Insight into the Nutraceutical Potential of Garcinia Species

Shreyasi      Karmakar; Urvashee      Gogoi; Riya      Saikia; Aparoop      Das
Abstract

Background: A wide variety of Garcinia species have been used over decades, as traditional home remedies starting from their use in flavored food to the treatment of various ailments. The presence of the essential primary and secondary metabolite with curative properties in Garcinia has enhanced its value in the therapeutic world. These have captivated the use of Garcinia in expanding nutritional values and adding extra health benefits. Hereby, observing the potential of different Garcinia species for their use as nutraceuticals.
Objective: The present-day lifestyle and current health trends are the reasons why the public has accumulated a lot of interest in the nutraceutical food market. Traditionally the various remedies used from plants, fruits, and fruit extracts used in the cure of multiple ailments since antiquity have now made their way into pharmaceutical nutraceuticals. The fruits of Garcinia species have many culinary, nutritional, and pharmaceutical uses. Therefore, the paper aims to focus on the different Garcinia species having nutritional potential along with various therapeutic properties.
Methods: Studies of different Garcinia species are reviewed, with a focus on their nutritional and medicinal actions on ailments that are the reason for today's lifestyles and current health trends.
Results: Different varieties of Garcinia species are found to have various potential primary and secondary metabolites which have curative properties like anti-diabetic, anti-obesity, anti-microbial, anti-cancer, anti-inflammation, and anti-bacterial potential.
Conclusion: The natural occurrences of the plant product with nutraceutical value have boosted the quality of life. The Garcinia species containing the essential primary and secondary constituents are accountable for numerous biological activities. Many of the Garcinia species are marketed these days for a better and healthy life. Thus, Garcinia could be used as a nutraceutical to alleviate several disease conditions.
Keywords: Nutraceuticals, Garcinia species, health benefit, medicinal fruits, primary metabolites, secondary metabolites.
Graphical Abstract

[1]
Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. Role of nutraceuticals in human health. J Food Sci Technol  2012; 49(2): 173-83.
 [http://dx.doi.org/10.1007/s13197-011-0269-4] [PMID: 23572839]

[2]
El-Seedi HR, Salem MA, Khattab OM, et al. Dietary xanthones. In: Xiao J, Sarker S, Asakawa Y, Eds. Handbook of Dietary Phytochemicals. Singapore: Springer 2020.
 [http://dx.doi.org/10.1007/978-981-13-1745-3_11-1]

[3]
Kumari M, Jain S, Singh J. Nutraceutical–medicine of future. J Global Biosci  2015; 4(7): 2790-4.

[4]
Ansari SH, Chauhan B, Kalam N, Kumar G. Current concepts and prospects of herbal nutraceutical: A review. J Adv Pharm Technol Res  2013; 4(1): 4-8.
 [http://dx.doi.org/10.4103/2231-4040.107494] [PMID: 23662276]

[5]
Jha SK, Roy P, Chakrabarty S. Nutraceuticals with pharmaceutics: Its import ance and their applications. Intl J Drug Develop Res  2021; 13(S3): 002.

[6]
Helal NA, Eassa HA, Amer AM, Eltokhy MA, Edafiogho I, Nounou MI. Nutraceuticals’ novel formulations: The good, the bad, the unknown and patents involved. Recent Pat Drug Deliv Formul  2019; 13(2): 105-56.
 [http://dx.doi.org/10.2174/1872211313666190503112040] [PMID: 31577201]

[7]
Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med  2014; 5(12): 1487-99.
 [PMID: 25709784]

[8]
Gruère G, Giuliani A, Smale M. Marketing underutilized plant species for the benefit of the poor: A conceptual framework. Intl Food Policy Res Inst 2006.
 [http://dx.doi.org/10.2139/ssrn.916572]

[9]
Parthasarathy U, Nandakishore OP. Nutrient properties of important Garcinia fruits of India.  In: Diversity of Garcinia species in the Western Ghats: Phytochemical Perspective Thruvananthapuram.  Jawaharlal Nehru Tropical Botanic Garden and Research Institute 2016; pp. 170-8.

[10]
Fardet A. A shift toward a new holistic paradigm will help to preserve and better process grain products’ food structure for improving their health effects. Food Funct  2015; 6(2): 363-82.
 [http://dx.doi.org/10.1039/C4FO00477A] [PMID: 25407943]

[11]
Parthasarathy U, Nandakishore OP. Morphological characterisation of some important indian garcinia species. In: Dataset Papers in Science 2014.
 [http://dx.doi.org/10.1155/2014/823705]

[12]
Khapare LS, Kadam JH, Shirke GD. Garcinia a medicinally potential genus in Western Ghats. J Pharmacogn Phytochem  2020; 9(5): 2750-2.

[13]
Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: A phytochemical and pharmacological review. Phytother Res  2009; 23(8): 1047-65.
 [http://dx.doi.org/10.1002/ptr.2730] [PMID: 19172667]

[14]
Ramachandran HD, Fayaz P, Kusum R. Plant profile, phytochemistry and pharmacology of garcinia indica: A review. Int J Pharm Sci Rev Res  2014; 27(1): 361-6.

[15]
Che Hassan NKN, Taher M, Susanti D. Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review. Biomed Pharmacother  2018; 106: 1378-89.
 [http://dx.doi.org/10.1016/j.biopha.2018.07.087] [PMID: 30119210]

[16]
Aravind AA, Menon LN, Rameshkumar KB. Structural diversity of secondary metabolites in Garcinia species. In: Diversity of Garcinia species in the Western Ghats.  Phytochemical Perspective 2016; pp. 19-75.

[17]
Demenciano SC, Silva MCBL, Alexandrino CAF, et al. Antiproliferative activity and antioxidant potential of extracts of Garcinia gardneriana. Molecules  2020; 25(14): 3201.
 [http://dx.doi.org/10.3390/molecules25143201] [PMID: 32674257]

[18]
Majeed M, Majeed S, Nagabhushanam K, Gnanamani M, Mundkur L. Lesser investigated natural ingredients for the management of obesity. Nutrients  2021; 13(2): 510.
 [http://dx.doi.org/10.3390/nu13020510] [PMID: 33557185]

[19]
Yang R, Li P, Li N, et al. Xanthones from the pericarp of Garcinia mangostana. Molecules  2017; 22(5): 683.
 [http://dx.doi.org/10.3390/molecules22050683] [PMID: 28441346]

[20]
Ovalle-Magallanes B, Eugenio-Pérez D, Pedraza-Chaverri J. Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update. Food Chem Toxicol  2017; 109(Pt 1): 102-22.
 [http://dx.doi.org/10.1016/j.fct.2017.08.021] [PMID: 28842267]

[21]
Abate M, Pagano C, Masullo M, et al. Mangostanin, a xanthone derived from Garcinia mangostana fruit, exerts protective and reparative effects on oxidative damage in human keratinocytes. Pharmaceuticals  2022; 15(1): 84.
 [http://dx.doi.org/10.3390/ph15010084] [PMID: 35056141]

[22]
Brito LC, Marques AM, da Cunha CF, Figueiredo MR. Garcinia spp: Products and by-products with potential pharmacological application in cancer. Food Biosci  2022; 50: 102110.
 [http://dx.doi.org/10.1016/j.fbio.2022.102110]

[23]
Hazarika TK, Lalnunsangi C. Exploring genetic diversity of Garcinia lanceifolia Roxb. (Clusiaceae), a highly medicinal and endangered fruit of north-east India. Genet Resour Crop Evol  2019; 66(1): 61-9.
 [http://dx.doi.org/10.1007/s10722-018-0695-5]

[24]
Patil MM, Appaiah KA. Garcinia: Bioactive compounds and health benefits. J Funct Foods  2015; 1: 110-25.

[25]
Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KS. Nutraceutical-a bright scope and opportunity of Indian healthcare market. Pharma Innov  2013; 1(S11)

[26]
Sachdeva V, Roy A, Bharadvaja N. Current prospects of nutraceuticals: A review. Curr Pharm Biotechnol  2020; 21(10): 884-96.
 [http://dx.doi.org/10.2174/1389201021666200130113441] [PMID: 32000642]

[27]
Aati HY, Ismail A, Rateb ME. AboulMagd AM, Hassan HM, Hetta MH. Garcinia cambogia phenolics as potent anti-COVID-19 agents: Phytochemical profiling, biological activities, and molecular docking. Plants  2022; 11(19): 2521.
 [http://dx.doi.org/10.3390/plants11192521] [PMID: 36235385]

[28]
Parthsarathy U, Nandakishore OP. A study on nutrient and medicinal compositions of selected Indian Garcinia species. Curr Bioact Compd  2014; 10(1): 55-61.
 [http://dx.doi.org/10.2174/157340721001140725001152]

[29]
Parthasarathy U, Nandakishore OP, Kumar RS, Babu KN, Zachariah TJ, Parthasarathy VA. Chromatographic fingerprinting and estimation of organic acids in selected Garcinia species. Int J Innovative Horticulture  2012; 1: 68-73.

[30]
Sullivan C, Triscari J. Metabolic regulation as a control for lipid disorders. I. Influence of (-)-hydroxycitrate on experimentally induced obesity in the rodent. Am J Clin Nutr  1977; 30(5): 767-76.
 [http://dx.doi.org/10.1093/ajcn/30.5.767] [PMID: 324261]

[31]
Qiang F. Effect of malate-oligosaccharide solution on antioxidant capacity of endurance athletes. Open Biomed Eng J  2015; 9(1): 326-9.
 [http://dx.doi.org/10.2174/1874120701509010326] [PMID: 26998183]

[32]
Fiume MM, Heldreth BA, Bergfeld WF, et al. Safety assessment of citric acid, inorganic citrate salts, and alkyl citrate esters as used in cosmetics. Int J Toxicol  2014; 33(S2): 16S-46S.
 [http://dx.doi.org/10.1177/1091581814526891] [PMID: 24861367]

[33]
Espirito Santo BLS, Santana LF, Kato Junior WH, et al. Medicinal potential of Garcinia species and their compounds. Molecules  2020; 25(19): 4513.
 [http://dx.doi.org/10.3390/molecules25194513] [PMID: 33019745]

[34]
Remali J, Sahidin I, Aizat WM. Xanthone biosynthetic pathway in plants: A review. Front Plant Sci  2022; 13: 809497.
 [http://dx.doi.org/10.3389/fpls.2022.809497] [PMID: 35463410]

[35]
Rameshkumar KB, Biotech S. plant kingdom represents an extraordinary reservoir of molecules that can 

[36]
Peres V, Nagem TJ, de Oliveira FF. Tetraoxygenated naturally occurring xanthones. Phytochemistry  2000; 55(7): 683-710.
 [http://dx.doi.org/10.1016/S0031-9422(00)00303-4] [PMID: 11190384]

[37]
Gales L, Damas AM. Xanthones--a structural perspective. Curr Med Chem  2005; 12(21): 2499-515.
 [http://dx.doi.org/10.2174/092986705774370727] [PMID: 16250874]

[38]
Pinto MMM, Sousa ME, Nascimento MSJ. Xanthone derivatives: New insights in biological activities. Curr Med Chem  2005; 12(21): 2517-38.
 [http://dx.doi.org/10.2174/092986705774370691] [PMID: 16250875]

[39]
Vieira LMM, Kijjoa A. Naturally-occurring xanthones: Recent developments. Curr Med Chem  2005; 12(21): 2413-46.
 [http://dx.doi.org/10.2174/092986705774370682] [PMID: 16250871]

[40]
El-Seedi H, El-Ghorab D, El-Barbary M, et al. Naturally occurring xanthones; latest investigations: Isolation, structure elucidation and chemosystematic significance. Curr Med Chem  2009; 16(20): 2581-626.
 [http://dx.doi.org/10.2174/092986709788682056] [PMID: 19601799]

[41]
Fotie J, Bohle DS. Pharmacological and biological activities of xanthones. Agents Med Chem  2006; 5(1): 15-31.
 [http://dx.doi.org/10.2174/187152106774755563]

[42]
Harms WB. Comparison of the antimicrobial activity of isoprenoid substituted aromatic secondary metabolites to some similar nonsubstituted derivatives. Mississippi State University 1993.

[43]
Jiang DJ, Dai Z, Li YJ. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovasc Drug Rev  2004; 22(2): 91-102.
 [http://dx.doi.org/10.1111/j.1527-3466.2004.tb00133.x] [PMID: 15179447]

[44]
Potterat O. Antioxidants and free radical scavengers of natural origin. Curr Org Chem  1997; 1(4): 415-40.
 [http://dx.doi.org/10.2174/1385272801666220126162734]

[45]
Liu Y, Zou L, Ma L, Chen WH, Wang B, Xu ZL. Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors. Bioorg Med Chem  2006; 14(16): 5683-90.
 [http://dx.doi.org/10.1016/j.bmc.2006.04.014] [PMID: 16651002]

[46]
Shagufta Ahmad I. Recent insight into the biological activities of synthetic xanthone derivatives. Eur J Med Chem  2016; 116: 267-80.
 [http://dx.doi.org/10.1016/j.ejmech.2016.03.058] [PMID: 27111599]

[47]
Sameem B. Synthesis of fluorinated benzophenones for biological activity probing (Doctoral dissertation, Macquarie University). 

[48]
Wu SB, Long C, Kennelly EJ. Structural diversity and bioactivities of natural benzophenones. Nat Prod Rep  2014; 31(9): 1158-74.
 [http://dx.doi.org/10.1039/C4NP00027G] [PMID: 24972079]

[49]
Rozmer Z, Perjési P. Naturally occurring chalcones and their biological activities. Phytochem Rev  2016; 15(1): 87-120.
 [http://dx.doi.org/10.1007/s11101-014-9387-8]

[50]
Mohamed GA, Ibrahim SRM. New benzophenones and a dihydroflavanonol from Garcinia mangostana pericarps and their antioxidant and cytotoxic activities. Phytochem Lett  2020; 39: 43-8.
 [http://dx.doi.org/10.1016/j.phytol.2020.07.007]

[51]
Liu B, Chen N, Chen Y, Shen J, Xu Y, Ji Y. A new benzophenone with biological activities purified from Aspergillus fumigatus SWZ01. Nat Prod Res  2021; 35(24): 5710-9.
 [http://dx.doi.org/10.1080/14786419.2020.1825427] [PMID: 32998585]

[52]
Pasaribu YP, Fadlan A, Fatmawati S, Ersam T. Biological activity evaluation and in silico studies of polyprenylated benzophenones from Garcinia celebica. Biomedicines  2021; 9(11): 1654.
 [http://dx.doi.org/10.3390/biomedicines9111654] [PMID: 34829884]

[53]
He X, Yang F, Huang X. Proceedings of chemistry, pharmacology, pharmacokinetics and synthesis of biflavonoids. Molecules  2021; 26(19): 6088.
 [http://dx.doi.org/10.3390/molecules26196088] [PMID: 34641631]

[54]
Tabares-Guevara JH, Lara-Guzmán OJ, Londoño-Londoño JA, et al. Natural biflavonoids modulate macrophage–oxidized LDL interaction in vitro and promote atheroprotection in vivo. Front Immunol  2017; 8: 923.
 [http://dx.doi.org/10.3389/fimmu.2017.00923] [PMID: 28824646]

[55]
Thapa A, Chi EY. Biflavonoids as potential small molecule therapeutics for Alzheimer’s disease. Adv Exp Med Biol  2015; 863: 55-77.
 [http://dx.doi.org/10.1007/978-3-319-18365-7_3]

[56]
Kim HP, Park H, Son KH, Chang HW, Kang SS. Biochemical pharmacology of biflavonoids: Implications for anti-inflammatory action. Arch Pharm Res  2008; 31(3): 265-73.
 [http://dx.doi.org/10.1007/s12272-001-1151-3] [PMID: 18409037]

[57]
Kshirsagar P, Gaikwad S, Pai S, Desai N, Bapat V. Evaluation of antioxidant capacity and phytochemical investigation of eleven Clusiaceae members from Western Ghats, India. Biocatal Agric Biotechnol  2022; 44: 102476.
 [http://dx.doi.org/10.1016/j.bcab.2022.102476]

[58]
Gámez MC, Pérez CR, Salas PG, Carretero AS. Polyphenols from the mediterranean diet: Structure, analysis and health evidence.In: Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits.  Hauppauge, NY: Nova Science Publishers, Incorporated 2014; p. 141.

[59]
Kaikabo AA. Isolation and characterization of antibacterial compounds from a Garcinia livingstonei (Clusiaceae) leaf extract (Doctoral dissertation, University of Pretoria) 2010.

[60]
Gontijo VS, Dos Santos MH, Viegas C Jr. Biological and chemical aspects of natural biflavonoids from plants: A brief review. Mini Rev Med Chem  2017; 17(10): 834-62.
 [PMID: 27823559]

[61]
Kuswandi A, Tarawaan VM, Goenawan H, Muchtaridi M, Lesmana R. Potential roles of Garcinia family as antimetabolic syndrome. J Adv Pharm Technol Res  2022; 13(1): 1-6.
 [PMID: 35223433]

[62]
Chuah LO, Ho WY, Beh BK, Yeap SK. Updates on antiobesity effect of garcinia origin (−)-HCA. Evid Based Complement Alternat Med  2013; 2013: 1-17.
 [http://dx.doi.org/10.1155/2013/751658] [PMID: 23990846]

[63]
Gogoi AN, Gogoi NA, Neog BI. Dubious anti-obesity agent hca from Garcinia: A systematic review. Int J Pharm Pharm Sci  2015; 7(7)

[64]
Tomar M, Rao RP, Dorairaj P, et al. A clinical and computational study on anti-obesity effects of hydroxycitric acid. RSC Advances  2019; 9(32): 18578-88.
 [http://dx.doi.org/10.1039/C9RA01345H] [PMID: 35547650]

[65]
Liu QY, Wang YT, Lin LG. New insights into the anti-obesity activity of xanthones from Garcinia mangostana. Food Funct  2015; 6(2): 383-93.
 [http://dx.doi.org/10.1039/C4FO00758A] [PMID: 25520256]

[66]
Angami T, Wangchu L, Debnath P, et al. Garcinia L.: A gold mine of future therapeutics. Genet Resour Crop Evol  2021; 68(1): 11-24.
 [http://dx.doi.org/10.1007/s10722-020-01057-5]

[67]
Zarena AS, Sankar KU. A study of antioxidant properties from Garcinia mangostana L. pericarp extract. Acta Sci Pol Technol Aliment  2009; 8(1): 23-34.

[68]
Kumar S, Yadav A, Yadav M, Yadav JP. Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f. BMC Res Notes  2017; 10(1): 60.
 [http://dx.doi.org/10.1186/s13104-017-2385-3] [PMID: 28118858]

[69]
Sylvie DD, Anatole PC, Cabral BP, Veronique PB. Comparison of in vitro antioxidant properties of extracts from three plants used for medical purpose in Cameroon: Acalypha racemosa, Garcinia lucida and Hymenocardia lyrata. Asian Pac J Trop Biomed  2014; 4: S625-32.
 [http://dx.doi.org/10.12980/APJTB.4.201414B168]

[70]
John OD, Brown L, Panchal SK. Garcinia fruits: Their potential to combat metabolic syndrome. In: Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery Ullah M, Ahmad A.  Wiley 2019; pp. 39-80.

[71]
Tjahjani S, Widowati W, Khiong K, Suhendra A, Tjokropranoto R. Antioxidant properties of Garcinia mangostana L (mangosteen) rind. Procedia Chem  2014; 13: 198-203.
 [http://dx.doi.org/10.1016/j.proche.2014.12.027]

[72]
Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol  2008; 46(10): 3227-39.
 [http://dx.doi.org/10.1016/j.fct.2008.07.024] [PMID: 18725264]

[73]
Adaramoye OA, Farombi EO, Adeyemi EO, Emerole GO. Comparative study on the antioxidant properties of flavonoids of Garcinia kola seeds. Pak J Med Sci  2005; 21(3): 331.

[74]
Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod  2008; 71(7): 1161-6.
 [http://dx.doi.org/10.1021/np8000255] [PMID: 18558747]

[75]
Jagtap P, Bhise K, Prakya V. A phytopharmacological review on Garcinia indica. Int J Herb Med  2015; 3(4): 2-7.

[76]
Payamalle S, Joseph KS, Bijjaragi SC, Aware C, Jadhav JP, Murthy HN. Anti-diabetic activity of Garcinia xanthochymus seeds. Comp Clin Pathol  2017; 26(2): 437-46.
 [http://dx.doi.org/10.1007/s00580-016-2396-9]

[77]
Banerjee M, Khursheed R, Yadav AK, et al. A systematic review on synthetic drugs and phytopharmaceuticals used to manage diabetes. Curr Diabetes Rev  2020; 16(4): 340-56.
 [http://dx.doi.org/10.2174/1573399815666190822165141] [PMID: 31438829]

[78]
Semwal RB, Semwal DK, Vermaak I, Viljoen A. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia  2015; 102: 134-48.
 [http://dx.doi.org/10.1016/j.fitote.2015.02.012] [PMID: 25732350]

[79]
Adaramoye OA. Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats. Afr Health Sci  2012; 12(4): 498-506.
 [PMID: 23515095]

[80]
Li Y, Chen Y, Xiao C, Chen D, Xiao Y, Mei Z. Rapid screening and identification of α-amylase inhibitors from Garcinia xanthochymus using enzyme-immobilized magnetic nanoparticles coupled with HPLC and MS. J Chromatogr B Analyt Technol Biomed Life Sci  2014; 960: 166-73.
 [http://dx.doi.org/10.1016/j.jchromb.2014.04.041] [PMID: 24814002]

[81]
Karim N, Rahman A, Chanudom L, Thongsom M, Tangpong J. Mangosteen vinegar rind from Garcinia mangostana prevents high‐fat diet and streptozotocin‐induced type II diabetes nephropathy and apoptosis. J Food Sci  2019; 84(5): 1208-15.
 [http://dx.doi.org/10.1111/1750-3841.14511] [PMID: 31012974]

[82]
Ali MY, Paul S, Tanvir EM, et al. Antihyperglycemic, antidiabetic, and antioxidant effects of Garcinia pedunculata in rats. Evid Based Complement Alternat Med  2017; 2017: 1-15.
 [http://dx.doi.org/10.1155/2017/2979760] [PMID: 29234381]

[83]
Susanti D, Amiroudine MZAM, Rezali MF, Taher M. Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes. Nat Prod Res  2013; 27(4-5): 417-24.
 [http://dx.doi.org/10.1080/14786419.2012.725399] [PMID: 22988818]

[84]
Chen TH, Tsai MJ, Fu YS, Weng CF. The exploration of natural compounds for anti-diabetes from distinctive species Garcinia linii with comprehensive review of the Garcinia family. Biomolecules  2019; 9(11): 641.
 [http://dx.doi.org/10.3390/biom9110641] [PMID: 31652794]

[85]
William-Olsson T. α-glucosidase inhibition in obesity. Acta Med Scand Suppl  1985; 706(S706): 1-39.
 [PMID: 3914827]

[86]
Trinh BTD, Quach TTT, Bui DN, Staerk D, Nguyen LHD, Jäger AK. Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity. Fitoterapia  2017; 118: 126-31.
 [http://dx.doi.org/10.1016/j.fitote.2017.03.003] [PMID: 28322990]

[87]
Kurniawan YS, Priyangga KTA, Jumina , et al. An update on the anticancer activity of xanthone derivatives: A review. Pharmaceuticals  2021; 14(11): 1144.
 [http://dx.doi.org/10.3390/ph14111144] [PMID: 34832926]

[88]
Choudhury B, Kandimalla R, Bharali R, et al. Anticancer activity of Garcinia morella on T-cell murine lymphoma via apoptotic induction. Front Pharmacol  2016; 7: 3.
 [http://dx.doi.org/10.3389/fphar.2016.00003] [PMID: 26858645]

[89]
Hemshekhar M, Sunitha K, Santhosh MS, et al. An overview on genus garcinia: Phytochemical and therapeutical aspects. Phytochem Rev  2011; 10(3): 325-51.
 [http://dx.doi.org/10.1007/s11101-011-9207-3]

[90]
Saadat N, Gupta SV. Potential role of garcinol as an anticancer agent. J Oncol  2012; 2012: 1-8.
 [http://dx.doi.org/10.1155/2012/647206] [PMID: 22745638]

[91]
Khan T, Ali M, Khan A, et al. Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules  2019; 10(1): 47.
 [http://dx.doi.org/10.3390/biom10010047] [PMID: 31892257]

[92]
Akao Y, Nakagawa Y, Nozawa Y, Nozawa Y. Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci  2008; 9(3): 355-70.
 [http://dx.doi.org/10.3390/ijms9030355] [PMID: 19325754]

[93]
Ong YS, Murugaiyah V, Goh BH, Khaw KY. Bioactive xanthones from Garcinia mangostana. In: Swamy M, Ed. Plant-derived Bioactives. Singapore: Springer 2020.
 [http://dx.doi.org/10.1007/978-981-15-2361-8_13]

[94]
Kopytko P, Piotrowska K, Janisiak J, Tarnowski M. Garcinol—a natural histone acetyltransferase inhibitor and new anti-cancer epigenetic drug. Int J Mol Sci  2021; 22(6): 2828.
 [http://dx.doi.org/10.3390/ijms22062828] [PMID: 33799504]

[95]
Lim SH, Lee HS, Lee CH, Choi CI. Pharmacological activity of Garcinia indica (Kokum): An updated review. Pharmaceuticals  2021; 14(12): 1338.
 [http://dx.doi.org/10.3390/ph14121338] [PMID: 34959738]

[96]
Naves VML, dos Santos MH, Ribeiro IS, et al. Antimicrobial and antioxidant activity of Garcinia brasiliensis extracts. S Afr J Bot  2019; 124: 244-50.
 [http://dx.doi.org/10.1016/j.sajb.2019.05.021]

[97]
Sutar RL, Mane SP, Ghosh JS. Antimicrobial activity of extracts of dried kokum (Garcinia indica C). Int Food Res J  2012; 9(3): 1207-10.

[98]
Hosakatte N, Dandin V, Dalawai D, Park SY, Paek K. Bioactive compounds from garcinia fruits of high economic value for food and health. Phytochem Spr Nature  2018; 1: 1-28.

[99]
Lakshmi C, Kumar KA, Dennis TJ, Kumar TS. Antibacterial activity of polyphenols of garcinia indica. Indian J Pharm Sci  2011; 73(4): 470-3.
 [PMID: 22707838]

[100]
Jacob KM, Ali MA, Vishnu H, Shylaja G, Mythili S, Sathiavelu A. Evaluation of antibacterial and antioxidant activity of Garcinia gummigutta. Int J Drug Dev Res  2015; 7: 57-9.

[101]
Lee KA, Moon SH, Lee JY, Kim KT, Park YS, Paik HD. Antibacterial activity of a novel flavonoid, 7-O-butyl naringenin, against methicillin-resistant Staphylococcus aureus (MRSA). Food Sci Biotechnol  2013; 22(6): 1725-8.
 [http://dx.doi.org/10.1007/s10068-013-0272-9]

[102]
Wahyuni FS, Israf Ali DA, Lajis NH. D D. Anti-inflammatory activity of isolated compounds from the stem bark of Garcinia cowa Roxb. Pharmacogn J  2016; 9(1): 55-7.
 [http://dx.doi.org/10.5530/pj.2017.1.10]

[103]
Negi PS, Jayaprakasha GK, Jena BS. Antibacterial activity of the extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata against food borne pathogens and spoilage bacteria. Lebensm Wiss Technol  2008; 41(10): 1857-61.
 [http://dx.doi.org/10.1016/j.lwt.2008.02.009]

[104]
Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev  2001; 53(1): 135-59.
 [PMID: 11171943]

[105]
Chen LG, Yang LL, Wang CC. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol  2008; 46(2): 688-93.
 [http://dx.doi.org/10.1016/j.fct.2007.09.096] [PMID: 18029076]

[106]
Santa-Cecília FV, Vilela FC, da Rocha CQ, et al. Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis. J Ethnopharmacol  2011; 133(2): 467-73.
 [http://dx.doi.org/10.1016/j.jep.2010.09.036] [PMID: 20955772]

[107]
Hamidon H, Taher M, Jaffri JM, et al. Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines. Makara J Health Res  2016; 20(1): 3.
 [http://dx.doi.org/10.7454/msk.v20i1.5599]

[108]
Suzuki H, Nishizawa T, Hibi T. Helicobacter pylori eradication therapy. Future Microbiol  2010; 5(4): 639-48.
 [http://dx.doi.org/10.2217/fmb.10.25] [PMID: 20353303]

[109]
Joseph KS, Dandin VS, Murthy HN. Chemistry and biological activity of Garcinia xanthochymus: A review. J Biol Act Prod Nat  2016; 6(3): 173-94.
 [http://dx.doi.org/10.1080/22311866.2016.1199285]

[110]
Mahendran P, Vanisree AJ, Shyamala DCS. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res  2002; 16(1): 80-3.
 [http://dx.doi.org/10.1002/ptr.946] [PMID: 11807973]

[111]
Yamaguchi F, Saito M, Ariga T, Yoshimura Y, Nakazawa H. Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind. J Agric Food Chem  2000; 48(6): 2320-5.
 [http://dx.doi.org/10.1021/jf990908c] [PMID: 10888544]

[112]
Mariano LNB, da Silva LM, de Souza P, et al. Gastroprotective xanthones isolated from Garcinia achachairu: Study on mucosal defensive factors and H+, K+-ATPase activity. Chem Biol Interact  2016; 258: 30-9.
 [http://dx.doi.org/10.1016/j.cbi.2016.08.009] [PMID: 27545833]

[113]
Dodu SRA. Emergence of cardiovascular diseases in developing countries. Cardiology  1988; 75(1): 56-64.
 [http://dx.doi.org/10.1159/000174349] [PMID: 3342425]

[114]
Chauhan S, Aeri BT. Prevalence of cardiovascular disease in India and it is economic impact-A review. Int J Sci Res Publ  2013; 3(10): 1-5.

[115]
Erdmann K, Cheung BWY, Schröder H. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem  2008; 19(10): 643-54.
 [http://dx.doi.org/10.1016/j.jnutbio.2007.11.010] [PMID: 18495464]

[116]
Parasharami V, Kunder G, Desai N. Recent pharmacological advances of endangered species of South India: Garcinia indica Choisy. J Sci Res Rep  2015; 8(5): 1-10.
 [http://dx.doi.org/10.9734/JSRR/2015/14550]

[117]
Korać R, Khambholja K. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev  2011; 5(10): 164-73.
 [http://dx.doi.org/10.4103/0973-7847.91114] [PMID: 22279374]

[118]
Warriar P, Barve K, Prabhakar B. Anti-arthritic effect of garcinol enriched fraction against adjuvant induced arthritis. Recent Pat Inflamm Allergy Drug Discov  2019; 13(1): 49-56.
 [http://dx.doi.org/10.2174/1872213X12666181120091528] [PMID: 30457056]

[119]
Nurrahma BA, Yeh TH, Hsieh RH, et al. Mangosteen pericarp extract supplementation boosts antioxidant status via rebuilding gut microbiota to attenuate motor deficit in 6-OHDA-induced Parkinson’s Disease. Antioxidants  2022; 11(12): 2396.
 [http://dx.doi.org/10.3390/antiox11122396] [PMID: 36552604]
Cite As
Current Traditional Medicine

Insight into the Nutraceutical Potential of Garcinia Species

Abstract

Graphical Abstract
