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Current Analytical Chemistry

Author(s): Chow Jie Chen, Bontha Venkata Subrahmanya Lokesh* and Gabriel Akyirem Akowuah

DOI: 10.2174/0115734110278516240129174949

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Quantitative Applications of ATR-FTIR Spectroscopy with Chemometrics for the Estimation of Amikacin in Amikacin Sulphate Injections

Page: [201 - 208] Pages: 8

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Abstract

Background: Amikacin belongs to the class of aminoglycoside antibiotics used in the treatment of gram-negative bacterial infections. It is resistant to the aminoglycosides modifying enzymes, making it a clinically effective drug in multidrug-resistant infections.

Methods: In this study, a simple Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy was used for the quantification of amikacin in amikacin sulphate injection. The infrared spectra were generated in the spectral range of 4000–667 cm-1. The calibration curve was computed through TQ Analyst Pro edition software, and the partial least square regression analysis found the linearity in the range of 10-60% w/w.

Results: The best calibration results were obtained in the spectral region from 1040 to 1020 cm-1 with a correlation coefficient (r2) of 1.000. The residual mean standard error (RMSEC) value was 0.00235. The percent relative standard deviation (%RSD) values for intra-day and inter-day precision were less than 8.0. The percent relative error (%RE) values were calculated and found in between the range of 0.52 to 5.60. The percent recovery of the amikacin estimation was 113.09 ± 4.27(n=3).

Conclusion: This validated method is considered a green method, which is suitable for the routine analysis of amikacin in amikacin sulphate injections.

Graphical Abstract

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