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Letters in Organic Chemistry

Author(s): Meng Liang, Jiaxia Pu, Xiaoying Jia, Lirong Han and Qinghan Li*

DOI: 10.2174/1570178620666230821142342

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Palladium-catalyzed Cross-coupling of 2-Benzo[b]thiophene or 2- Benzo[b]furan Aluminum with Heteroaryl or Alkynyl Bromides for the Synthesis of 2-Hetroaryl or Alkynyl Benzo[b]thiophene or Benzo[b]furan Derivatives

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Abstract

An alternative method for the synthesis of 2-heteroaryl or alkynyl benzo[b]thiophene or furan derivatives via direct palladium-catalyzed cross-coupling of 2-benzo[b]thiophene or furan aluminum with heteroaryl or alkynyl bromides, respectively, has been successfully developed. This case is remarkable as the same catalytic system could simultaneously produce either 2-substituted benzo[ b]thiophene or furan derivatives.

Keywords: Palladium, 2-benzo[b]thiophene, 2-benzo[b]furan, alkynyl bromide, heteroaryl aluminum, cross-coupling reaction.

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