Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats

Ismail      Bouadid; Adil      Qabouche; Mohamed      Eddouks

Abstract

Aims: The antihypertensive activity of Daphne gnidium was tested.

Background: Daphne gnidium (Thymelaeaceae) is used against hypertension.

Objective: The antihypertensive effect of Daphne gnidium was evaluated in this study.

Methods: The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.

Results: DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptoractivated calcium channels (ROCCs) without affecting ACE-2.

Conclusion: The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca²⁺ entry.

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Cite As

Cardiovascular & Hematological Agents in Medicinal Chemistry

Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats

Abstract