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Current Genomics

Author(s): Manyuan Li, Xufeng Deng, Dong Zhou, Xiaoqing Liu, Jigang Dai and Quanxing Liu*

DOI: 10.2174/0113892029277397231228062412

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A Novel Methylation-based Model for Prognostic Prediction in Lung Adenocarcinoma

Page: [26 - 40] Pages: 15

  • * (Excluding Mailing and Handling)

Abstract

Objectives: Specific methylation sites have shown promise in the early diagnosis of lung adenocarcinoma (LUAD). However, their utility in predicting LUAD prognosis remains unclear. This study aimed to construct a reliable methylation-based predictor for accurately predicting the prognosis of LUAD patients.

Methods: DNA methylation data and survival data from LUAD patients were obtained from the TCGA and a GEO series. A DNA methylation-based signature was developed using univariate least absolute shrinkage and selection operators and multivariate Cox regression models.

Results: Eight CpG sites were identified and validated as optimal prognostic signatures for the overall survival of LUAD patients. Receiver operating characteristic analysis demonstrated the high predictive ability of the eight-site methylation signature combined with clinical factors for overall survival.

Conclusion: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.

Graphical Abstract

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