Resistance Training Reduces Blood Pressure: Putative Molecular Mechanisms

Page: [52 - 56] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Arterial hypertension is a multifactorial clinical condition characterized by higher blood pressure levels. The main treatment for controlling high blood pressure consists of drug therapy, but the scientific literature has been pointing to the efficiency of aerobic and resistance exercises acting in a therapeutic and/or preventive way to reduce and control the blood pressure levels. Resistance training is characterized by sets and repetitions on a given muscle segment that uses overload, such as machine weights, bars, and dumbbells. As it successfully affects a number of variables associated to practitioners' functional and physiological features as well as emotional and social variables, resistance training has been a crucial part of physical exercise programs. Several reports highlight the various adaptive responses it provides, with a focus on the improvement in strength, balance, and muscular endurance that enables a more active and healthy lifestyle. Resistance training programs that are acute, sub-chronic, or chronic can help people with varying ages, conditions, and pathologies reduce their arterial hypertension. However, molecular mechanisms associated with resistance training to reduce blood pressure still need to be better understood. Thus, we aimed to understand the main effects of resistance training on blood pressure as well as the associated molecular mechanisms.

Graphical Abstract

[1]
Improta-Caria AC, Aras MG, Nascimento L, De Sousa RAL, Aras-Júnior R, Souza BSF. MicroRNAs regulating renin-angiotensin-aldosterone system, sympathetic nervous system and left ventricular hypertrophy in systemic arterial hypertension. Biomolecules 2021; 11(12): 1771.
[http://dx.doi.org/10.3390/biom11121771] [PMID: 34944415]
[2]
Unger T, Borghi C, Charchar F, et al. 2020 International society of hypertension global hypertension practice guidelines. Hypertension 2020; 75(6): 1334-57.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15026] [PMID: 32370572]
[3]
Improta Caria A, Nonaka C, Pereira C, Soares M, Macambira S, Souza B. Exercise training-induced changes in microRNAs: Beneficial regulatory effects in hypertension, type 2 diabetes, and obesity. Int J Mol Sci 2018; 19(11): 3608.
[http://dx.doi.org/10.3390/ijms19113608] [PMID: 30445764]
[4]
Improta-Caria AC. Physical exercise and MicroRNAs: Molecular mechanisms in hypertension and myocardial infarction. Arq Bras Cardiol 2022; 118(6): 1147-9.
[http://dx.doi.org/10.36660/abc.20210538] [PMID: 35703656]
[5]
Moesgaard L, Beck MM, Christiansen L, Aagaard P, Lundbye-Jensen J. Effects of periodization on strength and muscle hypertrophy in volume-equated resistance training programs: A systematic review and meta-analysis. Sports Med 2022; 52(7): 1647-66.
[http://dx.doi.org/10.1007/s40279-021-01636-1] [PMID: 35044672]
[6]
Ding D, Mutrie N, Bauman A, Pratt M, Hallal PRC, Powell KE. Physical activity guidelines 2020: comprehensive and inclusive recommendations to activate populations. Lancet 2020; 396(10265): 1780-2.
[http://dx.doi.org/10.1016/S0140-6736(20)32229-7] [PMID: 33248019]
[7]
Domingos E, Polito MD. Blood pressure response between resistance exercise with and without blood flow restriction: A systematic review and meta-analysis. Life Sci 2018; 209(August): 122-31.
[http://dx.doi.org/10.1016/j.lfs.2018.08.006] [PMID: 30086274]
[8]
de Sousa EC, Abrahin O, Ferreira ALL, Rodrigues RP, Alves EAC, Vieira RP. Resistance training alone reduces systolic and diastolic blood pressure in prehypertensive and hypertensive individuals: Meta-analysis. Hypertens Res 2017; 40(11): 927-31.
[http://dx.doi.org/10.1038/hr.2017.69] [PMID: 28769100]
[9]
Nascimento DC, da Silva CR, Valduga R, et al. Blood pressure response to resistance training in hypertensive and normotensive older women. Clin Interv Aging 2018; 13: 541-53.
[http://dx.doi.org/10.2147/CIA.S157479] [PMID: 29674845]
[10]
Morishita S, Tsubaki A, Nakamura M, Fu JB, Onishi H. Rating of perceived exertion on resistance training in elderly subjects. Expert Rev Cardiovas Ther 2019; 17(2): 135-42.
[11]
De Sousa RAL, Improta-Caria AC, Jesus-Silva FM, de . High-intensity resistance training induces changes in cognitive function, but not in locomotor activity or anxious behavior in rats induced to type 2 diabetes. Physiol Behav 2020; 223: 112998.
[http://dx.doi.org/10.1016/j.physbeh.2020.112998]
[12]
Kounoupis A, Papadopoulos S, Galanis N, Dipla K, Zafeiridis A. Are blood pressure and cardiovascular stress greater in isometric or in dynamic resistance exercise? Sports 2020; 8(4): 41.
[http://dx.doi.org/10.3390/sports8040041] [PMID: 32231128]
[13]
Schroeder EC, Franke WD, Id RLS. Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: A randomized controlled trial. PLoS One 2019; 14(1): e0210292.
[14]
Fernandes T, Soci UPR, Oliveira EM. Eccentric and concentric cardiac hypertrophy induced by exercise training: MicroRNAs and molecular determinants. Braz J Med Biol Res 2011; 44(9): 836-47.
[http://dx.doi.org/10.1590/S0100-879X2011007500112] [PMID: 21881810]
[15]
Melo SFS, Júnior NDS, Baraúna VG, Oliveira EM. Cardiovascular adaptations induced by resistance training in animal models. Int J Med Sci 2018; 15(4): 403-10.
[http://dx.doi.org/10.7150/ijms.23150] [PMID: 29511376]
[16]
Otsuki T, Nakamura F, Zempo-miyaki A. Nitric Oxide and decreases in resistance exercise blood pressure with aerobic exercise training in older individuals. Front Physiol 2019; 10: 1-9.
[17]
Silva V, Orsano M, Frade NM, et al. Comparison of the acute effects of traditional versus high velocity resistance training on metabolic , cardiovascular , and psychophysiological responses in elderly hypertensive women. Clin Interv Aging 2018; 13: 1331-40.
[18]
Alegre P, Division E, Aging C. Different exercise training modalities produce similar endothelial function improvements in individuals with prehypertension or hypertension: A randomized clinical trial Exercise, endothelium and blood pressure. Sci Rep 2020; 10(1): 1-9.
[19]
Polito MD, Papst R, Goessler K. Twelve weeks of resistance training performed with different number of sets: Effects on maximal strength and resting blood pressure of individuals with hypertension. Clin Exp Hypertens 2020; 43(2): 164-8.
[PMID: 33043697]
[20]
Macdonald H V, Johnson BT, Huedo-medina TB, Livingston J, Forsyth KC, Kraemer WJ, et al. Dynamic resistance training as stand-alone antihypertensive lifestyle therapy: A meta-analysis. J Am Heart Assoc 2016; 5(10): e003231.
[21]
Sousa RAL, Hagenbeck KF, Arsa G, Pardono E. Moderate/high resistance exercise is better to reduce blood glucose and blood pressure in middle-aged diabetic subjects. Rev Bras Educ Fís Esporte 2020; 34(1): 165-75.
[http://dx.doi.org/10.11606/1807-5509202000010165]
[22]
Trevizani GA, Seixas MB, Benchimol-barbosa PR. Copyright 2017 national strength and conditioning association. Clin Interv Aging 2018; 13: 541-53.
[23]
Fernandes T, Magalhães FC, Roque FR, Phillips MI, Oliveira EM. Exercise training prevents the microvascular rarefaction in hypertension balancing angiogenic and apoptotic factors: Role of microRNAs. Hypertens 1979; 59(2): 513-20.
[24]
Improta-Caria AC, De Sousa RAL, Roever L, et al. MicroRNAs in type 2 diabetes mellitus: Potential role of physical exercise. Rev Cardiovasc Med 2022; 23(1): 1.
[http://dx.doi.org/10.31083/j.rcm2301029] [PMID: 35092221]
[25]
de Cássia Cypriano Ervati Pinter R, Padilha AS, de Oliveira EM, Vassallo DV, de Fúcio Lizardo JH. Cardiovascular adaptive responses in rats submitted to moderate resistance training. Eur J Appl Physiol 2008; 103(5): 605-13.
[http://dx.doi.org/10.1007/s00421-008-0761-3] [PMID: 18470531]
[26]
Fernandes AA, Faria TO, Ribeiro Júnior RF, et al. A single resistance exercise session improves myocardial contractility in spontaneously hypertensive rats. Braz J Med Biol Res 2015; 48(9): 813-21.
[http://dx.doi.org/10.1590/1414-431x20154355] [PMID: 26176315]
[27]
Miguel-Dos-Santos R, Santos JFD, Macedo FN, et al. Strength training reduces cardiac and renal oxidative stress in rats with Renovascular hypertension. Arq Bras Cardiol 2021; 116(1): 4-11.
[http://dx.doi.org/10.36660/abc.20190391] [PMID: 33566958]
[28]
Tomeleri CM, Marcori AJ, Ribeiro AS, et al. Chronic blood pressure reductions and increments in plasma nitric oxide bioavailability. Int J Sports Med 2017; 38(4): 290-9.
[http://dx.doi.org/10.1055/s-0042-121896] [PMID: 28219107]
[29]
Ağgön E, Agirbaş Ö, Alp HH, Uçan I, Gürsoy R, Hackney AC. Effect of dynamic and static strength training on hormonal activity in elite boxers. Baltic J Health Phys Activity 2020; 12(3): 1-10.
[http://dx.doi.org/10.29359/BJHPA.12.3.01] [PMID: 33088594]
[30]
Legramante JM, Galante A, Massaro M, et al. Hemodynamic and autonomic correlates of postexercise hypotension in patients with mild hypertension. Am J Physiol - Regul Integr Comp Physiol 2002; 282(51): 1037-43.
[http://dx.doi.org/10.1152/ajpregu.00603.2001]
[31]
Carvalho CJ, Marins JCB, Lade CG, et al. Aerobic and resistance exercise in patients with resistant hypertension. Rev Bras Med Esporte 2019; 25(2): 107-11.
[http://dx.doi.org/10.1590/1517-869220192502175333]
[32]
De Sousa RAL, Improta-Caria AC, Souza BS de F. Exercise-linked irisin: Consequences on mental and cardiovascular health in type 2 diabetes. Int J Mol Sci 2021; 22: 2199.
[33]
Zhao J, Su Z, Qu C, Dong Y. Effects of 12 weeks resistance training on serum irisin in older male adults. Front Physiol 2017; 8(MAR): 171.
[http://dx.doi.org/10.3389/fphys.2017.00171] [PMID: 28382004]
[34]
Mazur-Bialy AI, Pocheć E, Zarawski M. Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/Myd88 signaling pathway activation. Int J Mol Sci 2017; 18(4): 701.
[http://dx.doi.org/10.3390/ijms18040701] [PMID: 28346354]
[35]
Zhang H, Wu X, Liang J, Kirberger M, Chen N. Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process. Ageing Res Rev 2022; 80(May): 101680.
[http://dx.doi.org/10.1016/j.arr.2022.101680] [PMID: 35793739]
[36]
Zhang D, Xie T, Leung PS. Irisin ameliorates glucolipotoxicity-associated β-cell dysfunction and apoptosis via AMPK signaling and anti-inflammatory actions. Cell Physiol Biochem 2018; 51(2): 924-37.
[http://dx.doi.org/10.1159/000495395] [PMID: 30466091]
[37]
Qin S, Tian Z, Boidin M, Buckley BJR, Thijssen DHJ, Lip GYH. Irisin is an effector molecule in exercise rehabilitation following myocardial infarction (Review). Front Physiol 2022; 13: 935772.
[http://dx.doi.org/10.3389/fphys.2022.935772] [PMID: 35845994]
[38]
Melo S, Barauna V, Júnior M, et al. Resistance training regulates cardiac function through modulation of miRNA-214. Int J Mol Sci 2015; 16(12): 6855-67.
[http://dx.doi.org/10.3390/ijms16046855] [PMID: 25822872]
[39]
Improta-Caria AC, Soci ÚPR, Rodrigues LF, Fernandes T, Oliveira EM. MicroRNAs regulating pathophysiological processes in obesity: The impact of exercise training. Curr Opin Physiol 2023; 33: 100648.
[http://dx.doi.org/10.1016/j.cophys.2023.100648]
[40]
Nosalski R, Siedlinski M, Denby L, et al. T-cell–derived miRNA-214 mediates perivascular fibrosis in hypertension. Circ Res 2020; 126(8): 988-1003.
[http://dx.doi.org/10.1161/CIRCRESAHA.119.315428] [PMID: 32065054]
[41]
Telles GD, Libardi CA, Conceição MS, et al. Time course of skeletal muscle miRNA expression after resistance, high-intensity interval, and concurrent exercise. Med Sci Sports Exerc 2021; 53(8): 1708-18.
[http://dx.doi.org/10.1249/MSS.0000000000002632] [PMID: 33731656]
[42]
Ogasawara R, Akimoto T, Umeno T, Sawada S, Hamaoka T, Fujita S. MicroRNA expression profiling in skeletal muscle reveals different regulatory patterns in high and low responders to resistance training. Physiol Genomics 2016; 48(4): 320-4.
[http://dx.doi.org/10.1152/physiolgenomics.00124.2015] [PMID: 26850043]