Abstract
Background: Urological cancers, encompassing prostate, kidney, and
bladder cancers, pose significant global health challenges. Current treatment
modalities, including chemotherapy, radiotherapy, and surgery, individually or in
combination, have limitations in efficacy and are associated with notable morbidity and
mortality.
Methods: This review explores alternative therapeutic avenues, emphasizing the
exploration of natural compounds, with a specific focus on berberine. Berberine's
potential as a treatment for urological cancers is investigated through an extensive
examination of cellular and molecular mechanisms.
Results: The comprehensive analysis reveals promising anticancer properties
associated with berberine, substantiated by a wealth of experimental studies. The
agent's impact on urological cancers is discussed, highlighting notable findings related
to its efficacy and safety profile.
Conclusions: Given the high mortality rates and potential side effects associated with
current standard treatments for urological cancers, the exploration of alternative,
effective, and safer options is imperative. This review underscores berberine's
therapeutic potential, shedding light on its anticancer effects and encouraging further
research in the pursuit of enhanced treatment strategies.
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