Current Perspectives of Matrix Metalloproteinase 11 (MMP11) as a Diagnostic
and Therapeutic Target for Cancer

Asokan      Shobana; Remella   Venkata   Deeksha; Syed   Ali Abdul   Rahman; Tiviya      Thangaswamy; Revathi   Paramasivam   Oviya; Gopal      Gopisetty
Abstract

Matrix metalloproteinase 11 (MMP11), also known as stromelysin-3, is a member of the matrix metalloproteinases family of proteins that are involved in physiological and pathological extracellular matrix remodelling. MMP11 does not hydrolyse classical MMP substrates, such as laminin and fibronectin, and many of its substrates remain unknown, piquing the interest of researchers. Several studies have reported the role of MMP11 in inducing tumour growth by inhibiting apoptosis and promoting cancer cell migration and invasion. Various reports have shown its potential as a diagnostic and prognostic marker in a majority of cancers. MMP11 also induces an immune response as a tumour-associated antigen, and recent evidence shows the involvement of many microRNAs in targeting MMP11 in cancer, with prospective future applications in cancer immunotherapy and gene silencing. Owing to the importance of MMP11 in both cancer diagnosis and therapy, there is a need for deeper understanding of its mechanism and role in tumour progression. The current review focuses on the role of MMP11 in cell signalling pathways, its expression status in various cancers, and its potential in cancer treatment.
Keywords: MMPs, MMP11, diagnostic marker, prognostic marker, cancer immunotherapy, gene therapy.
Graphical Abstract

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Cite As
Current Cancer Therapy Reviews

Current Perspectives of Matrix Metalloproteinase 11 (MMP11) as a Diagnostic and Therapeutic Target for Cancer

Abstract

Graphical Abstract
