Abstract

Functionalized 3-amino-2-azetidinones are important heterocyclic systems which can easily be transformed into functionally decorated heterocycles using β-lactam synthon protocol. The different synthetic methods have been explored for the transformation of functionalized 3-amino-2-azetidiones to various heterocyclic molecules, such as imidazolidin-2-ones, piperazines, hydantoins, 4-oxo-1H-pyrroles, 1,4-benzodiazepin-2-ones, amino pyrrolidine-2- carboxylates etc., and β-lactam- based conjugates having diverse biological activities, such as anti-malarial activity, anti-tuberculosis, anti-trichomonas activity etc. The present review article summarizes the various reports on the synthetic transformation of functionalized 3-amino-2- azetidinones for the synthesis of a variety of heterocyclic systems.

Keywords: β-lactam, 3-amino-2-azetidinones, β-lactam synthon methodology, imidazolidin-2-ones, 1, 2, 3-triazole tethered-β-lactam, thiazolidinone, 4-aminoquinoline-β-lactam.