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CNS & Neurological Disorders - Drug Targets

Author(s): Samah Kandeel*, Marwa M. Abd-Elsalam, Sherief Abd-Elsalam and Heba Hassan Elkaliny

DOI: 10.2174/0118715273280701231227100805

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The Possible Protective Effect of Taurine on Bisphenol Induced Structural Changes on the Cerebral Cortex of Rats: Histological and Immunohistochemical Study

Page: [1263 - 1274] Pages: 12

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Abstract

Introduction: Bisphenol A (BPA) is a chemical compound that has been used in many industries, such as paints and dental sealants. Taurine is a semi-essential amino acid with antioxidant, anti-inflammatory, and anti-apoptotic actions.

Aim: This study aimed to evaluate the possible protective effect of taurine on BPA-induced structural changes in the cerebral cortex of rats using histological and immunohistochemical methods.

Methods: 35 Wistar rats (180-200 gm) were divided into control: 10 rats; Group I: 5 rats received corn oil (0.5 mL/day); Group II (Bisphenol low dose; BPAL): 5 rats received a low dose of BPA (25 mg/kg/three times/week); Group III (Bisphenol high dose; BPAH): 5 rats received a high dose of BPA (100 mg/kg/three times/week; Group IV: (BPAL + taurine): 5 rats received taurine 100 mg/kg/day and BPAL (25 mg/kg/three times/week); Group V: (BPAH + taurine): 5 rats received taurine 100 mg/kg/day and BPH (100 mg/kg/ three times/week).

Results: BPAL& BPAH groups showed significant dose-dependent histological changes of the neuropil, pyramidal, and neuroglial cells at H&E stained sections, significantly increased GFAP, caspase- 3 immunohistochemical reaction with cells positive for Ki67 with many mitotic figures. BPAL + taurine and BPAH + taurine groups showed amelioration of the previously mentioned results.

Conclusion: Taurine ameliorated the structural changes induced by BPA in the cerebral cortex of rats.

Graphical Abstract

[1]
Ma Y, Liu H, Wu J, et al. The adverse health effects of bisphenol A and related toxicity mechanisms. Environ Res 2019; 176: 108575-87.
[http://dx.doi.org/10.1016/j.envres.2019.108575] [PMID: 31299621]
[2]
Akintunde JK, Akintola TE, Adenuga GO, Odugbemi ZA, Adetoye RO, Akintunde OG. Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats by abrogation of cerebral nucleotide depletion, oxidative damage and neuroinflammation. Neurotoxicology 2020; 81: 18-33.
[http://dx.doi.org/10.1016/j.neuro.2020.08.001] [PMID: 32810514]
[3]
Elbakry MMM, Mansour SZ, Helal H, Ahmed ESA. Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats. Environ Sci Pollut Res Int 2022; 29(49): 75086-100.
[http://dx.doi.org/10.1007/s11356-022-21126-9] [PMID: 35648353]
[4]
Oyovwi MO, Nwangwa EK, Ben-Azu B, Edesiri TP, Emojevwe V, Igweh JC. Taurine and coenzyme Q10 synergistically prevent and reverse chlorpromazine-induced psycho-neuroendocrine changes and cataleptic behavior in rats. Naunyn Schmiedebergs Arch Pharmacol 2021; 394(4): 717-34.
[http://dx.doi.org/10.1007/s00210-020-02003-z] [PMID: 33146779]
[5]
Zheng J, Qiu G, Zhou Y, Ma K, Cui S. Protective effects of taurine against inflammation and apoptosis in cadmium-induced hepatotoxicity. Res. Square 2021; pp. 1-15.
[6]
Apaydin FG, Aslanturk A, Uzunhisarcikli M, Bas H, Kalender S, Kalender Y. Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats. Environ Sci Pollut Res Int 2019; 26(12): 12302-10.
[http://dx.doi.org/10.1007/s11356-019-04578-4] [PMID: 30840252]
[7]
Jeong JE, Kim TY, Park HJ, et al. Taurine exerts neuroprotective effects via anti-apoptosis in hypoxic-ischemic brain injury in neonatal rats. Korean J Pediatr 2009; 52(12): 1337-47.
[http://dx.doi.org/10.3345/kjp.2009.52.12.1337]
[8]
Morgan AM, El-Ballal SS, El-Bialy BE, EL-Borai NB. Studies on the potential protective effect of cinnamon against bisphenol A- and octylphenol-induced oxidative stress in male albino rats. Toxicol Rep 2014; 1: 92-101.
[http://dx.doi.org/10.1016/j.toxrep.2014.04.003] [PMID: 28962230]
[9]
Aydoğan M, Korkmaz A, Barlas N, Kolankaya D. The effect of vitamin C on bisphenol A, nonylphenol and octylphenol induced brain damages of male rats. Toxicology 2008; 249(1): 35-9.
[http://dx.doi.org/10.1016/j.tox.2008.04.002] [PMID: 18508178]
[10]
Kamel AH, Foaud MA, Moussa HM. The adverse effects of bisphenol A on male albino rats. J Basic Appl Zool 2018; 79(1): 1-9.
[11]
Adedara IA, Olabiyi BF, Ojuade TD, Idris UF, Onibiyo EM, Farombi EO. Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats. Can J Physiol Pharmacol 2017; 95(9): 1019-29.
[http://dx.doi.org/10.1139/cjpp-2016-0641] [PMID: 28654759]
[12]
Suvarna KS, Layton C, Bancroft JD. Bancroft’s theory and practice of histological techniques E-Book. 8th edition.. UK: “Chapter 4. Layton CH, Bancroft J, Suvarna SK.” Elsevier Health Sciences. 2018; pp. 73-150.
[13]
Jalili C, Zamir-Nasta T, Abbasi A, Kakebaraie S, Ahmadi A, Pazhouhi M. Aflatoxin G1 exposure altered the expression of BDNF and GFAP, histopathological of brain tissue, and oxidative stress factors in male rats. Res Pharm Sci 2022; 17(6): 677-85.
[http://dx.doi.org/10.4103/1735-5362.359434] [PMID: 36704432]
[14]
Caglayan C, Kandemir FM, Ayna A, Gür C, Küçükler S, Darendelioğlu E. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metab Brain Dis 2022; 37(6): 1931-40.
[http://dx.doi.org/10.1007/s11011-022-01027-z] [PMID: 35699857]
[15]
Lee CY, Hyun SA, Ko MY, et al. Maternal Bisphenol A (BPA) exposure alters cerebral cortical morphogenesis and synaptic function in mice. Cereb Cortex 2021; 31(12): 5598-612.
[http://dx.doi.org/10.1093/cercor/bhab183] [PMID: 34171088]
[16]
Kandeel S, Balaha MS, Estfanous R. The possible ameliorative effect of granulocyte colony stimulating factor on rotenone-induced changes in the retinal photoreceptors of rats: Histological and immunohistochemical study. Egypt J Histol 2021; 44(2): 309-21.
[17]
Buchwalow IB, Böcker W. Immunohistochemistry: Basics and methods. 1st ed. Springer-Verlag Berlin Heidelberg 2010; pp. 1-8.
[18]
Ibrahim Fouad G, Ahmed KA. Neuroprotective potential of berberine against doxorubicin-induced toxicity in rat’s brain. Neurochem Res 2021; 46(12): 3247-63.
[http://dx.doi.org/10.1007/s11064-021-03428-5] [PMID: 34403065]
[19]
Dawson B, Trapp RG. Basic & clinical biostatistics. In: Basic & clinical biostatistics, Dawson B; Trapp R G. (4th ed.). New York: Lange Medical Books/McGraw-Hill 2004; pp. 438-8.
[20]
Drzewiecki CM, Brinks AS, Sellinger EP, Doshi AD, Koh JY, Juraska JM. Brief postnatal exposure to bisphenol A affects apoptosis and gene expression in the medial prefrontal cortex and social behavior in rats with sex specificity. Neurotoxicology 2023; 94: 126-34.
[http://dx.doi.org/10.1016/j.neuro.2022.11.011] [PMID: 36442689]
[21]
Vancamp P, Butruille L, Herranen A, et al. Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Environ Int 2023; 172: 107770-82.
[http://dx.doi.org/10.1016/j.envint.2023.107770] [PMID: 36706583]
[22]
Amin MAS, Sonpol HMA, Gouda RHE, Aboregela AM. Bisphenol A enhances apoptosis, fibrosis, and biochemical fluctuations in the liver of adult male rats with possible regression after recovery. Anat Rec 2023; 306(1): 213-25.
[http://dx.doi.org/10.1002/ar.25032] [PMID: 35773941]
[23]
Lama A, Del Piano F, Annunziata C, et al. Bisphenol A exacerbates anxiety-like behavior and neuroinflammation in prefrontal cortex of adult obese mice. Life Sci 2023; 313: 121301-12.
[http://dx.doi.org/10.1016/j.lfs.2022.121301] [PMID: 36535405]
[24]
Luo M, Li L, Ding M, et al. Long-term potentiation and depression regulatory microRNAs were highlighted in Bisphenol A induced learning and memory impairment by microRNA sequencing and bioinformatics analysis. PLoS One 2023; 18(1): e0279029.
[http://dx.doi.org/10.1371/journal.pone.0279029] [PMID: 36656826]
[25]
Aboul Ezz HS, Khadrawy YA, Mourad IM. The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats. Cytotechnology 2015; 67(1): 145-55.
[http://dx.doi.org/10.1007/s10616-013-9672-1] [PMID: 24337652]
[26]
Glushakova OY, Glushakov AV, Mannix R, Miller ER, Valadka AB, Hayes RL. The use of blood-based biomarkers to improve the design of clinical trials of traumatic brain injury. In: Handbook of neuroemergency clinical trials. (2nd ed.). Elsevier: Academic Press. 2018; pp. 139-66.
[http://dx.doi.org/10.1016/B978-0-12-804064-5.00008-4]
[27]
Vedantam A, Brennan J, Levin HS, et al. Early versus late profiles of inflammatory cytokines after mild traumatic brain injury and their association with neuropsychological outcomes. J Neurotrauma 2021; 38(1): 53-62.
[http://dx.doi.org/10.1089/neu.2019.6979] [PMID: 32600167]
[28]
Sara M, Abbas NA, Mousa MS. Influence of human umbilical cord blood mesenchymal stem cells on cerebrolysin amelioration of neurological deficit following cerebral ischemia-reperfusion injury in rats. Med J Cairo Univ 2018; 86: 2543-55.
[http://dx.doi.org/10.21608/mjcu.2018.58058]
[29]
Kandeel S, Elhosary NM, El-Noor MMA, Balaha M. Electric injury-induced Purkinje cell apoptosis in rat cerebellum: Histological and immunohistochemical study. J Chem Neuroanat 2017; 81: 87-96.
[http://dx.doi.org/10.1016/j.jchemneu.2017.02.010] [PMID: 28254550]
[30]
Wang C, He J, Xu T, et al. Bisphenol A(BPA), BPS and BPB-induced oxidative stress and apoptosis mediated by mitochondria in human neuroblastoma cell lines. Ecotoxicol Environ Saf 2021; 207: 111299-301.
[http://dx.doi.org/10.1016/j.ecoenv.2020.111299] [PMID: 32927158]
[31]
Munakata M, Watanabe M, Otsuki T, et al. Increased Ki-67 immunoreactivity in the white matter in hemimegalencephaly. Neurosci Lett 2013; 548: 244-8.
[http://dx.doi.org/10.1016/j.neulet.2013.05.033] [PMID: 23721782]
[32]
Mohammed AS, Al-Hassani AN, Alrawi RA, Tawfeeq RD. The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats. Ecancermedicalscience 2023; 17: 1499-510.
[PMID: 36816786]
[33]
Wu G. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids 2020; 52(3): 329-60.
[http://dx.doi.org/10.1007/s00726-020-02823-6] [PMID: 32072297]
[34]
Maleki V, Mahdavi R, Hajizadeh-Sharafabad F, Alizadeh M. The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Diabetol Metab Syndr 2020; 12(1): 9.
[http://dx.doi.org/10.1186/s13098-020-0518-7] [PMID: 32015761]
[35]
Nakatsuru Y, Murase-Mishiba Y, Bessho-Tachibana M, Terasaki J, Hanafusa T, Imagawa A. Taurine improves glucose tolerance in STZ-induced insulin-deficient diabetic mice. Diabetol Int 2018; 9(4): 234-42.
[http://dx.doi.org/10.1007/s13340-018-0353-3] [PMID: 30603373]