The Astonishing Accomplishment of Biological Drug Delivery using Lipid
Nanoparticles: An Ubiquitous Review

Devesh      Kapoor; Shirisha   C.   Chilkapalli; Bhupendra   G.   Prajapati; Paul      Rodriques; Ravish      Patel; Sudarshan      Singh; Sankha      Bhattacharya
Abstract

Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing processes make LNPs suitable for largescale production. Despite recent research efforts, challenges in stability, toxicity, and regulatory concerns have limited the commercial availability of LNP-based products. This review explores the applications, administration routes, challenges, and future directions of LNPs in delivering biopharmaceuticals.
Keywords: Lipid nanoparticles, biologicals, nucleic acids, protein-based products, vaccines, DNA/RNA therapies.
Graphical Abstract

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Cite As
Current Pharmaceutical Biotechnology

The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review

Abstract

Graphical Abstract
