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Current Diabetes Reviews

Author(s): Felipe Rodrigues de Almeida, Adelaine Maria de Sousa, Eduardo de Farias Barbosa, Bruna de Carvalho Farias Vajgel* and Renata Cimões

DOI: 10.2174/0115733998265346231027051336

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Evaluation of Salivary Glucose and Salivary Cortisol in Association with Periodontitis in People with Type II Diabetes: A Case-control Study

Article ID: e030124225194 Pages: 7

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Abstract

Background: The relationship between type II diabetes mellitus (DM) and periodontal disease (PD) has been discussed in recent years and may vary according to the patient's location, sex, age and family history.

Objective: In view of this possible association between periodontitis and DM, this study aimed to evaluate salivary glucose and salivary cortisol levels with periodontitis (staging and degree) in people with type II diabetes compared to non-diabetic individuals.

Methods: This was a case-control study, with 60 participants divided into two groups: DM2- people with type II diabetes (n=30) and NDM- non-diabetic individuals (n=30). For both, a clinical form and periogram were filled out, and blood samples (glycemia, glycated hemoglobin, and cortisol) and saliva (glucose and cortisol) were collected.

Results: The diagnosis of periodontitis was 100% in the DM2 group and 80% in the NDM group. As for staging and degree, in the DM2 group, 70% of the participants were in stage IV and 86.67% were in grade C, while in the NDM group, 58.3% of the participants were in stage I and 70.8% were in grade A. Significant differences were observed for the following variables: bleeding to probing and clinical attachment level. The laboratory data presented significant results regarding serum glucose, salivary glucose, and glycated hemoglobin.

Conclusion: Regarding the influence of salivary glucose and cortisol on periodontal status (staging and degree), these had higher means in the DM2 group when compared to the NDM group. An association of salivary glucose and cortisol levels with the periodontal condition presented by type II diabetic individuals compared to non-diabetic individuals is suggested.

[1]
Gupta S, Sandhu SV, Bansal H, Sharma D. Comparison of salivary and serum glucose levels in diabetic patients. J Diabetes Sci Technol 2015; 9(1): 91-6.
[http://dx.doi.org/10.1177/1932296814552673] [PMID: 25294888]
[2]
Ramos MMB, Mendonça MR, Pellizzer EP, Okamoto AC, Jardim ED Jr. Association between periodontal disease and chronic systemic disease - literature review. Arch Health Invest 2013; 2(1): 24-31.
[3]
Izu AM, Moreira K, Nascimento MCB, Peres R Jr. Diabetes and the relationship with periodontal disease. Rev Ceciliana 2010; 2(2): 23-5.
[4]
Dalbosco WO, Rech C. Influence of periodontal treatment on the glycemic level of diabetic patient. Journal of Oral Investigations 2013; 26(2): 27-31.
[http://dx.doi.org/10.18256/2238-510X/j.oralinvestigations.v2n2p27-31]
[5]
Alves CAD, Brandão MMA, Andion J, Menezes R, Carvalho F. Dental care for patients with diabetes mellitus: Recommendations for clinical practise. R Ci Med Biol 2006; 5(2): 97-110.
[6]
Alves C, Andion J, Brandão M, Menezes R. Pathogenic aspects of the periodontal disease associated to diabetes mellitus. Arq Bras Endocrinol Metabol 2007; 51(7): 1050-7.
[http://dx.doi.org/10.1590/S0004-27302007000700005] [PMID: 18157378]
[7]
Penteado MS, Oliveira TC. Associação estresse-diabetes mellitus tipo II. Revista Brasileira de Clínica Médica 2009; 7: 40-5.
[8]
Regional Council of Medicine of the state of São Paulo - Cremesp. Brazil: Center for Bioethics 2005.
[9]
Malta M, Cardoso LO, Bastos FI, Magnanini MMF, Silva CMFP. Iniciativa STROBE: Subsídios para a comunicação de estudos observacionais. Rev Saude Publica 2010; 44(3): 559-65.
[http://dx.doi.org/10.1590/S0034-89102010000300021] [PMID: 20549022]
[10]
Mesa F, Magán-Fernández A, Muñoz R, et al. Catecholamine metabolites in urine, as chronic stress biomarkers, are associated with higher risk of chronic periodontitis in adults. J Periodontol 2014; 85(12): 1755-62.
[http://dx.doi.org/10.1902/jop.2014.140209] [PMID: 24965061]
[11]
Miot HA. Tamanho da amostra em estudos clínicos e experimentais. J Vasc Bras 2011; 10(4): 275-8.
[http://dx.doi.org/10.1590/S1677-54492011000400001] [PMID: 30787944]
[12]
Sociedade Brasileira de Análises Clínicas Programa Nacional de Controle de Qualidade. SBAC: Manual de Coleta em Laboratório Clínico 2019.
[13]
Fernande LS, Gueiros LAM. Evaluation of stimulated sialometry techniques in patients with rheumatoid arthritis Annals of XXIII CONIC, VII CONITI, IV ENIT Dean of Research and Postgraduate Affairs (Propesq). Universidade Federal de Pernambuco 2015.
[14]
Humphrey SP, Williamson RT. A review of saliva: Normal composition, flow, and function. J Prosthet Dent 2001; 85(2): 162-9.
[http://dx.doi.org/10.1067/mpr.2001.113778] [PMID: 11208206]
[15]
Liquidato BM, Soler RC, Bussoloti Filho I. Assessment of agreement between sialometry and salivary gland scintigraphy in patients with dry mouth. Rev Bras Otorrinolaringol 2006; 72(1): 116-9.
[http://dx.doi.org/10.1590/S0034-72992006000100018]
[16]
Socidedade Brasileira de. Diabetes (2019) Diretrizes da Sociedade Brasileira de Diabetes. SBD: São Paulo. Ed. Clannad 2019.
[17]
Armitage GC. The complete periodontal examination. Periodontol 2000 2004; 34(1): 22-33.
[http://dx.doi.org/10.1046/j.0906-6713.2002.003422.x] [PMID: 14717853]
[18]
Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. J Clin Periodontol 2018; 45(S20) (Suppl. 20): S162-70.
[http://dx.doi.org/10.1111/jcpe.12946] [PMID: 29926490]
[19]
Prates FRPM, Rizzieri AG, Rõsing CK. Evaluation of periodontal conditions in diabetic and non-diabetic individuals. Stomatos 2006; 12(22): 11-8.
[20]
Tiongco RE, Bituin A, Arceo E, Rivera N, Singian E. Salivary glucose as a non-invasive biomarker of type 2 diabetes mellitus. J Clin Exp Dent 2018; 10(9): 0.
[http://dx.doi.org/10.4317/jced.55009] [PMID: 30386523]
[21]
Ragunathan H, Aswath N, Sarumathi T. Salivary glucose estimation: A noninvasive method. Indian Journal of Dental Sciences 2019; 11(1): 25-7.
[http://dx.doi.org/10.4103/IJDS.IJDS_78_18]
[22]
Lima RPE, Chaves KRS, Venturato FT. Associação entre periodontite e controle glicêmico do portador de diabetes melito tipo 2: Um estudo piloto. Periodontia 2014; 24(4): 7-14.
[23]
Sousa JNL, Nóbrega DRM, Araki AT. Profile and perception of diabetics on the relationship between diabetes and periodontal disease. Revista de Odontologia da UNESP, Araraquara 2014; 43(4): 265-72.
[24]
Borba TTD, Molz P, Santos CD, et al. Association between periodontitis and sociodemographic factors, body mass index and lifestyle characteristics. Journal of Epidemiology and Infection Control 2016; 6(4): 185-90.
[http://dx.doi.org/10.17058/reci.v6i4.8290]
[25]
Carvalho SS, Silva TMA, Coelho JMF. Contributions of non-pharmacological treatment for Type 2 Diabetes Mellitus. Journal of Epidemiology and Infection Control. Santa Cruz do Sul 2015; 5(2): 1-6.
[http://dx.doi.org/10.17058/reci.v5i2.5616]
[26]
Moreira AR, Soares MSM, Passos IA, Sampaio FC. Hyposalivation and increase of salivary glucose in diabetics. Rev Odontol 2007; 15(30): 78-82.
[http://dx.doi.org/10.15603/2176-1000/odonto.v15n30p78-82]
[27]
Cortelli JR, Pinheiro RMS, Costa FO, Aquino DR, Raslan SA, Cortelli SC. Salivary and microbiological parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus: A case-control study. Rev Odontol UNESP 2014; 43(3): 196-202. [On line].
[http://dx.doi.org/10.1590/rou.2014.030]
[28]
Mascarenhas P, Fatela B, Barahona I. Effect of diabetes mellitus type 2 on salivary glucose--a systematic review and meta-analysis of observational studies. PLoS One 2014; 9(7): e101706.
[http://dx.doi.org/10.1371/journal.pone.0101706] [PMID: 25025218]
[29]
Wang B, Du J, Zhu Z, Ma Z, Wang S, Shan Z. Evaluation of parotid salivary glucose level for clinical diagnosis and monitoring type 2 diabetes mellitus patients. BioMed Research International 2017; 2569707: 5.
[30]
Oliveira MTG, Furtado PGS, Cardoso RFC, Souza ACD, Lima RPE, Mendonça SMS. Association between Periodontitis and Hyperglycemia. Rev Gaúch Odontol 2018; 66(3): 199-204.
[31]
Cunha PO. Periodontal and salivary evaluation of a sample of patients with type 1 Diabetes mellitus from the city of Bauru – São Paulo 2015.
[32]
Hackett RA, Kivimäki M, Kumari M, Steptoe A. Diurnal Cortisol Patterns, Future Diabetes, and Impaired Glucose Metabolism in the Whitehall II Cohort Study. J Clin Endocrinol Metab 2016; 101(2): 619-25.
[http://dx.doi.org/10.1210/jc.2015-2853] [PMID: 26647151]
[33]
Seraphim APCG, Chiba FY, Pereira RF, Mattera MSLC, Moimaz SAS, Sumida DH. Relationship among periodontal disease, insulin resistance, salivary cortisol, and stress levels during pregnancy. Braz Dent J 2016; 27(2): 123-7.
[http://dx.doi.org/10.1590/0103-6440201600596] [PMID: 27058372]
[34]
Coelho JMF, Miranda SS, da Cruz SS, et al. Is there association between stress and periodontitis? Clin Oral Investig 2020; 24(7): 2285-94.
[http://dx.doi.org/10.1007/s00784-019-03083-9] [PMID: 31654249]
[35]
Ferreira NC, Bavaresco DV, Ceretta LB, Tuon L, Gomes KM, Amboni G. Estresse em pacientes com diabetes tipo 2. Inova Saúde 2015; 4(1): 88-98.
[http://dx.doi.org/10.18616/is.v4i1.1949]