Role of Polyphenols, their Nano-formulations, and Biomaterials in Diabetic
Wound Healing

Nasr   A.   Emad; Iqra      Zai; Saeem      Ahmad; Jayamenti      Pandit; Mohd   Ashif   Khan; Yasmin      Sultana
Abstract

A diabetic wound is one of the major complications arising from hyperglycemia, neuropathy, and oxidative stress in diabetic patients. Finding effective treatments for diabetic wounds has been difficult owing to the complex pathophysiology of diabetic wound environments. Chronic wounds are notoriously difficult to treat with conventional wound care methods. In recent years, polyphenols found in plants have received much interest as a potential treatment for diabetic wounds. Their key benefits are their safety and the fact that they act through many molecular routes to treat diabetic wounds. However, problems with their formulation development, including lipophilicity, light sensitivity, limited membrane permeability, rapid systemic elimination, and enzymatic degradation, prevented them from gaining clinical attention. This article highlights and discusses the mechanism of polyphenols and various polyphenol-based drug delivery systems used till now to treat diabetic wounds. The consideration that should be taken in polyphenols-based nano-formulations and their prospect for diabetic wounds are also discussed briefly.
Keywords: Polyphenols, diabetic wounds, nano formulation, reactive oxygen species, wound dressing, biomaterials.
Graphical Abstract

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Cite As
Endocrine, Metabolic & Immune Disorders - Drug Targets

Role of Polyphenols, their Nano-formulations, and Biomaterials in Diabetic Wound Healing

Abstract

Graphical Abstract
