Kessler, R.C.; Aguilar-Gaxiola, S.; Alonso, J.; Chatterji, S.; Lee, S.; Ormel, J.; Üstün, T.B.; Wang, P.S. The global burden of mental disorders: An update from the WHO World Mental Health (WMH) Surveys. Epidemiol. Psichiatr. Soc., 2009, 18(1), 23-33.
[http://dx.doi.org/10.1017/S1121189X00001421] [PMID: 19378696]

GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry, 2022, 9(2), 137-150.
[http://dx.doi.org/10.1016/S2215-0366(21)00395-3] [PMID: 35026139]

Kessler, R.C.; Aguilar-Gaxiola, S.; Alonso, J.; Benjet, C.; Bromet, E.J.; Cardoso, G. Trauma and PTSD in the WHO world mental health surveys. Eur. J. Psychotraumatol., 2017, 8, 1353383.
[http://dx.doi.org/10.1080/20008198.2017.1353383]

Vos, T.; Allen, C.; Arora, M.; Barber, R.M.; Bhutta, Z.A.; Brown, A.; Carter, A.; Casey, D.C.; Charlson, F.J.; Chen, A.Z.; Coggeshall, M.; Cornaby, L.; Dandona, L.; Dicker, D.J.; Dilegge, T.; Erskine, H.E.; Ferrari, A.J.; Fitzmaurice, C.; Fleming, T.; Forouzanfar, M.H.; Fullman, N.; Gething, P.W.; Goldberg, E.M.; Graetz, N.; Haagsma, J.A.; Hay, S.I.; Johnson, C.O.; Kassebaum, N.J.; Kawashima, T.; Kemmer, L.; Khalil, I.A.; Kinfu, Y.; Kyu, H.H.; Leung, J.; Liang, X.; Lim, S.S.; Lopez, A.D.; Lozano, R.; Marczak, L.; Mensah, G.A.; Mokdad, A.H.; Naghavi, M.; Nguyen, G.; Nsoesie, E.; Olsen, H.; Pigott, D.M.; Pinho, C.; Rankin, Z.; Reinig, N.; Salomon, J.A.; Sandar, L.; Smith, A.; Stanaway, J.; Steiner, C.; Teeple, S.; Thomas, B.A.; Troeger, C.; Wagner, J.A.; Wang, H.; Wanga, V.; Whiteford, H.A.; Zoeckler, L.; Abajobir, A.A.; Abate, K.H.; Abbafati, C.; Abbas, K.M.; Abd-Allah, F.; Abraham, B.; Abubakar, I.; Abu-Raddad, L.J.; Abu-Rmeileh, N.M.E.; Ackerman, I.N.; Adebiyi, A.O.; Ademi, Z.; Adou, A.K.; Afanvi, K.A.; Agardh, E.E.; Agarwal, A.; Kiadaliri, A.A.; Ahmadieh, H.; Ajala, O.N.; Akinyemi, R.O.; Akseer, N.; Al-Aly, Z.; Alam, K.; Alam, N.K.M.; Aldhahri, S.F.; Alegretti, M.A.; Alemu, Z.A.; Alexander, L.T.; Alhabib, S.; Ali, R.; Alkerwi, A.; Alla, F.; Allebeck, P.; Al-Raddadi, R.; Alsharif, U.; Altirkawi, K.A.; Alvis-Guzman, N.; Amare, A.T.; Amberbir, A.; Amini, H.; Ammar, W.; Amrock, S.M.; Andersen, H.H.; Anderson, G.M.; Anderson, B.O.; Antonio, C.A.T.; Aregay, A.F.; Ärnlöv, J.; Artaman, A.; Asayesh, H.; Assadi, R.; Atique, S.; Avokpaho, E.F.G.A.; Awasthi, A.; Quintanilla, B.P.A.; Azzopardi, P.; Bacha, U.; Badawi, A.; Balakrishnan, K.; Banerjee, A.; Barac, A.; Barker-Collo, S.L.; Bärnighausen, T.; Barregard, L.; Barrero, L.H.; Basu, A.; Bazargan-Hejazi, S.; Beghi, E.; Bell, B.; Bell, M.L.; Bennett, D.A.; Bensenor, I.M.; Benzian, H.; Berhane, A.; Bernabé, E.; Betsu, B.D.; Beyene, A.S.; Bhala, N.; Bhatt, S.; Biadgilign, S.; Bienhoff, K.; Bikbov, B.; Biryukov, S.; Bisanzio, D.; Bjertness, E.; Blore, J.; Borschmann, R.; Boufous, S.; Brainin, M.; Brazinova, A.; Breitborde, N.J.K.; Brown, J.; Buchbinder, R.; Buckle, G.C.; Butt, Z.A.; Calabria, B.; Campos-Nonato, I.R.; Campuzano, J.C.; Carabin, H.; Cárdenas, R.; Carpenter, D.O.; Carrero, J.J.; Castañeda-Orjuela, C.A.; Rivas, J.C.; Catalá-López, F.; Chang, J-C.; Chiang, P.P-C.; Chibueze, C.E.; Chisumpa, V.H.; Choi, J-Y.J.; Chowdhury, R.; Christensen, H.; Christopher, D.J.; Ciobanu, L.G.; Cirillo, M.; Coates, M.M.; Colquhoun, S.M.; Cooper, C.; Cortinovis, M.; Crump, J.A.; Damtew, S.A.; Dandona, R.; Daoud, F.; Dargan, P.I. das Neves, J.; Davey, G.; Davis, A.C.; Leo, D.D.; Degenhardt, L.; Gobbo, L.C.D.; Dellavalle, R.P.; Deribe, K.; Deribew, A.; Derrett, S.; Jarlais, D.C.D.; Dharmaratne, S.D.; Dhillon, P.K.; Diaz-Torné, C.; Ding, E.L.; Driscoll, T.R.; Duan, L.; Dubey, M.; Duncan, B.B.; Ebrahimi, H.; Ellenbogen, R.G.; Elyazar, I.; Endres, M.; Endries, A.Y.; Ermakov, S.P.; Eshrati, B.; Estep, K.; Farid, T.A.; Farinha, C.S.S.; Faro, A.; Farvid, M.S.; Farzadfar, F.; Feigin, V.L.; Felson, D.T.; Fereshtehnejad, S-M.; Fernandes, J.G.; Fernandes, J.C.; Fischer, F.; Fitchett, J.R.A.; Foreman, K.; Fowkes, F.G.R.; Fox, J.; Franklin, R.C.; Friedman, J.; Frostad, J.; Fürst, T.; Futran, N.D.; Gabbe, B.; Ganguly, P.; Gankpé, F.G.; Gebre, T.; Gebrehiwot, T.T.; Gebremedhin, A.T.; Geleijnse, J.M.; Gessner, B.D.; Gibney, K.B.; Ginawi, I.A.M.; Giref, A.Z.; Giroud, M.; Gishu, M.D.; Giussani, G.; Glaser, E.; Godwin, W.W.; Gomez-Dantes, H.; Gona, P.; Goodridge, A.; Gopalani, S.V.; Gotay, C.C.; Goto, A.; Gouda, H.N.; Grainger, R.; Greaves, F.; Guillemin, F.; Guo, Y.; Gupta, R.; Gupta, R.; Gupta, V.; Gutiérrez, R.A.; Haile, D.; Hailu, A.D.; Hailu, G.B.; Halasa, Y.A.; Hamadeh, R.R.; Hamidi, S.; Hammami, M.; Hancock, J.; Handal, A.J.; Hankey, G.J.; Hao, Y.; Harb, H.L.; Harikrishnan, S.; Haro, J.M.; Havmoeller, R.; Hay, R.J.; Heredia-Pi, I.B.; Heydarpour, P.; Hoek, H.W.; Horino, M.; Horita, N.; Hosgood, H.D.; Hoy, D.G.; Htet, A.S.; Huang, H.; Huang, J.J.; Huynh, C.; Iannarone, M.; Iburg, K.M.; Innos, K.; Inoue, M.; Iyer, V.J.; Jacobsen, K.H.; Jahanmehr, N.; Jakovljevic, M.B.; Javanbakht, M.; Jayaraman, S.P.; Jayatilleke, A.U.; Jee, S.H.; Jeemon, P.; Jensen, P.N.; Jiang, Y.; Jibat, T.; Jimenez-Corona, A.; Jin, Y.; Jonas, J.B.; Kabir, Z.; Kalkonde, Y.; Kamal, R.; Kan, H.; Karch, A.; Karema, C.K.; Karimkhani, C.; Kasaeian, A.; Kaul, A.; Kawakami, N.; Keiyoro, P.N.; Kemp, A.H.; Keren, A.; Kesavachandran, C.N.; Khader, Y.S.; Khan, A.R.; Khan, E.A.; Khang, Y-H.; Khera, S.; Khoja, T.A.M.; Khubchandani, J.; Kieling, C.; Kim, P.; Kim, C.; Kim, D.; Kim, Y.J.; Kissoon, N.; Knibbs, L.D.; Knudsen, A.K.; Kokubo, Y.; Kolte, D.; Kopec, J.A.; Kosen, S.; Kotsakis, G.A.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.; Defo, B.K.; Bicer, B.K.; Kudom, A.A.; Kuipers, E.J.; Kumar, G.A.; Kutz, M.; Kwan, G.F.; Lal, A.; Lalloo, R.; Lallukka, T.; Lam, H.; Lam, J.O.; Langan, S.M.; Larsson, A.; Lavados, P.M.; Leasher, J.L.; Leigh, J.; Leung, R.; Levi, M.; Li, Y.; Li, Y.; Liang, J.; Liu, S.; Liu, Y.; Lloyd, B.K.; Lo, W.D.; Logroscino, G.; Looker, K.J.; Lotufo, P.A.; Lunevicius, R.; Lyons, R.A.; Mackay, M.T.; Magdy, M.; Razek, A.E.; Mahdavi, M.; Majdan, M.; Majeed, A.; Malekzadeh, R.; Marcenes, W.; Margolis, D.J.; Martinez-Raga, J.; Masiye, F.; Massano, J.; McGarvey, S.T.; McGrath, J.J.; McKee, M.; McMahon, B.J.; Meaney, P.A.; Mehari, A.; Mejia-Rodriguez, F.; Mekonnen, A.B.; Melaku, Y.A.; Memiah, P.; Memish, Z.A.; Mendoza, W.; Meretoja, A.; Meretoja, T.J.; Mhimbira, F.A.; Millear, A.; Miller, T.R.; Mills, E.J.; Mirarefin, M.; Mitchell, P.B.; Mock, C.N.; Mohammadi, A.; Mohammed, S.; Monasta, L.; Hernandez, J.C.M.; Montico, M.; Mooney, M.D.; Moradi-Lakeh, M.; Morawska, L.; Mueller, U.O.; Mullany, E.; Mumford, J.E.; Murdoch, M.E.; Nachega, J.B.; Nagel, G.; Naheed, A.; Naldi, L.; Nangia, V.; Newton, J.N.; Ng, M.; Ngalesoni, F.N.; Nguyen, Q.L.; Nisar, M.I.; Pete, P.M.N.; Nolla, J.M.; Norheim, O.F.; Norman, R.E.; Norrving, B.; Nunes, B.P.; Ogbo, F.A.; Oh, I-H.; Ohkubo, T.; Olivares, P.R.; Olusanya, B.O.; Olusanya, J.O.; Ortiz, A.; Osman, M.; Ota, E.; Pa, M.; Park, E-K.; Parsaeian, M.; de Azeredo, P.V.M.; Caicedo, A.J.P.; Patten, S.B.; Patton, G.C.; Pereira, D.M.; Perez-Padilla, R.; Perico, N.; Pesudovs, K.; Petzold, M.; Phillips, M.R.; Piel, F.B.; Pillay, J.D.; Pishgar, F.; Plass, D.; Platts-Mills, J.A.; Polinder, S.; Pond, C.D.; Popova, S.; Poulton, R.G.; Pourmalek, F.; Prabhakaran, D.; Prasad, N.M.; Qorbani, M.; Rabiee, R.H.S.; Radfar, A.; Rafay, A.; Rahimi, K.; Rahimi-Movaghar, V.; Rahman, M.; Rahman, M.H.U.; Rahman, S.U.; Rai, R.K.; Rajsic, S.; Ram, U.; Rao, P.; Refaat, A.H.; Reitsma, M.B.; Remuzzi, G.; Resnikoff, S.; Reynolds, A.; Ribeiro, A.L.; Blancas, M.J.R.; Roba, H.S.; Rojas-Rueda, D.; Ronfani, L.; Roshandel, G.; Roth, G.A.; Rothenbacher, D.; Roy, A.; Sagar, R.; Sahathevan, R.; Sanabria, J.R.; Sanchez-Niño, M.D.; Santos, I.S.; Santos, J.V.; Sarmiento-Suarez, R.; Sartorius, B.; Satpathy, M.; Savic, M.; Sawhney, M.; Schaub, M.P.; Schmidt, M.I.; Schneider, I.J.C.; Schöttker, B.; Schwebel, D.C.; Scott, J.G.; Seedat, S.; Sepanlou, S.G.; Servan-Mori, E.E.; Shackelford, K.A.; Shaheen, A.; Shaikh, M.A.; Sharma, R.; Sharma, U.; Shen, J.; Shepard, D.S.; Sheth, K.N.; Shibuya, K.; Shin, M-J.; Shiri, R.; Shiue, I.; Shrime, M.G.; Sigfusdottir, I.D.; Silva, D.A.S.; Silveira, D.G.A.; Singh, A.; Singh, J.A.; Singh, O.P.; Singh, P.K.; Sivonda, A.; Skirbekk, V.; Skogen, J.C.; Sligar, A.; Sliwa, K.; Soljak, M.; Søreide, K.; Sorensen, R.J.D.; Soriano, J.B.; Sposato, L.A.; Sreeramareddy, C.T.; Stathopoulou, V.; Steel, N.; Stein, D.J.; Steiner, T.J.; Steinke, S.; Stovner, L.; Stroumpoulis, K.; Sunguya, B.F.; Sur, P.; Swaminathan, S.; Sykes, B.L.; Szoeke, C.E.I.; Tabarés-Seisdedos, R.; Takala, J.S.; Tandon, N.; Tanne, D.; Tavakkoli, M.; Taye, B.; Taylor, H.R.; Ao, B.J.T.; Tedla, B.A.; Terkawi, A.S.; Thomson, A.J.; Thorne-Lyman, A.L.; Thrift, A.G.; Thurston, G.D.; Tobe-Gai, R.; Tonelli, M.; Topor-Madry, R.; Topouzis, F.; Tran, B.X.; Truelsen, T.; Dimbuene, Z.T.; Tsilimbaris, M.; Tura, A.K.; Tuzcu, E.M.; Tyrovolas, S.; Ukwaja, K.N.; Undurraga, E.A.; Uneke, C.J.; Uthman, O.A.; van Gool, C.H.; Varakin, Y.Y.; Vasankari, T.; Venketasubramanian, N.; Verma, R.K.; Violante, F.S.; Vladimirov, S.K.; Vlassov, V.V.; Vollset, S.E.; Wagner, G.R.; Waller, S.G.; Wang, L.; Watkins, D.A.; Weichenthal, S.; Weiderpass, E.; Weintraub, R.G.; Werdecker, A.; Westerman, R.; White, R.A.; Williams, H.C.; Wiysonge, C.S.; Wolfe, C.D.A.; Won, S.; Woodbrook, R.; Wubshet, M.; Xavier, D.; Xu, G.; Yadav, A.K.; Yan, L.L.; Yano, Y.; Yaseri, M.; Ye, P.; Yebyo, H.G.; Yip, P.; Yonemoto, N.; Yoon, S-J.; Younis, M.Z.; Yu, C.; Zaidi, Z.; Zaki, M.E.S.; Zeeb, H.; Zhou, M.; Zodpey, S.; Zuhlke, L.J.; Murray, C.J.L. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet, 2016, 388(10053), 1545-1602.
[http://dx.doi.org/10.1016/S0140-6736(16)31678-6] [PMID: 27733282]

Santomauro, D.F.; Mantilla, H.A.M.; Shadid, J.; Zheng, P.; Ashbaugh, C.; Pigott, D.M.; Abbafati, C.; Adolph, C.; Amlag, J.O.; Aravkin, A.Y.; Bang-Jensen, B.L.; Bertolacci, G.J.; Bloom, S.S.; Castellano, R.; Castro, E.; Chakrabarti, S.; Chattopadhyay, J.; Cogen, R.M.; Collins, J.K.; Dai, X.; Dangel, W.J.; Dapper, C.; Deen, A.; Erickson, M.; Ewald, S.B.; Flaxman, A.D.; Frostad, J.J.; Fullman, N.; Giles, J.R.; Giref, A.Z.; Guo, G.; He, J.; Helak, M.; Hulland, E.N.; Idrisov, B.; Lindstrom, A.; Linebarger, E.; Lotufo, P.A.; Lozano, R.; Magistro, B.; Malta, D.C.; Månsson, J.C.; Marinho, F.; Mokdad, A.H.; Monasta, L.; Naik, P.; Nomura, S.; O’Halloran, J.K.; Ostroff, S.M.; Pasovic, M.; Penberthy, L.; Reiner, R.C., Jr; Reinke, G.; Ribeiro, A.L.P.; Sholokhov, A.; Sorensen, R.J.D.; Varavikova, E.; Vo, A.T.; Walcott, R.; Watson, S.; Wiysonge, C.S.; Zigler, B.; Hay, S.I.; Vos, T.; Murray, C.J.L.; Whiteford, H.A.; Ferrari, A.J. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet, 2021, 398(10312), 1700-1712.
[http://dx.doi.org/10.1016/S0140-6736(21)02143-7] [PMID: 34634250]

Harvard University. Center on the Developing Child. Key Concepts. Toxic Stress 2012. Available from: https://developingchild.harvard.edu/science/key-concepts/toxic-stress/

Garner, A.S.; Shonkoff, J.P.; Siegel, B.S.; Dobbins, M.I.; Earls, M.F.; Garner, A.S.; McGuinn, L.; Pascoe, J.; Wood, D.L. Committee on psychosocial aspects of child and family health; committee on early childhood, adoption, and dependent care; section on developmental and behavioral pediatrics. Early childhood adversity, toxic stress, and the role of the pediatrician: translating developmental science into lifelong health. Pediatrics, 2012, 129(1), e224-e231.
[http://dx.doi.org/10.1542/peds.2011-2662] [PMID: 22201148]

Kessler, R.C.; Berglund, P.; Demler, O.; Jin, R.; Merikangas, K.R.; Walters, E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry, 2005, 62(6), 593-602.
[http://dx.doi.org/10.1001/archpsyc.62.6.593] [PMID: 15939837]

Smoller, J.W. The genetics of stress-related disorders: PTSD, depression, and anxiety disorders. Neuropsychopharmacology, 2016, 41(1), 297-319.
[http://dx.doi.org/10.1038/npp.2015.266] [PMID: 26321314]

Coleman, J.R.I.; Gaspar, H.A.; Bryois, J.; Breen, G.; Byrne, E.M.; Forstner, A.J.; Holmans, P.A.; de Leeuw, C.A.; Mattheisen, M.; McQuillin, A.; Whitehead Pavlides, J.M.; Pers, T.H.; Ripke, S.; Stahl, E.A.; Steinberg, S.; Trubetskoy, V.; Trzaskowski, M.; Wang, Y.; Abbott, L.; Abdellaoui, A.; Adams, M.J.; Adolfsson, A.N.; Agerbo, E.; Akil, H.; Albani, D.; Alliey-Rodriguez, N.; Als, T.D.; Andlauer, T.F.M.; Anjorin, A.; Antilla, V.; Van der Auwera, S.; Awasthi, S.; Bacanu, S-A.; Badner, J.A.; Bækvad-Hansen, M.; Barchas, J.D.; Bass, N.; Bauer, M.; Beekman, A.T.F.; Belliveau, R.; Bergen, S.E.; Bigdeli, T.B.; Binder, E.B.; Bøen, E.; Boks, M.; Boocock, J.; Budde, M.; Bunney, W.; Burmeister, M.; Buttenschøn, H.N.; Bybjerg-Grauholm, J.; Byerley, W.; Cai, N.; Casas, M.; Castelao, E.; Cerrato, F.; Cervantes, P.; Chambert, K.; Charney, A.W.; Chen, D.; Christensen, J.H.; Churchhouse, C.; St Clair, D.; Clarke, T-K.; Colodro-Conde, L.; Coryell, W.; Couvy-Duchesne, B.; Craig, D.W.; Crawford, G.E.; Cruceanu, C.; Czerski, P.M.; Dale, A.M.; Davies, G.; Deary, I.J.; Degenhardt, F.; Del-Favero, J.; DePaulo, J.R.; Derks, E.M.; Direk, N.; Djurovic, S.; Dobbyn, A.L.; Dolan, C.V.; Dumont, A.; Dunn, E.C.; Eley, T.C.; Elvsåshagen, T.; Escott-Price, V.; Fan, C.C.; Finucane, H.K.; Fischer, S.B.; Flickinger, M.; Foo, J.C.; Foroud, T.M.; Forty, L.; Frank, J.; Fraser, C.; Freimer, N.B.; Frisén, L.; Gade, K.; Gage, D.; Garnham, J.; Giambartolomei, C.; Goes, F.S.; Goldstein, J.; Gordon, S.D.; Gordon-Smith, K.; Green, E.K.; Green, M.J.; Greenwood, T.A.; Grove, J.; Guan, W.; Hall, L.S.; Hamshere, M.L.; Hansen, C.S.; Hansen, T.F.; Hautzinger, M.; Heilbronner, U.; van Hemert, A.M.; Herms, S.; Hickie, I.B.; Hipolito, M.; Hoffmann, P.; Holland, D.; Homuth, G.; Horn, C.; Hottenga, J-J.; Huckins, L.; Ising, M.; Jamain, S.; Jansen, R.; Johnson, J.S.; de Jong, S.; Jorgenson, E.; Juréus, A.; Kandaswamy, R.; Karlsson, R.; Kennedy, J.L.; Hassan Kiadeh, F.F.; Kittel-Schneider, S.; Knowles, J.A.; Kogevinas, M.; Kohane, I.S.; Koller, A.C.; Kraft, J.; Kretzschmar, W.W.; Krogh, J.; Kupka, R.; Kutalik, Z.; Lavebratt, C.; Lawrence, J.; Lawson, W.B.; Leber, M.; Lee, P.H.; Levy, S.E.; Li, J.Z.; Li, Y.; Lind, P.A.; Liu, C.; Olde Loohuis, L.M.; Maaser, A.; MacIntyre, D.J.; MacKinnon, D.F.; Mahon, P.B.; Maier, W.; Maier, R.M.; Marchini, J.; Martinsson, L.; Mbarek, H.; McCarroll, S.; McGrath, P.; McGuffin, P.; McInnis, M.G.; McKay, J.D.; Medeiros, H.; Medland, S.E.; Mehta, D.; Meng, F.; Middeldorp, C.M.; Mihailov, E.; Milaneschi, Y.; Milani, L.; Mirza, S.S.; Mondimore, F.M.; Montgomery, G.W.; Morris, D.W.; Mostafavi, S.; Mühleisen, T.W.; Mullins, N.; Nauck, M.; Ng, B.; Nguyen, H.; Nievergelt, C.M.; Nivard, M.G.; Nwulia, E.A.; Nyholt, D.R.; O’Donovan, C.; O’Reilly, P.F.; Ori, A.P.S.; Oruc, L.; Ösby, U.; Oskarsson, H.; Painter, J.N.; Parra, J.G.; Pedersen, C.B.; Pedersen, M.G.; Perry, A.; Peterson, R.E.; Pettersson, E.; Peyrot, W.J.; Pfennig, A.; Pistis, G.; Purcell, S.M.; Quiroz, J.A.; Qvist, P.; Regeer, E.J.; Reif, A.; Reinbold, C.S.; Rice, J.P.; Riley, B.P.; Rivas, F.; Rivera, M.; Roussos, P.; Ruderfer, D.M.; Ryu, E.; Sánchez-Mora, C.; Schatzberg, A.F.; Scheftner, W.A.; Schoevers, R.; Schork, N.J.; Schulte, E.C.; Shehktman, T.; Shen, L.; Shi, J.; Shilling, P.D.; Shyn, S.I.; Sigurdsson, E.; Slaney, C.; Smeland, O.B.; Smit, J.H.; Smith, D.J.; Sobell, J.L.; Spijker, A.T.; Steffens, M.; Strauss, J.S.; Streit, F.; Strohmaier, J.; Szelinger, S.; Tansey, K.E.; Teismann, H.; Teumer, A.; Thompson, R.C.; Thompson, W.; Thomson, P.A.; Thorgeirsson, T.E.; Traylor, M.; Treutlein, J.; Uitterlinden, A.G.; Umbricht, D.; Vedder, H.; Viktorin, A.; Visscher, P.M.; Wang, W.; Watson, S.J.; Webb, B.T.; Weickert, C.S.; Weickert, T.W.; Weinsheimer, S.M.; Wellmann, J.; Willemsen, G.; Witt, S.H.; Wu, Y.; Xi, H.S.; Xu, W.; Yang, J.; Young, A.H.; Zandi, P.; Zhang, P.; Zhang, F.; Zollner, S.; Adolfsson, R.; Agartz, I.; Alda, M.; Arolt, V.; Backlund, L.; Baune, B.T.; Bellivier, F.; Berger, K.; Berrettini, W.H.; Biernacka, J.M.; Blackwood, D.H.R.; Boehnke, M.; Boomsma, D.I.; Corvin, A.; Craddock, N.; Daly, M.J.; Dannlowski, U.; Domenici, E.; Domschke, K.; Esko, T.; Etain, B.; Frye, M.; Fullerton, J.M.; Gershon, E.S.; de Geus, E.J.C.; Gill, M.; Goes, F.; Grabe, H.J.; Grigoroiu-Serbanescu, M.; Hamilton, S.P.; Hauser, J.; Hayward, C.; Heath, A.C.; Hougaard, D.M.; Hultman, C.M.; Jones, I.; Jones, L.A.; Kahn, R.S.; Kendler, K.S.; Kirov, G.; Kloiber, S.; Landén, M.; Leboyer, M.; Lewis, G.; Li, Q.S.; Lissowska, J.; Lucae, S.; Madden, P.A.F.; Magnusson, P.K.; Martin, N.G.; Mayoral, F.; McElroy, S.L.; McIntosh, A.M.; McMahon, F.J.; Melle, I.; Metspalu, A.; Mitchell, P.B.; Morken, G.; Mors, O.; Mortensen, P.B.; Müller-Myhsok, B.; Myers, R.M.; Neale, B.M.; Nimgaonkar, V.; Nordentoft, M.; Nöthen, M.M.; O’Donovan, M.C.; Oedegaard, K.J.; Owen, M.J.; Paciga, S.A.; Pato, C.; Pato, M.T.; Pedersen, N.L.; Penninx, B.W.J.H.; Perlis, R.H.; Porteous, D.J.; Posthuma, D.; Potash, J.B.; Preisig, M.; Ramos-Quiroga, J.A.; Ribasés, M.; Rietschel, M.; Rouleau, G.A.; Schaefer, C.; Schalling, M.; Schofield, P.R.; Schulze, T.G.; Serretti, A.; Smoller, J.W.; Stefansson, H.; Stefansson, K.; Stordal, E.; Tiemeier, H.; Turecki, G.; Uher, R.; Vaaler, A.E.; Vieta, E.; Vincent, J.B.; Völzke, H.; Weissman, M.M.; Werge, T.; Andreassen, O.A.; Børglum, A.D.; Cichon, S.; Edenberg, H.J.; Di Florio, A.; Kelsoe, J.; Levinson, D.F.; Lewis, C.M.; Nurnberger, J.I.; Ophoff, R.A.; Scott, L.J.; Sklar, P.; Sullivan, P.F.; Wray, N.R.; Byrne, E.M.; Forstner, A.J.; Holmans, P.A.; de Leeuw, C.A.; Mattheisen, M.; McQuillin, A.; Whitehead, P.J.M.; Pers, T.H.; Ripke, S.; Stahl, E.A.; Steinberg, S.; Trubetskoy, V.; Trzaskowski, M.; Wang, Y.; Abbott, L.; Abdellaoui, A.; Adams, M.J.; Adolfsson, A.N.; Agerbo, E.; Akil, H.; Albani, D.; Alliey-Rodriguez, N.; Als, T.D.; Andlauer, T.F.M.; Anjorin, A.; Antilla, V.; Van der Auwera, S.; Awasthi, S.; Bacanu, S-A.; Badner, J.A.; Bækvad-Hansen, M.; Barchas, J.D.; Bass, N.; Bauer, M.; Beekman, A.T.F.; Belliveau, R.; Bergen, S.E.; Bigdeli, T.B.; Binder, E.B.; Bøen, E.; Boks, M.; Boocock, J.; Budde, M.; Bunney, W.; Burmeister, M.; Buttenschøn, H.N.; Bybjerg-Grauholm, J.; Byerley, W.; Cai, N.; Casas, M.; Castelao, E.; Cerrato, F.; Cervantes, P.; Chambert, K.; Charney, A.W.; Chen, D.; Christensen, J.H.; Churchhouse, C.; St Clair, D.; Clarke, T-K.; Colodro-Conde, L.; Coryell, W.; Couvy-Duchesne, B.; Craig, D.W.; Crawford, G.E.; Cruceanu, C.; Czerski, P.M.; Dale, A.M.; Davies, G.; Deary, I.J.; Degenhardt, F.; Del-Favero, J.; DePaulo, J.R.; Derks, E.M.; Direk, N.; Djurovic, S.; Dobbyn, A.L.; Dolan, C.V.; Dumont, A.; Dunn, E.C.; Eley, T.C.; Elvsåshagen, T.; Escott-Price, V.; Fan, C.C.; Finucane, H.K.; Fischer, S.B.; Flickinger, M.; Foo, J.C.; Foroud, T.M.; Forty, L.; Frank, J.; Fraser, C.; Freimer, N.B.; Frisén, L.; Gade, K.; Gage, D.; Garnham, J.; Giambartolomei, C.; Goes, F.S.; Goldstein, J.; Gordon, S.D.; Gordon-Smith, K.; Green, E.K.; Green, M.J.; Greenwood, T.A.; Grove, J.; Guan, W.; Hall, L.S.; Hamshere, M.L.; Hansen, C.S.; Hansen, T.F.; Hautzinger, M.; Heilbronner, U.; van Hemert, A.M.; Herms, S.; Hickie, I.B.; Hipolito, M.; Hoffmann, P.; Holland, D.; Homuth, G.; Horn, C.; Hottenga, J-J.; Huckins, L.; Ising, M.; Jamain, S.; Jansen, R.; Johnson, J.S.; de Jong, S.; Jorgenson, E.; Juréus, A.; Kandaswamy, R.; Karlsson, R.; Kennedy, J.L.; Hassan Kiadeh, F.F.; Kittel-Schneider, S.; Knowles, J.A.; Kogevinas, M.; Kohane, I.S.; Koller, A.C.; Kraft, J.; Kretzschmar, W.W.; Krogh, J.; Kupka, R.; Kutalik, Z.; Lavebratt, C.; Lawrence, J.; Lawson, W.B.; Leber, M.; Lee, P.H.; Levy, S.E.; Li, J.Z.; Li, Y.; Lind, P.A.; Liu, C.; Olde Loohuis, L.M.; Maaser, A.; MacIntyre, D.J.; MacKinnon, D.F.; Mahon, P.B.; Maier, W.; Maier, R.M.; Marchini, J.; Martinsson, L.; Mbarek, H.; McCarroll, S.; McGrath, P.; McGuffin, P.; McInnis, M.G.; McKay, J.D.; Medeiros, H.; Medland, S.E.; Mehta, D.; Meng, F.; Middeldorp, C.M.; Mihailov, E.; Milaneschi, Y.; Milani, L.; Mirza, S.S.; Mondimore, F.M.; Montgomery, G.W.; Morris, D.W.; Mostafavi, S.; Mühleisen, T.W.; Mullins, N.; Nauck, M.; Ng, B.; Nguyen, H.; Nievergelt, C.M.; Nivard, M.G.; Nwulia, E.A.; Nyholt, D.R.; O’Donovan, C.; O’Reilly, P.F.; Ori, A.P.S.; Oruc, L.; Ösby, U.; Oskarsson, H.; Painter, J.N.; Parra, J.G.; Pedersen, C.B.; Pedersen, M.G.; Perry, A.; Peterson, R.E.; Pettersson, E.; Peyrot, W.J.; Pfennig, A.; Pistis, G.; Purcell, S.M.; Quiroz, J.A.; Qvist, P.; Regeer, E.J.; Reif, A.; Reinbold, C.S.; Rice, J.P.; Riley, B.P.; Rivas, F.; Rivera, M.; Roussos, P.; Ruderfer, D.M.; Ryu, E.; Sánchez-Mora, C.; Schatzberg, A.F.; Scheftner, W.A.; Schoevers, R.; Schork, N.J.; Schulte, E.C.; Shehktman, T.; Shen, L.; Shi, J.; Shilling, P.D.; Shyn, S.I.; Sigurdsson, E.; Slaney, C.; Smeland, O.B.; Smit, J.H.; Smith, D.J.; Sobell, J.L.; Spijker, A.T.; Steffens, M.; Strauss, J.S.; Streit, F.; Strohmaier, J.; Szelinger, S.; Tansey, K.E.; Teismann, H.; Teumer, A.; Thompson, R.C.; Thompson, W.; Thomson, P.A.; Thorgeirsson, T.E.; Traylor, M.; Treutlein, J.; Uitterlinden, A.G.; Umbricht, D.; Vedder, H.; Viktorin, A.; Visscher, P.M.; Wang, W.; Watson, S.J.; Webb, B.T.; Weickert, C.S.; Weickert, T.W.; Weinsheimer, S.M.; Wellmann, J.; Willemsen, G.; Witt, S.H.; Wu, Y.; Xi, H.S.; Xu, W.; Yang, J.; Young, A.H.; Zandi, P.; Zhang, P.; Zhang, F.; Zollner, S.; Adolfsson, R.; Agartz, I.; Alda, M.; Arolt, V.; Backlund, L.; Baune, B.T.; Bellivier, F.; Berger, K.; Berrettini, W.H.; Biernacka, J.M.; Blackwood, D.H.R.; Boehnke, M.; Boomsma, D.I.; Corvin, A.; Craddock, N.; Daly, M.J.; Dannlowski, U.; Domenici, E.; Domschke, K.; Esko, T.; Etain, B.; Frye, M.; Fullerton, J.M.; Gershon, E.S.; de Geus, E.J.C.; Gill, M.; Goes, F.; Grabe, H.J.; Grigoroiu-Serbanescu, M.; Hamilton, S.P.; Hauser, J.; Hayward, C.; Heath, A.C.; Hougaard, D.M.; Hultman, C.M.; Jones, I.; Jones, L.A.; Kahn, R.S.; Kendler, K.S.; Kirov, G.; Kloiber, S.; Landén, M.; Leboyer, M.; Lewis, G.; Li, Q.S.; Lissowska, J.; Lucae, S.; Madden, P.A.F.; Magnusson, P.K.; Martin, N.G.; Mayoral, F.; McElroy, S.L.; McIntosh, A.M.; McMahon, F.J.; Melle, I.; Metspalu, A.; Mitchell, P.B.; Morken, G.; Mors, O.; Mortensen, P.B.; Müller-Myhsok, B.; Myers, R.M.; Neale, B.M.; Nimgaonkar, V.; Nordentoft, M.; Nöthen, M.M.; O’Donovan, M.C.; Oedegaard, K.J.; Owen, M.J.; Paciga, S.A.; Pato, C.; Pato, M.T.; Pedersen, N.L.; Penninx, B.W.J.H.; Perlis, R.H.; Porteous, D.J.; Posthuma, D.; Potash, J.B.; Preisig, M.; Ramos-Quiroga, J.A.; Ribasés, M.; Rietschel, M.; Rouleau, G.A.; Schaefer, C.; Schalling, M.; Schofield, P.R.; Schulze, T.G.; Serretti, A.; Smoller, J.W.; Stefansson, H.; Stefansson, K.; Stordal, E.; Tiemeier, H.; Turecki, G.; Uher, R.; Vaaler, A.E.; Vieta, E.; Vincent, J.B.; Völzke, H.; Weissman, M.M.; Werge, T.; Andreassen, O.A.; Børglum, A.D.; Cichon, S.; Edenberg, H.J.; Di Florio, A.; Kelsoe, J.; Levinson, D.F.; Lewis, C.M.; Nurnberger, J.I.; Ophoff, R.A.; Scott, L.J.; Sklar, P.; Sullivan, P.F.; Wray, N.R. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biol. Psychiatry, 2020, 88(2), 169-184.
[http://dx.doi.org/10.1016/j.biopsych.2019.10.015] [PMID: 31926635]

Kendler, K.S.; Gatz, M.; Gardner, C.O.; Pedersen, N.L. Clinical indices of familial depression in the Swedish Twin Registry. Acta Psychiatr. Scand., 2007, 115(3), 214-220.
[http://dx.doi.org/10.1111/j.1600-0447.2006.00863.x] [PMID: 17302621]

Hettema, J.M.; Kettenmann, B.; Ahluwalia, V.; McCarthy, C.; Kates, W.R.; Schmitt, J.E.; Silberg, J.L.; Neale, M.C.; Kendler, K.S.; Fatouros, P. Pilot multimodal twin imaging study of generalized anxiety disorder. Depress. Anxiety, 2012, 29(3), 202-209.
[http://dx.doi.org/10.1002/da.20901] [PMID: 21994092]

Berardis, D.; Marini, S.; Serroni, N.; Iasevoli, F.; Tomasetti, C.; Bartolomeis, A.; Mazza, M.; Tempesta, D.; Valchera, A.; Fornaro, M.; Pompili, M.; Sepede, G.; Vellante, F.; Orsolini, L.; Martinotti, G.; Giannantonio, M. Targeting the noradrenergic system in posttraumatic stress disorder: A systematic review and meta-analysis of prazosin trials. Curr. Drug Targets, 2015, 16(10), 1094-1106.
[http://dx.doi.org/10.2174/1389450116666150506114108] [PMID: 25944011]

Tempesta, D.; Mazza, M.; Serroni, N.; Moschetta, F.S.; Di Giannantonio, M.; Ferrara, M.; De Berardis, D. Neuropsychological functioning in young subjects with generalized anxiety disorder with and without pharmacotherapy. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2013, 45, 236-241.
[http://dx.doi.org/10.1016/j.pnpbp.2013.06.006] [PMID: 23796524]

Ventriglio, A.; Bhugra, D.; Sampogna, G.; Luciano, M.; De Berardis, D.; Sani, G.; Fiorillo, A. From dysthymia to treatment-resistant depression: Evolution of a psychopathological construct. Int. Rev. Psychiatry, 2020, 32(5-6), 471-476.
[http://dx.doi.org/10.1080/09540261.2020.1765517]

Michopoulos, V.; Powers, A.; Gillespie, C.F.; Ressler, K.J.; Jovanovic, T. Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacology, 2017, 42(1), 254-270.
[http://dx.doi.org/10.1038/npp.2016.146] [PMID: 27510423]

Serra-Blasco, M.; Radua, J.; Soriano-Mas, C.; Gómez-Benlloch, A.; Porta-Casteràs, D.; Carulla-Roig, M.; Albajes-Eizagirre, A.; Arnone, D.; Klauser, P.; Canales-Rodríguez, E.J.; Hilbert, K.; Wise, T.; Cheng, Y.; Kandilarova, S.; Mataix-Cols, D.; Vieta, E.; Via, E.; Cardoner, N. Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis. Neurosci. Biobehav. Rev., 2021, 129, 269-281.
[http://dx.doi.org/10.1016/j.neubiorev.2021.07.002] [PMID: 34256069]

Verbitsky, A.; Dopfel, D.; Zhang, N. Rodent models of post-traumatic stress disorder: Behavioral assessment. Transl. Psychiatry, 2020, 10(1), 132.
[http://dx.doi.org/10.1038/s41398-020-0806-x] [PMID: 32376819]

Planchez, B.; Surget, A.; Belzung, C. Animal models of major depression: Drawbacks and challenges. J. Neural Transm., 2019, 126(11), 1383-1408.
[http://dx.doi.org/10.1007/s00702-019-02084-y] [PMID: 31584111]

Yehuda, R.; Antelman, S.M. Criteria for rationally evaluating animal models of postraumatic stress disorder. Biol. Psychiatry, 1993, 33(7), 479-486.
[http://dx.doi.org/10.1016/0006-3223(93)90001-T] [PMID: 8513032]

Franklin, T.B.; Saab, B.J.; Mansuy, I.M. Neural mechanisms of stress resilience and vulnerability. Neuron, 2012, 75(5), 747-761.
[http://dx.doi.org/10.1016/j.neuron.2012.08.016] [PMID: 22958817]

Armario, A.; Escorihuela, R.M.; Nadal, R. Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals. Neurosci. Biobehav. Rev., 2008, 32(6), 1121-1135.
[http://dx.doi.org/10.1016/j.neubiorev.2008.04.003] [PMID: 18514314]

Campos, A.C.; Fogaça, M.V.; Aguiar, D.C.; Guimarães, F.S. Animal models of anxiety disorders and stress. Rev. Bras. Psiquiatr., 2013, 35(Suppl. 2), S101-S111.
[http://dx.doi.org/10.1590/1516-4446-2013-1139] [PMID: 24271222]

Finnell, J.E.; Lombard, C.M.; Padi, A.R.; Moffitt, C.M.; Wilson, L.B.; Wood, C.S.; Wood, S.K. Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences. PLoS One, 2017, 12(2), e0172868.
[http://dx.doi.org/10.1371/journal.pone.0172868] [PMID: 28241050]

Márquez, C.; Belda, X.; Armario, A. Post-stress recovery of pituitary-adrenal hormones and glucose, but not the response during exposure to the stressor, is a marker of stress intensity in highly stressful situations. Brain Res., 2002, 926(1-2), 181-185.
[http://dx.doi.org/10.1016/S0006-8993(01)03112-2] [PMID: 11814422]

Belda, X.; Fuentes, S.; Nadal, R.; Armario, A. A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors. Horm. Behav., 2008, 54(5), 654-661.
[http://dx.doi.org/10.1016/j.yhbeh.2008.07.003] [PMID: 18675818]

Andero, R.; Heldt, S.A.; Ye, K.; Liu, X.; Armario, A.; Ressler, K.J. Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am. J. Psychiatry, 2011, 168(2), 163-172.
[http://dx.doi.org/10.1176/appi.ajp.2010.10030326] [PMID: 21123312]

Velasco, E.R.; Florido, A.; Flores, Á.; Senabre, E.; Gomez-Gomez, A.; Torres, A.; Roca, A.; Norrholm, S.; Newman, E.L.; Das, P.; Ross, R.A.; Lori, A.; Pozo, O.J.; Ressler, K.J.; Garcia-Esteve, L.L.; Jovanovic, T.; Andero, R. PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus. Nat. Commun., 2022, 13(1), 4374.
[http://dx.doi.org/10.1038/s41467-022-31442-w] [PMID: 35902577]

Sanz-García, A.; Knafo, S.; Pereda-Pérez, I.; Esteban, J.A.; Venero, C.; Armario, A. Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity. Hippocampus, 2016, 26(9), 1179-1188.
[http://dx.doi.org/10.1002/hipo.22599] [PMID: 27068341]

Zhang, J.H.; Han, F.; Shi, Y.X. Single prolonged stress induces changes in the expression of mineralocorticoid receptor in the medial prefrontal cortex in a rat model of post-traumatic stress disorder. Mol. Med. Rep., 2012, 6(2), 330-334.
[http://dx.doi.org/10.3892/mmr.2012.937] [PMID: 22684778]

Willner, P. The validity of animal models of depression. Psychopharmacology, 1984, 83(1), 1-16.
[http://dx.doi.org/10.1007/BF00427414] [PMID: 6429692]

Willner, P.; Belzung, C. Treatment-resistant depression: are animal models of depression fit for purpose? Psychopharmacology, 2015, 232(19), 3473-3495.
[http://dx.doi.org/10.1007/s00213-015-4034-7] [PMID: 26289353]

Willner, P.; Scheel-Krüger, J.; Belzung, C. The neurobiology of depression and antidepressant action. Neurosci. Biobehav. Rev., 2013, 37(10), 2331-2371.
[http://dx.doi.org/10.1016/j.neubiorev.2012.12.007] [PMID: 23261405]

Belzung, C.; Willner, P.; Philippot, P. Depression: From psychopathology to pathophysiology. Curr. Opin. Neurobiol., 2015, 30, 24-30.
[http://dx.doi.org/10.1016/j.conb.2014.08.013] [PMID: 25218233]

Badcock, P.; Allen, N. Adaptive social reasoning in depressed mood and depressive vulnerability. Cogn. Emotion, 2003, 17(4), 647-670.
[http://dx.doi.org/10.1080/02699930302299] [PMID: 29715734]

Berton, O.; McClung, C.A.; DiLeone, R.J.; Krishnan, V.; Renthal, W.; Russo, S.J. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science, 2006, 311(5762), 864-868.

Björkqvist, K. Social defeat as a stressor in humans. Physiol. Behav., 2001, 73(3), 435-442.
[http://dx.doi.org/10.1016/S0031-9384(01)00490-5] [PMID: 11438372]

Rohde, P. The relevance of hierarchies, territories, defeat for depression in humans: Hypotheses and clinical predictions. J. Affect. Disord., 2001, 65(3), 221-230.
[http://dx.doi.org/10.1016/S0165-0327(00)00219-6] [PMID: 11511402]

Hultman, R.; Mague, S.D.; Li, Q.; Katz, B.M.; Michel, N.; Lin, L.; Wang, J.; David, L.K.; Blount, C.; Chandy, R.; Carlson, D.; Ulrich, K.; Carin, L.; Dunson, D.; Kumar, S.; Deisseroth, K.; Moore, S.D.; Dzirasa, K. Dysregulation of prefrontal cortex-mediated slow-evolving limbic dynamics drives stress-induced emotional pathology. Neuron, 2016, 91(2), 439-452.
[http://dx.doi.org/10.1016/j.neuron.2016.05.038] [PMID: 27346529]

Han, Q.Q.; Yang, L.; Huang, H.J.; Wang, Y.L.; Yu, R.; Wang, J.; Pilot, A.; Wu, G.C.; Liu, Q.; Yu, J. Differential GR expression and translocation in the hippocampus mediates susceptibility vs. resilience to chronic social defeat stress. Front. Neurosci., 2017, 11, 287.
[http://dx.doi.org/10.3389/fnins.2017.00287] [PMID: 28588443]

Tsankova, N.M.; Berton, O.; Renthal, W.; Kumar, A.; Neve, R.L.; Nestler, E.J. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat. Neurosci., 2006, 9(4), 519-525.
[http://dx.doi.org/10.1038/nn1659] [PMID: 16501568]

Hill, M.N.; Hellemans, K.G.C.; Verma, P.; Gorzalka, B.B.; Weinberg, J. Neurobiology of chronic mild stress: Parallels to major depression. Neurosci. Biobehav. Rev., 2012, 36(9), 2085-2117.
[http://dx.doi.org/10.1016/j.neubiorev.2012.07.001] [PMID: 22776763]

Willner, P. The chronic mild stress (CMS) model of depression: History, evaluation and usage. Neurobiol. Stress, 2017, 6, 78-93.
[http://dx.doi.org/10.1016/j.ynstr.2016.08.002] [PMID: 28229111]

Kalueff, A.V.; Wheaton, M.; Murphy, D.L. What’s wrong with my mouse model? Behav. Brain Res., 2007, 179(1), 1-18.
[http://dx.doi.org/10.1016/j.bbr.2007.01.023] [PMID: 17306892]

Gale, G.D.; Anagnostaras, S.G.; Godsil, B.P.; Mitchell, S.; Nozawa, T.; Sage, J.R.; Wiltgen, B.; Fanselow, M.S. Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats. J. Neurosci., 2004, 24(15), 3810-3815.
[http://dx.doi.org/10.1523/JNEUROSCI.4100-03.2004] [PMID: 15084662]

McEwen, B.S.; De Kloet, E.R.; Rostene, W. Adrenal steroid receptors and actions in the nervous system. Physiol. Rev., 1986, 66(4), 1121-1188.
[http://dx.doi.org/10.1152/physrev.1986.66.4.1121] [PMID: 3532143]

Amaya, J.M.; Suidgeest, E.; Sahut-Barnola, I.; Dumontet, T.; Montanier, N.; Pagès, G.; Keller, C.; van der Weerd, L.; Pereira, A.M.; Martinez, A.; Meijer, O.C. Effects of long-term endogenous corticosteroid exposure on brain volume and glial cells in the AdKO mouse. Front. Neurosci., 2021, 15(2), 604103.
[http://dx.doi.org/10.3389/fnins.2021.604103] [PMID: 33642975]

Wellman, C.L. Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J. Neurobiol., 2001, 49(3), 245-253.

Cook, S.C.; Wellman, C.L. Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J. Neurobiol., 2004, 60(2), 236-248.
[http://dx.doi.org/10.1002/neu.20025] [PMID: 15266654]

Sapolsky, R.M.; Krey, L.C.; McEwen, B.S. Prolonged glucocorticoid exposure reduces hippocampal neuron number: Implications for aging. J. Neurosci., 1985, 5(5), 1222-1227.
[http://dx.doi.org/10.1523/JNEUROSCI.05-05-01222.1985] [PMID: 3998818]

Sapolsky, R.M.; Uno, H.; Rebert, C.S.; Finch, C.E. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J. Neurosci., 1990, 10(9), 2897-2902.
[http://dx.doi.org/10.1523/JNEUROSCI.10-09-02897.1990] [PMID: 2398367]

Mitra, R.; Sapolsky, R.M. Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy. Proc. Natl. Acad. Sci. USA, 2008, 105(14), 5573-5578.
[http://dx.doi.org/10.1073/pnas.0705615105] [PMID: 18391224]

Magarinos, A.M.; McEwen, B.S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience, 1995, 69(1), 89-98.
[http://dx.doi.org/10.1016/0306-4522(95)00259-L] [PMID: 8637636]

Herman, J.P.; Patel, P.D.; Akil, H.; Watson, S.J. Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat. Mol. Endocrinol., 1989, 3(11), 1886-1894.
[http://dx.doi.org/10.1210/mend-3-11-1886] [PMID: 2558306]

Jacobson, L.; Sapolsky, R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr. Rev., 1991, 12(2), 118-134.
[http://dx.doi.org/10.1210/edrv-12-2-118] [PMID: 2070776]

Sapolsky, R.M.; Zola-Morgan, S.; Squire, L.R. Inhibition of glucocorticoid secretion by the hippocampal formation in the primate. J. Neurosci., 1991, 11(12), 3695-3704.
[http://dx.doi.org/10.1523/JNEUROSCI.11-12-03695.1991] [PMID: 1744687]

Herman, J.P.; Cullinan, W.E. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci., 1997, 20(2), 78-84.
[http://dx.doi.org/10.1016/S0166-2236(96)10069-2] [PMID: 9023876]

Alexandra, K.M.; Fenster, R.J.; Laurent, E.S.; Ressler, K.J.; Phelps, E.A. Prefrontal cortex, amygdala, and threat processing: implications for PTSD. Neuropsychopharmacology, 2022, 47(1), 247-259.
[http://dx.doi.org/10.1038/s41386-021-01155-7] [PMID: 34545196]

Watanabe, Y.; Gould, E.; McEwen, B.S. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res., 1992, 588(2), 341-345.
[http://dx.doi.org/10.1016/0006-8993(92)91597-8] [PMID: 1393587]

Magariños, A.M.; McEwen, B.S.; Flügge, G.; Fuchs, E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J. Neurosci., 1996, 16(10), 3534-3540.
[http://dx.doi.org/10.1523/JNEUROSCI.16-10-03534.1996] [PMID: 8627386]

Conrad, C.D.; Galea, L.A.M.; Kuroda, Y.; McEwen, B.S. Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine treatment. Behav. Neurosci., 1996, 110(6), 1321-1334.
[http://dx.doi.org/10.1037/0735-7044.110.6.1321] [PMID: 8986335]

Sousa, N.; Lukoyanov, N.V.; Madeira, M.D.; Almeida, O.F.X.; Paula-Barbosa, M.M. Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience, 2000, 97(2), 253-266.
[http://dx.doi.org/10.1016/S0306-4522(00)00050-6] [PMID: 10799757]

Kole, M.H.P.; Czéh, B.; Fuchs, E. Homeostatic maintenance in excitability of tree shrew hippocampal CA3 pyramidal neurons after chronic stress. Hippocampus, 2004, 14(6), 742-751.
[http://dx.doi.org/10.1002/hipo.10212] [PMID: 15318332]

Vyas, A.; Mitra, R.; Shankaranarayana, R.B.S.; Chattarji, S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J. Neurosci., 2002, 22(15), 6810-6818.
[http://dx.doi.org/10.1523/JNEUROSCI.22-15-06810.2002] [PMID: 12151561]

Oitzl, M.S.; Champagne, D.L.; van der Veen, R.; de Kloet, E.R. Brain development under stress: Hypotheses of glucocorticoid actions revisited. Neurosci. Biobehav. Rev., 2010, 34(6), 853-866.
[http://dx.doi.org/10.1016/j.neubiorev.2009.07.006] [PMID: 19631685]

Sapolsky, R.M.; Krey, L.C.; Mcewen, B.S. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Endocr. Rev., 1986, 7(3), 284-301.
[http://dx.doi.org/10.1210/edrv-7-3-284] [PMID: 3527687]

Conrad, C.D. Chronic stress-induced hippocampal vulnerability: The glucocorticoid vulnerability hypothesis. Rev. Neurosci., 2008, 19(6), 395-411.
[http://dx.doi.org/10.1515/REVNEURO.2008.19.6.395] [PMID: 19317179]

Andero, R.; Choi, D.C.; Ressler, K.J. BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders. Prog. Mol. Biol. Transl. Sci., 2014, 122, 169-192.
[http://dx.doi.org/10.1016/B978-0-12-420170-5.00006-4] [PMID: 24484701]

Duric, V.; Duman, R.S. Depression and treatment response: Dynamic interplay of signaling pathways and altered neural processes. Cell. Mol. Life Sci., 2013, 70(1), 39-53.
[http://dx.doi.org/10.1007/s00018-012-1020-7] [PMID: 22585060]

Felger, J.C.; Lotrich, F.E. Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications. Neuroscience, 2013, 246, 199-229.
[http://dx.doi.org/10.1016/j.neuroscience.2013.04.060] [PMID: 23644052]

Stepanichev, M.; Dygalo, N.N.; Grigoryan, G.; Shishkina, G.T.; Gulyaeva, N. Rodent models of depression: Neurotrophic and neuroinflammatory biomarkers. BioMed Res. Int., 2014, 2014, 932757.

Lowy, M.T.; Gault, L.; Yamamoto, B.K. Adrenalectomy attenuates stress-induced elevations in extracellular glutamate concentrations in the hippocampus. J. Neurochem., 1993, 61(5), 1957-1960.
[http://dx.doi.org/10.1111/j.1471-4159.1993.tb09839.x] [PMID: 7901339]

Lowy, M.T.; Wittenberg, L.; Yamamoto, B.K. Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats. J. Neurochem., 1995, 65(1), 268-274.
[http://dx.doi.org/10.1046/j.1471-4159.1995.65010268.x] [PMID: 7790870]

Reznikov, L.R.; Grillo, C.A.; Piroli, G.G.; Pasumarthi, R.K.; Reagan, L.P.; Fadel, J. Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment. Eur. J. Neurosci., 2007, 25(10), 3109-3114.
[http://dx.doi.org/10.1111/j.1460-9568.2007.05560.x] [PMID: 17561824]

Venero, C.; Borrell, J. Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats. Eur. J. Neurosci., 1999, 11(7), 2465-2473.
[http://dx.doi.org/10.1046/j.1460-9568.1999.00668.x] [PMID: 10383636]

Bagley, J.; Moghaddam, B. Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam. Neuroscience, 1997, 77(1), 65-73.
[http://dx.doi.org/10.1016/S0306-4522(96)00435-6] [PMID: 9044375]

Moghaddam, B. Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia. J. Neurochem., 1993, 60(5), 1650-1657.
[http://dx.doi.org/10.1111/j.1471-4159.1993.tb13387.x] [PMID: 8097232]

Martin, K.P.; Wellman, C.L. NMDA receptor blockade alters stress-induced dendritic remodeling in medial prefrontal cortex. Cereb. Cortex, 2011, 21(10), 2366-2373.
[http://dx.doi.org/10.1093/cercor/bhr021] [PMID: 21383235]

Yin, Y.; Edelman, G.M.; Vanderklish, P.W. The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes. Proc. Natl. Acad. Sci. USA, 2002, 99(4), 2368-2373.
[http://dx.doi.org/10.1073/pnas.042693699] [PMID: 11842217]

Okuno, H. Regulation and function of immediate-early genes in the brain: Beyond neuronal activity markers. Neurosci. Res., 2011, 69(3), 175-186.
[http://dx.doi.org/10.1016/j.neures.2010.12.007] [PMID: 21163309]

Hunter, C.J.; Remenyi, J.; Correa, S.A.; Privitera, L.; Reyskens, K.M.S.E.; Martin, K.J.; Toth, R.; Frenguelli, B.G.; Arthur, J.S.C. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS Open Bio, 2017, 7(6), 821-834.
[http://dx.doi.org/10.1002/2211-5463.12232] [PMID: 28593137]

Robinson, S.; Mogul, A.S.; Taylor-Yeremeeva, E.M.; Khan, A.; Tirabassi, A.D.; Wang, H.Y. Stress diminishes BDNF-stimulated TrkB signaling, TrkB-NMDA receptor linkage and neuronal activity in the rat brain. Neuroscience, 2021, 473, 142-158.
[http://dx.doi.org/10.1016/j.neuroscience.2021.07.011] [PMID: 34298123]

Messaoudi, E.; Ying, S.W.; Kanhema, T.; Croll, S.D.; Bramham, C.R. Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J. Neurosci., 2002, 22(17), 7453-7461.
[http://dx.doi.org/10.1523/JNEUROSCI.22-17-07453.2002] [PMID: 12196567]

Ying, S.W.; Futter, M.; Rosenblum, K.; Webber, M.J.; Hunt, S.P.; Bliss, T.V.P.; Bramham, C.R. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J. Neurosci., 2002, 22(5), 1532-1540.
[http://dx.doi.org/10.1523/JNEUROSCI.22-05-01532.2002] [PMID: 11880483]

Bramham, C.R.; Alme, M.N.; Bittins, M.; Kuipers, S.D.; Nair, R.R.; Pai, B.; Panja, D.; Schubert, M.; Soule, J.; Tiron, A.; Wibrand, K. The Arc of synaptic memory. Exp. Brain Res., 2010, 200(2), 125-140.
[http://dx.doi.org/10.1007/s00221-009-1959-2] [PMID: 19690847]

Bekinschtein, P.; Cammarota, M.; Katche, C.; Slipczuk, L.; Rossato, J.I.; Goldin, A.; Izquierdo, I.; Medina, J.H. BDNF is essential to promote persistence of long-term memory storage. Proc. Natl. Acad. Sci. USA, 2008, 105(7), 2711-2716.
[http://dx.doi.org/10.1073/pnas.0711863105] [PMID: 18263738]

Bramham, C.R.; Messaoudi, E. BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis. Prog. Neurobiol., 2005, 76(2), 99-125.
[http://dx.doi.org/10.1016/j.pneurobio.2005.06.003] [PMID: 16099088]

Schmidt, H.D.; Duman, R.S. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacol., 2010, 35(12), 2378-2391.
[http://dx.doi.org/10.1038/npp.2010.114]

Zhang, W.; Wu, J.; Ward, M.D.; Yang, S.; Chuang, Y.A.; Xiao, M.; Li, R.; Leahy, D.J.; Worley, P.F. Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron, 2015, 86(2), 490-500.
[http://dx.doi.org/10.1016/j.neuron.2015.03.030] [PMID: 25864631]

Dwivedi, Y.; Rizavi, H.S.; Conley, R.R.; Roberts, R.C.; Tamminga, C.A.; Pandey, G.N. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch. Gen. Psychiatry, 2003, 60(8), 804-815.
[http://dx.doi.org/10.1001/archpsyc.60.8.804] [PMID: 12912764]

Karege, F.; Vaudan, G.; Schwald, M.; Perroud, N.; La Harpe, R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res. Mol. Brain Res., 2005, 136(1-2), 29-37.
[http://dx.doi.org/10.1016/j.molbrainres.2004.12.020] [PMID: 15893584]

Thompson, R.M. Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J. Psychiatry Neurosci., 2011, 36(3), 195-203.

Nibuya, M.; Takahashi, M.; Russell, D.S.; Duman, R.S. Repeated stress increases catalytic TrkB mRNA in rat hippocampus. Neurosci. Lett., 1999, 267(2), 81-84.
[http://dx.doi.org/10.1016/S0304-3940(99)00335-3] [PMID: 10400217]

Kozlovsky, N.; Matar, M.A.; Kaplan, Z.; Kotler, M.; Zohar, J.; Cohen, H. Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response. Int. J. Neuropsychopharmacol., 2007, 10(6), 741-758.
[http://dx.doi.org/10.1017/S1461145707007560] [PMID: 17291374]

Shi, S.S.; Shao, S.; Yuan, B.; Pan, F.; Li, Z.L. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med. J., 2010, 51(5), 661-671.
[http://dx.doi.org/10.3349/ymj.2010.51.5.661] [PMID: 20635439]

Nasrallah, P.; Haidar, E.A.; Stephan, J.S.; El Hayek, L.; Karnib, N.; Khalifeh, M.; Barmo, N.; Jabre, V.; Houbeika, R.; Ghanem, A.; Nasser, J.; Zeeni, N.; Bassil, M.; Sleiman, S.F. Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling. Neurobiol. Stress, 2019, 11, 100170.
[http://dx.doi.org/10.1016/j.ynstr.2019.100170] [PMID: 31193350]

Dantzer, R.; O’Connor, J.C.; Freund, G.G.; Johnson, R.W.; Kelley, K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci., 2008, 9(1), 46-56.
[http://dx.doi.org/10.1038/nrn2297] [PMID: 18073775]

Koo, J.W.; Duman, R.S. IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. USA, 2008, 105(2), 751-756.
[http://dx.doi.org/10.1073/pnas.0708092105] [PMID: 18178625]

Miller, A.H.; Maletic, V.; Raison, C.L. Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biol. Psychiatry, 2009, 65(9), 732-741.
[http://dx.doi.org/10.1016/j.biopsych.2008.11.029] [PMID: 19150053]

Koo, J.W.; Russo, S.J.; Ferguson, D.; Nestler, E.J.; Duman, R.S. Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. USA, 2010, 107(6), 2669-2674.
[http://dx.doi.org/10.1073/pnas.0910658107] [PMID: 20133768]

Troubat, R.; Barone, P.; Leman, S.; Desmidt, T.; Cressant, A.; Atanasova, B.; Brizard, B.; El Hage, W.; Surget, A.; Belzung, C.; Camus, V. Neuroinflammation and depression: A review. Eur. J. Neurosci., 2021, 53(1), 151-171.
[http://dx.doi.org/10.1111/ejn.14720] [PMID: 32150310]

Miller, A.H.; Haroon, E.; Raison, C.L.; Felger, J.C. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress. Anxiety, 2013, 30(4), 297-306.
[http://dx.doi.org/10.1002/da.22084] [PMID: 23468190]

Barrientos, R.M.; Sprunger, D.B.; Campeau, S.; Higgins, E.A.; Watkins, L.R.; Rudy, J.W.; Maier, S.F. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience, 2003, 121(4), 847-853.
[http://dx.doi.org/10.1016/S0306-4522(03)00564-5] [PMID: 14580934]

ben Menachem-Zidon, O.; Goshen, I.; Kreisel, T.; ben Menahem, Y.; Reinhartz, E.; ben Hur, T. Intrahippocampal transplantation of transgenic neural precursor cells overexpressing Interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology, 2008, 33(9), 2251-2262.

Wu, C.W.; Chen, Y.C.; Yu, L.; Chen, H.; Jen, C.J.; Huang, A.M.; Tsai, H.J.; Chang, Y.T.; Kuo, Y.M. Treadmill exercise counteracts the suppressive effects of peripheral lipopolysaccharide on hippocampal neurogenesis and learning and memory. J. Neurochem., 2007, 103(6), 2471-2481.
[http://dx.doi.org/10.1111/j.1471-4159.2007.04987.x] [PMID: 17953674]

Ida, T.; Hara, M.; Nakamura, Y.; Kozaki, S.; Tsunoda, S.; Ihara, H. Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide. Neurosci. Lett., 2008, 432(3), 232-236.
[http://dx.doi.org/10.1016/j.neulet.2007.12.047] [PMID: 18255223]

Haydon, P.G.; Carmignoto, G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol. Rev., 2006, 86(3), 1009-1031.
[http://dx.doi.org/10.1152/physrev.00049.2005] [PMID: 16816144]

Gavillet, M.; Allaman, I.; Magistretti, P.J. Modulation of astrocytic metabolic phenotype by proinflammatory cytokines. Glia, 2008, 56(9), 975-989.
[http://dx.doi.org/10.1002/glia.20671] [PMID: 18383346]

Thornton, P.; Pinteaux, E.; Gibson, R.M.; Allan, S.M.; Rothwell, N.J. Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release. J. Neurochem., 2006, 98(1), 258-266.
[http://dx.doi.org/10.1111/j.1471-4159.2006.03872.x] [PMID: 16805812]

Pepys, M.B.; Hirschfield, G.M. C-reactive protein: A critical update. J. Clin. Invest., 2003, 111(12), 1805-1812.
[http://dx.doi.org/10.1172/JCI200318921] [PMID: 12813013]

Köhler-Forsberg, O.; Buttenschøn, H.N.; Tansey, K.E.; Maier, W.; Hauser, J.; Dernovsek, M.Z.; Henigsberg, N.; Souery, D.; Farmer, A.; Rietschel, M.; McGuffin, P.; Aitchison, K.J.; Uher, R.; Mors, O. Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. Brain Behav. Immun., 2017, 62, 344-350.
[http://dx.doi.org/10.1016/j.bbi.2017.02.020] [PMID: 28257825]

De Berardis, D.; Campanella, D.; Gambi, F.; La Rovere, R.; Carano, A.; Conti, C.M.; Silvestrini, C.; Serroni, N.; Piersanti, D.; Di Giuseppe, B.; Moschetta, F.S.; Cotellessa, C.; Fulcheri, M.; Salerno, R.M.; Ferro, F.M. The role of C-reactive protein in mood disorders. Int. J. Immunopathol. Pharmacol., 2006, 19(4), 721-725.
[http://dx.doi.org/10.1177/039463200601900402] [PMID: 17166394]

Hsuchou, H.; Kastin, A.J.; Pan, W. Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis. J. Mol. Neurosci., 2012, 47(2), 267-277.
[http://dx.doi.org/10.1007/s12031-012-9734-4]

Blossom, V.; Gokul, M.; Kumar, N.A.; Kini, R.D.; Nayak, S.; Bhagyalakshmi, K. Chronic unpredictable stress-induced inflammation and quantitative analysis of neurons of distinct brain regions in Wistar rat model of comorbid depression. Vet. World, 2020, 13(9), 1870.

Hamon, M.; Blier, P. Monoamine neurocircuitry in depression and strategies for new treatments. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2013, 45, 54-63.
[http://dx.doi.org/10.1016/j.pnpbp.2013.04.009] [PMID: 23602950]

Maddison, D.C.; Giorgini, F. The kynurenine pathway and neurodegenerative disease. Semin. Cell Dev. Biol., 2015, 40, 134-141.
[http://dx.doi.org/10.1016/j.semcdb.2015.03.002] [PMID: 25773161]

Henckens, M.J.A.G.; van der Marel, K.; van der Toorn, A.; Pillai, A.G.; Fernández, G.; Dijkhuizen, R.M.; Joëls, M. Stress-induced alterations in large-scale functional networks of the rodent brain. Neuroimage, 2015, 105, 312-322.
[http://dx.doi.org/10.1016/j.neuroimage.2014.10.037] [PMID: 25462693]

Anacker, C.; Scholz, J.; O’Donnell, K.J.; Allemang-Grand, R.; Diorio, J.; Bagot, R.C.; Nestler, E.J.; Hen, R.; Lerch, J.P.; Meaney, M.J. Neuroanatomic differences associated with stress susceptibility and resilience. Biol. Psychiatry, 2016, 79(10), 840-849.
[http://dx.doi.org/10.1016/j.biopsych.2015.08.009] [PMID: 26422005]

Magalhães, R.; Bourgin, J.; Boumezbeur, F.; Marques, P.; Bottlaender, M.; Poupon, C.; Djemaï, B.; Duchesnay, E.; Mériaux, S.; Sousa, N.; Jay, T.M.; Cachia, A. White matter changes in microstructure associated with a maladaptive response to stress in rats. Transl. Psychiatry, 2017, 7(1), e1009.
[http://dx.doi.org/10.1038/tp.2016.283] [PMID: 28117841]

Magalhães, R.; Barrière, D.A.; Novais, A.; Marques, F.; Marques, P.; Cerqueira, J.; Sousa, J.C.; Cachia, A.; Boumezbeur, F.; Bottlaender, M.; Jay, T.M.; Mériaux, S.; Sousa, N. The dynamics of stress: A longitudinal MRI study of rat brain structure and connectome. Mol. Psychiatry, 2018, 23(10), 1998-2006.
[http://dx.doi.org/10.1038/mp.2017.244] [PMID: 29203852]

Liu, X.; Yuan, J.; Guang, Y.; Wang, X.; Feng, Z. Longitudinal in vivo diffusion tensor imaging detects differential microstructural alterations in the hippocampus of chronic social defeat stress-susceptible and resilient mice. Front. Neurosci., 2018, 12, 613.
[http://dx.doi.org/10.3389/fnins.2018.00613] [PMID: 30210285]

Nagy, S.A.; Vranesics, A.; Varga, Z.; Csabai, D.; Bruszt, N.; Bali, Z.K.; Perlaki, G.; Hernádi, I.; Berente, Z.; Miseta, A.; Dóczi, T.; Czéh, B. Stress-induced microstructural alterations correlate with the cognitive performance of rats: A longitudinal in vivo diffusion tensor imaging study. Front. Neurosci., 2020, 14, 474.
[http://dx.doi.org/10.3389/fnins.2020.00474] [PMID: 32581670]

Luby, J.L.; Barch, D.; Whalen, D.; Tillman, R.; Belden, A. Association between early life adversity and risk for poor emotional and physical health in adolescence a putative mechanistic neurodevelopmental pathway. JAMA Pediatr., 2017, 171(12), 1168-1175.
[http://dx.doi.org/10.1001/jamapediatrics.2017.3009] [PMID: 29084329]

Sowell, E.R.; Peterson, B.S.; Thompson, P.M.; Welcome, S.E.; Henkenius, A.L.; Toga, A.W. Mapping cortical change across the human life span. Nat. Neurosci., 2003, 6(3), 309-315.
[http://dx.doi.org/10.1038/nn1008] [PMID: 12548289]

Sturman, D.A.; Moghaddam, B. The neurobiology of adolescence: Changes in brain architecture, functional dynamics, and behavioral tendencies. Neurosci. Biobehav. Rev., 2011, 35(8), 1704-1712.
[http://dx.doi.org/10.1016/j.neubiorev.2011.04.003] [PMID: 21527288]

Tau, G.Z.; Peterson, B.S. Normal development of brain circuits. Neuropsychopharmacology, 2010, 35(1), 147-168.
[http://dx.doi.org/10.1038/npp.2009.115] [PMID: 19794405]

Fox, S.E.; Levitt, P.; Nelson, C.A., III How the timing and quality of early experiences influence the development of brain architecture. Child Dev., 2010, 81(1), 28-40.
[http://dx.doi.org/10.1111/j.1467-8624.2009.01380.x] [PMID: 20331653]

Gogtay, N.; Giedd, J.N.; Lusk, L.; Hayashi, K.M.; Greenstein, D.; Vaituzis, A.C.; Nugent, T.F., III; Herman, D.H.; Clasen, L.S.; Toga, A.W.; Rapoport, J.L.; Thompson, P.M. Dynamic mapping of human cortical development during childhood through early adulthood. Proc. Natl. Acad. Sci. USA, 2004, 101(21), 8174-8179.
[http://dx.doi.org/10.1073/pnas.0402680101] [PMID: 15148381]

Knickmeyer, R.C.; Gouttard, S.; Kang, C.; Evans, D.; Wilber, K.; Smith, J.K.; Hamer, R.M.; Lin, W.; Gerig, G.; Gilmore, J.H. A structural MRI study of human brain development from birth to 2 years. J. Neurosci., 2008, 28(47), 12176-12182.
[http://dx.doi.org/10.1523/JNEUROSCI.3479-08.2008] [PMID: 19020011]

Kaczkurkin, A.N.; Raznahan, A.; Satterthwaite, T.D. Sex differences in the developing brain: Insights from multimodal neuroimaging. Neuropsychopharmacology, 2019, 44(1), 71-85.
[http://dx.doi.org/10.1038/s41386-018-0111-z] [PMID: 29930385]

Hart, H.; Rubia, K. Neuroimaging of child abuse: A critical review. Front. Hum. Neurosci., 2012, 6(6), 52.
[http://dx.doi.org/10.3389/fnhum.2012.00052] [PMID: 22457645]

Lupien, S.J.; McEwen, B.S.; Gunnar, M.R.; Heim, C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci., 2009, 10(6), 434-445.
[http://dx.doi.org/10.1038/nrn2639] [PMID: 19401723]

Bennett, M.; Lagopoulos, J. Stress, trauma and synaptic plasticity; Stress. Trauma Synaptic Plasticity, 2019, pp. 1-231.

McEwen, B.S.; Nasca, C.; Gray, J.D. Stress effects on neuronal structure: Hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology, 2016, 41(1), 3-23.
[http://dx.doi.org/10.1038/npp.2015.171] [PMID: 26076834]

Graham, A.M.; Doyle, O.; Tilden, E.L.; Sullivan, E.L.; Gustafsson, H.C.; Marr, M.; Allen, M.; Mackiewicz, S.K.L. Effects of maternal psychological stress during pregnancy on offspring brain development: Considering the role of inflammation and potential for preventive intervention. Biol. Psychiatry Cogn. Neurosci. Neuroimaging, 2022, 7(5), 461-470.
[http://dx.doi.org/10.1016/j.bpsc.2021.10.012] [PMID: 34718150]

De Asis-Cruz, J.; Andescavage, N.; Limperopoulos, C. Adverse prenatal exposures and fetal brain development: Insights from advanced fetal magnetic resonance imaging. Biol. Psychiatry Cogn. Neurosci. Neuroimaging, 2022, 7(5), 480-490.
[http://dx.doi.org/10.1016/j.bpsc.2021.11.009] [PMID: 34848383]

Lubczyńska, M.J.; Muetzel, R.L.; El Marroun, H.; Hoek, G.; Kooter, I.M.; Thomson, E.M.; Hillegers, M.; Vernooij, M.W.; White, T.; Tiemeier, H.; Guxens, M. Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents. Environ. Res., 2021, 198, 110446.
[http://dx.doi.org/10.1016/j.envres.2020.110446] [PMID: 33221303]

Triplett, R.L.; Lean, R.E.; Parikh, A.; Miller, J.P.; Alexopoulos, D.; Kaplan, S.; Meyer, D.; Adamson, C.; Smyser, T.A.; Rogers, C.E.; Barch, D.M.; Warner, B.; Luby, J.L.; Smyser, C.D. Association of prenatal exposure to early-life adversity with neonatal brain volumes at birth. JAMA Netw. Open, 2022, 5(4), e227045.
[http://dx.doi.org/10.1001/jamanetworkopen.2022.7045] [PMID: 35412624]

Herringa, R. J. Trauma, PTSD, and the developing brain. Curr. Psychiatry Rep., 2017, 19(10), 69.
[http://dx.doi.org/10.1007/s11920-017-0825-3] [PMID: 28823091]

Paquola, C.; Bennett, M.R.; Lagopoulos, J. Understanding heterogeneity in grey matter research of adults with childhood maltreatment-a meta-analysis and review. Neurosci. Biobehav. Rev., 2016, 69, 299-312.
[http://dx.doi.org/10.1016/j.neubiorev.2016.08.011] [PMID: 27531235]

Teicher, M.H.; Samson, J.A.; Anderson, C.M.; Ohashi, K. The effects of childhood maltreatment on brain structure, function and connectivity. Nat. Rev. Neurosci., 2016, 17(10), 652-666.
[http://dx.doi.org/10.1038/nrn.2016.111] [PMID: 27640984]

Callaghan, B.L.; Tottenham, N. The Stress Acceleration Hypothesis: Effects of early-life adversity on emotion circuits and behavior. Curr. Opin. Behav. Sci., 2016, 7, 76-81.
[http://dx.doi.org/10.1016/j.cobeha.2015.11.018] [PMID: 29644262]

Gur, R.E.; Moore, T.M.; Rosen, A.F.G.; Barzilay, R.; Roalf, D.R.; Calkins, M.E.; Ruparel, K.; Scott, J.C.; Almasy, L.; Satterthwaite, T.D.; Shinohara, R.T.; Gur, R.C. Burden of environmental adversity associated with psychopathology, maturation, and brain behavior parameters in youths. JAMA Psychiatry, 2019, 76(9), 966-975.
[http://dx.doi.org/10.1001/jamapsychiatry.2019.0943] [PMID: 31141099]

McLaughlin, K.A.; Weissman, D.; Bitrán, D. Childhood adversity and neural development: A systematic review. Ann. Rev. Develop. Psychol., 2019, 1(1), 277-312.
[http://dx.doi.org/10.1146/annurev-devpsych-121318-084950] [PMID: 32455344]

Calem, M.; Bromis, K.; McGuire, P.; Morgan, C.; Kempton, M.J. Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples. Neuroimage Clin., 2017, 14, 471-479.
[http://dx.doi.org/10.1016/j.nicl.2017.02.016] [PMID: 28275547]

Keding, T.J.; Heyn, S.A.; Russell, J.D.; Zhu, X.; Cisler, J.; McLaughlin, K.A.; Herringa, R.J. Differential patterns of delayed emotion circuit maturation in abused girls with and without internalizing psychopathology. Am. J. Psychiatry, 2021, 178(11), 1026-1036.
[http://dx.doi.org/10.1176/appi.ajp.2021.20081192] [PMID: 34407623]

Whittle, S.; Dennison, M.; Vijayakumar, N.; Simmons, J.G.; Yücel, M.; Lubman, D.I.; Pantelis, C.; Allen, N.B. Childhood maltreatment and psychopathology affect brain development during adolescence. J. Am. Acad. Child Adolesc. Psychiatry, 2013, 52(9), 940-952.e1.
[http://dx.doi.org/10.1016/j.jaac.2013.06.007] [PMID: 23972696]

Morey, R.A.; Haswell, C.C.; Hooper, S.R.; De Bellis, M.D. Amygdala, hippocampus, and ventral medial prefrontal cortex volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. Neuropsychopharmacology, 2016, 41(3), 791-801.
[http://dx.doi.org/10.1038/npp.2015.205] [PMID: 26171720]

Keding, T.J.; Herringa, R.J. Abnormal structure of fear circuitry in pediatric post-traumatic stress disorder. Neuropsychopharmacology, 2015, 40(3), 537-545.
[http://dx.doi.org/10.1038/npp.2014.239] [PMID: 25212487]

Bremner, J.D.; Vythilingam, M.; Vermetten, E.; Southwick, S.M.; McGlashan, T.; Nazeer, A.; Khan, S.; Vaccarino, L.V.; Soufer, R.; Garg, P.K.; Ng, C.K.; Staib, L.H.; Duncan, J.S.; Charney, D.S. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. Am. J. Psychiatry, 2003, 160(5), 924-932.
[http://dx.doi.org/10.1176/appi.ajp.160.5.924] [PMID: 12727697]

Whittle, S.; Lichter, R.; Dennison, M.; Vijayakumar, N.; Schwartz, O.; Byrne, M.L.; Simmons, J.G.; Yücel, M.; Pantelis, C.; McGorry, P.; Allen, N.B. Structural brain development and depression onset during adolescence: a prospective longitudinal study. Am. J. Psychiatry, 2014, 171(5), 564-571.
[http://dx.doi.org/10.1176/appi.ajp.2013.13070920] [PMID: 24577365]

Frodl, T.; Reinhold, E.; Koutsouleris, N.; Reiser, M.; Meisenzahl, E.M. Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression. J. Psychiatr. Res., 2010, 44(13), 799-807.
[http://dx.doi.org/10.1016/j.jpsychires.2010.01.006] [PMID: 20122698]

Gee, D.G.; Gabard-Durnam, L.J.; Flannery, J.; Goff, B.; Humphreys, K.L.; Telzer, E.H.; Hare, T.A.; Bookheimer, S.Y.; Tottenham, N. Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation. Proc. Natl. Acad. Sci. USA, 2013, 110(39), 15638-15643.
[http://dx.doi.org/10.1073/pnas.1307893110] [PMID: 24019460]

Rickard, I.J.; Frankenhuis, W.E.; Nettle, D. Why are childhood family factors associated with timing of maturation? a role for internal prediction. Perspect. Psychol. Sci., 2014, 9(1), 3-15.
[http://dx.doi.org/10.1177/1745691613513467] [PMID: 26173236]

Herringa, R.J.; Burghy, C.A.; Stodola, D.E.; Fox, M.E.; Davidson, R.J.; Essex, M.J. Enhanced prefrontal-amygdala connectivity following childhood adversity as a protective mechanism against internalizing in adolescence. Biol. Psychiatry Cogn. Neurosci. Neuroimaging, 2016, 1(4), 326-334.
[http://dx.doi.org/10.1016/j.bpsc.2016.03.003] [PMID: 27725969]

Luby, J.L.; Tillman, R.; Barch, D.M. Association of timing of adverse childhood experiences and caregiver support with regionally specific brain development in adolescents. JAMA Netw. Open, 2019, 2(9), e1911426-e1911426.
[http://dx.doi.org/10.1001/jamanetworkopen.2019.11426] [PMID: 31532514]

Killion, B.E.; Weyandt, L.L. Brain structure in childhood maltreatment-related PTSD across the lifespan: A systematic review. Appl. Neuropsychol. Child, 2020, 9(1), 68-82.
[http://dx.doi.org/10.1080/21622965.2018.1515076] [PMID: 30351191]

Opel, N.; Redlich, R.; Dohm, K.; Zaremba, D.; Goltermann, J.; Repple, J.; Kaehler, C.; Grotegerd, D.; Leehr, E.J.; Böhnlein, J.; Förster, K.; Meinert, S.; Enneking, V.; Sindermann, L.; Dzvonyar, F.; Emden, D.; Leenings, R.; Winter, N.; Hahn, T.; Kugel, H.; Heindel, W.; Buhlmann, U.; Baune, B.T.; Arolt, V.; Dannlowski, U. Mediation of the influence of childhood maltreatment on depression relapse by cortical structure: A 2-year longitudinal observational study. Lancet Psychiatry, 2019, 6(4), 318-326.
[http://dx.doi.org/10.1016/S2215-0366(19)30044-6] [PMID: 30904126]

Fujisawa, T.X.; Shimada, K.; Takiguchi, S.; Mizushima, S.; Kosaka, H.; Teicher, M.H. Type and timing of childhood maltreatment and reduced visual cortex volume in children and adolescents with reactive attachment disorder. Neuroimage Clin., 2018, 20, 216-221.
[http://dx.doi.org/10.1016/j.nicl.2018.07.018]

Shimada, K.; Takiguchi, S.; Mizushima, S.; Fujisawa, T.X.; Saito, D.N.; Kosaka, H.; Okazawa, H.; Tomoda, A. Reduced visual cortex grey matter volume in children and adolescents with reactive attachment disorder. Neuroimage Clin., 2015, 9, 13-19.
[http://dx.doi.org/10.1016/j.nicl.2015.07.001] [PMID: 26288752]

Madonna, D.; Delvecchio, G.; Soares, J.C.; Brambilla, P. Structural and functional neuroimaging studies in generalized anxiety disorder: A systematic review. Br. J. Psychiatry, 2019, 41(4), 336-362.
[http://dx.doi.org/10.1590/1516-4446-2018-0108] [PMID: 31116259]

Woon, F.L.; Sood, S.; Hedges, D.W. Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2010, 34(7), 1181-1188.
[http://dx.doi.org/10.1016/j.pnpbp.2010.06.016]

Rauch, S.L.; Shin, L.M.; Phelps, E.A. Neurocircuitry models of posttraumatic stress disorder and extinction: Human neuroimaging research—past, present, and future. Biol. Psychiatry, 2006, 60(4), 376-382.
[http://dx.doi.org/10.1016/j.biopsych.2006.06.004]

Shin, L.M.; Rauch, S.L.; Pitman, R.K. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. In: Ann. N. Y. Acad. Sci., 2006, 1071, 67-79.
[http://dx.doi.org/10.1196/annals.1364.007]

Tavanti, M.; Battaglini, M.; Borgogni, F.; Bossini, L.; Calossi, S.; Marino, D.; Vatti, G.; Pieraccini, F.; Federico, A.; Castrogiovanni, P.; De Stefano, N. Evidence of diffuse damage in frontal and occipital cortex in the brain of patients with post-traumatic stress disorder. Neurol. Sci., 2012, 33(1), 59-68.
[http://dx.doi.org/10.1007/s10072-011-0659-4] [PMID: 21710131]

Bossini, L.; Santarnecchi, E.; Casolaro, I.; Koukouna, D.; Caterini, C.; Cecchini, F.; Fortini, V.; Vatti, G.; Marino, D.; Fernandez, I.; Rossi, A.; Fagiolini, A. Morphovolumetric changes after EMDR treatment in drug-naïve PTSD patients. Riv. Psichiatr., 2017, 52(1), 24-31.
[PMID: 28287194]

Nardo, D.; Högberg, G.; Looi, J.C.L.; Larsson, S.; Hällström, T.; Pagani, M. Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients. J. Psychiatr. Res., 2010, 44(7), 477-485.
[http://dx.doi.org/10.1016/j.jpsychires.2009.10.014] [PMID: 19942229]

Tan, L.; Zhang, L.; Qi, R.; Lu, G.; Li, L.; Liu, J.; Li, W. Brain structure in post-traumatic stress disorder: A voxel-based morphometry analysis. Neural Regen. Res., 2013, 8(26), 2405-2414.
[PMID: 25206550]

Zhang, J.; Tan, Q.; Yin, H.; Zhang, X.; Huan, Y.; Tang, L.; Wang, H.; Xu, J.; Li, L. Decreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD. Psychiatry Res. Neuroimaging, 2011, 192(2), 84-90.
[http://dx.doi.org/10.1016/j.pscychresns.2010.09.001] [PMID: 21498053]

Del Casale, A.; Ferracuti, S.; Barbetti, A.S.; Bargagna, P.; Zega, P.; Iannuccelli, A.; Caggese, F.; Zoppi, T.; De Luca, G.P.; Parmigiani, G.; Berardelli, I.; Pompili, M. Grey matter volume reductions of the left hippocampus and amygdala in PTSD: A coordinate-based meta-analysis of magnetic resonance imaging studies. Neuropsychobiology, 2022, 81(4), 257-264.
[http://dx.doi.org/10.1159/000522003] [PMID: 35158360]

Boccia, M.; D’Amico, S.; Bianchini, F.; Marano, A.; Giannini, A.M.; Piccardi, L. Different neural modifications underpin PTSD after different traumatic events: An fMRI meta-analytic study. Brain Imaging Behav., 2016, 10(1), 226-237.
[http://dx.doi.org/10.1007/s11682-015-9387-3] [PMID: 25913645]

Baldaçara, L.; Borgio, J.G.F.; Araújo, C.; Nery-Fernandes, F.; Lacerda, A.L.T.; Moraes, W.A.S.; Montaño, M.B.M.M.; Rocha, M.; Quarantini, L.C.; Schoedl, A.; Pupo, M.; Mello, M.F.; Andreoli, S.B.; Miranda-Scippa, A.; Ramos, L.R.; Mari, J.J.; Bressan, R.A.; Jackowski, A.P. Relationship between structural abnormalities in the cerebellum and dementia, posttraumatic stress disorder and bipolar disorder. Dement. Neuropsychol., 2012, 6(4), 203-211.
[http://dx.doi.org/10.1590/S1980-57642012DN06040003] [PMID: 29213799]

Tae, W-S. Regional gray matter volume reduction associated with major depressive disorder: A voxel-based morphometry. Investig. Magn. Reson. Imaging, 2015, 19(1), 10-18.
[http://dx.doi.org/10.13104/imri.2015.19.1.10]

Vythilingam, M.; Heim, C.; Newport, J.; Miller, A.H.; Anderson, E.; Bronen, R.; Brummer, M.; Staib, L.; Vermetten, E.; Charney, D.S.; Nemeroff, C.B.; Bremner, J.D. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am. J. Psychiatry, 2002, 159(12), 2072-2080.
[http://dx.doi.org/10.1176/appi.ajp.159.12.2072] [PMID: 12450959]

Opel, N.; Redlich, R.; Zwanzger, P.; Grotegerd, D.; Arolt, V.; Heindel, W.; Konrad, C.; Kugel, H.; Dannlowski, U. Hippocampal atrophy in major depression: A function of childhood maltreatment rather than diagnosis? Neuropsychopharmacology, 2014, 39(12), 2723-2731.
[http://dx.doi.org/10.1038/npp.2014.145] [PMID: 24924799]

Soriano-Mas, C.; Hernández-Ribas, R.; Pujol, J.; Urretavizcaya, M.; Deus, J.; Harrison, B.J.; Ortiz, H.; López-Solà, M.; Menchón, J.M.; Cardoner, N. Cross-sectional and longitudinal assessment of structural brain alterations in melancholic depression. Biol. Psychiatry, 2011, 69(4), 318-325.
[http://dx.doi.org/10.1016/j.biopsych.2010.07.029] [PMID: 20875637]

Colle, R.; Dupong, I.; Colliot, O.; Deflesselle, E.; Hardy, P.; Falissard, B.; Ducreux, D.; Chupin, M.; Corruble, E. Smaller hippocampal volumes predict lower antidepressant response/remission rates in depressed patients: A meta-analysis. World J. Biol. Psychiatry, 2018, 19(5), 360-367.
[http://dx.doi.org/10.1080/15622975.2016.1208840] [PMID: 27376473]

Gyger, L.; Ramponi, C.; Mall, J.F.; Swierkosz-Lenart, K.; Stoyanov, D.; Lutti, A.; von Gunten, A.; Kherif, F.; Draganski, B. Temporal trajectory of brain tissue property changes induced by electroconvulsive therapy. Neuroimage, 2021, 232, 117895.
[http://dx.doi.org/10.1016/j.neuroimage.2021.117895] [PMID: 33617994]

Fonseka, T.M.; MacQueen, G.M.; Kennedy, S.H. Neuroimaging biomarkers as predictors of treatment outcome in major depressive disorder. J. Affect. Disord., 2018, 233, 21-35.
[http://dx.doi.org/10.1016/j.jad.2017.10.049] [PMID: 29150145]

Watanabe, K.; Kakeda, S.; Katsuki, A.; Ueda, I.; Ikenouchi, A.; Yoshimura, R.; Korogi, Y. Whole-brain structural covariance network abnormality in first-episode and drug-naïve major depressive disorder. Psychiatry Res. Neuroimaging, 2020, 300, 111083.
[http://dx.doi.org/10.1016/j.pscychresns.2020.111083] [PMID: 32298948]

Shen, Z.; Cheng, Y.; Yang, S.; Dai, N.; Ye, J.; Liu, X.; Lu, J.; Li, N.; Liu, F.; Lu, Y.; Sun, X.; Xu, X. Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset. Neuroimage Clin., 2016, 12, 492-498.
[http://dx.doi.org/10.1016/j.nicl.2016.08.016] [PMID: 27668175]

Espinoza Oyarce, D.A.; Shaw, M.E.; Alateeq, K.; Cherbuin, N. Volumetric brain differences in clinical depression in association with anxiety: A systematic review with meta-analysis. J. Psychiatry Neurosci., 2020, 45(6), 406-429.
[http://dx.doi.org/10.1503/jpn.190156] [PMID: 32726102]

Hamilton, J.P.; Siemer, M.; Gotlib, I.H. Amygdala volume in major depressive disorder: A meta-analysis of magnetic resonance imaging studies. Mol. Psychiatry, 2008, 13(11), 993-1000.
[http://dx.doi.org/10.1038/mp.2008.57] [PMID: 18504424]

Roddy, D.; Kelly, J.R.; Farrell, C.; Doolin, K.; Roman, E.; Nasa, A.; Frodl, T.; Harkin, A.; O’Mara, S.; O’Hanlon, E.; O’Keane, V. Amygdala substructure volumes in Major Depressive Disorder. Neuroimage Clin., 2021, 31, 102781.
[http://dx.doi.org/10.1016/j.nicl.2021.102781] [PMID: 34384996]

Kim, H.; Han, K.M.; Choi, K.W.; Tae, W.S.; Kang, W.; Kang, Y.; Kim, A.; Ham, B.J. Volumetric alterations in subregions of the amygdala in adults with major depressive disorder. J. Affect. Disord., 2021, 295, 108-115.
[http://dx.doi.org/10.1016/j.jad.2021.08.012] [PMID: 34419778]

Wise, T.; Radua, J.; Via, E.; Cardoner, N.; Abe, O.; Adams, T.M. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis. Mol. Psychiatry, 2015, 2016, 1-9.
[PMID: 27217146]

Jung, J.; Kang, J.; Won, E.; Nam, K.; Lee, M.S.; Tae, W.S.; Ham, B.J. Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in Major Depressive Disorder: A voxel-based morphometry study. J. Affect. Disord., 2014, 169, 179-187.
[http://dx.doi.org/10.1016/j.jad.2014.08.018] [PMID: 25200096]

Lai, C.H.; Wu, Y.T. Frontal-insula gray matter deficits in first-episode medication-naïve patients with major depressive disorder. J. Affect. Disord., 2014, 160, 74-79.
[http://dx.doi.org/10.1016/j.jad.2013.12.036] [PMID: 24445133]

Abe, O.; Yamasue, H.; Kasai, K.; Yamada, H.; Aoki, S.; Inoue, H.; Takei, K.; Suga, M.; Matsuo, K.; Kato, T.; Masutani, Y.; Ohtomo, K. Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Res. Neuroimaging, 2010, 181(1), 64-70.
[http://dx.doi.org/10.1016/j.pscychresns.2009.07.007] [PMID: 19959342]

Vasic, N.; Walter, H.; Höse, A.; Wolf, R.C. Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: A voxel-based morphometry study. J. Affect. Disord., 2008, 109(1-2), 107-116.
[http://dx.doi.org/10.1016/j.jad.2007.11.011] [PMID: 18191459]

Leung, K.K.; Lee, T.M.C.; Wong, M.M.C.; Li, L.S.W.; Yip, P.S.F.; Khong, P.L. Neural correlates of attention biases of people with major depressive disorder: A voxel-based morphometric study. Psychol. Med., 2009, 39(7), 1097-1106.
[http://dx.doi.org/10.1017/S0033291708004546] [PMID: 18945378]

Serra-Blasco, M.; Portella, M.J.; Gómez-Ansón, B.; de Diego-Adeliño, J.; Vives-Gilabert, Y.; Puigdemont, D.; Granell, E.; Santos, A.; Álvarez, E.; Pérez, V. Effects of illness duration and treatment resistance on grey matter abnormalities in majordepression. Br. J. Psychiatry, 2013, 202(6), 434-440.
[http://dx.doi.org/10.1192/bjp.bp.112.116228] [PMID: 23620451]

Chen, C.; Liu, Z.; Xi, C.; Tan, W.; Fan, Z.; Cheng, Y.; Yang, J.; Palaniyappan, L.; Yang, J. Multimetric structural covariance in first-episode major depressive disorder: A graph theoretical analysis. J. Psychiatry Neurosci., 2022, 47(3), E176-E185.
[http://dx.doi.org/10.1503/jpn.210204] [PMID: 35508328]

Kandilarova, S.; Stoyanov, D.; Sirakov, N.; Maes, M.; Specht, K. Reduced grey matter volume in frontal and temporal areas in depression: Contributions from voxel-based morphometry study. Acta Neuropsychiatr., 2019, 31(5), 252-257.
[http://dx.doi.org/10.1017/neu.2019.20] [PMID: 31234950]

Schmaal, L.; Hibar, D.P.; Sämann, P.G.; Hall, G.B.; Baune, B.T.; Jahanshad, N.; Cheung, J.W.; van Erp, T.G.M.; Bos, D.; Ikram, M.A.; Vernooij, M.W.; Niessen, W.J.; Tiemeier, H.; Hofman, A.; Wittfeld, K.; Grabe, H.J.; Janowitz, D.; Bülow, R.; Selonke, M.; Völzke, H.; Grotegerd, D.; Dannlowski, U.; Arolt, V.; Opel, N.; Heindel, W.; Kugel, H.; Hoehn, D.; Czisch, M.; Couvy-Duchesne, B.; Rentería, M.E.; Strike, L.T.; Wright, M.J.; Mills, N.T.; de Zubicaray, G.I.; McMahon, K.L.; Medland, S.E.; Martin, N.G.; Gillespie, N.A.; Goya-Maldonado, R.; Gruber, O.; Krämer, B.; Hatton, S.N.; Lagopoulos, J.; Hickie, I.B.; Frodl, T.; Carballedo, A.; Frey, E.M.; van Velzen, L.S.; Penninx, B.W.J.H.; van Tol, M-J.; van der Wee, N.J.; Davey, C.G.; Harrison, B.J.; Mwangi, B.; Cao, B.; Soares, J.C.; Veer, I.M.; Walter, H.; Schoepf, D.; Zurowski, B.; Konrad, C.; Schramm, E.; Normann, C.; Schnell, K.; Sacchet, M.D.; Gotlib, I.H.; MacQueen, G.M.; Godlewska, B.R.; Nickson, T.; McIntosh, A.M.; Papmeyer, M.; Whalley, H.C.; Hall, J.; Sussmann, J.E.; Li, M.; Walter, M.; Aftanas, L.; Brack, I.; Bokhan, N.A.; Thompson, P.M.; Veltman, D.J. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Mol. Psychiatry, 2017, 22(6), 900-909.
[http://dx.doi.org/10.1038/mp.2016.60] [PMID: 27137745]

Grieve, S.M.; Korgaonkar, M.S.; Koslow, S.H.; Gordon, E.; Williams, L.M. Widespread reductions in gray matter volume in depression. Neuroimage Clin., 2013, 3, 332-339.
[http://dx.doi.org/10.1016/j.nicl.2013.08.016] [PMID: 24273717]

Salvadore, G.; Nugent, A.C.; Lemaitre, H.; Luckenbaugh, D.A.; Tinsley, R.; Cannon, D.M.; Neumeister, A.; Zarate, C.A., Jr; Drevets, W.C. Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder. Neuroimage, 2011, 54(4), 2643-2651.
[http://dx.doi.org/10.1016/j.neuroimage.2010.11.011] [PMID: 21073959]

Machino, A.; Kunisato, Y.; Matsumoto, T.; Yoshimura, S.; Ueda, K.; Yamawaki, Y.; Okada, G.; Okamoto, Y.; Yamawaki, S. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study. J. Affect. Disord., 2014, 168, 229-235.
[http://dx.doi.org/10.1016/j.jad.2014.06.030] [PMID: 25064808]

Serra-Blasco, M.; de Diego-Adeliño, J.; Vives-Gilabert, Y.; Trujols, J.; Puigdemont, D.; Carceller-Sindreu, M.; Pérez, V.; Álvarez, E.; Portella, M.J. Naturalistic course of major depressive disorder predicted by clinical and structural neuroimaging data: A 5-Year Follow-Up. Depress. Anxiety, 2016, 33(11), 1055-1064.
[http://dx.doi.org/10.1002/da.22522] [PMID: 27159902]

Costafreda, S.G.; Chu, C.; Ashburner, J.; Fu, C.H.Y. Prognostic and diagnostic potential of the structural neuroanatomy of depression. PLoS One, 2009, 4(7), e6353.
[http://dx.doi.org/10.1371/journal.pone.0006353] [PMID: 19633718]

Caetano, S.C.; Kaur, S.; Brambilla, P.; Nicoletti, M.; Hatch, J.P.; Sassi, R.B.; Mallinger, A.G.; Keshavan, M.S.; Kupfer, D.J.; Frank, E.; Soares, J.C. Smaller cingulate volumes in unipolar depressed patients. Biol. Psychiatry, 2006, 59(8), 702-706.
[http://dx.doi.org/10.1016/j.biopsych.2005.10.011] [PMID: 16414029]

Leech, R.; Sharp, D.J. The role of the posterior cingulate cortex in cognition and disease. Brain, 2014, 137(1), 12-32.
[http://dx.doi.org/10.1093/brain/awt162] [PMID: 23869106]

Greicius, M.D.; Krasnow, B.; Reiss, A.L.; Menon, V. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proc. Natl. Acad. Sci. USA, 2003, 100(1), 253-258.
[http://dx.doi.org/10.1073/pnas.0135058100] [PMID: 12506194]

Rolls, E.T. The cingulate cortex and limbic systems for emotion, action, and memory. In: Brain Structure and Function; Springer, 2019; 224, p. 3001-18.
[http://dx.doi.org/10.1016/B978-0-444-64196-0.00002-9]

Yeh, P.H.; Zhu, H.; Nicoletti, M.A.; Hatch, J.P.; Brambilla, P.; Soares, J.C. Structural equation modeling and principal component analysis of gray matter volumes in major depressive and bipolar disorders: Differences in latent volumetric structure. Psychiatry Res. Neuroimaging, 2010, 184(3), 177-185.
[http://dx.doi.org/10.1016/j.pscychresns.2010.07.007] [PMID: 21051206]

Serra-Blasco, M.; Lam, R.W. Clinical and functional characteristics of cognitive dysfunction in major depressive disorder. In: Cognitive Dimensions of Major Depressive Disorder; Harmer, C.J.; Baune, B.T., Eds.; Oxford University Press: Oxford, 2019; pp. 45-58.
[http://dx.doi.org/10.1093/med/9780198810940.003.0005]

López-Solà, C.; Subirà, M.; Serra-Blasco, M.; Vicent-Gil, M.; Navarra-Ventura, G.; Aguilar, E.; Acebillo, S.; Palao, D.J.; Cardoner, N. Is cognitive dysfunction involved in difficult-to-treat depression? Characterizing resistance from a cognitive perspective. Eur. Psychiatry, 2020, 63(1), e74.
[http://dx.doi.org/10.1192/j.eurpsy.2020.65] [PMID: 32571441]

Serra-Blasco, M.; de Vita, S.; Rodríguez, M.R.; de Diego-Adeliño, J.; Puigdemont, D.; Martín-Blanco, A.; Pérez-Egea, R.; Molet, J.; Álvarez, E.; Pérez, V.; Portella, M.J. Cognitive functioning after deep brain stimulation in subcallosal cingulate gyrus for treatment-resistant depression: An exploratory study. Psychiatry Res., 2015, 225(3), 341-346.
[http://dx.doi.org/10.1016/j.psychres.2014.11.076] [PMID: 25592978]

Cui, L.; Wang, F.; Yin, Z.; Chang, M.; Song, Y.; Wei, Y.; Lv, J.; Zhang, Y.; Tang, Y.; Gong, X.; Xu, K. Effects of the LHPP gene polymorphism on the functional and structural changes of gray matter in major depressive disorder. Quant. Imaging Med. Surg., 2020, 10(1), 257-268.
[http://dx.doi.org/10.21037/qims.2019.12.01] [PMID: 31956547]

Gogolla, N. The insular cortex. In: Current Biology; Cell Press, 2017; 27, p. R580-6.
[http://dx.doi.org/10.1016/j.cub.2017.05.010]

Zhao, Y.; Chen, L.; Zhang, W.; Xiao, Y.; Shah, C.; Zhu, H.; Yuan, M.; Sun, H.; Yue, Q.; Jia, Z.; Zhang, W.; Kuang, W.; Gong, Q.; Lui, S. Gray matter abnormalities in non-comorbid medication-naive patients with major depressive disorder or social anxiety disorder. EBioMedicine, 2017, 21, 228-235.
[http://dx.doi.org/10.1016/j.ebiom.2017.06.013] [PMID: 28633986]

Zhang, Y.; Yang, Y.; Zhu, L.; Zhu, Q.; Jia, Y.; Zhang, L. Volumetric deficit within the fronto-limbic-striatal circuit in first-episode drug naïve patients with major depression disorder. Front. Psychiatry, 2021, 11, 1623.

Ge, R.; Hassel, S.; Arnott, S.R.; Davis, A.D.; Harris, J.K.; Zamyadi, M.; Milev, R.; Frey, B.N.; Strother, S.C.; Müller, D.J.; Rotzinger, S.; MacQueen, G.M.; Kennedy, S.H.; Lam, R.W.; Vila-Rodriguez, F. Structural covariance pattern abnormalities of insula in major depressive disorder: A CAN-BIND study report. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2021, 111, 110194.
[http://dx.doi.org/10.1016/j.pnpbp.2020.110194] [PMID: 33296696]

Yang, J.; Yin, Y.; Svob, C.; Long, J.; He, X.; Zhang, Y.; Xu, Z.; Li, L.; Liu, J.; Dong, J.; Zhang, Z.; Wang, Z.; Yuan, Y. Amygdala atrophy and its functional disconnection with the cortico-striatal-pallidal-thalamic circuit in major depressive disorder in females. PLoS One, 2017, 12(1), e0168239.
[http://dx.doi.org/10.1371/journal.pone.0168239] [PMID: 28107446]

Wise, T.; Radua, J.; Nortje, G.; Cleare, A.J.; Young, A.H.; Arnone, D. Voxel-based meta-Analytical evidence of structural disconnectivity in major depression and bipolar disorder. Biol. Psychiatry, 2016, 79(4), 293-302.
[http://dx.doi.org/10.1016/j.biopsych.2015.03.004] [PMID: 25891219]

Peng, J.; Liu, J.; Nie, B.; Li, Y.; Shan, B.; Wang, G.; Li, K. Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: A voxel-based morphometry study. Eur. J. Radiol., 2011, 80(2), 395-399.
[http://dx.doi.org/10.1016/j.ejrad.2010.04.006] [PMID: 20466498]

Lee, H.Y.; Tae, W.S.; Yoon, H.K.; Lee, B.T.; Paik, J.W.; Son, K.R.; Oh, Y.W.; Lee, M.S.; Ham, B.J. Demonstration of decreased gray matter concentration in the midbrain encompassing the dorsal raphe nucleus and the limbic subcortical regions in major depressive disorder: An optimized voxel-based morphometry study. J. Affect. Disord., 2011, 133(1-2), 128-136.
[http://dx.doi.org/10.1016/j.jad.2011.04.006] [PMID: 21546094]

Han, S.; Zheng, R.; Li, S.; Liu, L.; Wang, C.; Jiang, Y.; Wen, M.; Zhou, B.; Wei, Y.; Pang, J.; Li, H.; Zhang, Y.; Chen, Y.; Cheng, J. Progressive brain structural abnormality in depression assessed with MR imaging by using causal network analysis. Psychol. Med., 2023, 53(5), 2146-2155.
[http://dx.doi.org/10.1017/S0033291721003986] [PMID: 34583785]

Depping, M.S.; Schmitgen, M.M.; Kubera, K.M.; Wolf, R.C. Cerebellar Contributions to Major Depression; Frontiers in Psychiatry. Frontiers Media S.A., 2018, 9, 634.

Friedman, M.J.; Resick, P.A.; Bryant, R.A.; Strain, J.; Horowitz, M.; Spiegel, D. Classification of trauma and stressor-related disorders in DSM-5. Depress. Anxiety, 2011, 28(9), 737-749.
[http://dx.doi.org/10.1002/da.20845] [PMID: 21681870]

Bandelow, B.; Baldwin, D.; Abelli, M.; Altamura, C.; Dell’Osso, B.; Domschke, K.; Fineberg, N.A.; Grünblatt, E.; Jarema, M.; Maron, E.; Nutt, D.; Pini, S.; Vaghi, M.M.; Wichniak, A.; Zai, G.; Riederer, P. Biological markers for anxiety disorders, OCD and PTSD-a consensus statement. Part I: Neuroimaging and genetics. World J. Biol. Psychiatry, 2016, 17(5), 321-365.
[http://dx.doi.org/10.1080/15622975.2016.1181783] [PMID: 27403679]

Norton, P.J.; Paulus, D.J. Transdiagnostic models of anxiety disorder: Theoretical and empirical underpinnings. Clin. Psychol. Rev., 2017, 56, 122-137.
[http://dx.doi.org/10.1016/j.cpr.2017.03.004] [PMID: 28450042]

Hur, J.; Smith, J.F.; DeYoung, K.A.; Anderson, A.S.; Kuang, J.; Kim, H.C.; Tillman, R.M.; Kuhn, M.; Fox, A.S.; Shackman, A.J. Anxiety and the neurobiology of temporally uncertain threat anticipation. J. Neurosci., 2020, 40(41), 7949-7964.
[http://dx.doi.org/10.1523/JNEUROSCI.0704-20.2020] [PMID: 32958570]

Chen, Y.H.; Wu, J.L.; Hu, N.Y.; Zhuang, J.P.; Li, W.P.; Zhang, S.R.; Li, X.W.; Yang, J.M.; Gao, T.M. Distinct projections from the infralimbic cortex exert opposing effects in modulating anxiety and fear. J. Clin. Invest., 2021, 131(14), e145692.
[http://dx.doi.org/10.1172/JCI145692] [PMID: 34263737]

Huggins, A.A.; Weis, C.N.; Parisi, E.A.; Bennett, K.P.; Miskovic, V.; Larson, C.L. Neural substrates of human fear generalization: A 7T-fMRI investigation. Neuroimage, 2021, 239, 118308.
[http://dx.doi.org/10.1016/j.neuroimage.2021.118308] [PMID: 34175426]

Sangha, S.; Diehl, M.M.; Bergstrom, H.C.; Drew, M.R. Know safety, no fear. Neurosci. Biobehav. Rev., 2020, 108, 218-230.
[http://dx.doi.org/10.1016/j.neubiorev.2019.11.006] [PMID: 31738952]

Bian, X.L.; Qin, C.; Cai, C.Y.; Zhou, Y.; Tao, Y.; Lin, Y.H.; Wu, H.Y.; Chang, L.; Luo, C.X.; Zhu, D.Y. Anterior cingulate cortex to ventral hippocampus circuit mediates contextual fear generalization. J. Neurosci., 2019, 39(29), 5728-5739.
[http://dx.doi.org/10.1523/JNEUROSCI.2739-18.2019] [PMID: 31097621]

Mah, L.; Szabuniewicz, C.; Fiocco, A.J. Can anxiety damage the brain? Curr. Opin. Psychiatry, 2016, 29(1), 56-63.
[http://dx.doi.org/10.1097/YCO.0000000000000223] [PMID: 26651008]

Kolesar, T.A.; Bilevicius, E.; Wilson, A.D.; Kornelsen, J. Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging. Neuroimage Clin., 2019, 24, 102016.
[http://dx.doi.org/10.1016/j.nicl.2019.102016] [PMID: 31835287]

Moon, C.M.; Jeong, G.W. Abnormalities in gray and white matter volumes associated with explicit memory dysfunction in patients with generalized anxiety disorder. Acta Radiol., 2017, 58(3), 353-361.
[http://dx.doi.org/10.1177/0284185116649796] [PMID: 27273376]

Chen, Y.; Cui, Q.; Fan, Y.S.; Guo, X.; Tang, Q.; Sheng, W.; Lei, T.; Li, D.; Lu, F.; He, Z.; Yang, Y.; Hu, S.; Deng, J.; Chen, H. Progressive brain structural alterations assessed via causal analysis in patients with generalized anxiety disorder. Neuropsychopharmacology, 2020, 45(10), 1689-1697.
[http://dx.doi.org/10.1038/s41386-020-0704-1] [PMID: 32396920]

Takaishi, M.; Asami, T.; Yoshida, H.; Nakamura, R.; Yoshimi, A.; Hirayasu, Y. Smaller volume of right hippocampal CA2/3 in patients with panic disorder. Brain Imaging Behav., 2021, 15(1), 320-326.
[http://dx.doi.org/10.1007/s11682-020-00259-w] [PMID: 32125615]

Sheng, L.Q.; Ma, H.R.; Yao, L.Z.; Dai, Z.Y. Consistent brain grey matter volume alterations in adult patients with panic disorder and social anxiety disorder revisited. J. Affect. Disord., 2020, 2021(286), 120-122.

Wang, X.; Cheng, B.; Wang, S.; Lu, F.; Luo, Y.; Long, X.; Kong, D. Distinct grey matter volume alterations in adult patients with panic disorder and social anxiety disorder: A systematic review and voxel-based morphometry meta-analysis. J. Affect. Disord., 2021, 281(8), 805-823.
[http://dx.doi.org/10.1016/j.jad.2020.11.057] [PMID: 33243552]

Rauch, S.L.; Shin, L.M.; Wright, C. Neuroimaging studies of amygdala function in anxiety disorders. Ann. N. Y. Acad. Sci., 2003, 985(1), 389-410.
[http://dx.doi.org/10.1111/j.1749-6632.2003.tb07096.x] [PMID: 12724173]

Etkin, A.; Wager, T.D. Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry, 2007, 164(10), 1476-1488.
[http://dx.doi.org/10.1176/appi.ajp.2007.07030504] [PMID: 17898336]

Davis, M. The role of the amygdala in fear and anxiety. Annu. Rev. Neurosci., 1992, 15(1), 353-375.
[http://dx.doi.org/10.1146/annurev.ne.15.030192.002033] [PMID: 1575447]

Britton, J.C.; Rauch, S.L. Neuroanatomy and Neuroimaging of Anxiety Disorders; Oxford Handbook of Anxiety and Related Disorders, 2018.

Massana, G.; Serra-Grabulosa, J.M.; Salgado-Pineda, P.; Gastó, C.; Junqué, C.; Massana, J.; Mercader, J.M.; Gómez, B.; Tobeña, A.; Salamero, M. Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging. Neuroimage, 2003, 19(1), 80-90.
[http://dx.doi.org/10.1016/S1053-8119(03)00036-3] [PMID: 12781728]

Asami, T.; Yamasue, H.; Hayano, F.; Nakamura, M.; Uehara, K.; Otsuka, T.; Roppongi, T.; Nihashi, N.; Inoue, T.; Hirayasu, Y. Sexually dimorphic gray matter volume reduction in patients with panic disorder. Psychiatry Res. Neuroimaging, 2009, 173(2), 128-134.
[http://dx.doi.org/10.1016/j.pscychresns.2008.10.004] [PMID: 19560907]

Asami, T.; Nakamura, R.; Takaishi, M.; Yoshida, H.; Yoshimi, A.; Whitford, T.J. Smaller volumes in the lateral and basal nuclei of the amygdala in patients with panic disorder. PLoS One, 2018, 13(11), e0207163.
[http://dx.doi.org/10.1371/journal.pone.0207163]

Hayano, F.; Nakamura, M.; Asami, T.; Uehara, K.; Yoshida, T.; Roppongi, T.; Otsuka, T.; Inoue, T.; Hirayasu, Y. Smaller amygdala is associated with anxiety in patients with panic disorder. Psychiatry Clin. Neurosci., 2009, 63(3), 266-276.
[http://dx.doi.org/10.1111/j.1440-1819.2009.01960.x] [PMID: 19566756]

Kunas, S.L.; Hilbert, K.; Yang, Y.; Richter, J.; Hamm, A.; Wittmann, A.; Ströhle, A.; Pfleiderer, B.; Herrmann, M.J.; Lang, T.; Lotze, M.; Deckert, J.; Arolt, V.; Wittchen, H.U.; Straube, B.; Kircher, T.; Gerlach, A.L.; Lueken, U. The modulating impact of cigarette smoking on brain structure in panic disorder: A voxel-based morphometry study. Soc. Cogn. Affect. Neurosci., 2020, 15(8), 849-859.
[http://dx.doi.org/10.1093/scan/nsaa103] [PMID: 32734299]

Hilbert, K.; Lueken, U.; Beesdo-Baum, K. Neural structures, functioning and connectivity in Generalized Anxiety Disorder and interaction with neuroendocrine systems: A systematic review. J. Affect. Disord., 2014, 158, 114-126.
[http://dx.doi.org/10.1016/j.jad.2014.01.022] [PMID: 24655775]

Makovac, E.; Meeten, F.; Watson, D.R.; Garfinkel, S.N.; Critchley, H.D.; Ottaviani, C. Neurostructural abnormalities associated with axes of emotion dysregulation in generalized anxiety. Neuroimage Clin., 2016, 10, 172-181.
[http://dx.doi.org/10.1016/j.nicl.2015.11.022] [PMID: 26759791]

Ma, Z.; Wang, C.; Hines, C.S.; Lu, X.; Wu, Y.; Xu, H.; Li, J.; Wang, Q.; Pang, M.; Zhong, Y.; Zhang, N. Frontoparietal network abnormalities of gray matter volume and functional connectivity in patients with generalized anxiety disorder. Psychiatry Res. Neuroimaging, 2019, 286, 24-30.
[http://dx.doi.org/10.1016/j.pscychresns.2019.03.001] [PMID: 30877889]

Bas-Hoogendam, J.M.; van Steenbergen, H.; Tissier, R.L.M.; Houwing-Duistermaat, J.J.; Westenberg, P.M.; van der Wee, N.J.A. Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder - A multiplex multigenerational neuroimaging study. EBioMedicine, 2018, 36, 410-428.
[http://dx.doi.org/10.1016/j.ebiom.2018.08.048] [PMID: 30266294]

Fisler, M.S.; Federspiel, A.; Horn, H.; Dierks, T.; Schmitt, W.; Wiest, R.; de Quervain, D.J.F.; Soravia, L.M. Spider phobia is associated with decreased left amygdala volume: A cross-sectional study. BMC Psychiatry, 2013, 13(1), 70.
[http://dx.doi.org/10.1186/1471-244X-13-70] [PMID: 23442196]

Hilbert, K.; Evens, R.; Isabel, M.N.; Wittchen, H.U.; Lueken, U. Neurostructural correlates of two subtypes of specific phobia: A voxel-based morphometry study. Psychiatry Res. Neuroimaging, 2015, 231(2), 168-175.
[http://dx.doi.org/10.1016/j.pscychresns.2014.12.003] [PMID: 25561374]

Linares, I.M.P.; Jackowski, A.P.; Trzesniak, C.M.F.; Arrais, K.C.; Chagas, M.H.N.; Sato, J.R.; Santos, A.C.; Hallak, J.E.C.; Zuardi, A.W.; Nardi, A.E.; Coimbra, N.C.; Crippa, J.A.S. Cortical thinning of the right anterior cingulate cortex in spider phobia: A magnetic resonance imaging and spectroscopy study. Brain Res., 2014, 1576, 35-42.
[http://dx.doi.org/10.1016/j.brainres.2014.05.040] [PMID: 24892191]

Rauch, S.L.; Wright, C.I.; Martis, B.; Busa, E.; McMullin, K.G.; Shin, L.M.; Dale, A.M.; Fischl, B. A magnetic resonance imaging study of cortical thickness in animal phobia. Biol. Psychiatry, 2004, 55(9), 946-952.
[http://dx.doi.org/10.1016/j.biopsych.2003.12.022] [PMID: 15110739]

Fareri, D.S.; Tottenham, N. Effects of early life stress on amygdala and striatal development. Dev. Cogn. Neurosci., 2016, 19, 233-247.
[http://dx.doi.org/10.1016/j.dcn.2016.04.005] [PMID: 27174149]

Brandl, F.; Weise, B.; Mulej Bratec, S.; Jassim, N.; Hoffmann, A.D.; Bertram, T.; Ploner, M.; Sorg, C. Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: A transdiagnostic multimodal meta-analysis of structural and functional MRI studies. Neuropsychopharmacology, 2022, 47(5), 1071-1080.
[http://dx.doi.org/10.1038/s41386-022-01271-y] [PMID: 35058584]

Adhikari, A.; Lerner, T.N.; Finkelstein, J.; Pak, S.; Jennings, J.H.; Davidson, T.J.; Ferenczi, E.; Gunaydin, L.A.; Mirzabekov, J.J.; Ye, L.; Kim, S.Y.; Lei, A.; Deisseroth, K. Basomedial amygdala mediates top-down control of anxiety and fear. Nature, 2015, 527(7577), 179-185.
[http://dx.doi.org/10.1038/nature15698] [PMID: 26536109]

Shiba, Y.; Santangelo, A.M.; Roberts, A.C.; Adhikari, A.; Bissonette, G.B. Rudebeck, pH beyond the medial regions of prefrontal cortex in the regulation of fear and anxiety. Front. Syst. Neurosci., 2016, 10, 12.
[http://dx.doi.org/10.3389/fnsys.2016.00012]

Duval, E.R.; Javanbakht, A.; Liberzon, I. Neural circuits in anxiety and stress disorders: A focused review. Ther. Clin. Risk Manag., 2015, 11, 115-126.
[PMID: 25670901]

Cho, J.H.; Deisseroth, K.; Bolshakov, V.Y. Synaptic encoding of fear extinction in mPFC-amygdala circuits. Neuron, 2013, 80(6), 1491-1507.
[http://dx.doi.org/10.1016/j.neuron.2013.09.025] [PMID: 24290204]

Schiller, D.; Delgado, M.R. Overlapping neural systems mediating extinction, reversal and regulation of fear. Trends Cogn. Sci., 2010, 14(6), 268-276.
[http://dx.doi.org/10.1016/j.tics.2010.04.002] [PMID: 20493762]

Wang, H.Y.; Zhang, X.X.; Si, C.P.; Xu, Y.; Liu, Q.; Bian, H.T.; Zhang, B.W.; Li, X.L.; Yan, Z.R. Prefrontoparietal dysfunction during emotion regulation in anxiety disorder: A meta-analysis of functional magnetic resonance imaging studies. Neuropsychiatr. Dis. Treat., 2018, 14, 1183-1198.
[http://dx.doi.org/10.2147/NDT.S165677] [PMID: 29785110]

Killgore, W.D.S.; Britton, J.C.; Schwab, Z.J.; Price, L.M.; Weiner, M.R.; Gold, A.L.; Rosso, I.M.; Simon, N.M.; Pollack, M.H.; Rauch, S.L. Cortico-limbic responses to masked affective faces across ptsd, panic disorder, and specific phobia. Depress. Anxiety, 2014, 31(2), 150-159.
[http://dx.doi.org/10.1002/da.22156] [PMID: 23861215]

Liu, W.Z.; Zhang, W.H.; Zheng, Z.H.; Zou, J.X.; Liu, X.X.; Huang, S.H.; You, W.J.; He, Y.; Zhang, J.Y.; Wang, X.D.; Pan, B.X. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nat. Commun., 2020, 11(1), 2221.
[http://dx.doi.org/10.1038/s41467-020-15920-7] [PMID: 32376858]

Shang, J.; Fu, Y.; Ren, Z.; Zhang, T.; Du, M.; Gong, Q.; Lui, S.; Zhang, W. The common traits of the ACC and PFC in anxiety disorders in the DSM-5: Meta-analysis of voxel-based morphometry studies. PLoS One, 2014, 9(3), e93432.
[http://dx.doi.org/10.1371/journal.pone.0093432] [PMID: 24676455]

Li, H.; Zhang, B.; Hu, Q.; Zhang, L.; Jin, Y.; Wang, J.; Cui, H.; Pang, J.; Li, C. Altered heartbeat perception sensitivity associated with brain structural alterations in generalised anxiety disorder. Gen. Psychiatr., 2020, 33(1), e100057.
[http://dx.doi.org/10.1136/gpsych-2019-100057] [PMID: 32175522]

Andreescu, C.; Tudorascu, D.; Sheu, L.K.; Rangarajan, A.; Butters, M.A.; Walker, S.; Berta, R.; Desmidt, T.; Aizenstein, H. Brain structural changes in late-life generalized anxiety disorder. Psychiatry Res. Neuroimaging, 2017, 268(23), 15-21.
[http://dx.doi.org/10.1016/j.pscychresns.2017.08.004] [PMID: 28837828]

Harrewijn, A.; Cardinale, E.M.; Groenewold, N.A.; Bas-Hoogendam, J.M.; Aghajani, M.; Hilbert, K.; Cardoner, N.; Porta-Casteràs, D.; Gosnell, S.; Salas, R.; Jackowski, A.P.; Pan, P.M.; Salum, G.A.; Blair, K.S.; Blair, J.R.; Hammoud, M.Z.; Milad, M.R.; Burkhouse, K.L.; Phan, K.L.; Schroeder, H.K.; Strawn, J.R.; Beesdo-Baum, K.; Jahanshad, N.; Thomopoulos, S.I.; Buckner, R.; Nielsen, J.A.; Smoller, J.W.; Soares, J.C.; Mwangi, B.; Wu, M.J.; Zunta-Soares, G.B.; Assaf, M.; Diefenbach, G.J.; Brambilla, P.; Maggioni, E.; Hofmann, D.; Straube, T.; Andreescu, C.; Berta, R.; Tamburo, E.; Price, R.B.; Manfro, G.G.; Agosta, F.; Canu, E.; Cividini, C.; Filippi, M. Kostić M.; Munjiza Jovanovic, A.; Alberton, B.A.V.; Benson, B.; Freitag, G.F.; Filippi, C.A.; Gold, A.L.; Leibenluft, E.; Ringlein, G.V.; Werwath, K.E.; Zwiebel, H.; Zugman, A.; Grabe, H.J.; Van der Auwera, S.; Wittfeld, K.; Völzke, H.; Bülow, R.; Balderston, N.L.; Ernst, M.; Grillon, C.; Mujica-Parodi, L.R.; van Nieuwenhuizen, H.; Critchley, H.D.; Makovac, E.; Mancini, M.; Meeten, F.; Ottaviani, C.; Ball, T.M.; Fonzo, G.A.; Paulus, M.P.; Stein, M.B.; Gur, R.E.; Gur, R.C.; Kaczkurkin, A.N.; Larsen, B.; Satterthwaite, T.D.; Harper, J.; Myers, M.; Perino, M.T.; Sylvester, C.M.; Yu, Q.; Lueken, U.; Veltman, D.J.; Thompson, P.M.; Stein, D.J.; Van der Wee, N.J.A.; Winkler, A.M.; Pine, D.S. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Transl. Psychiatry, 2021, 11(1), 502.
[http://dx.doi.org/10.1038/s41398-021-01622-1] [PMID: 34599145]

Na, K.S.; Ham, B.J.; Lee, M.S.; Kim, L.; Kim, Y.K.; Lee, H.J.; Yoon, H.K. Decreased gray matter volume of the medial orbitofrontal cortex in panic disorder with agoraphobia: A preliminary study. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2013, 45, 195-200.
[http://dx.doi.org/10.1016/j.pnpbp.2013.04.014] [PMID: 23628432]

Uchida, R.R.; Del-Ben, C.M.; Busatto, G.F.; Duran, F.L.S.; Guimarães, F.S.; Crippa, J.A.S.; Araújo, D.; Santos, A.C.; Graeff, F.G. Regional gray matter abnormalities in panic disorder: A voxel-based morphometry study. Psychiatry Res. Neuroimaging, 2008, 163(1), 21-29.
[http://dx.doi.org/10.1016/j.pscychresns.2007.04.015] [PMID: 18417322]

Ni, M.F.; Wang, X.M.; Wang, H.Y.; Chang, Y.; Huang, X.F.; Zhang, B.W. Regional cortical thinning and cerebral hypoperfusion in patients with panic disorder. J. Affect. Disord., 2020, 277, 138-145.
[http://dx.doi.org/10.1016/j.jad.2020.07.139] [PMID: 32828000]

Liao, W.; Xu, Q.; Mantini, D.; Ding, J.; Machado-de-Sousa, J.P.; Hallak, J.E.C.; Trzesniak, C.; Qiu, C.; Zeng, L.; Zhang, W.; Crippa, J.A.S.; Gong, Q.; Chen, H. Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Res., 2011, 1388, 167-177.
[http://dx.doi.org/10.1016/j.brainres.2011.03.018] [PMID: 21402057]

Zhang, X.; Luo, Q.; Wang, S.; Qiu, L.; Pan, N.; Kuang, W.; Lui, S.; Huang, X.; Yang, X.; Kemp, G.J.; Gong, Q. Dissociations in cortical thickness and surface area in non-comorbid never-treated patients with social anxiety disorder. EBioMedicine, 2020, 58, 102910.
[http://dx.doi.org/10.1016/j.ebiom.2020.102910] [PMID: 32739867]

Bas-Hoogendam, J.M.; van Steenbergen, H.; Nienke Pannekoek, J.; Fouche, J.P.; Lochner, C.; Hattingh, C.J.; Cremers, H.R.; Furmark, T.; Månsson, K.N.T.; Frick, A.; Engman, J.; Boraxbekk, C.J.; Carlbring, P.; Andersson, G.; Fredrikson, M.; Straube, T.; Peterburs, J.; Klumpp, H.; Phan, K.L.; Roelofs, K.; Veltman, D.J.; van Tol, M.J.; Stein, D.J.; van der Wee, N.J.A. Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. Neuroimage Clin., 2017, 16, 678-688.
[http://dx.doi.org/10.1016/j.nicl.2017.08.001] [PMID: 30140607]

Lai, C.H.; Wu, Y.T. The gray matter alterations in major depressive disorder and panic disorder: Putative differences in the pathogenesis. J. Affect. Disord., 2015, 186, 1-6.
[http://dx.doi.org/10.1016/j.jad.2015.07.022] [PMID: 26208214]

Atmaca, M.; Koc, M.; Mermi, O.; Korkmaz, S.; Aslan, S.; Yildirim, H. Insula volumes are altered in patients with social anxiety disorder. Behav. Brain Res., 2021, 400, 113012.
[http://dx.doi.org/10.1016/j.bbr.2020.113012] [PMID: 33181184]

Kawaguchi, A.; Nemoto, K.; Nakaaki, S.; Kawaguchi, T.; Kan, H.; Arai, N.; Shiraishi, N.; Hashimoto, N.; Akechi, T. Insular volume reduction in patients with social anxiety disorder. Front. Psychiatry, 2016, 7, 3.
[http://dx.doi.org/10.3389/fpsyt.2016.00003] [PMID: 26834652]

Syal, S.; Hattingh, C.J.; Fouché, J.P.; Spottiswoode, B.; Carey, P.D.; Lochner, C.; Stein, D.J. Grey matter abnormalities in social anxiety disorder: A pilot study. Metab. Brain Dis., 2012, 27(3), 299-309.
[http://dx.doi.org/10.1007/s11011-012-9299-5] [PMID: 22527992]

Marchand, W.R. Cortico-basal ganglia circuitry: A review of key research and implications for functional connectivity studies of mood and anxiety disorders. Brain Struct. Funct., 2010, 215(2), 73-96.
[http://dx.doi.org/10.1007/s00429-010-0280-y] [PMID: 20938681]

Zhang, X.; Suo, X.; Yang, X.; Lai, H.; Pan, N.; He, M.; Li, Q.; Kuang, W.; Wang, S.; Gong, Q. Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder. Transl. Psychiatry, 2022, 12(1), 26.
[http://dx.doi.org/10.1038/s41398-022-01791-7] [PMID: 35064097]

Yoo, H.K.; Kim, M.J.; Kim, S.J.; Sung, Y.H.; Sim, M.E.; Lee, Y.S.; Song, S.Y.; Kee, B.S.; Lyoo, I.K. Putaminal gray matter volume decrease in panic disorder: An optimized voxel-based morphometry study. Eur. J. Neurosci., 2005, 22(8), 2089-2094.
[http://dx.doi.org/10.1111/j.1460-9568.2005.04394.x] [PMID: 16262646]

Yoshida, H.; Asami, T.; Takaishi, M.; Nakamura, R.; Yoshimi, A.; Whitford, T.J.; Hirayasu, Y. Structural abnormalities in nucleus accumbens in patients with panic disorder. J. Affect. Disord., 2020, 271, 201-206.
[http://dx.doi.org/10.1016/j.jad.2020.03.172] [PMID: 32479317]

Wang, X.; Cheng, B.; Luo, Q.; Qiu, L.; Wang, S. Gray matter structural alterations in social anxiety disorder: A voxel-based meta-analysis. Front. Psychiatry, 2018, 9, 449.
[http://dx.doi.org/10.3389/fpsyt.2018.00449] [PMID: 30298028]

Asami, T.; Yoshida, H.; Takaishi, M.; Nakamura, R.; Yoshimi, A.; Whitford, T.J.; Hirayasu, Y. Thalamic shape and volume abnormalities in female patients with panic disorder. PLoS One, 2018, 13(12), 1-12.
[http://dx.doi.org/10.1371/journal.pone.0208152]

Talati, A.; Pantazatos, S.P.; Schneier, F.R.; Weissman, M.M.; Hirsch, J. Gray matter abnormalities in social anxiety disorder: Primary, replication, and specificity studies. Biol. Psychiatry, 2013, 73(1), 75-84.
[http://dx.doi.org/10.1016/j.biopsych.2012.05.022] [PMID: 22748614]

Tükel, R. Aydın, K.; Yüksel, Ç.; Ertekin, E.; Koyuncu, A.; Taş C. Gray matter abnormalities in patients with social anxiety disorder: A voxel-based morphometry study. Psychiatry Res. Neuroimaging, 2015, 234(1), 106-112.
[http://dx.doi.org/10.1016/j.pscychresns.2015.09.003] [PMID: 26371455]

Pujol, J.; Harrison, B.J.; Ortiz, H.; Deus, J.; Soriano-Mas, C.; López-Solà, M.; Yücel, M.; Perich, X.; Cardoner, N. Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. Psychol. Med., 2009, 39(7), 1177-1187.
[http://dx.doi.org/10.1017/S003329170800500X] [PMID: 19154647]

Cuthbert, B.N.; Insel, T.R. Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Med., 2013, 11(1), 126.
[http://dx.doi.org/10.1186/1741-7015-11-126] [PMID: 23672542]

Howard, D.M.; Adams, M.J.; Clarke, T.K.; Hafferty, J.D.; Gibson, J.; Shirali, M.; Coleman, J.R.I.; Hagenaars, S.P.; Ward, J.; Wigmore, E.M.; Alloza, C.; Shen, X.; Barbu, M.C.; Xu, E.Y.; Whalley, H.C.; Marioni, R.E.; Porteous, D.J.; Davies, G.; Deary, I.J.; Hemani, G.; Berger, K.; Teismann, H.; Rawal, R.; Arolt, V.; Baune, B.T.; Dannlowski, U.; Domschke, K.; Tian, C.; Hinds, D.A.; Trzaskowski, M.; Byrne, E.M.; Ripke, S.; Smith, D.J.; Sullivan, P.F.; Wray, N.R.; Breen, G.; Lewis, C.M.; McIntosh, A.M. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat. Neurosci., 2019, 22(3), 343-352.
[http://dx.doi.org/10.1038/s41593-018-0326-7] [PMID: 30718901]

Schiele, M.A.; Gottschalk, M.G.; Domschke, K. The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention. Clin. Psychol. Rev., 2020, 77, 101830.
[http://dx.doi.org/10.1016/j.cpr.2020.101830] [PMID: 32163803]

Pfeiffer, J.R.; Mutesa, L.; Uddin, M. Traumatic stress epigenetics. Curr. Behav. Neurosci. Rep., 2018, 5(1), 81-93.
[http://dx.doi.org/10.1007/s40473-018-0143-z]

Jawaid, A.; Roszkowski, M.; Mansuy, I.M. Transgenerational epigenetics of traumatic stress. Prog. Mol. Biol. Transl. Sci., 2018, 158, 273-298.
[http://dx.doi.org/10.1016/bs.pmbts.2018.03.003]

Dupont, C.; Armant, D.; Brenner, C. Epigenetics: Definition, mechanisms and clinical perspective. Semin. Reprod. Med., 2009, 27(5), 351-357.
[http://dx.doi.org/10.1055/s-0029-1237423] [PMID: 19711245]

Zugman, A.; Harrewijn, A.; Cardinale, E.M.; Zwiebel, H.; Freitag, G.F.; Werwath, K.E. Mega-analysis methods in enigma: The experience of the generalized anxiety disorder working group. Hum. Brain Mapp., 2020, 1-23.
[PMID: 32596977]

Lijffijt, M.; Green, C.E.; Balderston, N.; Iqbal, T.; Atkinson, M. Vo-Le, Brittany, B.; Vo-Le, Bylinda, B.; O’Brien, B.; Grillon, C.; Swann, A.C.; Mathew, S.J. A proof-of-mechanism study to test effects of the NMDA receptor antagonist lanicemine on behavioral sensitization in individuals with symptoms of PTSD. Front. Psychiatry, 2019, 10, 846.
[http://dx.doi.org/10.3389/fpsyt.2019.00846] [PMID: 31920733]

Newport, D.J.; Carpenter, L.L.; McDonald, W.M.; Potash, J.B.; Tohen, M.; Nemeroff, C.B. Ketamine and other NMDA antagonists: Early clinical trials and possible mechanisms in depression. Am. J. Psychiatry, 2015, 172(10), 950-966.
[http://dx.doi.org/10.1176/appi.ajp.2015.15040465] [PMID: 26423481]

Ates-Alagoz, Z.; Adejare, A. NMDA receptor antagonists for treatment of depression. Pharmaceuticals, 2013, 6(4), 480-499.
[http://dx.doi.org/10.3390/ph6040480] [PMID: 24276119]

Lorigooini, Z.; Nasiri, B.S.; Balali-Dehkordi, S.; Ebrahimi, L.; Bijad, E.; Rahimi-Madiseh, M.; Amini-Khoei, H. Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress. Heliyon, 2020, 6(9), e04833.
[http://dx.doi.org/10.1016/j.heliyon.2020.e04833] [PMID: 32944669]