Abstract
Background: Dental caries is one of the Periodontal diseases that has been recognized
as a major public health problem for decades throughout the world. It occurs in all groups, ethnicities,
races, and genders at all socioeconomic levels. Natural remedies are more acceptable in the belief
that they are safer with fewer side effects than synthetic ones. Clove and coriander oil are established
herbal drugs for periodontal diseases.
Objective: This research work was intended to formulate a dental gel containing clove and Coriander
as the major constituents and evaluate it for dental caries treatment. Both of the herbal oils have
a vast range of antimicrobial activity against a great number of periodontal pathogens; therefore,
they are used for periodontitis treatment.
Methods: The combination gel was prepared using carbopol 934 as a gelling agent, clove oil and
coriander oil as therapeutic constituents, polyethylene glycol as a co-solvent, methyl paraben and
propyl paraben as a preservative and a required quantity of distilled water as vehicle.
Results: The gel was analyzed for various properties like antimicrobial activity, pH, spreadability,
extrudability, drug content etc., and it was shown that the combination gel is a satisfactory dosage
form that is used in periodontitis treatment. The combination gel revealed the ZI (zone of inhibition)
of about 22.05±0.04 mm.
Conclusion: The present study concluded that the combination gel preparations of clove oil and coriander
oil reported satisfactory physicochemical properties along with good drug content compared
to the single gel preparation.
Keywords:
Clove oil, coriander oil, carbopol 934, periodontitis, antimicrobial activity, zone of inhibition.
Graphical Abstract
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