Abstract

Cancer therapy has evolved beyond targeting malignant cells alone, recognizing the pivotal role of the tumor microenvironment (TME) in disease progression. Enzyme micellar systems, a subset of nanomedicine, offer a cutting-edge approach by exploiting the intricate interplay between therapeutic delivery and the TME. Engineered to respond to enzymatic cues, these systems enable targeted drug delivery, controlled release, and modulation of the tumor milieu. This review delves into the cross-talk between enzyme micellar systems and the TME, showcasing their potential as a transformative strategy for tackling cancer. The principles of system design, the dynamic interactions within the TME, and their collective impact on therapeutic outcomes are explored through case studies, challenges, and ethical considerations. By bridging the advances in nanotechnology and the complexities of the TME, enzyme micellar systems emerge as a paradigm shift, redefining the landscape of cancer therapy toward precision and efficacy.

Keywords: Cancer, tumor microenvironment, enzyme micelles, therapeutic interventions, VEGFs, molecular biology.