Abstract

Numerous photoprotective techniques have been employed to successfully shield against the harmful effects of ultraviolet radiation. Current photoprotective techniques have limitations due to the amount of topical application, insufficient physical protection, and adverse responses to topical agents. A newer option that offers a promising defense against solar radiation is systemic agents, the well-researched Polypodium leucotomos is significant in this category, and several studies have found to be effective ―oral sunscreen. Polypodium leucotomos (PL) extract has gained significant attention as a potential therapeutic agent in the field of dermatology, particularly in the photoprotection and management of various dermatological conditions. This abstract provides a comprehensive overview of the mechanism, safety, and efficacy of Polypodium leucotomos extract in relation to photoprotection and dermatological conditions. Our primary aim is to review Polypodium leucotomos' photoprotective results from studies that are currently available, and our secondary goal is to describe Polypodium leucotomos' applications in different dermatological conditions. Articles discussing Polypodium leucotomos uses in photoprotection and dermatologic conditions are searched and downloaded from publicly available databases such as PubMed, JSTOR, PLOS, Science Direct, DOAJ, Google Scholar, and Web of Science and evaluate the outcomes of the Polypodium leucotomos effect. Firstly, we delve into the mechanisms underlying the photoprotective properties of PL extract. Extensive research has demonstrated that PL extract exerts its protective effects through multiple pathways, including antioxidant activity, DNA repair stimulation, immunomodulation, and inhibition of inflammatory mediators. These mechanisms collectively contribute to the prevention of photodamage, such as sunburn, DNA damage, and photoaging. Furthermore, we explore the safety profile of PL extract, emphasizing its remarkable tolerability and minimal adverse effects reported in clinical studies. The absence of systemic absorption and its compatibility with other treatments make PL extract a promising option for long-term use in photoprotection and dermatological care. A promising alternative to traditional photoprotection may be Polypodium leucotomos. Additional thorough clinical trials are necessary to ascertain its role and effectiveness more accurately. The efficacy of PL extract in managing various dermatological conditions is also discussed. Multiple studies have demonstrated its beneficial effects in conditions such as vitiligo, melasma, psoriasis, and atopic dermatitis. The anti-inflammatory and immunomodulatory properties of PL extract have shown promise in reducing disease severity, improving skin symptoms, and enhancing the quality of life for patients. Additionally, the abstract highlights the potential future directions and areas of research for PL extract. Investigating its combination therapy with other photoprotective agents, exploring optimal dosage regimens, and further elucidating the molecular mechanisms are areas that warrant attention. In conclusion, this abstract provides an insightful overview of the mechanisms, safety, and efficacy of PL extract in photoprotection and dermatological conditions. The remarkable properties of PL extract, combined with its favorable safety profile, position it as a promising therapeutic intervention in dermatology. Further research and clinical trials are needed to fully exploit its potential and establish its place in the management of various skin conditions.

Graphical Abstract