Abstract

Background: Herbal medicines have been used in both traditional and modern medicine for the treatment of numerous kinds of human disorders and associated secondary complications. Lindera species has an important place in traditional medicine and provides a great source of structurally diverse molecules with important pharmacological potential. Lindera strychnifolia is used as remedies for the treatment of menstruation complications, frequent urination, and vomiting. Isolinderalactone is a sesquiterpene class phytochemical isolated from the root extracts of Lindera aggregate.

Methods: Biological importance and pharmacological activities of isolinderalactone have been investigated in the present work through scientific data analysis of different scientific research work. Scientific data on isolinderalactone have been collected from Google, Google Scholar, ScienceDirect, PubMed and Scopus using the terms isolinderalactone, Lindera species, and terpenes and analyzed in the present work in order to know its therapeutic potential in medicine.

Results: Present work signified the biological importance of isolinderalactone in medicine, which can modulate several physiological functions in the human body. Isolinderalactone exhibits distinct anticancer profiles both in vitro and in vivo. Present review data signified the biological importance of isolinderalactone in medicine, as it exhibits significant potential on human ovarian cancer cells, glioblastoma, breast cancer, and non-small cell lung cancer. Furthermore, its biological effectiveness is mainly because of its anti-inflammatory activity, prolyl endopeptidase inhibitory potential, angiogenic activity, and anti-metastatic effect in medicine. The present study also summarized the biological significance of Lindera species and sesquiterpenoids in medicine reported for different pharmacological activities.

Conclusion: The present work highlighted the biological importance and therapeutic potential of isolinderalactone in medicine.