Int., 2023, 35(6), 37-48.
[http://dx.doi.org/10.9734/jpri/2023/v35i67333]
[14]
Santopolo, G.; Clemente, A.; Rojo-Molinero, E.; Fernández, S.; Álvarez, M.C.; Oliver, A.; de la Rica, R. Improved cytometric analysis of untouched lung leukocytes by enzymatic liquefaction of sputum samples. Biol. Proced. Online, 2022, 24(1), 17.
[http://dx.doi.org/10.1186/s12575-022-00181-z] [PMID: 36396988]
[15]
Fisher, E.; Urakov, A.; Svetova, M.; Suntsova, D.; Yagudin, I. Covid-19: Intrapulmonary alkaline hydrogen peroxide can immediately increase blood oxygenation. Medicinski casopis, 2021, 55(4), 135-138.
[http://dx.doi.org/10.5937/mckg55-35424]
[16]
Urakov, A.; Shabanov, P.; Gurevich, K.; Fisher, E.; Stolyarenko, A.; Suntsova, D.; Yagudin, I.; Muhutdinov, N. Intrapulmonary use of hydrogen peroxide in respiratory obstruction: Initial results demonstrate the possibility of airway recanalization and blood reoxygenation through the lungs: An update. J. Pharm. Res. Int., 2023, 35(9), 33-37.
[http://dx.doi.org/10.9734/jpri/2023/v35i97348]
[17]
Urakov, A.L.; Urakova, N.A. COVID-19: Intrapulmonary injection of hydrogen peroxide solution eliminates hypoxia and normalizes respiratory biomechanics. Russ J Biomech., 2021, 25, 350-356.
[18]
Urakov, A.l.; Yagudin, I.I.; Suntsova, D.O.; Svetova, M.D.; Samorodov, A.V. Artificial sputum for modeling respiratory obstruction in Covid-19. RU Patent 2,748,999, 2021.