Pharmacological Activities of the Roots of Stemona tuberosa Medicinal Plant: An Overview

Article ID: e160823219802 Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Since childhood, plants and plant products have been used extensively as medicine. The majority of rural residents still rely on natural resources and the old-fashioned medical system for their daily needs. The biological richness of Arunachal Pradesh is renowned, as is its rich cultural diversity. The native population uses a number of aromatic and medicinal plant species to cure a wide range of illnesses. The current review deals with the biological activity of Stemona tuberosa, a possible medicinal plant species of Arunachal Pradesh. Extract from tuberous roots has numerous properties, including anti-bacterial, anti-inflammatory, anti-tobacco mosaic virus, antitussive, wound healing, and anti-herpes. The roots' powder is employed as a preservation and insect deterrent. Alkaloids, sugars and glycosides, phenolic compounds, trace amounts of proteins, saponin, flavonoids, and gum mucilage, were all found during the phytochemical analysis, which shows that the species has a significant potential for therapeutic use. As a result, it is possible to think of the examined species as a potential source of beneficial medications.

Graphical Abstract

[1]
Bharali P, Paul A, Dutta P, Gogoi G, Das AK, Baruah AM. Ethnopharmacognosy of Stemona tuberosa lour., a potential medicinal plant species of arunachal Pradesh, India. World J Pharm Pharm Sci 2014; 3: 1072-81.
[2]
Schinnerl J, Brem B, But PPH, Vajrodaya S, Hofer O, Greger H. Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species. Phytochemistry 2007; 68(10): 1417-27.
[http://dx.doi.org/10.1016/j.phytochem.2007.03.002] [PMID: 17449078]
[3]
Brem B, Seger C, Pacher T, Hofer O, Vajrodaya S, Greger H. Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticides. J Agric Food Chem 2002; 50(22): 6383-8.
[http://dx.doi.org/10.1021/jf0205615] [PMID: 12381121]
[4]
Pilli RA, Rosso GB, De Oliveira MDCF. The Stemona Alkaloids. In: The Alkaloids. Chemistry and Biology 2005; pp. 77-173.
[5]
Chen G, Sun W, Wang X, Kongkiatpaiboon S, Cai X. Conserving threatened widespread species: A case study using a traditional medicinal plant in Asia. Biodivers Conserv 2019; 28(1): 213-27.
[http://dx.doi.org/10.1007/s10531-018-1648-1]
[6]
Hu ZX, Tang HY, Guo J, Aisa HA, Zhang Y, Hao XJ. Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities. Tetrahedron 2019; 75(12): 1711-6.
[http://dx.doi.org/10.1016/j.tet.2018.11.064]
[7]
Pudjiastuti P, Pyne SG. Sugiyanto, Lie W. Isolation of tuberospironine A, a novel croomine derivative from Stemona tuberosa Lour. Phytochem Lett 2012; 5(2): 358-60.
[http://dx.doi.org/10.1016/j.phytol.2012.03.001]
[8]
Yue Y, Deng AJ, Xu DS, Qin HL. Two new stemona alkaloids from Stemona tuberosa Lour. J Asian Nat Prod Res 2013; 15(2): 145-50.
[http://dx.doi.org/10.1080/10286020.2012.757595] [PMID: 23323763]
[9]
Zhang RR, Tian HY, Wu Y, et al. Isolation and chemotaxonomic significance of stenine- and stemoninine-type alkaloids from the roots of Stemona tuberosa. Chin Chem Lett 2014; 25(9): 1252-5.
[http://dx.doi.org/10.1016/j.cclet.2014.03.051]
[10]
Xu YT, Shaw PC, Jiang RW, Hon PM, Chan YM, But PPH. Antitussive and central respiratory depressant effects of Stemona tuberosa. J Ethnopharmacol 2010; 128(3): 679-84.
[http://dx.doi.org/10.1016/j.jep.2010.02.018] [PMID: 20219659]
[11]
Greger H. Structural relationships, distribution and biological activities of stemona alkaloids. Planta Med 2006; 72(2): 99-113.
[http://dx.doi.org/10.1055/s-2005-916258] [PMID: 16491444]
[12]
Alevcan K, Erteki̇n AS, Gündüzer E. Molecular phylogenetic analyses of vicia L. (Fabaceae) taxa growing in the southeastern anatolia region based on chloroplast trnl sequences. Int J Nat Life Sci 2021; 5: 11-22.
[13]
Hitotsuyanagi Y, Shigemori G, Fukaya H, et al. Stemona-amines C–E, new alkaloids from Stemona tuberosa. Tetrahedron Lett 2013; 54(51): 6995-8.
[http://dx.doi.org/10.1016/j.tetlet.2013.10.014]
[14]
Jiang JM, Shi ZH, Yang XW, et al. Structural revision of the Stemona alkaloids tuberostemonine O, dehydrocroomines A and B, and dehydrocroomine. J Nat Prod 2022; 85(8): 2110-5.
[http://dx.doi.org/10.1021/acs.jnatprod.2c00332] [PMID: 35969376]
[15]
Zhao W, Qin G, Ye Y, Xu R, Le X. Bibenzyls from Stemona tuberosa. Phytochemistry 1995; 38(3): 711-3.
[http://dx.doi.org/10.1016/0031-9422(94)00655-D] [PMID: 7766165]
[16]
Stephen GP, Ung AT, Jatisatienr A, Pitchaya M. The pyrido[1,2-a]azepine stemona alkaloids. Maejo Int J Sci 2007; 01: 157-65.
[17]
Li HM, He TT, Zhang M, et al. Stilbenoids from the roots of Stemona tuberosa. Nat Prod Res 2022; 36(3): 695-700.
[http://dx.doi.org/10.1080/14786419.2020.1798662] [PMID: 32713205]
[18]
Cai XH, Luo XD. Alkaloids from Stemona mairei. Planta Med 2007; 73(2): 170-3.
[http://dx.doi.org/10.1055/s-2006-957064] [PMID: 17415878]
[19]
Lin LG, Zhong QX, Cheng TY, et al. Stemoninines from the roots of Stemona tuberosa. J Nat Prod 2006; 69(7): 1051-4.
[http://dx.doi.org/10.1021/np0505317] [PMID: 16872143]
[20]
Sastraruji T, Jatisatienr A, Pyne SG, Ung AT, Lie W, Williams MC. Phytochemical studies on stemona plants: Isolation of stemofoline alkaloids. J Nat Prod 2005; 68(12): 1763-7.
[http://dx.doi.org/10.1021/np050361y] [PMID: 16378370]
[21]
Singh B, Borthakur SK, Phukan SJP, Sinha BK. Assessing ethnobotanical values and threat status of wild asparagus (Stemona tuberosa Lour.): A case study in Eastern Himalaya, India. Int J Conserv Sci 2012; 3: 319-24.
[22]
Pyne SG, Jatisatienr A, Mungkornasawakul P, et al. Phytochemical, synthetic and biological studies on Stemona and stichoneuron plants and alkaloids: A personal perspective. Nat Prod Commun 2017; 12(8): 1934578X1701200.
[http://dx.doi.org/10.1177/1934578X1701200848]
[23]
Chen G, Brecker L, Felsinger S, Cai XH, Kongkiatpaiboon S, Schinnerl J. Morphological and chemical variation of Stemona tuberosa from southern China - Evidence for heterogeneity of this medicinal plant species. Plant Biol 2017; 19(5): 835-42.
[http://dx.doi.org/10.1111/plb.12587] [PMID: 28580601]
[24]
Liao PH, Li DL, Tong HY. The complete chloroplast genome of Stemona tuberosa Lour (Stemonaceae). Mitochondrial DNA B Resour 2021; 6(4): 1317-8.
[http://dx.doi.org/10.1080/23802359.2021.1907806] [PMID: 33898747]
[25]
Hu J-P, Yang D-H, Lin W-H, Cai S-Q. Alkaloids from the roots of Stemona tuberosa. Helv Chim Acta 2009; 92(10): 2125-33.
[http://dx.doi.org/10.1002/hlca.200900124]
[26]
Schinnerl J, Kaltenegger E, Pacher T, Vajrodaya S, Hofer O, Greger H. New pyrrolo[1,2-a]azepine type alkaloids from stemona and stichoneuron (Stemonaceae). Monatsh Chem 2005; 136: 1671-80.
[27]
Olivier WJ, Henneveld JS, Smith JA, Hawkins BC, Bissember AC. Strategies for the synthesis of Stemona alkaloids: an update. Nat Prod Rep 2022; 39(12): 2308-35.
[http://dx.doi.org/10.1039/D2NP00058J] [PMID: 36218078]
[28]
Chung HS, Hon PM, Lin G, But PPH, Dong H. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med 2003; 69(10): 914-20.
[http://dx.doi.org/10.1055/s-2003-45100] [PMID: 14648394]
[29]
Zhou X, Ho Henry Leung P, Li N, et al. Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa. Planta Med 2009; 75(6): 575-80.
[http://dx.doi.org/10.1055/s-0029-1185363] [PMID: 19214944]
[30]
Lin LG, Li KM, Tang CP, et al. Antitussive stemoninine alkaloids from the roots of Stemona tuberosa. J Nat Prod 2008; 71(6): 1107-10.
[http://dx.doi.org/10.1021/np070651+] [PMID: 18452334]
[31]
Lin LG, Pak-Ho Leung H, Zhu JY, et al. Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity. Tetrahedron 2008; 64(44): 10155-61.
[http://dx.doi.org/10.1016/j.tet.2008.08.046]
[32]
Jiang RW, Hon PM, Xu YT, et al. Isolation and chemotaxonomic significance of tuberostemospironine-type alkaloids from Stemona tuberosa. Phytochemistry 2006; 67(1): 52-7.
[http://dx.doi.org/10.1016/j.phytochem.2005.10.004] [PMID: 16300811]
[33]
Shi ZH, Zhou ZB, Qin WN, et al. New Stemona alkaloids from the roots of Stemona tuberosa and structural revision of stemonatuberone B. Tetrahedron Lett 2020; 61(22)151925
[http://dx.doi.org/10.1016/j.tetlet.2020.151925]
[34]
Gao Y, Wang J, Zhang CF, Xu XH, Zhang M, Kong LY. Seven new alkaloids from the roots of Stemona tuberosa. Tetrahedron 2014; 70(4): 967-74.
[http://dx.doi.org/10.1016/j.tet.2013.12.003]
[35]
Lee KY, Sung SH, Kim YC. Neuroprotective bibenzyl glycosides of Stemona tuberosa roots. J Nat Prod 2006; 69(4): 679-81.
[http://dx.doi.org/10.1021/np0504154] [PMID: 16643052]
[36]
Jung KH, Kil YS, Jung J, et al. Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice. Phytomedicine 2016; 23(1): 79-86.
[http://dx.doi.org/10.1016/j.phymed.2015.11.015] [PMID: 26902410]
[37]
Kil YS, Park J, Han AR, Woo H, Seo EK. A new 9,10-dihydrophenanthrene and cell proliferative 3,4-δ-dehydrotocopherols from Stemona tuberosa. Molecules 2015; 20(4): 5965-74.
[http://dx.doi.org/10.3390/molecules20045965] [PMID: 25854758]
[38]
Lin LG, Yang XZ, Tang CP, Ke CQ, Zhang JB, Ye Y. Antibacterial stilbenoids from the roots of Stemona tuberosa. Phytochemistry 2008; 69(2): 457-63.
[http://dx.doi.org/10.1016/j.phytochem.2007.07.012] [PMID: 17826806]
[39]
Chaliewchalad P, Thongwai N, Tragoolpua Y. Inhibitory effect of rhinacanthus nasutus (Linn.) Kurz. and Stemona tuberosa (Lour.) extracts on herpes simplex virus infection. J Med Plants Res 2013; 7: 76-84.
[40]
Lee H, Jung KH, Park S, et al. Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model. BMC Complement Altern Med 2014; 14(1): 513.
[http://dx.doi.org/10.1186/1472-6882-14-513] [PMID: 25528348]
[41]
Phuong NTM, Cuong TT, Quang DN. Anti-inflammatory activity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac J Trop Med 2014; 7: S327-31.
[http://dx.doi.org/10.1016/S1995-7645(14)60254-6] [PMID: 25312145]
[42]
Fang L, Song XQ, He TT, et al. Two new polyketides from the roots of Stemona tuberosa. Fitoterapia 2018; 129: 150-3.
[http://dx.doi.org/10.1016/j.fitote.2018.06.025] [PMID: 29964177]