Contrast-enhanced Ultrasonography for Diagnosis of Small Intestinal Leiomyosarcoma with Hepatic Metastasis: A Clinical Report of One Case and Review of the Literature

Article ID: e15734056243285 Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Background: Small intestinal leiomyosarcoma is a rare malignant tumor of the gastrointestinal tract. Clinical symptoms are atypical and can be complicated by gastrointestinal bleeding and intestinal obstruction.

Case Presentation: We report a case of a 73-year-old patient with small intestinal smooth muscle sarcoma with hepatic metastasis. No significant abnormalities were seen on examination of the abdomen. We performed abdominal enhancement CT, contrast-enhanced ultrasonography (CEUS), and ultrasoundguided pelvic mass puncture biopsy, and we found a heterogeneous density and echogenicity of the pelvic mass, and the enhancement was progressive with sustained hyperenhancement. The postoperative pathology was smooth muscle sarcoma of the small intestine. The typical fast-in, fast-out bull's-eye sign of metastases, characterized the liver presented with multiple hypodense and echogenic nodules and the enhancement. The clinical presentation, imaging, histologic features, and treatment are also discussed in this article.

Conclusion: This article briefly reviews the literature on small intestinal leiomyosarcoma. The purpose of this case report is to emphasize the specificity of the case and evaluate the imaging presentation of ultrasound (US) and CEUS and the main differential diagnosis of this rare gastrointestinal tumor.

[1]
Maccioni F, Rossi P, Gourtsoyiannis N, Bezzi M, Di Nardo L, Broglia L. US and CT findings of small bowel neoplasms. Eur Radiol 1997; 7(9): 1398-409.
[http://dx.doi.org/10.1007/s003300050307] [PMID: 9369505]
[2]
Tanaka A, Ozeki N, Takahashi Y, et al. A case of giant mesosigmoid leiomyosarcoma--review of Japanese literature. J Jpn Soc Shogaki 1990; 87(5): 1258-62.
[PMID: 2200907]
[3]
Blanchard DK, Budde JM, Hatch GF III, et al. Tumors of the small intestine. World J Surg 2000; 24(4): 421-9.
[http://dx.doi.org/10.1007/s002689910067] [PMID: 10706914]
[4]
Evans HL, Chawla SP, Simpson C, Finn KP. Smooth muscle neoplasms of the uterus other than ordinary leiomyoma: A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 1988; 62(10): 2239-47.
[http://dx.doi.org/10.1002/1097-0142(19881115)62:10<2239::AID-CNCR2820621028>3.0.CO;2-Y] [PMID: 3179938]
[5]
Chiang JM, Lin YS. Tumor spectrum of adult intussusception. J Surg Oncol 2008; 98(6): 444-7.
[http://dx.doi.org/10.1002/jso.21117] [PMID: 18668640]
[6]
Katz SC, DeMatteo RP. Gastrointestinal stromal tumors and leiomyosarcomas. J Surg Oncol 2008; 97(4): 350-9.
[http://dx.doi.org/10.1002/jso.20970] [PMID: 18286477]
[7]
Paski SC, Semrad CE. Small bowel tumors. Gastrointest Endosc Clin N Am 2009; 19(3): 461-79.
[http://dx.doi.org/10.1016/j.giec.2009.04.012] [PMID: 19647652]
[8]
Aggarwal G, Sharma S, Zheng M, et al. Primary leiomyosarcomas of the gastrointestinal tract in the post–gastrointestinal stromal tumor era. Ann Diagn Pathol 2012; 16(6): 532-40.
[http://dx.doi.org/10.1016/j.anndiagpath.2012.07.005] [PMID: 22917807]
[9]
Hilal L, Barada K, Mukherji D, Temraz S, Shamseddine A. Gastrointestinal (GI) leiomyosarcoma (LMS) case series and review on diagnosis, management, and prognosis. Med Oncol 2016; 33(2): 20.
[http://dx.doi.org/10.1007/s12032-016-0730-3] [PMID: 26786155]
[10]
Kochi K, Shigemoto S, Isono M, et al. A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. Hiroshima J Med Sci 1993; 42(3): 125-8.
[PMID: 8253608]
[11]
Fernández-Trigo V, Sugarbaker PH. Sarcomas involving the abdominal and pelvic cavity. Tumori 1993; 79(2): 77-91.
[http://dx.doi.org/10.1177/030089169307900201] [PMID: 8346570]
[12]
Kazerooni EA, Quint LE, Francis IR. Duodenal neoplasms: predictive value of CT for determining malignancy and tumor resectability. AJR Am J Roentgenol 1992; 159(2): 303-9.
[http://dx.doi.org/10.2214/ajr.159.2.1632344] [PMID: 1632344]
[13]
Kurugoglu S, Ogut G, Mihmanli I, Korman U, Durak H. Abdominal leiomyosarcomas: radiologic appearances at various locations. Eur Radiol 2002; 12(12): 2933-42.
[http://dx.doi.org/10.1007/s00330-002-1358-6] [PMID: 12439573]
[14]
Baur A, Stäbler A, Wendtner CM, et al. MR-imaging changes of musculoskeletal soft-tissue sarcomas associated with neoadjuvant chemotherapy and hyperthermia. Int J Hyperthermia 2003; 19(4): 391-401.
[http://dx.doi.org/10.1080/0265673021000058366] [PMID: 12850925]
[15]
Kim SH, Kwon HJ, Cho JH, et al. Atypical radiological features of a leiomyosarcoma that arose from the ovarian vein and mimicked a vascular tumour. Br J Radiol 2010; 83(989): e95-7.
[http://dx.doi.org/10.1259/bjr/50917539] [PMID: 20418463]
[16]
Singapore Cancer Network (SCAN) Colorectal Cancer Systemic Therapy Workgroup. Singapore Cancer Network (SCAN) guidelines for systemic therapy of colorectal cancer. Ann Acad Med Singap 2015; 44(10): 379-87.
[http://dx.doi.org/10.47102/annals-acadmedsg.V44N10p379] [PMID: 26763055]
[17]
McLeod AJ, Zornoza J, Shirkhoda A. Leiomyosarcoma: computed tomographic findings. Radiology 1984; 152(1): 133-6.
[http://dx.doi.org/10.1148/radiology.152.1.6729102] [PMID: 6729102]
[18]
Soyer P, Riopel M, Bluemke DA, Scherrer A. Hepatic metastases from leiomyosarcoma: MR features with histopathologic correlation. Abdom Imaging 1997; 22(1): 67-71.
[http://dx.doi.org/10.1007/s002619900142] [PMID: 9000359]
[19]
de Mizio R, Romano S, D’Amario F, Rossi AG, Scaglione M, Grassi R. Unusual feature of jejunal leiomyosarcoma studied with US and CT-enteroclysis. Clin Imaging 2003; 27(5): 337-9.
[http://dx.doi.org/10.1016/S0899-7071(02)00565-X] [PMID: 12932686]
[20]
Soyer P, Bluemke DA, Riopel M, Hruban RH, Fishman EK. Hepatic leiomyosarcomas: CT features with pathologic correlation. Eur J Radiol 1995; 19(3): 177-82.
[http://dx.doi.org/10.1016/0720-048X(94)00592-Z] [PMID: 7601167]
[21]
David E, Del Gaudio G, Drudi FM, et al. Contrast enhanced ultrasound compared with mri and ct in the evaluation of post-renal transplant complications. Tomography 2022; 8(4): 1704-15.
[http://dx.doi.org/10.3390/tomography8040143] [PMID: 35894008]
[22]
Yamaguchi U, Hasegawa T, Masuda T, et al. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch 2004; 445(2): 142-50.
[http://dx.doi.org/10.1007/s00428-004-1055-8] [PMID: 15232741]
[23]
Koczkowska M, Lipska BS, Grzeszewska J, Limon J, Biernat W, Jassem J. Primary leiomyosarcoma of the mesentery in two sisters: clinical and molecular characteristics. Pol J Pathol 2013; 1(1): 59-63.
[http://dx.doi.org/10.5114/pjp.2013.34605] [PMID: 23625602]