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Current Bioactive Compounds

Author(s): Chandra Shekhar Yadav, Iqbal Azad*, Abdul Rahman Khan, Naseem Ahmad, Shishir Kumar Gupta, Vijay Kumar Verma, Dhananjoy Hansda and Minaxi B. Lohani*

DOI: 10.2174/0115734072266590231023094928

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Exploring the Therapeutic Potential of Chalcones in Oncology: A Comprehensive Review

Article ID: e031123223102 Pages: 36

  • * (Excluding Mailing and Handling)

Abstract

Chalcone is a bioactive flavonoid found in various plants, such as Angelica archangelica, Pueraria lobata, and Glycyrrhiza glabra. It has been studied extensively in the field of pharmaceutical sciences due to its significant role in therapeutic potential including antibacterial, antiinflammatory, analgesic, cytotoxic, and antitumor properties. A plenty of study indicated numerous chalcone derivatives exhibit enhanced potency and reduced toxicity as compared to natural analogues. In this review, we have introduced chalcone and its various derivatives including 1- naphthylacetophenone, 2-benzimidazolyl, 2-furoyloxy, 3-(furan-2-yl)pyrazol-4-yl, 4'-alkoxy, 4- anilinoquinolinyl, 4-aryloxyquinazolines, acridine, benzamide, benzenesulfonamide, bischalcone, cinnamoylthiazoles, D-glucosyl azides, dialkylamino, dihydropyrimidinone, indole, isoquinoline, ligustrazine, morpholinothiazole, naphthalene, quinoline, sulphonamide, thiazoleimidazopyridine, thienyl, thiophene, triazines, triazole-benzimidazole, tri-methoxyphenyl, and α- trifluoromethyl hybrids which display activity against various cancer cell lines, such as breast cancer, prostate cancer, colon cancer, lung cancer, cervical cancer, and liver cancer.

Graphical Abstract

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