Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review

Page: [963 - 975] Pages: 13

  • * (Excluding Mailing and Handling)

Abstract

Background: Post-mortem examination of the brain is a key strategy to increase our understanding of the neurobiology of mental disorders. While extensive post-mortem research has been undertaken on some mental disorders, others appear to have been relatively neglected.

Objective: The objective of the study was to conduct a systematic review of post-mortem research on obsessive-compulsive disorder (OCD).

Methods: A systematic review was performed in accordance with PRISMA guidelines to provide an overview of quantitative, qualitative, or mixed methods primary research studies on OCD. Search platforms included NCBI Pubmed, SCOPUS, and Web of Science.

Results: A total of 52 publications were found, and after the removal of works not meeting the inclusion criteria, six (6) peer-reviewed publications remained. These post-mortem studies have provided data on DNA methylation, cellular and molecular alterations, and gene expression profiling in brain areas associated with OCD.

Discussion and Conclusion: Included studies highlight the potential value of post-mortem brains from well-characterized individuals with OCD and suggest the need for additional work in this area.

Graphical Abstract

[1]
Phillips, K.A.; Stein, D.J.; Rauch, S.L.; Hollander, E.; Fallon, B.A.; Barsky, A.; Fineberg, N.; Mataix-Cols, D.; Ferrão, Y.A.; Saxena, S.; Wilhelm, S.; Kelly, M.M.; Clark, L.A.; Pinto, A.; Bienvenu, O.J.; Farrow, J.; Leckman, J. Should an obsessive-compulsive spectrum grouping of disorders be included in DSM-V? Depress. Anxiety, 2010, 27(6), 528-555.
[http://dx.doi.org/10.1002/da.20705] [PMID: 20533367]
[2]
Stein, D.J.; Kogan, C.S.; Atmaca, M.; Fineberg, N.A.; Fontenelle, L.F.; Grant, J.E.; Matsunaga, H.; Reddy, Y.C.J.; Simpson, H.B.; Thomsen, P.H.; van den Heuvel, O.A.; Veale, D.; Woods, D.W.; Reed, G.M. The classification of obsessive-compulsive and related disorders in the ICD-11. J. Affect. Disord., 2016, 190, 663-674.
[http://dx.doi.org/10.1016/j.jad.2015.10.061] [PMID: 26590514]
[3]
Stein, D.J.; Craske, M.G.; Friedman, M.J.; Phillips, K.A. Meta-structure issues for the DSM-5: how do anxiety disorders, obsessive-compulsive and related disorders, post-traumatic disorders, and dissociative disorders fit together? Curr. Psychiatry Rep., 2011, 13(4), 248-250.
[http://dx.doi.org/10.1007/s11920-011-0207-1] [PMID: 21603904]
[4]
Ruscio, A.M.; Stein, D.J.; Chiu, W.T.; Kessler, R.C. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol. Psychiatry, 2010, 15(1), 53-63.
[http://dx.doi.org/10.1038/mp.2008.94] [PMID: 18725912]
[5]
Fontenelle, L.F.; Mendlowicz, M.V.; Versiani, M. The descriptive epidemiology of obsessive–compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2006, 30(3), 327-337.
[http://dx.doi.org/10.1016/j.pnpbp.2005.11.001] [PMID: 16412548]
[6]
Fawcett, E.J.; Power, H.; Fawcett, J.M. Women are at greater risk of OCD than men. J. Clin. Psychiatry, 2020, 81(4), 19r13085.
[http://dx.doi.org/10.4088/JCP.19r13085] [PMID: 32603559]
[7]
Murray, C.J.L.; Lopez, A.D. Evidence-based health policy--lessons from the Global Burden of Disease Study. Science, 1996, 274(5288), 740-743.
[http://dx.doi.org/10.1126/science.274.5288.740] [PMID: 8966556]
[8]
World Health Organization. Depression and other common mental disorders: global health estimates; World Health Organization, 2017.
[9]
World Health Organization. The global burden of disease  2004 update; World Health Organization, 2008, p. 146p.
[10]
Simpson, H.B.; Huppert, J.D.; Petkova, E.; Foa, E.B.; Liebowitz, M.R. Response versus remission in obsessive-compulsive disorder. J. Clin. Psychiatry, 2006, 67(2), 269-276.
[http://dx.doi.org/10.4088/JCP.v67n0214] [PMID: 16566623]
[11]
Pallanti, S.; Quercioli, L. Treatment-refractory obsessive-compulsive disorder: Methodological issues, operational definitions and therapeutic lines. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2006, 30(3), 400-412.
[http://dx.doi.org/10.1016/j.pnpbp.2005.11.028] [PMID: 16503369]
[12]
Greist, J.H.; Bandelow, B.; Hollander, E.; Marazziti, D.; Montgomery, S.A.; Nutt, D.J.; Okasha, A.; Swinson, R.P.; Zohar, J. WCA recommendations for the long-term treatment of obsessive-compulsive disorder in adults. CNS Spectr., 2003, 8(S1), 7-16.
[http://dx.doi.org/10.1017/S1092852900006908] [PMID: 14767394]
[13]
Middleton, R.; Wheaton, M.G.; Kayser, R.S.H. Treatment resistance in obsessive-compulsive disorder. In: Treatment Resistance in Psychiatry; Yk, K., Ed.; Springer Singapore: Singapore, 2019.
[http://dx.doi.org/10.1007/978-981-10-4358-1_11]
[14]
Simpson, H.B.; Hezel, D.M. Exposure and response prevention for obsessive-compulsive disorder: A review and new directions. Indian J. Psychiatry, 2019, 61(7)(Suppl. 1), 85.
[http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_516_18] [PMID: 30745681]
[15]
Wolmarans, D.W.; Scheepers, I.M.; Stein, D.J.; Harvey, B.H. Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges. Metab. Brain Dis., 2018, 33(2), 443-455.
[http://dx.doi.org/10.1007/s11011-017-0161-7] [PMID: 29214602]
[16]
Szechtman, H; Ahmari, SE; Beninger, RJ; Eilam, D; Harvey, BH; Edemann-Callesen, H Obsessive-compulsive disorder: Insights from animal models. Neurosci Biobehav Rev, 2017, 76(Pt B), 254-79.
[17]
Ahmari, S.E.; Spellman, T.; Douglass, N.L.; Kheirbek, M.A.; Simpson, H.B.; Deisseroth, K.; Gordon, J.A.; Hen, R. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science, 2013, 340(6137), 1234-1239.
[http://dx.doi.org/10.1126/science.1234733] [PMID: 23744948]
[18]
Andersen, S.L.; Greene-Colozzi, E.A.; Sonntag, K.C. A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals. Biol. Psychiatry, 2010, 68(8), 741-747.
[http://dx.doi.org/10.1016/j.biopsych.2010.05.011] [PMID: 20619828]
[19]
Burguière, E.; Monteiro, P.; Feng, G.; Graybiel, A.M. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science, 2013, 340(6137), 1243-1246.
[http://dx.doi.org/10.1126/science.1232380] [PMID: 23744950]
[20]
Camilla d’Angelo, L.S.; Eagle, D.M.; Grant, J.E.; Fineberg, N.A.; Robbins, T.W.; Chamberlain, S.R. Animal models of obsessive-compulsive spectrum disorders. CNS Spectr., 2014, 19(1), 28-49.
[http://dx.doi.org/10.1017/S1092852913000564] [PMID: 24093759]
[21]
Joel, D.; Klavir, O. The effects of temporary inactivation of the orbital cortex in the signal attenuation rat model of obsessive compulsive disorder. Behav. Neurosci., 2006, 120(4), 976-983.
[http://dx.doi.org/10.1037/0735-7044.120.4.976] [PMID: 16893303]
[22]
Korff, S.; Stein, D.J.; Harvey, B.H. Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008, 32(2), 348-355.
[http://dx.doi.org/10.1016/j.pnpbp.2007.08.032] [PMID: 17888556]
[23]
Shmelkov, S.V.; Hormigo, A.; Jing, D.; Proenca, C.C.; Bath, K.G.; Milde, T.; Shmelkov, E.; Kushner, J.S.; Baljevic, M.; Dincheva, I.; Murphy, A.J.; Valenzuela, D.M.; Gale, N.W.; Yancopoulos, G.D.; Ninan, I.; Lee, F.S.; Rafii, S. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice. Nat. Med., 2010, 16(5), 598-602.
[http://dx.doi.org/10.1038/nm.2125] [PMID: 20418887]
[24]
Welch, J.M.; Lu, J.; Rodriguiz, R.M.; Trotta, N.C.; Peca, J.; Ding, J.D.; Feliciano, C.; Chen, M.; Adams, J.P.; Luo, J.; Dudek, S.M.; Weinberg, R.J.; Calakos, N.; Wetsel, W.C.; Feng, G. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature, 2007, 448(7156), 894-900.
[http://dx.doi.org/10.1038/nature06104] [PMID: 17713528]
[25]
Wood, J.; LaPalombara, Z.; Ahmari, S.E. Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour. Philos. Trans. R. Soc. Lond. B Biol. Sci., 2018, 373(1742), 20170023.
[http://dx.doi.org/10.1098/rstb.2017.0023] [PMID: 29352023]
[26]
Ahmari, S.E. Using mice to model Obsessive Compulsive Disorder: From genes to circuits. Neuroscience, 2016, 321, 121-137.
[http://dx.doi.org/10.1016/j.neuroscience.2015.11.009] [PMID: 26562431]
[27]
Chamberlain, B.L.; Ahmari, S.E. Animal Models for OCD Research. In: Current Topics in Behavioral Neurosciences; Fineberg, N.A.; Robbins, T.W., Eds.; Springer International Publishing: Cham, 2021; pp. 55-96. [Internet]
[28]
Fernandez, T.V.; Leckman, J.F.; Pittenger, C. Genetic susceptibility in obsessive-compulsive disorder. Handb. Clin. Neurol., 2018, 148, 767-781.
[http://dx.doi.org/10.1016/B978-0-444-64076-5.00049-1] [PMID: 29478613]
[29]
Mataix-Cols, D.; Boman, M.; Monzani, B.; Rück, C.; Serlachius, E.; Långström, N.; Lichtenstein, P. Population-based, multigenerational family clustering study of obsessive-compulsive disorder. JAMA Psychiatry, 2013, 70(7), 709-717.
[http://dx.doi.org/10.1001/jamapsychiatry.2013.3] [PMID: 23699935]
[30]
Brander, G.; Kuja-Halkola, R.; Rosenqvist, M.A.; Rück, C.; Serlachius, E.; Fernández de la Cruz, L.; Lichtenstein, P.; Crowley, J.J.; Larsson, H.; Mataix-Cols, D. A population-based family clustering study of tic-related obsessive-compulsive disorder. Mol. Psychiatry, 2021, 26(4), 1224-1233.
[http://dx.doi.org/10.1038/s41380-019-0532-z] [PMID: 31616041]
[31]
Pauls, D.L.; Abramovitch, A.; Rauch, S.L.; Geller, D.A. Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective. Nat. Rev. Neurosci., 2014, 15(6), 410-424.
[http://dx.doi.org/10.1038/nrn3746] [PMID: 24840803]
[32]
Chakrabarty, K.; Bhattacharyya, S.; Christopher, R.; Khanna, S. Glutamatergic dysfunction in OCD. Neuropsychopharmacology, 2005, 30(9), 1735-1740.
[33]
Kariuki-Nyuthe, C.; Gomez-Mancilla, B.; Stein, D.J. Obsessive compulsive disorder and the glutamatergic system. Curr. Opin. Psychiatry, 2014, 27(1), 32-37.
[http://dx.doi.org/10.1097/YCO.0000000000000017] [PMID: 24270485]
[34]
Wu, K.; Hanna, G.L.; Rosenberg, D.R.; Arnold, P.D. The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder. Pharmacol. Biochem. Behav., 2012, 100(4), 726-735.
[http://dx.doi.org/10.1016/j.pbb.2011.10.007] [PMID: 22024159]
[35]
Wu, K.; Hanna, G.L.; Easter, P.; Kennedy, J.L.; Rosenberg, D.R.; Arnold, P.D. Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: A preliminary study. Psychiatry Res. Neuroimaging, 2013, 211(3), 214-220.
[http://dx.doi.org/10.1016/j.pscychresns.2012.07.003] [PMID: 23154099]
[36]
Arnold, P.D.; Askland, K.D.; Barlassina, C.; Bellodi, L.; Bienvenu, O.J.; Black, D. Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis. Mol. Psychiatry, 2018, 23(5), 1181-1188.
[http://dx.doi.org/10.1038/mp.2017.154] [PMID: 28761083]
[37]
Mahjani, B.; Bey, K.; Boberg, J.; Burton, C. Genetics of obsessive-compulsive disorder. Psychol. Med., 2021, 51(13), 2247-2259.
[http://dx.doi.org/10.1017/S0033291721001744] [PMID: 34030745]
[38]
Pauls, D.L. The genetics of obsessive-compulsive disorder: a review. Dialogues Clin. Neurosci., 2010, 12(2), 149-163.
[http://dx.doi.org/10.31887/DCNS.2010.12.2/dpauls] [PMID: 20623920]
[39]
Mataix-Cols, D.; Wooderson, S.; Lawrence, N.; Brammer, M.J.; Speckens, A.; Phillips, M.L. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2004, 61(6), 564-576.
[http://dx.doi.org/10.1001/archpsyc.61.6.564] [PMID: 15184236]
[40]
Bandelow, B.; Baldwin, D.; Abelli, M.; Bolea-Alamanac, B.; Bourin, M.; Chamberlain, S.R. Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition. World J. Biol. Psychiatry, 2017, 18(3), 162-214.
[41]
Bhattacharyya, S.; Khanna, S.; Chakrabarty, K.; Mahadevan, A.; Christopher, R.; Shankar, S.K. Anti-brain autoantibodies and altered excitatory neurotransmitters in obsessive-compulsive disorder. Neuropsychopharmacology, 2009, 34(12), 2489-2496.
[42]
Guo, H.R.; Huang, B.L.; Wang, Y.L.; Zhang, Y.Y.; Ma, Q.G.; Lv, P.P.; Ren, Y.M. Effect of escitalopram on serum GDNF and BDNF levels and 5-HT level of brain tissue of obsessive-compulsive disorder rats. Cell. Mol. Neurobiol., 2020, 40(6), 991-997.
[http://dx.doi.org/10.1007/s10571-020-00788-4] [PMID: 31927718]
[43]
Lustberg, D.; Iannitelli, A.F.; Tillage, R.P.; Pruitt, M.; Liles, L.C.; Weinshenker, D. Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder. Psychopharmacology (Berl.), 2020, 237(7), 1973-1987.
[http://dx.doi.org/10.1007/s00213-020-05512-0] [PMID: 32313981]
[44]
Stein, D.J.; Costa, D.L.C.; Lochner, C.; Miguel, E.C.; Reddy, Y.C.J.; Shavitt, R.G.; van den Heuvel, O.A.; Simpson, H.B. Obsessive-compulsive disorder. Nat. Rev. Dis. Primers, 2019, 5(1), 52.
[http://dx.doi.org/10.1038/s41572-019-0102-3] [PMID: 31371720]
[45]
van den Heuvel, O.A.; van Wingen, G.; Soriano-Mas, C.; Alonso, P.; Chamberlain, S.R.; Nakamae, T. Brain circuitry of compulsivity. Eur. Neuropsychopharmacol., 2016, 26(5), 810-827.
[46]
Kwon, J.S.; Jang, J.H.; Choi, J.S.; Kang, D.H. Neuroimaging in obsessive–compulsive disorder. Expert Rev. Neurother., 2009, 9(2), 255-269.
[http://dx.doi.org/10.1586/14737175.9.2.255] [PMID: 19210199]
[47]
Baxter, L.R., Jr; Schwartz, J.M.; Bergman, K.S.; Szuba, M.P.; Guze, B.H.; Mazziotta, J.C.; Alazraki, A.; Selin, C.E.; Ferng, H.K.; Munford, P. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1992, 49(9), 681-689.
[http://dx.doi.org/10.1001/archpsyc.1992.01820090009002] [PMID: 1514872]
[48]
Chamberlain, S.R.; Menzies, L.; Hampshire, A.; Suckling, J.; Fineberg, N.A.; del Campo, N.; Aitken, M.; Craig, K.; Owen, A.M.; Bullmore, E.T.; Robbins, T.W.; Sahakian, B.J. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science, 2008, 321(5887), 421-422.
[http://dx.doi.org/10.1126/science.1154433] [PMID: 18635808]
[49]
Maia, T.V.; Cooney, R.E.; Peterson, B.S. The neural bases of obsessive–compulsive disorder in children and adults. Dev. Psychopathol., 2008, 20(4), 1251-1283.
[http://dx.doi.org/10.1017/S0954579408000606] [PMID: 18838041]
[50]
Pujol, J.; Soriano-Mas, C.; Alonso, P.; Cardoner, N.; Menchón, J.M.; Deus, J.; Vallejo, J. Mapping structural brain alterations in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2004, 61(7), 720-730.
[http://dx.doi.org/10.1001/archpsyc.61.7.720] [PMID: 15237084]
[51]
Saxena, S.; Bota, R.G.; Brody, A.L. Brain-behavior relationships in obsessive-compulsive disorder. Semin. Clin. Neuropsychiatry, 2001, 6(2), 82-101.
[http://dx.doi.org/10.1053/scnp.2001.21833] [PMID: 11296309]
[52]
Saxena, S.; Brody, A.L.; Schwartz, J.M.; Baxter, L.R. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br. J. Psychiatry, 1998, 173(S35), 26-37.
[http://dx.doi.org/10.1192/S0007125000297870] [PMID: 9829024]
[53]
Saxena, S.; Rauch, S.L. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr. Clin. North Am., 2000, 23(3), 563-586.
[http://dx.doi.org/10.1016/S0193-953X(05)70181-7] [PMID: 10986728]
[54]
van den Heuvel, O.A.; Veltman, D.J.; Groenewegen, H.J.; Cath, D.C.; van Balkom, A.J.L.M.; van Hartskamp, J.; Barkhof, F.; van Dyck, R. Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2005, 62(3), 301-309.
[http://dx.doi.org/10.1001/archpsyc.62.3.301] [PMID: 15753243]
[55]
Heuvel, O.A.; Boedhoe, P.S.W.; Bertolin, S.; Bruin, W.B.; Francks, C.; Ivanov, I.; Jahanshad, N.; Kong, X.Z.; Kwon, J.S.; O’Neill, J.; Paus, T.; Patel, Y.; Piras, F.; Schmaal, L.; Soriano-Mas, C.; Spalletta, G.; Wingen, G.A.; Yun, J.Y.; Vriend, C.; Simpson, H.B.; Rooij, D.; Hoexter, M.Q.; Hoogman, M.; Buitelaar, J.K.; Arnold, P.; Beucke, J.C.; Benedetti, F.; Bollettini, I.; Bose, A.; Brennan, B.P.; De Nadai, A.S.; Fitzgerald, K.; Gruner, P.; Grünblatt, E.; Hirano, Y.; Huyser, C.; James, A.; Koch, K.; Kvale, G.; Lazaro, L.; Lochner, C.; Marsh, R.; Mataix-Cols, D.; Morgado, P.; Nakamae, T.; Nakao, T.; Narayanaswamy, J.C.; Nurmi, E.; Pittenger, C.; Reddy, Y.C.J.; Sato, J.R.; Soreni, N.; Stewart, S.E.; Taylor, S.F.; Tolin, D.; Thomopoulos, S.I.; Veltman, D.J.; Venkatasubramanian, G.; Walitza, S.; Wang, Z.; Thompson, P.M.; Stein, D.J.; Abe, Y.; Alonso, P.; Assogna, F.; Banaj, N.; Batistuzzo, M.C.; Brem, S.; Ciullo, V.; Feusner, J.; Martínez-Zalacaín, I.; Menchón, J.M.; Miguel, E.C.; Piacentini, J.; Piras, F.; Sakai, Y.; Wolters, L.; Yamada, K. An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration. Hum. Brain Mapp., 2022, 43(1), 23-36.
[http://dx.doi.org/10.1002/hbm.24972] [PMID: 32154629]
[56]
Bu, X.; Hu, X.; Zhang, L.; Li, B.; Zhou, M.; Lu, L.; Hu, X.; Li, H.; Yang, Y.; Tang, W.; Gong, Q.; Huang, X. Investigating the predictive value of different resting-state functional MRI parameters in obsessive-compulsive disorder. Transl. Psychiatry, 2019, 9(1), 17.
[http://dx.doi.org/10.1038/s41398-018-0362-9] [PMID: 30655506]
[57]
Narayanaswamy, J.C.; Hazari, N.; Venkatasubramanian, G. Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings. Indian J. Psychiatry, 2019, 61(7)(Suppl. 1), 9.
[http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_525_18] [PMID: 30745673]
[58]
Tian, L.; Meng, C.; Jiang, Y.; Tang, Q.; Wang, S.; Xie, X.; Fu, X.; Jin, C.; Zhang, F.; Wang, J. Abnormal functional connectivity of brain network hubs associated with symptom severity in treatment-naive patients with obsessive–compulsive disorder: A resting-state functional MRI study. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2016, 66, 104-111.
[http://dx.doi.org/10.1016/j.pnpbp.2015.12.003] [PMID: 26683173]
[59]
Gürsel, D.A.; Avram, M.; Sorg, C.; Brandl, F.; Koch, K. Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity. Neurosci. Biobehav. Rev., 2018, 87, 151-160.
[http://dx.doi.org/10.1016/j.neubiorev.2018.01.016] [PMID: 29410103]
[60]
Gonçalves, Ó.F.; Soares, J.M.; Carvalho, S.; Leite, J.; Ganho-Ávila, A.; Fernandes-Gonçalves, A.; Pocinho, F.; Carracedo, A.; Sampaio, A. Patterns of default mode network deactivation in obsessive compulsive disorder. Sci. Rep., 2017, 7(1), 44468.
[http://dx.doi.org/10.1038/srep44468] [PMID: 28287615]
[61]
Stern, E.R.; Fitzgerald, K.D.; Welsh, R.C.; Abelson, J.L.; Taylor, S.F. Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder. PLoS One, 2012, 7(5), e36356.
[http://dx.doi.org/10.1371/journal.pone.0036356] [PMID: 22570705]
[62]
Hansen, E.S.; Hasselbalch, S.; Law, I.; Bolwig, T.G. The caudate nucleus in obsessive–compulsive disorder. Reduced metabolism following treatment with paroxetine: a PET study. Int. J. Neuropsychopharmacol., 2002, 5(1), 1-10.
[http://dx.doi.org/10.1017/S1461145701002681] [PMID: 12057027]
[63]
Perani, D.; Colombo, C.; Bressi, S.; Bonfanti, A.; Grassi, F.; Scarone, S.; Bellodi, L.; Smeraldi, E.; Fazio, F. [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment. Br. J. Psychiatry, 1995, 166(2), 244-250.
[http://dx.doi.org/10.1192/bjp.166.2.244] [PMID: 7728370]
[64]
Saxena, S.; Brody, A.L.; Maidment, K.M.; Dunkin, J.J.; Colgan, M.; Alborzian, S. Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology, 1999, 21(6), 683-693.
[65]
Gerentes, M.; Pelissolo, A.; Rajagopal, K.; Tamouza, R.; Hamdani, N. Obsessive-compulsive disorder. Autoimmunity and Neuroinflammation. Curr. Psychiatry Rep., 2019, 21(8), 78.
[http://dx.doi.org/10.1007/s11920-019-1062-8] [PMID: 31367805]
[66]
Attwells, S.; Setiawan, E.; Wilson, A.A.; Rusjan, P.M.; Mizrahi, R.; Miler, L.; Xu, C.; Richter, M.A.; Kahn, A.; Kish, S.J.; Houle, S.; Ravindran, L.; Meyer, J.H. Inflammation in the neurocircuitry of obsessive-compulsive disorder. JAMA Psychiatry, 2017, 74(8), 833-840.
[http://dx.doi.org/10.1001/jamapsychiatry.2017.1567] [PMID: 28636705]
[67]
Turna, J.; Grosman Kaplan, K.; Anglin, R.; Van Ameringen, M. “What’s bugging the gut in OCD?” A review of the gut microbiome in obsessive-compulsive disorder. Depress. Anxiety, 2016, 33(3), 171-178.
[http://dx.doi.org/10.1002/da.22454] [PMID: 26629974]
[68]
Renna, M.E.; O’Toole, M.S.; Spaeth, P.E.; Lekander, M.; Mennin, D.S. The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: A systematic review and meta-analysis. Depress. Anxiety, 2018, 35(11), 1081-1094.
[http://dx.doi.org/10.1002/da.22790] [PMID: 30199144]
[69]
Lewis, D.A. The human brain revisited: Opportunities and challenges in postmortem studies of psychiatric disorders. Neuropsychopharmacology, 2002, 26(2), 143-154.
[70]
de Lange, G.M. Understanding the cellular and molecular alterations in PTSD brains: The necessity of post-mortem brain tissue. Eur. J. Psychotraumatol., 2017, 8(1), 1341824.
[http://dx.doi.org/10.1080/20008198.2017.1341824] [PMID: 28680541]
[71]
Page, M.J.; McKenzie, J.E.; Bossuyt, P.M.; Boutron, I.; Hoffmann, T.C.; Mulrow, C.D.; Shamseer, L.; Tetzlaff, J.M.; Akl, E.A.; Brennan, S.E.; Chou, R.; Glanville, J.; Grimshaw, J.M.; Hróbjartsson, A.; Lalu, M.M.; Li, T.; Loder, E.W.; Mayo-Wilson, E.; McDonald, S.; McGuinness, L.A.; Stewart, L.A.; Thomas, J.; Tricco, A.C.; Welch, V.A.; Whiting, P.; Moher, D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021, 372(71), n71.
[http://dx.doi.org/10.1136/bmj.n71] [PMID: 33782057]
[72]
Downes, M.J.; Brennan, M.L.; Williams, H.C.; Dean, R.S. Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). BMJ Open, 2016, 6(12), e011458.
[http://dx.doi.org/10.1136/bmjopen-2016-011458] [PMID: 27932337]
[73]
Jaffe, A.E.; Deep-Soboslay, A.; Tao, R.; Hauptman, D.T.; Kaye, W.H.; Arango, V.; Weinberger, D.R.; Hyde, T.M.; Kleinman, J.E. Genetic neuropathology of obsessive psychiatric syndromes. Transl. Psychiatry, 2014, 4(9), e432.
[http://dx.doi.org/10.1038/tp.2014.68] [PMID: 25180571]
[74]
Lipska, B.K.; Deep-Soboslay, A.; Weickert, C.S.; Hyde, T.M.; Martin, C.E.; Herman, M.M.; Kleinman, J.E. Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia. Biol. Psychiatry, 2006, 60(6), 650-658.
[http://dx.doi.org/10.1016/j.biopsych.2006.06.019] [PMID: 16997002]
[75]
Ruden, J.B.; Dugan, L.L.; Konradi, C. Parvalbumin interneuron vulnerability and brain disorders. Neuropsychopharmacology, 2021, 46(2), 279-287.
[http://dx.doi.org/10.1038/s41386-020-0778-9]
[76]
Hoseth, E.Z.; Krull, F.; Dieset, I.; Mørch, R.H.; Hope, S.; Gardsjord, E.S.; Steen, N.E.; Melle, I.; Brattbakk, H.R.; Steen, V.M.; Aukrust, P.; Djurovic, S.; Andreassen, O.A.; Ueland, T. Attenuated Notch signaling in schizophrenia and bipolar disorder. Sci. Rep., 2018, 8(1), 5349.
[http://dx.doi.org/10.1038/s41598-018-23703-w] [PMID: 29593239]
[77]
de Oliveira, K.C.; Grinberg, L.T.; Hoexter, M.Q.; Brentani, H.; Suemoto, C.K.; Nery, F.G.; Lima, L.C.; Alho, A.T.D.L.; Farfel, J.M.; Ferretti-Rebustini, R.E.L.; Leite, R.E.P.; Moretto, A.C.; da Silva, A.V.; Lafer, B.; Miguel, E.C.; Nitrini, R.; Jacob-Filho, W.; Heinsen, H.; Pasqualucci, C.A. Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder. Brain Struct. Funct., 2019, 224(1), 191-203.
[http://dx.doi.org/10.1007/s00429-018-1752-8] [PMID: 30298291]
[78]
Hoexter, M.Q.; Diniz, J.B.; Lopes, A.C.; Batistuzzo, M.C.; Shavitt, R.G.; Dougherty, D.D.; Duran, F.L.S.; Bressan, R.A.; Busatto, G.F.; Miguel, E.C.; Sato, J.R. Orbitofrontal thickness as a neasure for treatment response prediction in obsessive-compulsive disorder. Depress. Anxiety, 2015, 32(12), 900-908.
[http://dx.doi.org/10.1002/da.22380] [PMID: 26032588]
[79]
Christian, C.J.; Lencz, T.; Robinson, D.G.; Burdick, K.E.; Ashtari, M.; Malhotra, A.K.; Betensky, J.D.; Szeszko, P.R. Gray matter structural alterations in obsessive–compulsive disorder: Relationship to neuropsychological functions. Psychiatry Res. Neuroimaging, 2008, 164(2), 123-131.
[http://dx.doi.org/10.1016/j.pscychresns.2008.03.005] [PMID: 18938065]
[80]
Kim, J.J.; Lee, M.C.; Kim, J.; Kim, I.Y.; Kim, S.I.; Han, M.H.; Chang, K.H.; Kwon, J.S. Grey matter abnormalities in obsessive–compulsive disorder. Br. J. Psychiatry, 2001, 179(4), 330-334.
[http://dx.doi.org/10.1192/bjp.179.4.330] [PMID: 11581113]
[81]
Valente, A.A., Jr; Miguel, E.C.; Castro, C.C.; Amaro, E., Jr; Duran, F.L.S.; Buchpiguel, C.A.; Chitnis, X.; McGuire, P.K.; Busatto, G.F. Regional gray matter abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study. Biol. Psychiatry, 2005, 58(6), 479-487.
[http://dx.doi.org/10.1016/j.biopsych.2005.04.021] [PMID: 15978549]
[82]
Hoexter, M.Q.; de Souza Duran, F.L.; D’Alcante, C.C.; Dougherty, D.D.; Shavitt, R.G.; Lopes, A.C. Gray matter volumes in obsessive-compulsive disorder before and after fluoxetine or cognitive-behavior therapy: A randomized clinical trial. Neuropsychopharmacology, 2012, 37(3), 45.
[83]
Rotge, J-Y.; Langbour, N.; Guehl, D.; Bioulac, B.; Jaafari, N.; Allard, M. Gray matter alterations in obsessive-compulsive disorder: An anatomic likelihood estimation meta-analysis. Neuropsychopharmacology, 2010, 35(3), 686-691.
[84]
Szeszko, P.R.; Robinson, D.; Alvir, J.M.J.; Bilder, R.M.; Lencz, T.; Ashtari, M.; Wu, H.; Bogerts, B. Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1999, 56(10), 913-919.
[http://dx.doi.org/10.1001/archpsyc.56.10.913] [PMID: 10530633]
[85]
Togao, O.; Yoshiura, T.; Nakao, T.; Nabeyama, M.; Sanematsu, H.; Nakagawa, A.; Noguchi, T.; Hiwatashi, A.; Yamashita, K.; Nagao, E.; Kanba, S.; Honda, H. Regional gray and white matter volume abnormalities in obsessive–compulsive disorder: A voxel-based morphometry study. Psychiatry Res. Neuroimaging, 2010, 184(1), 29-37.
[http://dx.doi.org/10.1016/j.pscychresns.2010.06.011] [PMID: 20833001]
[86]
Yoo, S.Y.; Roh, M.S.; Choi, J.S.; Kang, D.H.; Ha, T.H.; Lee, J.M.; Kim, I.Y.; Kim, S.I.; Kwon, J.S. Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder. J. Korean Med. Sci., 2008, 23(1), 24-30.
[http://dx.doi.org/10.3346/jkms.2008.23.1.24] [PMID: 18303194]
[87]
Gillan, C.M.; Apergis-Schoute, A.M.; Morein-Zamir, S.; Urcelay, G.P.; Sule, A.; Fineberg, N.A.; Sahakian, B.J.; Robbins, T.W. Functional neuroimaging of avoidance habits in obsessive-compulsive disorder. Am. J. Psychiatry, 2015, 172(3), 284-293.
[http://dx.doi.org/10.1176/appi.ajp.2014.14040525] [PMID: 25526600]
[88]
Harrison, B.J.; Pujol, J.; Soriano-Mas, C.; Hernández-Ribas, R.; López-Solà, M.; Ortiz, H.; Alonso, P.; Deus, J.; Menchon, J.M.; Real, E.; Segalàs, C.; Contreras-Rodríguez, O.; Blanco-Hinojo, L.; Cardoner, N. Neural correlates of moral sensitivity in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2012, 69(7), 741-749.
[http://dx.doi.org/10.1001/archgenpsychiatry.2011.2165] [PMID: 22752238]
[89]
Maltby, N.; Tolin, D.F.; Worhunsky, P.; O’Keefe, T.M.; Kiehl, K.A. Dysfunctional action monitoring hyperactivates frontal–striatal circuits in obsessive–compulsive disorder: an event-related fMRI study. Neuroimage, 2005, 24(2), 495-503.
[http://dx.doi.org/10.1016/j.neuroimage.2004.08.041] [PMID: 15627591]
[90]
Radua, J.; Mataix-Cols, D. Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder. Br. J. Psychiatry, 2009, 195(5), 393-402.
[http://dx.doi.org/10.1192/bjp.bp.108.055046] [PMID: 19880927]
[91]
Lisboa, B.C.G.; Oliveira, K.C.; Tahira, A.C.; Barbosa, A.R.; Feltrin, A.S.A.; Gouveia, G.; Lima, L.; Feio dos Santos, A.C.; Martins, D.C., Jr; Puga, R.D.; Moretto, A.C.; De Bragança Pereira, C.A.; Lafer, B.; Leite, R.E.P.; Ferretti-Rebustini, R.E.D.L.; Farfel, J.M.; Grinberg, L.T.; Jacob-Filho, W.; Miguel, E.C.; Hoexter, M.Q.; Brentani, H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Sci. Rep., 2019, 9(1), 3086.
[http://dx.doi.org/10.1038/s41598-019-38965-1] [PMID: 30816141]
[92]
Milad, M.R.; Pitman, R.K.; Ellis, C.B.; Gold, A.L.; Shin, L.M.; Lasko, N.B.; Zeidan, M.A.; Handwerger, K.; Orr, S.P.; Rauch, S.L. Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biol. Psychiatry, 2009, 66(12), 1075-1082.
[http://dx.doi.org/10.1016/j.biopsych.2009.06.026] [PMID: 19748076]
[93]
Milad, M.R.; Rauch, S.L. Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends Cogn. Sci., 2012, 16(1), 43-51.
[http://dx.doi.org/10.1016/j.tics.2011.11.003] [PMID: 22138231]
[94]
Tschernegg, M.; Pletzer, B.; Schwartenbeck, P.; Ludersdorfer, P.; Hoffmann, U.; Kronbichler, M. Impulsivity relates to striatal gray matter volumes in humans: evidence from a delay discounting paradigm. Front. Hum. Neurosci., 2015, 9, 384.
[http://dx.doi.org/10.3389/fnhum.2015.00384] [PMID: 26190993]
[95]
Piras, F.; Piras, F.; Chiapponi, C.; Girardi, P.; Caltagirone, C.; Spalletta, G. Widespread structural brain changes in OCD: A systematic review of voxel-based morphometry studies. Cortex, 2015, 62, 89-108.
[http://dx.doi.org/10.1016/j.cortex.2013.01.016] [PMID: 23582297]
[96]
Parkes, L.; Fulcher, B.D.; Yücel, M.; Fornito, A. Transcriptional signatures of connectomic subregions of the human striatum. Genes Brain Behav., 2017, 16(7), 647-663.
[http://dx.doi.org/10.1111/gbb.12386] [PMID: 28421658]
[97]
de Oliveira, K.C.; Camilo, C.; Gastaldi, V.D.; Sant’Anna Feltrin, A.; Lisboa, B.C.G.; de Jesus Rodrigues de Paula, V. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC genomic data, 2021, 22(1), 45.
[98]
Yue, W.; Cheng, W.; Liu, Z.; Tang, Y.; Lu, T.; Zhang, D.; Tang, M.; Huang, Y. Genome-wide DNA methylation analysis in obsessive-compulsive disorder patients. Sci. Rep., 2016, 6(1), 31333.
[http://dx.doi.org/10.1038/srep31333] [PMID: 27527274]
[99]
Nissen, J.B.; Hansen, C.S.; Starnawska, A.; Mattheisen, M.; Børglum, A.D.; Buttenschøn, H.N.; Hollegaard, M. DNA Methylation at the neonatal state and at the time of diagnosis: Preliminary support for an association with the estrogen receptor 1, gamma-aminobutyric acid B receptor 1, and myelin oligodendrocyte glycoprotein in female adolescent patients with OCD. Front. Psychiatry, 2016, 7, 35.
[http://dx.doi.org/10.3389/fpsyt.2016.00035] [PMID: 27047397]
[100]
Cappi, C.; Diniz, J.B.; Requena, G.L.; Lourenço, T.; Lisboa, B.C.G.; Batistuzzo, M.C.; Marques, A.H.; Hoexter, M.Q.; Pereira, C.A.; Miguel, E.C.; Brentani, H. Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder. BMC Neurosci., 2016, 17(1), 79.
[http://dx.doi.org/10.1186/s12868-016-0313-4] [PMID: 27903255]
[101]
D’Addario, C.; Bellia, F.; Benatti, B.; Grancini, B.; Vismara, M.; Pucci, M.; De Carlo, V.; Viganò, C.; Galimberti, D.; Fenoglio, C.; Scarpini, E.; Maccarrone, M.; Dell’Osso, B. Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder. J. Psychiatr. Res., 2019, 114, 17-23.
[http://dx.doi.org/10.1016/j.jpsychires.2019.04.006] [PMID: 31004918]
[102]
Grünblatt, E.; Marinova, Z.; Roth, A.; Gardini, E.; Ball, J.; Geissler, J.; Wojdacz, T.K.; Romanos, M.; Walitza, S. Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder. J. Psychiatr. Res., 2018, 96, 209-217.
[http://dx.doi.org/10.1016/j.jpsychires.2017.10.010] [PMID: 29102815]
[103]
Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol., 2013, 14(10), R115.
[http://dx.doi.org/10.1186/gb-2013-14-10-r115] [PMID: 24138928]
[104]
Marazziti, D.; Mucci, F.; Fontenelle, L.F. Immune system and obsessive-compulsive disorder. Psychoneuroendocrinology, 2018, 93, 39-44.
[http://dx.doi.org/10.1016/j.psyneuen.2018.04.013] [PMID: 29689421]
[105]
Rodriguez, N.; Morer, A.; González-Navarro, E.A.; Gassó, P.; Boloc, D.; Serra-Pagès, C. Human-leukocyte antigen class II genes in early-onset obsessive-compulsive disorder. World J. Biol. Psychiatry, 2019, 20(5), 352-358.
[106]
Piantadosi, S.C.; Chamberlain, B.L.; Glausier, J.R.; Lewis, D.A.; Ahmari, S.E. Lower excitatory synaptic gene expression in orbitofrontal cortex and striatum in an initial study of subjects with obsessive compulsive disorder. Mol. Psychiatry, 2021, 26(3), 986-998.
[http://dx.doi.org/10.1038/s41380-019-0431-3] [PMID: 31168067]
[107]
Harrison, B.J.; Soriano-Mas, C.; Pujol, J.; Ortiz, H.; López-Solà, M.; Hernández-Ribas, R.; Deus, J.; Alonso, P.; Yücel, M.; Pantelis, C.; Menchon, J.M.; Cardoner, N. Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2009, 66(11), 1189-1200.
[http://dx.doi.org/10.1001/archgenpsychiatry.2009.152] [PMID: 19884607]
[108]
Menzies, L.; Achard, S.; Chamberlain, S.R.; Fineberg, N.; Chen, C.H.; del Campo, N.; Sahakian, B.J.; Robbins, T.W.; Bullmore, E. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain, 2007, 130(12), 3223-3236.
[http://dx.doi.org/10.1093/brain/awm205] [PMID: 17855376]
[109]
Menzies, L.; Chamberlain, S.R.; Laird, A.R.; Thelen, S.M.; Sahakian, B.J.; Bullmore, E.T. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited. Neurosci. Biobehav. Rev., 2008, 32(3), 525-549.
[http://dx.doi.org/10.1016/j.neubiorev.2007.09.005] [PMID: 18061263]
[110]
Rauch, S.L.; Savage, C.R.; Alpert, N.M.; Dougherty, D.; Kendrick, A.; Curran, T.; Brown, H.D.; Manzo, P.; Fischman, A.J.; Jenike, M.A. Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning. J. Neuropsychiatry Clin. Neurosci., 1997, 9(4), 568-573.
[http://dx.doi.org/10.1176/jnp.9.4.568] [PMID: 9447498]
[111]
Rotge, J.Y.; Guehl, D.; Dilharreguy, B.; Tignol, J.; Bioulac, B.; Allard, M.; Burbaud, P.; Aouizerate, B. Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biol. Psychiatry, 2009, 65(1), 75-83.
[http://dx.doi.org/10.1016/j.biopsych.2008.06.019] [PMID: 18718575]
[112]
Piantadosi, S.C.; McClain, L.L.; Klei, L.; Wang, J.; Chamberlain, B.L.; Springer, S.A.; Lewis, D.A.; Devlin, B.; Ahmari, S.E. Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder. Transl. Psychiatry, 2021, 11(1), 171.
[http://dx.doi.org/10.1038/s41398-021-01290-1] [PMID: 33723209]
[113]
First, M.B.; Spitzer, R.L.; Gobbon, M.; Williams, J.B.W. Structured clinical interview for DSM-IV Axis I disorders - Patient edition; New York State Psychiatric Institute, Biometrics Research Department: New York, 1998.
[114]
Goodman, W.K.; Price, L.H.; Rasmussen, S.A.; Mazure, C.; Fleischmann, R.L.; Hill, C.L.; Heninger, G.R.; Charney, D.S. The Yale-Brown obsessive-compulsive scale: I. Development, use, and reliability. Arch. Gen. Psychiatry, 1989, 46(11), 1006-1011.
[http://dx.doi.org/10.1001/archpsyc.1989.01810110048007] [PMID: 2684084]
[115]
Harrison, P.J. Using our brains: the findings, flaws, and future of postmortem studies of psychiatric disorders. Biol. Psychiatry, 2011, 69(2), 102-103.
[116]
Sidorchuk, A.; Kuja-Halkola, R.; Runeson, B.; Lichtenstein, P.; Larsson, H.; Rück, C.; D’Onofrio, B.M.; Mataix-Cols, D.; Fernández de la Cruz, L. Genetic and environmental sources of familial coaggregation of obsessive-compulsive disorder and suicidal behavior: a population-based birth cohort and family study. Mol. Psychiatry, 2021, 26(3), 974-985.
[http://dx.doi.org/10.1038/s41380-019-0417-1] [PMID: 30962511]
[117]
McCullumsmith, R.E.; Hammond, J.H.; Shan, D.; Meador-Woodruff, J.H. Postmortem brain: an underutilized substrate for studying severe mental illness. Neuropsychopharmacology, 2014, 39(1), 65-87.
[118]
Vidal-Ribas, P.; Stringaris, A.; Rück, C.; Serlachius, E.; Lichtenstein, P.; Mataix-Cols, D. Are stressful life events causally related to the severity of obsessive-compulsive symptoms? A monozygotic twin difference study. Eur. Psychiatry, 2015, 30(2), 309-316.
[119]
Murayama, K.; Nakao, T.; Ohno, A.; Tsuruta, S.; Tomiyama, H.; Hasuzawa, S.; Mizobe, T.; Kato, K.; Kanba, S. Impacts of stressful life events and traumatic experiences on onset of obsessive-compulsive disorder. Front. Psychiatry, 2020, 11, 561266.
[http://dx.doi.org/10.3389/fpsyt.2020.561266] [PMID: 33343411]
[120]
Rademaker, M.C.; de Lange, G.M.; Palmen, S.J.M.C. The Netherlands Brain Bank for Psychiatry. Handb. Clin. Neurol., 2018, 150, 3-16.
[http://dx.doi.org/10.1016/B978-0-444-63639-3.00001-3] [PMID: 29496148]
[121]
Ikonomovic, M.D.; Buckley, C.J.; Heurling, K.; Sherwin, P.; Jones, P.A.; Zanette, M.; Mathis, C.A.; Klunk, W.E.; Chakrabarty, A.; Ironside, J.; Ismail, A.; Smith, C.; Thal, D.R.; Beach, T.G.; Farrar, G.; Smith, A.P.L. Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection. Acta Neuropathol. Commun., 2016, 4(1), 130.
[http://dx.doi.org/10.1186/s40478-016-0399-z] [PMID: 27955679]
[122]
Yendiki, A.; Aggarwal, M.; Axer, M.; Howard, A.F.D.; van Walsum, A.M.C.; Haber, S.N. Post mortem mapping of connectional anatomy for the validation of diffusion MRI. Neuroimage, 2022, 256, 119146.
[http://dx.doi.org/10.1016/j.neuroimage.2022.119146] [PMID: 35346838]
[123]
de Oliveira, K.C.; Nery, F.G.; Ferreti, R.E.L.; Lima, M.C.; Cappi, C.; Machado-Lima, A.; Polichiso, L.; Carreira, L.L.; Ávila, C.; Alho, A.T.D.L.; Brentani, H.P.; Miguel, E.C.; Heinsen, H.; Jacob-Filho, W.; Pasqualucci, C.A.; Lafer, B.; Grinberg, L.T. Brazilian psychiatric brain bank: A new contribution tool to network studies. Cell Tissue Bank., 2012, 13(2), 315-326.
[http://dx.doi.org/10.1007/s10561-011-9258-0] [PMID: 21562728]
[124]
de Lange, G.M.; Rademaker, M.; Boks, M.P.; Palmen, S.J.M.C. Brain donation in psychiatry: results of a Dutch prospective donor program among psychiatric cohort participants. BMC Psychiatry, 2017, 17(1), 347.
[http://dx.doi.org/10.1186/s12888-017-1513-x] [PMID: 29058593]