Abstract

One-step synthesis of multifaceted heterocycles employing Multicomponent Reactions (MCRs) corresponds to a viable, innovative, and prospective strategy. In recognition of their noteworthy physiological, biological, and pharmacological behavior, 2-aminopyridines secure an exceptional spot among heterocycles. The current analysis comprises an overview of the scientific literature concerning the multicomponent reactions of substituted 2-aminopyridine synthesis. The stipulated outcomes have been thoroughly categorized according to the number and nature of the components. The past 11 years of literary work (2011–2022) are specifically incorporated. This review article will assist in advancing the development of cutting-edge and enhanced approaches towards the synthesis of 2-aminopyridines and their counterparts.