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Cardiovascular & Hematological Agents in Medicinal Chemistry

Author(s): Ayoub Amssayef, Mohammed Ajebli and Mohamed Eddouks*

DOI: 10.2174/0118715257243190231024164358

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Study of the Antihypertensive Effect of Scorzonera undulata ssp. deliciosa in Albino Wistar Rats

Page: [159 - 167] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Aims: The study aimed to investigate the antihypertensive activity of Scorzonera undulata ssp. deliciosa.

Background: Scorzonera undulata ssp deliciosa, locally known as “Guiz”, is used in traditional medicine in Morocco as a diuretic and mainly against snake bites.

Objectives: This study investigated the possible antihypertensive effect of the aqueous extract of Scorzonera undulata (AESU).

Materials and Methods: In the present study, the antihypertensive activity of AESU was tested in normotensive and hypertensive rats

Results: The results indicated that AESU decreased the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. The data revealed that AESU exerted its antihypertensive effect through vasodilatory properties. Interestingly, the study demonstrated that the vasorelaxation ability of AESU might be mediated through receptor-operated calcium channels (ROCCs). However, AESU dhad effect on inhibiting ACE-2.

Conclusion: The present study indicates the antihypertensive and vasorelaxant activities of AESU in hypertensive rats.

Graphical Abstract

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