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Letters in Organic Chemistry

Author(s): Ankita M. Rayate and Manoj R. Gaware*

DOI: 10.2174/0115701786286587240130114029

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Thiourea-Ammonium Chloride Mediated Knoevenagel Condensation as an Intermediate in the Synthesis of Pyrimidine Scaffolds under Solvent-free Condition

Page: [749 - 755] Pages: 7

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Abstract

In this paper, we have reported solvent solvent-free method for Knoevenagel condensation reaction of various aldehydes with active methylene compounds using thiourea and ammonium chloride. The developed method demonstrated high efficiency in the formation of C-C bond. The reaction proceeds smoothly under mild and solvent-free conditions and the products obtained are in excellent yield in very short duration. This method is applicable to a wide range of aldehydes with active methylene compounds.

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