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Current Drug Therapy

Author(s): Sunil Kumar Kadiri, Deepak S. Khobragade* and Samaresh Pal Roy

DOI: 10.2174/1574885518666230804113303

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Preclinical Appraisal of the Aphrodisiac Effects of Emblica officinalis Seed Extract on Stress-induced Sexual Behavior in Albino Rats

Page: [594 - 603] Pages: 10

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Abstract

Background: The king of herbs, Emblica officinalis, is one of the most important herbs in Ayurveda. It contains significant amounts of Vitamin C and has been reported to have antioxidant, anticancer, antiretroviral, antidepressant, antiulcerogenic, wound healing, and many other medicinal properties.

Objective: The current study is designed to investigate the aphrodisiac effects of E. officinalis seed extract on albino Wistar rats as well as its effects on stress-related sexual behaviour.

Materials and Methods: The aphrodisiac effect of E. officinalis was evaluated by mating the pretreated male rats with female rats. For 30 days, test group rats (n=6) were given methanolic extracts (95%) from E. officinalis seeds (500 and 1000 mg/kg). Control rats received saline. Standard group rats received testosterone (0.5 mg/ kg, i.m). The sexual behavior study tracked Mount Latency (ML), Intromission Latency (IL), Mounting Frequency (MF), Intromission Frequency (IF), sniffing, and licking on days 0 through 30. After 30 days, rats were sacrificed, and the anabolic effect was assessed using body weight, reproductive organ weight, sperm concentration, and histopathology of the testes. The stress was induced by immobilization stress in the stress-affected alteration in the sexual behavior model, and the above procedure was repeated for evaluation.

Results: The 95% methanolic extract (1000 mg/kg) of E. officinalis significantly reduced ML and IL while significantly increasing MF, IF, sniffing, licking, body weight, reproductive organ weight, and sperm concentration. Methanolic extract of E. officinalis increased sexual activities in the stress-free group and restored the stress-affected group's altered sexual behaviour.

Conclusion: The current study's findings indicate that 95% methanolic extract of E. officinalis has dose-dependent aphrodisiac activity and restores sexual behavior in a stress-induced group.

Graphical Abstract

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