Abstract
Lung cancer is one of the leading causes of death across the world. There are numerous
challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug
resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive.
Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research
areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically
active agents at the site of action. This approach can also be employed in molecular and cellular
imaging, precise and early detection, screening, and targeting drugs for lung cancer treatment. A
proper understanding of the disease and timely diagnosis using strategically designed effective
nanocarriers can be a promising approach to effectively managing cancer. The present review explores
issues related to lung cancer chemotherapy and the promises and hurdles of newer approaches
like nanomedicine. The article also summarizes the preclinical studies on diagnosis and
treatment, pitfalls, and challenges in the clinical translation of nanomedicines for lung cancer therapy.
Graphical Abstract
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